Osteopontin in Immune-mediated Diseases

Alcoholic Liver Disease: The Gut Microbiome and Liver Cross Talk

(2015) Phillipp Hartmann et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

The osteopontin transgenic mouse is a new model for Sjögren's syndrome

(2015) Sehba Husain-Krautter et al.   CLINICAL IMMUNOLOGY

Osteopontin deficiency affects imiquimod-induced psoriasis-like murine skin inflammation and lymphocyte distribution in skin, draining lymph nodes and spleen

(2015) Denis F. Frenzel et al.   EXPERIMENTAL DERMATOLOGY

Plasma Osteopontin Predicts Inflammatory Bowel Disease Activities

(2015) Shihoko Komine-Aizawa et al.   INTERNATIONAL SURGERY

Osteopontin binding to the alpha 4 integrin requires highest affinity integrin conformation, but is independent of post-translational modifications of osteopontin

(2015) Tommy Hui et al.   MATRIX BIOLOGY

The anti-DNA antibody: origin and impact, dogmas and controversies

(2015) Ole P. Rekvig   Nature Reviews Rheumatology

T follicular regulatory cells in the regulation of B cell responses

(2015) Peter T. Sage et al.   TRENDS IN IMMUNOLOGY

Mechanisms of Autoantibody Production in Systemic Lupus Erythematosus

(2015) Shuhong Han et al.   Frontiers in Immunology

Identification of secreted phosphoprotein 1 gene as a new rheumatoid arthritis susceptibility gene

(2014) Steven Gazal et al.   ANNALS OF THE RHEUMATIC DISEASES

Role of Osteopontin in Systemic Lupus Erythematosus

(2014) Beata Kaleta   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Osteopontin deficiency does not prevent but promotes alcoholic neutrophilic hepatitis in mice

(2014) Raul Lazaro et al.   HEPATOLOGY

Opposite Effects of Interferon Regulatory Factor 1 and Osteopontin on the Apoptosis of Epithelial Cells Induced by TNF-α in Inflammatory Bowel Disease

(2014) Ruihan Tang et al.   INFLAMMATORY BOWEL DISEASES

Thrombin Cleavage of Osteopontin Disrupts a Pro-chemotactic Sequence for Dendritic Cells, Which Is Compensated by the Release of Its Pro-chemotactic C-terminal Fragment

(2014) Zhifei Shao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Osteopontin Expression in Dendritic Cells Amplifies IL-17 Production by CD4+ T Cells in Experimental Autoimmune Encephalomyelitis and in Multiple Sclerosis

(2014) G. Murugaiyan et al.   JOURNAL OF IMMUNOLOGY

A p85α-osteopontin axis couples the receptor ICOS to sustained Bcl-6 expression by follicular helper and regulatory T cells

(2014) Jianmei W Leavenworth et al.   NATURE IMMUNOLOGY

A Novel Cryptic Binding Motif, LRSKSRSFQVSDEQY, in the C-Terminal Fragment of MMP-3/7-Cleaved Osteopontin as a Novel Ligand for α9β1 Integrin Is Involved in the Anti-Type II Collagen Antibody-Induced Arthritis

(2014) Shigeyuki Kon et al.   PLoS One

Osteopontin expression by CD103−dendritic cells drives intestinal inflammation

(2014) Evangelia Kourepini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Osteopontin is an important mediator of alcoholic liver diseaseviahepatic stellate cell activation

(2014) Devanshi Seth   WORLD JOURNAL OF GASTROENTEROLOGY

Milk osteopontin, a nutritional approach to prevent alcohol-induced liver injury

(2013) Xiaodong Ge et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Cooperative Unfolding of Compact Conformations of the Intrinsically Disordered Protein Osteopontin

(2013) Dennis Kurzbach et al.   BIOCHEMISTRY

Serum level of osteopontin as an inflammatory marker does not indicate disease activity or responsiveness to therapeutic treatments in patients with rheumatoid arthritis

