Article
Medicine, General & Internal
Andrew P. Sindone, Carmine De Pasquale, John Amerena, Christine Burdeniuk, Alicia Chan, Andrew Coats, David L. Hare, Peter Macdonald, Aaron Sverdlov, John J. Atherton
Summary: This article provides new recommendations for the pharmacological management of heart failure based on studies reported in Australia. The use of SGLT2 inhibitors and mineralocorticoid receptor antagonists are recommended in different patient populations, and there are additional therapies that provide benefits in persistent heart failure with reduced left ventricular ejection fraction.
MEDICAL JOURNAL OF AUSTRALIA
(2022)
Article
Immunology
Christine Nguyen-Buckley, Dmitri S. Bezinover, Pooja Bhangui, Gianni Biancofiore, Annabel Blasi, Ryan Chadha, Aliaksei Pustavoitau, Antoni Sabate, Fuat H. Saner, Gebhard Wagener, Christopher L. Wray, Jeron Zerillo, Terry Ling Te Pan
Summary: This study aims to establish consensus on the essential skills, knowledge, and attributes that a liver transplant anesthesiologist should possess. Through the modified Delphi methodology, key competencies were identified in preoperative management, intraoperative management, crisis management, and postoperative care.
Article
Cardiac & Cardiovascular Systems
Lauren E. Parker, Andrew P. Landstrom
Summary: Congenital heart disease, particularly left-sided obstructive lesions, are common in newborns. The search for disease-causing variants has found both rare and common variants in genes associated with LSOLs, but only a small proportion of patients can currently be explained. The combinatorial effects of common and rare variants are emerging as a cause of LSOLs.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Aarti Asnani, Javid J. Moslehi, Bishow B. Adhikari, Alan H. Baik, Andreas M. Beyer, Rudolf A. de Boer, Alessandra Ghigo, Isabella M. Grumbach, Salvia Jain, Han Zhu
Summary: Cardio-oncology has emerged as a new field focusing on the cardiovascular toxicity associated with cancer therapy, aiming to understand the underlying molecular mechanisms to improve patient outcomes. The intersection of cancer and heart disease has led to the discovery of genetic and environmental risk factors predisposing to both conditions. Preclinical models serve as the foundation for mechanistic studies in the development of biomarkers and cardioprotective therapies.
CIRCULATION RESEARCH
(2021)
Article
Medicine, General & Internal
Tracey Thompson, Ashley Phimister, Alexander Raskin
Summary: Heart failure occurs as a result of pressure or volume overload in congenital and acquired heart diseases, and its treatment varies depending on the underlying cause.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Review
Cardiac & Cardiovascular Systems
Adam L. Dorfman, Tal Geva, Margaret M. Samyn, Gerald Greil, Rajesh Krishnamurthy, Daniel Messroghli, Pierluigi Festa, Aurelio Secinaro, Brian Soriano, Andrew Taylor, Michael D. Taylor, Rene M. Botnar, Wyman W. Lai
Summary: This article provides guidelines for the performance and reporting of CMR in the pediatric population for non-structural heart diseases. It discusses disease-specific protocols, limitations and pitfalls, and newer techniques under development. The guidelines aim to optimize the CMR examination in infants and children compared to adults.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2022)
Article
Veterinary Sciences
Marnin A. Forman, Joerg M. Steiner, P. Jane Armstrong, Melinda S. Camus, Lorrie Gaschen, Steve L. Hill, Caroline S. Mansfield, Katja Steiger
Summary: Diagnosis and management of pancreatitis in cats present many challenges and require further research support. Diagnosis of pancreatitis in cats is more focused than treatment, with acute pancreatitis easier to diagnose compared to chronic pancreatitis.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Joerg Herrmann, Daniel Lenihan, Saro Armenian, Ana Barac, Anne Blaes, Daniela Cardinale, Joseph Carver, Susan Dent, Bonnie Ky, Alexander R. Lyon, Teresa Lopez-Fernandez, Michael G. Fradley, Sarju Ganatra, Giuseppe Curigliano, Joshua D. Mitchell, Giorgio Minotti, Ninian N. Lang, Jennifer E. Liu, Tomas G. Neilan, Anju Nohria, Rupal O'Quinn, Iskra Pusic, Charles Porter, Kerry L. Reynolds, Kathryn J. Ruddy, Paaladinesh Thavendiranathan, Peter Valent
Summary: The discipline of Cardio-Oncology focuses on the cardiovascular care of cancer patients and the management of cardiovascular complications of cancer therapies. This document provides consensus definitions for common cardiovascular toxicities and aims to improve communication and outcomes in clinical practice and research.
