Article
Dentistry, Oral Surgery & Medicine
Y. Kurushima, P. M. Wells, R. C. E. Bowyer, N. Zoheir, S. Doran, J. P. Richardson, D. D. Sprockett, D. A. Relman, C. J. Steves, L. Nibali
Summary: Limited evidence is available on how host genetic variants affect microbiota composition. This study examines the associations between candidate host genetic variants and microbial composition in saliva and gut. The findings suggest that certain genetic variants are associated with microbial diversity and composition, and periodontal status may drive variations in the microbiota.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Medicine, General & Internal
Ana Maria Ramirez-Pena, Arturo Sanchez-Perez, Matilde Campos-Aranda, Francisco Javier Hidalgo-Tallon
Summary: This study assessed the effectiveness of ozone therapy as an adjunct to mechanical therapy in periodontitis patients. The results showed that ozone treatment significantly reduced the gingival index, improved clinical attachment, reduced mobility, and showed significant differences in subgingival flora. This suggests that ozone therapy is effective and well tolerated in cases of generalized chronic periodontitis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Neurosciences
Mhd Ammar Kouki, Anna Barlach Pritchard, Jane Elizabeth Alder, StJohn Crean
Summary: The blood-brain barrier plays a crucial role in protecting the central nervous system from pathogens. There is a link between periodontitis and neuroinflammation as well as pathology similar to Alzheimer's disease, but the mechanism by which bacteria cross the blood-brain barrier and influence neuropathology is still unknown.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Dentistry, Oral Surgery & Medicine
L. Nibali, V Sousa, M. Davrandi, L. S. Liu, D. Spratt, N. Donos
Summary: This study compared the subgingival microbiota of patients with aggressive and chronic periodontitis to healthy individuals and explored their associations with host genetic variants. The results showed limited microbial differences between AgP and CP, challenging the notion that periodontitis is associated with increased subgingival microbial diversity compared with periodontal health. Different microbial abundances were observed between periodontitis patients and healthy individuals, but no associations between genetic variants and microbial findings were detected.
JOURNAL OF DENTISTRY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Flavia R. F. Teles, Michael C. Lynch, Michele Patel, Gay Torresyap, Lynn Martin
Summary: The study found that minocycline microspheres lead to a transient increase in minocycline resistant species in saliva and subgingival plaque samples, with levels decreasing after a period of time. Additionally, resistant isolates of Gemella morbillorum and Eubacterium saburreum significantly increased at 6 months, while antibiotic resistance from Aggregatibacter actinomycetemcomitans, Tannerella forsythia, and Porphyromonas gingivalis was either absent or infrequent.
JOURNAL OF PERIODONTOLOGY
(2021)
Review
Infectious Diseases
Ionut Luchian, Ancuta Goriuc, Maria Alexandra Martu, Mihai Covasa
Summary: Periodontal disease is a common oral infectious and inflammatory disease that can lead to tooth loss. Treatment typically involves mechanical debridement of biofilm and antibiotic use, with clindamycin being a broad-spectrum antibiotic that has shown effectiveness in periodontal therapy. Its bacteriostatic effect and ability to enhance host immune response make it a suitable option for periodontal treatment.
Article
Biochemistry & Molecular Biology
Irfan Ahmad, Safia Irfan, Mohammed Abohashrh, Shadma Wahab, Shahabe Saquib Abullais, Mukhatar Ahmed Javali, Nazima Nisar, Mohammad Mahtab Alam, Saurabh Srivastava, Mohd Saleem, Gaffar Sarwar Zaman, Irshad Ahmad, Nasrin Mansuri
Summary: The ethanolic extract of Nepeta deflersiana showed significant antibacterial effects against red-complex bacteria in chronic periodontitis patients, inhibiting bacterial adhesion and biofilm production. These findings suggest that N. deflersiana extract could be used to develop valuable antibacterial compounds for treating chronic and acute periodontitis, making it an important natural source for future drug development.