(2013) Hye-In Ji et al.   CLINICAL RHEUMATOLOGY

Human and experimental evidence supporting a role for osteopontin in alcoholic hepatitis

(2013) Oriol Morales-Ibanez et al.   HEPATOLOGY

Plasma osteopontin is correlated with bone resorption markers in rheumatoid arthritis patients

(2013) Haruyo Iwadate et al.   International Journal of Rheumatic Diseases

Evaluation of circulating osteopontin levels in an unselected cohort of patients with multiple sclerosis: relevance for biomarker development

(2013) Pia Kivisäkk et al.   Multiple Sclerosis Journal

NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease

(2012) Wing-Kin Syn et al.   GUT

Disease Biomarkers in Multiple Sclerosis

(2012) Violaine K. Harris et al.   Molecular Diagnosis & Therapy

The Osteopontin Level in Liver, Adipose Tissue and Serum Is Correlated with Fibrosis in Patients with Alcoholic Liver Disease

(2012) Stéphanie Patouraux et al.   PLoS One

Cigarette Smoke Induction of Osteopontin (SPP1) Mediates TH17 Inflammation in Human and Experimental Emphysema

(2012) M. Shan et al.   Science Translational Medicine

Safety, tolerability, pharmacokinetics, pharmacodynamics and efficacy of the monoclonal antibody ASK8007 blocking osteopontin in patients with rheumatoid arthritis: a randomised, placebo controlled, proof-of-concept study

(2011) M J H Boumans et al.   ANNALS OF THE RHEUMATIC DISEASES

Role of osteopontin, a multifunctional protein, in allergy and asthma

(2011) S. Konno et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Osteopontin Ablation Attenuates Progression of Colitis in TNBS Model

(2011) Helieh S. Oz et al.   DIGESTIVE DISEASES AND SCIENCES

Osteopontin in macrophage function

(2011) Susan R. Rittling   EXPERT REVIEWS IN MOLECULAR MEDICINE

Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets

(2011) Bin Gao et al.   GASTROENTEROLOGY

Osteopontin, an oxidant stress sensitive cytokine, up-regulates collagen-I via integrin αVβ3 engagement and PI3K/pAkt/NFκB signaling

(2011) Raquel Urtasun et al.   HEPATOLOGY

C-terminal Modification of Osteopontin Inhibits Interaction with the αVβ3-Integrin

(2011) Brian Christensen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aire Controls Mesenchymal Stem Cell-mediated Suppression in Chronic Colitis

(2011) Biju Parekkadan et al.   MOLECULAR THERAPY

Osteopontin, intrinsic tissue regulator of intractable inflammatory diseases

(2011) Toshimitsu Uede   PATHOLOGY INTERNATIONAL

The Role of Osteopontin (OPN/SPP1) Haplotypes in the Susceptibility to Crohn's Disease

(2011) Jürgen Glas et al.   PLoS One

NMR characterization of intramolecular interaction of osteopontin, an intrinsically disordered protein with cryptic integrin-binding motifs

(2010) Yoshiki Yamaguchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Intracellular osteopontin (iOPN) and immunity

(2010) Makoto Inoue et al.   IMMUNOLOGIC RESEARCH

MFG-E8 Attenuates Intestinal Inflammation in Murine Experimental Colitis by Modulating Osteopontin-Dependent  v 3 Integrin Signaling

(2009) Md. M. Aziz et al.   JOURNAL OF IMMUNOLOGY

Receptor crosstalk: reprogramming B cell receptor signalling to an alternate pathway results in expression and secretion of the autoimmunity-associated cytokine, osteopontin

(2009) T. L. Rothstein et al.   JOURNAL OF INTERNAL MEDICINE

Osteopontin attenuation of dextran sulfate sodium-induced colitis in mice

(2009) Andre Paes Batista da Silva et al.   LABORATORY INVESTIGATION

Osteopontin as two-sided mediator of intestinal inflammation

(2008) Katja Heilmann et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE