Review
Hematology
Tze-Fan Chao, Boyoung Joung, Yoshihide Takahashi, Toon Wei Lim, Eue-Keun Choi, Yi-Hsin Chan, Yutao Guo, Charn Sriratanasathavorn, Seil Oh, Ken Okumura, Gregory Y. H. Lip
Summary: The consensus on stroke prevention in atrial fibrillation by the APHRS in 2017 provided clinical guidance for healthcare professionals in the Asia-Pacific region. The updated 2021 focused update highlighted issues such as the AF Better Care pathway, advantages of NOACs for Asians, and the use of oral anticoagulants during the COVID-19 pandemic. While acknowledging gaps and uncertainties in current knowledge of AF, the importance of physician's decision-making in AF management was emphasized.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Critical Care Medicine
Evans R. Fernandez Perez, William D. Travis, David A. Lynch, Kevin K. Brown, Kerri A. Johannson, Moises Selman, Jay H. Ryu, Athol U. Wells, Yuh-Chin Tony Huang, Carlos A. C. Pereira, Mary-Beth Scholand, Ana Villar, Naohiko Inase, Richard B. Evans, Stephen A. Mette, Lindsy Frazer-Green
Summary: The article summarizes evidence-based and consensus-derived guidance for clinicians to improve individual diagnostic decision-making for hypersensitivity pneumonitis (HP) and emphasizes the use of a multidisciplinary assessment approach in HP diagnosis. All evidence was of very low quality, indicating the need for further research on the performance and generalizability of diagnostic tools.
Review
Oncology
Martin C. Tom, Michael T. Milano, Samuel T. Chao, Scott G. Soltys, Jonathan P. S. Knisely, Arjun Sahgal, Seema Nagpal, Simon S. Lo, Siavash Jabbari, Tony J. C. Wang, Manmeet S. Ahluwalia, Marian Simonson, Joshua D. Palmer, Melanie Hayden Gephart, Lia M. Halasz, Amit K. Garg, Veronica L. S. Chiang, Eric L. Chang
Summary: This study provides consensus guidelines for the postoperative management of lower grade gliomas. Close surveillance is appropriate for well-selected grade 2 gliomas, while immediate adjuvant therapy is recommended for high-risk grade 2 and grade 3 gliomas. Radiation and planned chemotherapy are strongly recommended over monotherapy, and specific chemotherapy options are provided based on the mutation status. The recommended radiotherapy doses are also presented for different grades of gliomas.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
R. Scott McClure, Thomas F. Lindsay, Michelle Keir, Jason P. Bayne, Robert F. Berry, Michael W. A. Chu, Jennifer C. -Y. Chung, Francois Dagenais, Robin A. Ducas, Audra Duncan, Gabrielle Horne, Darren Klass, Francois-Pierre Mongeon, Julie Richer, Kenton L. Rommens
Summary: Diseases of the aorta require expertise from multiple specialties, and a collaborative approach is advocated for decision-making and treatment. Regionalization of care ensures a wide range of treatment options and maintains favorable outcomes for high-risk procedures. Understanding best practice care pathways can improve the management of aortic disease.
CANADIAN JOURNAL OF CARDIOLOGY
(2023)
Article
Infectious Diseases
Ariana Saatchi, Jennifer N. Reid, Marcus Povitz, Salimah Z. Shariff, Michael Silverman, Andrew M. Morris, Romina C. Reyes, David M. Patrick, Fawziah Marra
Summary: Antimicrobials are widely prescribed in Canada, with seniors being particularly vulnerable to adverse drug events and antimicrobial resistance. This study in British Columbia (BC) and Ontario (ON) found steady and inappropriate prescribing of antibiotics in outpatient settings for seniors, with 50% of all prescriptions being unnecessary for common infections. The study highlights the need for improvement in prescribing practices to address the issue of antimicrobial overuse in Canadian outpatient settings.
