Article
Cardiac & Cardiovascular Systems
Jeremy Bernard, Lionel Tastet, Romain Capoulade, Mylene Shen, Marine Clisson, Ezequiel Guzzetti, Eric Larose, Marie Arsenault, Elisabeth Bedard, Nancy Cote, Marie-Annick Clavel, Philippe Pibarot
Summary: LV asymmetric remodeling (LVAR) is present in approximately 20% of patients with mild or moderate AS, and is mainly associated with older age, reduced LV longitudinal systolic function, and elevated Nt-proBNP levels. This adverse LV remodeling feature is significantly linked to increased risk of major adverse cardiac events and death, highlighting the importance of closer clinical and echocardiographic monitoring for patients with LVAR.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jin Kyung Oh, Sun Hack Lee, Seung-Ah Lee, Do-Yoon Kang, Sahmin Lee, Ho Jin Kim, Jung-Min Ahn, Joon Bum Kim, Duk-Woo Park, Jong-Min Song, Suk Jung Choo, Duk-Hyun Kang, Jae-Kwan Song, Seung-Jung Park, Dae-Hee Kim
Summary: The degree of LVMi regression is an independent predictor of postoperative outcomes after TAVR in patients with severe AS who received successful TAVR without significant PVR.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Federico Fortuni, Steele C. Butcher, Frank van der Kley, Rodolfo P. Lustosa, Ioannis Karalis, Arend de Weger, Silvia G. Priori, Pieter van der Bijl, Jeroen J. Bax, Victoria Delgado, Nina Ajmone Marsan
Summary: A novel method to assess LV function, LVMW, was developed and found to have independent associations with heart failure symptoms in severe AS patients. LV global work index and global constructive work showed particular significance in predicting heart failure symptoms.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2021)
Article
Cardiac & Cardiovascular Systems
Jan Stassen, See Hooi Ewe, Kensuke Hirasawa, Steele C. Butcher, Gurpreet K. Singh, Mohammed R. Amanullah, Kenny Y. K. Sin, Zee P. Ding, Stephan M. Pio, Nicholas W. S. Chew, Ching-Hui Sia, William K. F. Kong, Kian Keong Poh, David J. Cohen, Philippe Genereux, Martin B. Leon, Nina Ajmone Marsan, Victoria Delgado, Jeroen J. Bax
Summary: This study evaluated the association between different left ventricular remodelling patterns and outcomes in patients with moderate aortic stenosis. The results showed that patients with concentric hypertrophy and eccentric hypertrophy had higher mortality rates and were more likely to experience death or aortic valve replacement.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Medicine, General & Internal
Aleksandra Budkiewicz, Michal A. Surdacki, Aleksandra Gamrat, Katarzyna Trojanowicz, Andrzej Surdacki, Bernadeta Chyrchel
Summary: Although traditional ECG-LVH criteria have some association with echocardiographic LVH, they show distinct relationships with stenosis severity in aortic stenosis. Among these criteria, the Cornell voltage criterion has a moderate diagnostic superiority in identifying anatomic LVH.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Steele C. Butcher, Stephan M. Pio, William K. F. Kong, Gurpreet K. Singh, Arnold C. T. Ng, Rebecca Perry, Ching-Hui Sia, Kian Keong Poh, Ana G. Almeida, Ariana Gonzalez, Mylene Shen, Tiong Cheng Yeo, Miriam Shanks, Bogdan A. Popescu, Laura Galian Gay, Marcin Fijalkowski, Michael Liang, Edgar Tay, Nina Ajmone Marsan, Joseph Selvanayagam, Fausto Pinto, Jose L. Zamorano, Philippe Pibarot, Arturo Evangelista, Jeroen J. Bax, Victoria Delgado
Summary: The study found that LV hypertrophy or remodelling were independently associated with the composite endpoint of AV repair/replacement and all-cause mortality for patients with isolated AS and isolated AR, although not for patients with MAVD.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Ladina Erhart, Thierry Donati, Shehab Anwer, Matthias Schindler, Miriam Gremminger, Melanie Renzulli, Nazar Kuzo, Anna L. Walther, Dominik Zurcher, Sara Hosseini, Matthias Eberhard, Barbara E. Stahli, Felix C. Tanner
Summary: This study investigated the short-term changes of left ventricular twist induced by TAVI and found that pre-TAVI apical peak systolic rotation, twist, and torsion as well as their changes post-TAVI were associated with all-cause mortality at 2 years, providing incremental prognostic value to LVEF and GLS.