EUROPEAN HEART JOURNAL
(2022)
Review
Medicine, General & Internal
Ratko Lasica, Lazar Djukanovic, Lidija Savic, Gordana Krljanac, Marija Zdravkovic, Marko Ristic, Andjelka Lasica, Milika Asanin, Arsen Ristic
Summary: The incidence of myocarditis is increasing due to improved diagnostic criteria and methods. Immune-mediated processes and the use of immune checkpoint inhibitors have added complexity to the etiology. Cardiac magnetic resonance imaging is the preferred non-invasive diagnostic method, while endomyocardial biopsy is reserved for severe cases. Treatment involves conservative management of heart failure, immunomodulatory and immunosuppressive therapy, mechanical circulatory support, and heart transplantation.
Article
Transplantation
Stefan Kohl, Fred E. Avni, Peter Boor, Valentina Capone, William L. Clapp, Diego De Palma, Tess Harris, Laurence Heidet, Alina C. Hilger, Helen Liapis, Marc Lilien, Gianantonio Manzoni, Giovanni Montini, Susanna Negrisolo, Marie-Jeanne Pierrat, Ann Raes, Heiko Reutter, Michiel F. Schreuder, Stefanie Weber, Paul J. D. Winyard, Adrian S. Woolf, Franz Schaefer, Max C. Liebau
Summary: Kidney dysplasia is a common cause of chronic kidney failure in children, but the lack of clear clinical parameters leads to imprecise communication among healthcare professionals and patients. Suggestions based on structured literature search have been made to improve disease understanding and treatment.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Cardiac & Cardiovascular Systems
Petar M. Seferovic, Hiroyuki Tsutsui, Dennis M. McNamara, Arsen D. Ristic, Cristina Basso, Biykem Bozkurt, Leslie T. Cooper, Gerasimos Filippatos, Tomomi Ide, Takayuki Inomata, Karin Klingel, Ales Linhart, Alexander R. Lyon, Mandeep R. Mehra, Marija Polovina, Ivan Milinkovic, Kazufumi Nakamura, Stefan D. Anker, Ivana Veljic, Tomohito Ohtani, Takahiro Okumura, Thomas Thum, Carsten Tschope, Giuseppe Rosano, Andrew J. S. Coats, Randall C. Starling
Summary: Endomyocardial biopsy (EMB) is an invasive procedure commonly used for monitoring heart transplant rejection and diagnosing various cardiac disorders. Advances in EMB equipment and techniques have improved diagnostic precision. An expert consensus document provides a comprehensive overview on EMB, covering practical approaches, updated indications, revised surveillance plans, the impact of multimodality imaging, and current global clinical practices.
EUROPEAN JOURNAL OF HEART FAILURE
(2021)
Article
Cardiac & Cardiovascular Systems
Petar M. Seferovic, Hiroyuki Tsutsui, Dennis M. Mcnamara, Arsen D. Ristic, Cristina Basso, Biykem Bozkurt, Leslie T. Cooper, Gerasimos Filippatos, Tomomi Ide, Takayuki Inomata, Karin Klingel, Ales Linhart, Alexander R. Lyon, Mandeep R. Mehra, Marija Polovina, Ivan Milinkovic, Kazufumi Nakamura, Stefan D. Anker, Ivana Veljic, Tomohito Ohtani, Takahiro Okumura, Thomas Thum, Carsten Tschoepe, Giuseppe Rosano, Andrew J. S. Coats, Randall C. Starling
Summary: Endomyocardial biopsy (EMB) is an important diagnostic tool for various cardiac disorders, especially heart transplant rejection. Advances in EMB equipment and techniques have significantly improved diagnostic precision. A recent expert consensus document focuses on practical approaches to EMB, updated indications, surveillance for transplant rejection, impact of multimodality imaging, and global clinical practices.
JOURNAL OF CARDIAC FAILURE
(2021)
Article
Surgery
Islam Omar, Karl Miller, Brijesh Madhok, Bassem Amr, Rishi Singhal, Yitka Graham, Sjaak Pouwels, Mohammad Abu Hilal, Sandeep Aggarwal, Irfan Ahmed, Ali Aminian, Basil Jaser Ammori, Tan Arulampalam, Altaf Awan, Jose Maria Balibrea, Aneel Bhangu, Richard Raymond Brady, Wendy Brown, Manish Chand, Ara Darzi, Talvinder Singh Gill, Ramen Goel, Bussa R. Gopinath, Mark van Berge Henegouwen, Jacques M. Himpens, David Daniel Kerrigan, Misha Luyer, Christian Macutkiewicz, Julio Mayol, Sanjay Purkayastha, Raul Jacobo Rosenthal, Scott Alan Shikora, Peter Kenneth Small, Neil James Smart, Mark A. Taylor, Tehemton E. Udwadia, Tim Underwood, Yirupaiahgari KS. Viswanath, Neil Thomas Welch, Steven D. Wexner, Michael Samuel James Wilson, Des C. Winter, Kamal K. Mahawar
Summary: This study aimed to achieve an expert consensus on important principles of laparoscopic GI surgery. The consensus covered various aspects of laparoscopic surgery and could facilitate training and improve patient outcomes.