Article
Psychology, Developmental
Leanne Tamm, Allison K. Zoromski, Ellen E. Kneeskern, Meera Patel, Heather M. Lacey, Aaron J. Vaughn, Heather A. Ciesielski, Hannah K. Weadick, Amie W. Duncan
Summary: Middle school youth with autism spectrum disorders (ASD) often struggle academically due to executive functioning (EF) deficits. A new intervention, Achieving Independence and Mastery in School (AIMS), shows promising results in improving EF skills, particularly in organization and materials management. This highlights the potential for intervention development to enhance academic EF skills in youth with ASD.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2021)
Article
Pharmacology & Pharmacy
Naoyuki Odaguchi, Atsushi Sakima, Seigo Nakada
Summary: The study showed that most hypertensive patients had blood pressure values below 140/90 mmHg, with only a small proportion achieving values below 130/80 mmHg. Obesity appeared to be a contributing factor to insufficient blood pressure control in hypertensive patients in a real-world setting.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2021)
Article
Cardiac & Cardiovascular Systems
Ariel Cohen, Erwan Donal, Victoria Delgado, Mauro Pepi, Teresa Tsang, Bernhard Gerber, Laurie Soulat-Dufour, Gilbert Habib, Patrizio Lancellotti, Arturo Evangelista, Bibiana Cujec, Nowell Fine, Maria Joao Andrade, Muriel Sprynger, Marc Dweck, Thor Edvardsen, Bogdan A. Popescu
Summary: Cardioaortic embolism to the brain is a common cause of ischemic strokes, often referred to as 'cardioembolic stroke'. The diagnosis of cardioembolic stroke remains challenging, with up to 30% of cases classified as cryptogenic strokes. Various cardiac imaging modalities, such as TTE, TOE, CT, and MRI, play an important role in identifying potential sources of embolism, with contrast TTE/TOE showing high accuracy in detecting specific conditions.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2021)
Review
Biochemistry & Molecular Biology
Alberto Palazzuoli, Matteo Beltrami, Peter A. McCullough
Summary: The relationship between heart failure (HF) and COVID-19 is still uncertain. Some reports suggest decreased HF events during pandemics, while others show higher mortality and sudden death in HF patients. The infection may directly cause myocardial damage and certain medications used for COVID-19 may have negative effects on the cardiovascular system. HF patients require tailored management to prevent complications and fluid retention. This review discusses the complex interplay between COVID-19 and HF, the evolving trend of infection with related cardiovascular events, and specific management strategies.
Article
Radiology, Nuclear Medicine & Medical Imaging
Mini Pakkal, Carole Dennie, Cameron J. Hague, Daria Manos, Elsie T. Nguyen, Yeli Pi, Carolina Souza, Jana Taylor, Brett F. Memauri
Summary: This article introduces the core and advanced content of the cardiac imaging curriculum developed by the Canadian Society of Thoracic Radiology, aiming to enhance the educational experience of residents and fellows, and provide an educational framework for clinical supervisors and program directors.
ACADEMIC RADIOLOGY
(2023)
Review
Otorhinolaryngology
Danielle N. Margalit, Assuntina G. Sacco, Jay S. Cooper, John A. Ridge, Richard L. Bakst, Beth M. Beadle, Jonathan J. Beitler, Steven S. Chang, Allen M. Chen, Tom J. Galloway, Shlomo A. Koyfman, Carol Mita, Jared R. Robbins, C. Jillian Tsai, Minh T. Truong, Sue S. Yom, Farzan Siddiqui
Summary: This systematic review evaluated the impact of postoperative therapy for resected squamous cell carcinoma of the head and neck on oncologic and non-oncologic outcomes. Prospective clinical studies and systematic reviews provided evidence for consensus statements regarding the appropriate use of postoperative therapy. Further research is needed in domains where consensus could not be achieved.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Clinical Neurology
Hiba Naveed, Naveed Akhtar, Salman Al-Jerdi, Ryan Ty Uy, Sujatha Joseph, Deborah Morgan, Blessy Babu, Shobana Shanthi, Ashfaq Shuaib
Summary: This study based on the Qatar Stroke Database reveals that despite the existence of guidelines, a significant number of TIA and stroke patients are being discharged from the hospital with inappropriate antiplatelet treatment.
FRONTIERS IN NEUROLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Florian von Knobelsdorff-Brenkenhoff, Jeanette Schulz-Menger
Summary: This study summarizes the current evidence and role of cardiovascular magnetic resonance (CMR) in the guidelines of the European Society of Cardiology (ESC). It found that 70.4% of the guidelines contain relevant text passages regarding CMR, with 92 specific recommendations regarding its use. Most of the recommendations have level C evidence and cover various aspects of CMR applications.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2023)
Article
Multidisciplinary Sciences
Timothy Coyle, Samuel M. John
Summary: The study evaluated the use of albumin in a community hospital setting over a 6-month period, finding that the most common indications for albumin administration were sepsis or septic shock, hypotension or hypovolemia, and intradialytic hypotension. Critical care, nephrology, and surgery were the departments most frequently ordering albumin.