Review
Biotechnology & Applied Microbiology
Fazlurrahman Khan, Geum-Jae Jeong, Nazia Tabassum, Akanksha Mishra, Young-Mog Kim
Summary: This review examines the change of filamentous morphology in bacteria under environmental stress and its underlying mechanisms. Filamentous morphology plays a significant role in bacterial infection, biofilm formation, and antimicrobial resistance. Understanding these mechanisms can aid in drug development and reduce bacterial virulence.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Review
Dentistry, Oral Surgery & Medicine
P. D. Veith, M. D. Glew, D. G. Gorasia, E. Cascales, E. C. Reynolds
Summary: Bacteria in severe periodontitis utilize the T9SS system to release virulence factors that dysregulate the host immune response, leading to chronic inflammatory destruction of tooth supporting tissues. The molecular structure and secretion mechanism of T9SS are crucial for understanding this process.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Microbiology
Lucila Garcia, Maria Celeste Molina, Kaylie Allyson Padgett-Pagliai, Pablo S. Torres, Roberto E. Bruna, Eleonora Garcia Vescovi, Claudio F. Gonzalez, Jose Gadea, Maria Rosa Marano
Summary: This study identifies a putative protease in the pathogen of Huanglongbing disease, which plays an important role in the virulence of the bacteria. Further experiments demonstrate that this protease regulates the shape, exopolysaccharide production, and biofilm formation of the bacteria, affecting their growth and disease development in plant cells.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
William Johnston, Bob T. Rosier, Miguel Carda-Dieguez, Michael Paterson, Paddy Watson, Krystyna Piela, Marilyn Goulding, Gordon Ramage, Divyashri Baranyia, Tsute Chen, Nezar N. Al-Hebshi, Alex Mira, Shauna Culshaw
Summary: This study investigated the early and later changes in subgingival biofilm following periodontal treatment and found that hand and ultrasonic instruments had similar impacts on the composition of the subgingival plaque microbiome. There were marked changes in biofilm composition in the early stages after treatment, but limited evidence of these changes being associated with treatment outcomes.
JOURNAL OF PERIODONTOLOGY
(2023)
Review
Microbiology
Jackson Luu, Valerie J. Carabetta
Summary: Protein acetylation is a crucial posttranslational modification in bacteria, regulated by enzymatic and nonenzymatic mechanisms. Research on acetylation in bacterial virulence and biofilm formation is ongoing, shedding light on its impact on host-pathogen interactions and antimicrobial resistance.
Article
Nanoscience & Nanotechnology
Fei Tong, Pei Wang, Ziqiang Chen, Yifan Liu, Lianguo Wang, Jun Guo, Zhihua Li, Hu Cai, Junchao Wei
Summary: In this study, Fe3O4 magnetic nanoparticles loading minocycline (FPM NPs) were constructed to physically penetrate and effectively eliminate periodontal biofilm. The results showed that FPM NPs had anti-biofilm activity both in vitro and in vivo, and possessed good biocompatibility. In rat models, FPM NPs improved periodontal tissue inflammation. This study provides experimental support for the clinical application of magnetic-targeted nanoparticles.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
C. Zhang, Z. Yang, B. Hou
Summary: The study aimed to characterize the bacterial community in extraradicular biofilm and periradicular lesions associated with persistent apical periodontitis. Different bacterial populations were found in these regions, with several genera and species significantly associated with the formation of extraradicular biofilms.
INTERNATIONAL ENDODONTIC JOURNAL
(2021)
Article
Biology
Marwan El Mobadder, Samir Nammour, Melanie Namour, Amaury Namour, Kinga Grzech-Lesniak
Summary: The successful treatment of periodontitis depends on the effective elimination of periodontopathogens during non-surgical and surgical mechanical debridement. This retrospective study found that irrigation with 3% hydrogen peroxide and irradiation with a 980 nm diode laser after scaling and root planing (SRP) can enhance disinfection of periodontal pockets > 5 mm.