Article
Cardiac & Cardiovascular Systems
Jan Stassen, Stephan M. Pio, See Hooi Ewe, Gurpreet K. Singh, Kensuke Hirasawa, Steele C. Butcher, David J. Cohen, Philippe Genereux, Martin B. Leon, Nina Ajmone Marsan, Victoria Delgado, Jeroen J. Bax
Summary: This study found that reduced left ventricular global longitudinal strain is associated with an increased risk of all-cause mortality in patients with moderate aortic stenosis, even if left ventricular ejection fraction is preserved.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2022)
Article
Cardiac & Cardiovascular Systems
Reika Nagata, Masaru Obokata, Miki Matsui, Hiroki Matsui, Yuko Seki, Takamichi Igarashi, Hiroaki Sunaga, Ryo Kawakami, Tomonari Harada, Kazuki Kagami, Hiroshi Saeki, Ken Shirabe, Tatsuya Iso, Hideki Ishii
Summary: In this study, researchers investigated the impact of qualitative and quantitative abnormalities of visceral fat on left ventricular diastolic dysfunction (LVDD). It was found that patients with LVDD had larger visceral fat area, which was correlated with BNP levels, LV mass index, mitral e' velocity, and E/e' ratio.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Hoi W. Wu, Federico Fortuni, Steele C. Butcher, Frank van der Kley, Arend de Weger, Victoria Delgado, J. Wouter Jukema, Jeroen J. Bax, Nina Ajmone Marsan
Summary: This study aimed to evaluate the prognostic value of left ventricular myocardial work (LVMW) indices in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR). The study found that LV global work index (LV GWI) was independently associated with all-cause mortality and had a higher prognostic value compared to conventional and advanced parameters of LV systolic function.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Darijan Ribic, Espen W. Remme, Otto A. Smiseth, Richard J. Massey, Christian H. Eek, John-Peder Escobar Kvitting, Lars Gullestad, Kaspar Broch, Kristoffer Russell
Summary: The non-invasive myocardial work index (MWI) has been validated in patients with aortic stenosis (AS). The accuracy of estimated left ventricular pressure (LVP) curves improved when matching the pressure at aortic valve opening to diastolic cuff pressure, which improved the accuracy of regional MWI assessment.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Yujin Yang, Jung-Min Ahn, Do-Yoon Kang, Euihong Ko, Seonok Kim, Tae Oh Kim, Ju Hyeon Kim, Junghoon Lee, Seung-Ah Lee, Dae-Hee Kim, Ho Jin Kim, Joon Bum Kim, Suk Jung Choo, Seung-Jung Park, Duk-Woo Park
Summary: In patients with severe aortic stenosis undergoing transcatheter aortic valve replacement, electrocardiographic left ventricular hypertrophy (LVH) assessed by Cornell criteria was significantly associated with lower risks of major adverse cardiac or cerebrovascular events (MACCE), all-cause mortality, and cardiovascular mortality.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Biotechnology & Applied Microbiology
Salvatore Cutugno, Tommaso Ingrassia, Vincenzo Nigrelli, Salvatore Pasta
Summary: The left ventricle undergoes remodeling in response to aortic stenosis, and statistical shape analysis can quantitatively visualize geometric and functional patterns in LV changes. Shape modes are positively correlated with LV volume, providing insights into LV impairment. The predictive model built with shape modes shows better performance in predicting adverse events compared to using clinical demographic data alone. This study demonstrates the potential of SSA approaches in detecting complex 3D shape features associated with LV function.