Review
Cardiac & Cardiovascular Systems
Bartosz Hudzik, Aleksandra Blachut, Maciej Lesiak, Jacek Kubica, Wojciech Wojakowski, Mariusz Gasior
Summary: This review summarizes ESC guidelines on dual antiplatelet therapy post-PCI, compiling recommendations into one document and creating an algorithm for quick navigation on DAPT selection based on ischemic and bleeding risks. The review also includes important studies, meta-analyses, and practical pointers for managing bleeding complications and urgent surgery in DAPT patients.
KARDIOLOGIA POLSKA
(2022)
Review
Cardiac & Cardiovascular Systems
Motasem Alyamani, Sandra Campbell, Eliano Navarese, Robert C. Welsh, Kevin R. Bainey
Summary: Meta-analysis of studies suggests that targeted intracoronary thrombolytic therapy as an adjunct to primary percutaneous coronary intervention may be safe and potentially effective in improving complete ST-segment resolution and reducing in-hospital major adverse cardiac events, with no significant difference in bleeding outcomes. Further validation in larger randomized controlled trials is needed.
CANADIAN JOURNAL OF CARDIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Robert C. Welsh, Warren J. Cantor, Mouhieddin Traboulsi, Erick Schampaert, Michel Le May
Summary: The management of acute ST-elevation myocardial infarction has shifted from observation and reactive treatment to accelerated reperfusion and evidence-based treatment. International research has highlighted the importance of timely reperfusion therapy and different approaches such as fibrinolysis and primary PCI. Clinician leaders have developed comprehensive care systems to optimize patient outcomes.
CANADIAN JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Bradley Sarak, Anamaria Savu, Padma Kaul, Finlay A. McAlister, Robert C. Welsh, Andrew T. Yan, Shaun G. Goodman
Summary: Within 90 days of incident ACS, approximately 80% of patients did not meet guideline-recommended lipid thresholds and more than one-third would potentially be eligible for PCSK9i treatment.
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2021)
Article
Cardiac & Cardiovascular Systems
Razi Khan, Padma Kaul, Sunjidatul Islam, Anamaria Savu, Akshay Bagai, Sean van Diepen, Kevin R. Bainey, Robert C. Welsh, Shaun G. Goodman
Summary: Non-revascularized MI patients who did not undergo angiography had low adherence rates to guideline-based medications and higher long-term risk, indicating potential areas for treatment improvement to enhance prognosis in non-invasively managed MI patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Pishoy Gouda, Chinthanie Ramasundarahettige, Sonia Anand, Eva Muhlhoffer, Scott Berkowitz, Keith Aa Fox, John Eikelboom, Robert Welsh
Summary: This study assessed clinical factors predicting the presence of PAD in patients with CAD, revealing that routinely available clinical information has limited utility in identifying patients with CAD and concomitant PAD.
Article
Cardiac & Cardiovascular Systems
Payam Dehghani, Warren J. Cantor, Jia Wang, David A. Wood, Robert F. Storey, Roxana Mehran, Kevin R. Bainey, Robert C. Welsh, Josep Rodes-Cabau, Sunil Rao, Shahar Lavi, James L. Velianou, Madhu K. Natarajan, Antonios Ziakas, Vincenzo Guiducci, Francisco Fernandez-Aviles, John A. Cairns, Shamir R. Mehta
Summary: Complete revascularization with multivessel PCI consistently reduces major cardiovascular events in patients with ST-segment-elevation myocardial infarction and multivessel disease, whether they are undergoing an initial pharmacoinvasive strategy or primary PCI.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Robert C. Welsh, Jay S. Shavadia, Yinggan Zheng, Benjamin D. Tyrrell, Raymond Leung, Kevin R. Bainey
Summary: This study compared outcomes in STEMI patients who continued on clopidogrel versus those who switched to ticagrelor after fibrinolysis treatment. The results showed that switching to ticagrelor was associated with a lower risk of recurrent ischemic events at 1-year compared to continuing clopidogrel, with no significant differences in major bleeding or intracranial hemorrhage. These findings support the idea of switching pharmacoinvasive treated STEMI patients to ticagrelor in clinical practice.