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Dana P. McGlothlin, John Granton, Walter Klepetko, Maurice Beghetti, Erika B. Rosenzweig, Paul A. Corris, Evelyn Horn, Manreet K. Kanwar, Karen Mcrae, Antonio Roman, Ryan Tedford, Roberto Badagliacca, Sonja Bartolome, Raymond Benza, Marco Caccamo, Rebecca Cogswell, Celine Dewachter, Laura Donahoe, Elie Fadel, Harrison W. Farber, Jeffrey Feinstein, Veronica Franco, Robert Frantz, Michael Gatzoulis, Choon Hwa (Anne) Goh, Marco Guazzi, Georg Hansmann, Stuart Hastings, Paul M. Heerdt, Anna Hemnes, Antoine Herpain, Chih-Hsin Hsu, Kim Kerr, Nicholas A. Kolaitis, Jasleen Kukreja, Michael Madani, Stuart McCluskey, Michael McCulloch, Bernhard Moser, Manchula Navaratnam, Goran Radegran, Cara Reimer, Laurent Savale, Oksana A. Shlobin, Jana Svetlichnaya, Keith Swetz, Jessica Tashjian, Thenappan Thenappan, Carmine Dario Vizza, Shawn West, Warren Zuckerman, Andreas Zuckermann, Teresa De Marco
Summary: This document is the first international consensus statement on the perioperative management of patients with pulmonary hypertension and right heart failure. It provides recommendations for managing patients with pulmonary hypertension being considered for surgery, including preoperative risk assessment, planning, intra- and postoperative monitoring and management strategies that can improve outcomes.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Review
Endocrinology & Metabolism
Kyu-Sun Lee, Junghyun Noh, Seong-Mi Park, Kyung Mook Choi, Seok-Min Kang, Kyu-Chang Won, Hyun-Jai Cho, Min Kyong Moon
Summary: Diabetes mellitus is a significant risk factor for heart failure, with worse prognosis in diabetic patients. Early diagnosis and proper management of heart failure in diabetic patients are crucial. This review discusses the diagnosis criteria, screening tools, recommended pharmacological therapies, and effects of anti-diabetic medications on heart failure.
DIABETES & METABOLISM JOURNAL
(2023)
Article
Gerontology
Amanda Aguilar da Nova, George Heckman, Lora M. Giangregorio, Mohamed Alarakhia
Summary: The objective of this study was to co-develop an interRAI-based clinical information sharing tool with primary care providers. The tool, called the Patient Falls Risk Report, was found to have good usability and the potential to support patient care. Areas for improvement include providing more detailed and clear information, as well as better support for shared care planning.
CANADIAN JOURNAL ON AGING-REVUE CANADIENNE DU VIEILLISSEMENT
(2023)
Review
Cardiac & Cardiovascular Systems
Pishoy Gouda, Justin Ezekowitz
Summary: The use of electronic medical records has provided new opportunities for cardiovascular research, such as improving quality of care and examining genetic and pharmacological associations. However, further assessment of true clinical utility is needed before fully embracing these opportunities.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Review
Cardiac & Cardiovascular Systems
Eloisa Colin-Ramirez, Nariman Sepehrvand, Sarah Rathwell, Heather Ross, Jorge Escobedo, Peter Macdonald, Richard Troughton, Clara Saldarriaga, Fernando Lanas, Robert Doughty, Finlay A. McAlister, Justin A. Ezekowitz
Summary: This study analyzed data from randomized controlled trials to evaluate the effects of sodium restriction on clinical outcomes in heart failure patients. The results showed that sodium restriction did not reduce the risk of death or hospitalization, but it may improve symptoms and quality of life.
CIRCULATION-HEART FAILURE
(2023)
Article
Physiology
Carmelo J. Mastrandrea, Eric T. Hedge, Andrew D. Robertson, George A. Heckman, Joanne Ho, Federico Granados Unger, Richard L. Hughson
Summary: Prolonged bedrest can cause orthostatic hypotension and intolerance of upright posture. This randomized controlled trial investigated if exercise could mitigate orthostatic intolerance in healthy older adults after 14-day head-down bedrest. The results showed that high-intensity interval exercise did not benefit post-HDBR orthostatic tolerance in older adults, and multiple factors were associated with the reduction in cerebral blood velocity leading to intolerance.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2023)
Article
Ethics
Rabia Kashur, Justin Ezekowitz, Shane Kimber, Robert C. Welsh
Summary: The study compared patients' understanding and attitudes towards verbal and written consents in acute myocardial infarction trials. The results showed that patients with verbal assent had similar understanding to those with written consent.