BIOENGINEERING-BASEL
(2021)
Article
Cardiac & Cardiovascular Systems
Nicholas W. S. Chew, Jinghao Nicholas Ngiam, Benjamin Yong-Qiang Tan, Ching-Hui Sia, Wen Ruan, Hui-Wen Sim, William K. F. Kong, Edgar L. W. Tay, Tiong-Cheng Yeo, Kian Keong Poh
Summary: This study investigated the prognostic impact of inadequately low left ventricular mass in patients with significant aortic stenosis, showing that patients with i-lowLVM had improved survival outcomes compared to those with adequate left ventricular mass.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Matthias Koschutnik, Varius Dannenberg, Christian Nitsche, Carolina Dona, Jolanta M. Siller-Matula, Max-Paul Winter, Martin Andreas, Amna Zafar, Philipp E. Bartko, Dietrich Beitzke, Christian Loewe, Stefan Aschauer, Anahit Anvari-Pirsch, Georg Goliasch, Christian Hengstenberg, Andreas A. Kammerlander, Julia Mascherbauer
Summary: In patients undergoing TAVR, right ventricular dysfunction (RVD) as defined by echocardiography was associated with NT-proBNP levels, but failed to accurately predict outcomes. However, right ventricular ejection fraction (RVEF) measured by cardiovascular magnetic resonance (CMR) was independently associated with heart failure hospitalization and death.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Constance Delwarde, Claire Toquet, Pascal Aumond, Amir Hossein Kayvanjoo, Adrien Foucal, Benjamin Le Vely, Manon Baudic, Benjamin Lauzier, Stephanie Blandin, Joelle Veziers, Perrine Paul-Gilloteaux, Simon Lecointe, Estelle Baron, Ilaria Massaiu, Paolo Poggio, Severine Remy, Ignacio Anegon, Herve Le Marec, Laurent Monassier, Jean Jacques Schott, Elvira Mass, Julien Barc, Thierry Le Tourneau, Jean Merot, Romain Capoulade
Summary: This study aimed to identify the main pathophysiological pathways involved in degenerative mitral valve dystrophy (MVD) through multimodality imaging and transcriptomic analysis of a unique knock-in rat model. The study found that extracellular matrix organization, epithelial cell migration, response to mechanical stress, and immune cell contribution are the main signaling pathways leading to MVD.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Adham K. Alkurashi, Jeremy J. Thaden, Jwan A. Naser, Edward A. El-Am, Sorin V. Pislaru, Kevin L. Greason, Sara M. Negrotto, Marie-Annick Clavel, Patricia A. Pellikka, Joseph J. Maleszewski, Vuyisile T. Nkomo
Summary: This study compared aortic valve weight and aortic valve weight/MG ratio in patients with atrial fibrillation (AF) and sinus rhythm (SR), and found that both parameters were significantly higher in male patients with high-gradient AF.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Article
Cardiac & Cardiovascular Systems
Iria Silva, Pierre Yves Turgeon, Jean-Michel Paradis, Jonathan Beaudoin, Kim O'Connor, Julien Ternacle, Alberto Alperi, Vassili Panagides, Jules Mesnier, Caroline Gravel, Marie-Annick Clavel, Francois Dagenais, Eric Dumont, Siamak Mohammadi, Philippe Pibarot, Mathieu Bernier, Josep Rodes-Cabacus, Erwan Salaun
Summary: The use of transcatheter edge-to-edge mitral valve repair (TEER) has significantly increased in symptomatic patients with severe mitral regurgitation (MR) in recent years. Current guidelines recommend TEER as a viable option for patients with primary or chronic secondary severe MR and high or prohibitive surgical risk. However, anatomical and morphological limitations of the mitral valve have initially restricted the use of this mini-invasive technique. The introduction of the latest fourth generation (G4) MitraClip system has overcome these limitations and expanded the applications of TEER.
STRUCTURAL HEART-THE JOURNAL OF THE HEART TEAM
(2023)
Article
Cardiac & Cardiovascular Systems
Michel Pompeu Sa, Xander Jacquemyn, Jef Van den Eynde, Panagiotis Tasoudis, Ozgun Erten, Serge Sicouri, Francisco Yuri Macedo, Tilak Pasala, Ryan Kaple, Alexander Weymann, Arjang Ruhparwar, Marie-Annick Clavel, Philippe Pibarot, Basel Ramlawi
Summary: This study aimed to evaluate the impact of paravalvular leak (PVL) on outcomes after transcatheter aortic valve implantation (TAVI). The findings show that patients with any degree of PVL, even mild, have a higher risk of all-cause mortality, rehospitalization, and cardiovascular mortality following TAVI. These results support the implementation of strategies to prevent any degree of PVL during TAVI.