Article
Biochemistry & Molecular Biology
Yasuo Yoshida, Mitsunari Sato, Keiji Nagano, Yoshiaki Hasegawa, Takashi Okamoto, Fuminobu Yoshimura
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2015)
Article
Dentistry, Oral Surgery & Medicine
J. A. Hutcherson, J. Bagaitkar, K. Nagano, F. Yoshimura, H. Wang, D. A. Scott
MOLECULAR ORAL MICROBIOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Yasuo Yoshida, Mitsunari Sato, Yuichiro Kezuka, Yoshiaki Hasegawa, Keiji Nagano, Jun Takebe, Fuminobu Yoshimura
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2016)
Article
Dentistry, Oral Surgery & Medicine
Y. Hasegawa, Y. Iijima, K. Persson, K. Nagano, Y. Yoshida, R. J. Lamont, T. Kikuchi, A. Mitani, F. Yoshimura
JOURNAL OF DENTAL RESEARCH
(2016)
Article
Immunology
Rangsini Mahanonda, Chantrakorn Champaiboon, Keskanya Subbalekha, Noppadol Sa-Ard-Iam, Warattaya Rattanathammatada, Saranya Thawanaphong, Pimprapa Rerkyen, Fuminobu Yoshimura, Keiji Nagano, Niklaus P. Lang, Sathit Pichyangkul
JOURNAL OF IMMUNOLOGY
(2016)
Article
Microbiology
Mitsunari Sato, Yasuo Yoshida, Keiji Nagano, Yoshiaki Hasegawa, Jun Takebe, Fuminobu Yoshimura
FRONTIERS IN MICROBIOLOGY
(2016)
Article
Dentistry, Oral Surgery & Medicine
Masafumi Tomino, Keiji Nagano, Tatsuhide Hayashi, Kenjiro Kuroki, Tatsushi Kawai
JOURNAL OF ORAL SCIENCE
(2016)
Article
Immunology
Keiji Nagano, Yoshiaki Hasegawa, Yasuo Yoshida, Fuminobu Yoshimura
MICROBIAL PATHOGENESIS
(2017)
Article
Multidisciplinary Sciences
Keiji Nagano, Yoshiaki Hasegawa, Yasuo Yoshida, Fuminobu Yoshimura
Article
Immunology
Yoshio Kondo, Keiko Sato, Keiji Nagano, Miyuki Nishiguchi, Tomonori Hoshino, Taku Fujiwara, Koji Nakayama
MICROBIOLOGY AND IMMUNOLOGY
(2018)
Article
Multidisciplinary Sciences
Ryota Ikai, Yoshiaki Hasegawa, Masashi Izumigawa, Keiji Nagano, Yasuo Yoshida, Noriyuki Kitai, Richard J. Lamont, Fuminobu Yoshimura, Yukitaka Murakami
Article
Multidisciplinary Sciences
Keiji Nagano, Yoshiaki Hasegawa, Yura Iijima, Takeshi Kikuchi, Akio Mitani
Article
Oncology
Maiko Shimosato, Keita Asai, Naosuke Yokomichi, Keiji Nagano, Naoki Sakane
Summary: The study found that patient-reported dry mouth is not a reliable indicator for assessing oral dryness in terminally ill cancer patients.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Multidisciplinary Sciences
Kotaro Sakae, Keiji Nagano, Miyuna Furuhashi, Yoshiaki Hasegawa
Summary: In this study, the genotypes of 74 strains of Porphyromonas gingivalis were analyzed. It was found that the mfa1 genotype could be classified into two main types, 53 and 70, with subtype 70 further divided into 70A and 70B. The mfa5 gene showed five distinct genotypes (A to E), with genotype A further divided into subtypes A1 and A2. The study also revealed homology in protein structure among Mfa1 to Mfa4, and the presence of a von Willebrand factor domain only in genotypes A to C.
Article
Multidisciplinary Sciences
Tadaharu Yokogawa, Keiji Nagano, Mari Fujita, Hiroshi Miyakawa, Masahiro Iijima
Summary: Researchers discovered a mutant strain derived from Trepoenema denticola with a mutation on the chromosome, exhibiting different characteristics compared to the original strain. The mutant strain grew denser, formed colonies on agar medium, but had decreased motility and adhesion. This mutant strain could be useful for studying the genetic background responsible for the physiological and pathogenic characteristics of T. denticola.