BMC MEDICAL ETHICS
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Jonathan G. Howlett
CANADIAN JOURNAL OF CARDIOLOGY
(2023)
Article
Emergency Medicine
Fabrice I. Mowbray, George Heckman, John P. Hirdes, Andrew P. Costa, Olivier Beauchet, Patrick Archambault, Debra Eagles, Han Ting Wang, Jeffrey J. Perry, Samir K. Sinha, Micaela Jantzi, Paul Hebert
Summary: The study aimed to evaluate the agreement and discriminative accuracy of three emergency department vulnerability screeners, including the InterRAI ED Screener, ER2, and PRISMA-7. The results showed fair agreement between the screeners and their association with important patient outcomes. The interRAI ED Screener best identified older ED patients at greatest risk, while PRISMA-7 and ER2 were more sensitive instruments.
CANADIAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Letter
Cardiac & Cardiovascular Systems
G. Michael Felker, Rebecca North, Hillary Mulder, W. Schuyler Jones, Kevin J. Anstrom, Mahesh J. Patel, Javed Butler, Justin A. Ezekowitz, Carolyn Lam, Christopher M. O'Connor, Lothar Roessig, Adrian F. Hernandez, Paul W. Armstrong, VICTORIA Study Group
Letter
Cardiac & Cardiovascular Systems
Eloisa Colin-Ramirez, Nariman Sepehrvand, Justin A. Ezekowitz
CIRCULATION-HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Nariman Sepehrvand, Majid Nabipoor, Erik Youngson, Finlay A. Mcalister, Justin A. Ezekowitz
Summary: This study aimed to explore the time to initiation of triple therapy and identify barriers to its use in patients with de novo heart failure with reduced ejection fraction (HFrEF). The results showed that the time to initiation of triple therapy was slow and its utilization rate was low in patients with HFrEF. Patients who received triple therapy had better clinical outcomes compared to those who did not receive it.
JOURNAL OF CARDIAC FAILURE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Justin A. Ezekowitz
CANADIAN JOURNAL OF CARDIOLOGY
(2023)
Article
Gerontology
Melissa Northwood, Nicole Didyk, Sophie Hogeveen, Amanda Nova, Elizabeth Kalles, George Heckman
Summary: This study aimed to remotely assess patients receiving specialized geriatric services using a software-enabled self-report instrument. The research found that the instrument was easy to use for staff and helped in planning care. Most patients urgently required a geriatrician assessment and had cognitive and functional impairments, depressive symptoms, loneliness, daily pain, and distressed caregivers. The implementation considerations include providing ongoing support and facilitating intersectoral collaboration. The self-report instrument enhanced the geriatric assessment process by tracking all immediate and future care needs at the patient and program level.
CANADIAN JOURNAL ON AGING-REVUE CANADIENNE DU VIEILLISSEMENT
(2023)
Article
Public, Environmental & Occupational Health
Melissa Northwood, Elizabeth Kalles, Cathy Harrington, Sophie Hogeveen, George Heckman
Summary: The interRAI COVID-19 Vulnerability Screener (CVS) was developed as a standardized tool to identify and triage older adults at risk during the COVID-19 pandemic. This study evaluated the implementation of the CVS by a community support service organization. Findings showed successful utilization of the CVS in identifying and supporting vulnerable clients, who may have been overlooked otherwise, highlighting the importance of its use in community support services.
HEALTH & SOCIAL CARE IN THE COMMUNITY
(2023)
Article
Primary Health Care
Linda Lee, Aaron Jones, Tejal Patel, Loretta M. Hillier, George A. Heckman, Andrew P. Costa
Summary: This study aimed to describe the prevalence of frailty among patients attending a primary care-based memory clinic and to determine if prevalence rates differ based on the screening tool that is used. The prevalence of frailty was found to be 16% by Fried criteria and 48% by the CFS. The findings suggest that measure selection should be based on the objectives and context in which frailty screening occurs.
Article
Medicine, General & Internal
Akshay Valsaraj, Sunil Vasu Kalmady, Vaibhav Sharma, Matthew Frost, Weijie Sun, Nariman Sepehrvand, Marcus Ong, Cyril Equilbec, Jason R. B. Dyck, Todd Anderson, Harald Becher, Sarah Weeks, Jasper Tromp, Chung-Lieh Hung, Justin A. Ezekowitz, Padma Kaul
Summary: In this study, machine learning models based on echocardiography were developed to predict all-cause mortality. The models showed high accuracy and correlated with patients' quality of life. These models can be used for automated risk stratification in clinical settings.