STRUCTURAL HEART-THE JOURNAL OF THE HEART TEAM
(2023)
Article
Cardiac & Cardiovascular Systems
Michel Pompeu Sa, Xander Jacquemyn, Jef Van den Eynde, Ozgun Erten, Tulio Caldonazo, Torsten Doenst, Mateo Marin-Cuartas, Michael A. Borger, Marie-Annick Clavel, Philippe Pibarot, Roberto Rodriguez, Basel Ramlawi, Scott Goldman
STRUCTURAL HEART-THE JOURNAL OF THE HEART TEAM
(2023)
Article
Cardiac & Cardiovascular Systems
Hao Yu Chen, Christian Dina, Aeron M. Small, Christian M. Shaffer, Rebecca T. Levinson, Anna Helgadottir, Romain Capoulade, Hans Markus Munter, Andreas Martinsson, Benjamin J. Cairns, Linea C. Trudso, Mary Hoekstra, Hannah A. Burr, Thomas W. Marsh, Scott M. Damrauer, Line Dufresne, Solena Le Scouarnec, David Messika-Zeitoun, Dilrini K. Ranatunga, Rachel A. Whitmer, Amelie Bonnefond, Garoar Sveinbjornsson, Ragnar Danielsen, David O. Arnar, Gudmundur Thorgeirsson, Unnur Thorsteinsdottir, Daniel F. Gudbjartsson, Hilma Holm, Jonas Ghouse, Morten Salling Olesen, Alex H. Christensen, Susan Mikkelsen, Rikke Louise Jacobsen, Joseph Dowsett, Ole Birger Vesterage Pedersen, Christian Erikstrup, Sisse R. Ostrowski, Christopher J. O'Donnell, Matthew J. Budoff, Vilmundur Gudnason, Wendy S. Post, Jerome Rotter, Mark Lathrop, Henning Bundgaard, Bengt Johansson, Johan Ljungberg, Ulf Naslund, Thierry Le Tourneau, J. Gustav Smith, Quinn S. Wells, Stefan Soderberg, Kari Stefansson, Jean-Jacques Schott, Daniel J. Rader, Robert Clarke, James C. Engert, George Thanassoulis
Summary: This study conducted a genome-wide meta-analysis and discovered 17 loci associated with calcific aortic stenosis. The integration of functional, expression, and cross-phenotype data revealed the mechanisms of this disease. Dyslipidemia, inflammation, calcification, and adiposity were identified as important factors in the etiology of calcific aortic stenosis.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Olivier Huttin, Nicolas Girerd, Antoine Jobbe-Duval, Anne-Laure Constant Dit Beaufils, Thomas Senage, Laura Filippetti, Caroline Cueff, Kevin Duarte, Antoine Fraix, Nicolas Piriou, Damien Mandry, Nathalie Pace, Solena Le Scouarnec, Romain Capoulade, Matthieu Echivard, Jean Marc Sellal, Marie Marrec, Marine Beaumont, Gabriella Hossu, Jean-Noel Trochu, Nicolas Sadoul, Pierre-Yves Marie, Charles Guenancia, Jean-Jacques Schott, Jean-Christian Roussel, Jean-Michel Serfaty, Christine Selton-Suty, Thierry Le Tourneau
JACC-CARDIOVASCULAR IMAGING
(2023)
Review
Cardiac & Cardiovascular Systems
Constance Delwarde, Romain Capoulade, Jean Merot, Solena Le Scouarnec, Nabila Bouatia-Naji, Mengyao Yu, Olivier Huttin, Christine Selton-Suty, Jean-Marc Sellal, Nicolas Piriou, Jean-Jacques Schott, Christian Dina, Thierry Le Tourneau
Summary: Mitral valve prolapse (MVP) is a common condition affecting 2-3% of the general population, with a complication rate up to 10-15% per year. Complications include mitral regurgitation, heart failure, atrial fibrillation, ventricular arrhythmia, and cardiovascular death. MVP can be syndromic or non-syndromic, and the genetic defects associated with MVP are still being studied. Animal models are used to advance the understanding of MVP genetics and pathophysiology. Genetic counseling is important in managing patients with MVP.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Guillaume Jean, Nils Sofus Borg Mogensen, Marie-Annick Clavel
Summary: The decision of intervention in AS patients with HF depends on the severity of AS and further examination may be required due to discordant measurements. The choice of intervention for severe AS patients with HF can be difficult due to their intermediate-to-high operative risk and should be discussed with the patient. There is no current recommendation for AVR in patients with moderate AS and HFrEF, but ongoing studies are examining its clinical significance.
