4.6 Article

A new label-free and turn-on fluorescence probe for hydrogen peroxide and glucose detection based on DNA-silver nanoclusters

Journal

ANALYTICAL METHODS
Volume 7, Issue 19, Pages 7989-7994

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ay01546d

Keywords

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Funding

  1. National Natural Science Foundation of China [21275045]
  2. Hunan Provincial Natural Science Foundation of China [12JJ1004]
  3. [NCET-11-0121]

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We have developed a reliable, sensitive, label-free and turn-on sensor for H2O2 and glucose based on the cleavage of ssDNA by cOH and the fluorescence enhancement effect when guanine-rich (G-rich) DNA sequences are in proximity to DNA-silver nanoclusters (DNA-Ag NCs). In addition, we have also proved that cOH is indeed produced in the sensing system by adding antioxidants.

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