CLINICAL CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Robert C. Welsh, Payam Dehghani, Renato Lopes, Daniel M. Wojdyla, Ronald Aronson, Christopher B. Granger, Stephan Windecker, Amit N. Vora, Dragos Vinereanu, Sigrun Halvorsen, Alexander Parkhomenko, Roxana Mehran, John H. Alexander, Shaun Goodman
Summary: In patients with atrial fibrillation and acute coronary syndrome and/or percutaneous coronary intervention, prior oral anticoagulant use was associated with a reduced risk of ischemic events but not increased bleeding. The results of the AUGUSTUS trial can be applied to patients regardless of their prior anticoagulant treatment status.
Article
Cardiac & Cardiovascular Systems
Pishoy Gouda, Douglas C. Dover, Anamaria Savu, Kevin Bainey, Shaun G. Goodman, Robert Welsh, Padma Kaul, Roopinder Kaur Sandhu
Summary: Patients with a history of nonvalvular atrial fibrillation (NVAF) have worse short-term outcomes in acute coronary syndrome (ACS), but the long-term prognosis is unclear. This study found that patients with previous NVAF had a higher risk of adverse outcomes, particularly in STEMI and NSTEMI, compared to those without NVAF.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Robert C. Welsh, Robert Kay, Kevin R. Bainey
Article
Cardiac & Cardiovascular Systems
Keith A. A. Fox, Victor Aboyans, E. Sebastian Debus, Uwe Zeymer, Martin R. Cowie, Manesh Patel, Robert C. Welsh, Jackie Bosch, Alain Gay, Kai Vogtlaender, Sonia S. Anand
Summary: The study investigated the characteristics and outcomes of patients with coronary artery disease, peripheral artery disease, or both, initiating dual pathway inhibition with rivaroxaban plus aspirin in clinical practice, finding that high-risk vascular patients prioritize DPI with outcomes consistent with the COMPASS trial, suggesting a favorable net clinical benefit.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2022)
Review
Obstetrics & Gynecology
Dalal A. Tawati, Wee-Shian Chan
Summary: The frequency of posterior reversible encephalopathy syndrome (PRES) in severe preeclampsia or eclampsia was investigated. Neuroimaging commonly revealed PRES in women with eclampsia/severe preeclampsia, suggesting the need for re-evaluation of the role of neuroimaging in these conditions.
OBSTETRIC MEDICINE
(2023)
Article
Ethics
Rabia Kashur, Justin Ezekowitz, Shane Kimber, Robert C. Welsh
Summary: The study compared patients' understanding and attitudes towards verbal and written consents in acute myocardial infarction trials. The results showed that patients with verbal assent had similar understanding to those with written consent.
BMC MEDICAL ETHICS
(2023)
Article
Medical Laboratory Technology
Vilte E. Barakauskas, Mary Kathryn Bohn, Emma Branch, Amelie Boutin, Arianne Albert, Sabrina Luke, Michelle Dittrick, Victoria Higgins, Khosrow Adeli, Hilary Vallance, Benjamin Jung, Kent Dooley, Leanne Dahlgren-Scott, Wee-Shian Chan
Summary: This study retrospectively derived pregnancy RIs using LIS data linked to provincial perinatal registry data. Analyses of CBC data during pregnancy revealed that trimester-specific bins may not be suitable for some parameters, supporting the use of gestational age or empirically derived bins for defining CBC normal values during pregnancy.
CLINICAL CHEMISTRY
(2023)
Review
Hematology
Robert A. Ariens, Beverley J. Hunt, Ejaife O. Agbani, Josefin Ahnstrom, Robert Ahrends, Raza Alikhan, Alice Assinger, Zsuzsa Bagoly, Alessandra Balduini, Elena Barbon, Christopher D. Barrett, Paul Batty, Jorge David Aivazoglou Carneiro, Wee Shian Chan, Moniek de Maat, Kerstin de Wit, Cecile Denis, Martin H. Ellis, Renee Eslick, Hongxia Fu, Catherine P. M. Hayward, Benoit Ho-Tin-Noe, Frederikus A. Klok, Riten Kumar, Karin Leiderman, Rustem I. Litvinov, Nigel Mackman, Zoe McQuilten, Matthew D. Neal, William A. E. Parker, Roger J. S. Preston, Julie Rayes, Alireza R. Rezaie, Lara N. Roberts, Bianca Rocca, Susan Shapiro, Deborah M. Siegal, Lirlandia P. Sousa, Katsue Suzuki-Inoue, Tahira Zafar, Jiaxi Zhou
Summary: The ISTH London 2022 Congress is the first face-to-face conference since the COVID-19 pandemic. The conference proceedings are also streamed online for those unable to attend. The scientific program covers a wide range of topics and the Illustrated Review article is a revolutionary way to communicate research.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2022)