HEART FAILURE CLINICS
(2023)
Article
Cardiac & Cardiovascular Systems
Jerry Ash, Gurmandeep S. Sandhu, Jose Arriola-Montenegro, Dzhalal Agakishiev, Marie-Annick Clavel, Philippe Pibarot, Sue Duval, Prabhjot S. Nijjar
Summary: This study investigated the usefulness of CT-derived aortic valve areas (AVAs) in determining the severity of aortic stenosis (AS). The results showed that CT-derived AVAs have poor discrimination for AS severity, and using an AVA(CT) <1.2-cm(2) threshold to define severe AS can lead to significant error. However, larger AVA(CT) thresholds improve specificity.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Michel Pompeu Sa, Xander Jacquemyn, Jef van den Eynde, Derek Serna-Gallegos, Danny Chu, Marie-Annick Clavel, Philippe Pibarot, Ibrahim Sultan
Summary: A meta-analysis of reconstructed time-to-event data from randomized controlled trials and propensity-score matched studies showed that, in low-risk patients, surgical aortic valve replacement (SAVR) appeared to be associated with improved survival beyond 2 years compared to transcatheter aortic valve replacement (TAVR).
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Cardiac & Cardiovascular Systems
Andreanne Powers, Marie-Annick Clavel
Summary: This review examines the current clinical value of aortic valve calcification (AVC) in classifying aortic valve stenosis (AS) severity, refining patient's follow-up, and improving outcomes for AS patients. The review also addresses the limitations and important particularities regarding sex, valve phenotype, and ethnicity.
CURRENT CARDIOLOGY REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Jeremy Bernard, Guillaume Jean, David Bienjonetti-Boudreau, Frederic Jacques, Lionel Tastet, Erwan Salaun, Marie-Annick Clavel
Summary: This study aimed to assess the incremental prognostic value of N-terminal-pro-B-type natriuretic peptide (Nt-proBNP) for risk stratification in mixed aortic valve disease (MAVD) patients. The results showed that Nt-proBNP ratio was a powerful predictor of early and long-term mortality, even in patients with both non-severe AS/AR. Therefore, Nt-proBNP can be used as a strong prognostic factor for predicting mortality in this group of patients.
Article
Cardiac & Cardiovascular Systems
Jeremy Bernard, Gabriel Georges, Sebastien Hecht, Philippe Pibarot, Marie-Annick Clavel, Shervin Babaki, Dimitri Kalavrouziotis, Siamak Mohammadi
Summary: This retrospective study evaluated the mid-term safety and echocardiographic performance of the INSPIRIS aortic valve compared to the ME valve. The study found that the INSPIRIS valve had similar clinical outcomes to the ME valve in the short and mid-term, but had better cardiac load at discharge and during follow-up.
INTERDISCIPLINARY CARDIOVASCULAR AND THORACIC SURGERY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Alexandre Altes, Jeremy Bernard, Helene Dumortier, Marlene Dupuis, Oumhani Toubal, Haifa Mahjoub, Jean Tartar, Nancy Cote, Marie-Annick Clavel, Kim O'Connorb, Mathieu Bernierb, Jonathan Beaudoin, Andre Vincentellic, Philippe Pibarot, Sylvestre Marechaux