Review
Food Science & Technology
Abigail Garcia-Castro, Alma Delia Roman-Gutierrez, Araceli Castaneda-Ovando, Raquel Carino-Cortes, Otilio Arturo Acevedo-Sandoval, Patricia Lopez-Perea, Fabiola Araceli Guzman-Ortiz
Summary: Cereals contain bioactive compounds that can inhibit the angiotensin-converting enzyme, lower blood pressure, and potentially reduce the virulence of COVID-19.
Review
Chemistry, Medicinal
Naoyuki Otani, Takashi Tomoe, Atsuhiko Kawabe, Takushi Sugiyama, Yasuto Horie, Hiroyuki Sugimura, Takanori Yasu, Takaaki Nakamoto
Summary: Pulmonary arterial hypertension (PAH) is a disease that leads to right-sided heart failure and death. Basic research has identified the decrease in levels of endogenous vasodilators and increase in levels of endogenous vasoconstrictors in PAH patients, leading to the development of therapeutic agents. Current treatments target specific pathways to improve prognosis.
Review
Pharmacology & Pharmacy
Theodoros Christophides, Alberto Somaschini, Andrea Demarchi, Stefano Cornara, Maria Androulaki, Emmanuel Androulakis
Summary: Essential hypertension is a crucial factor in global cardiovascular diseases and mortality, highlighting the need for continuous research and development of novel agents with good tolerability to manage uncontrolled hypertension. Future strategies may involve personalized approaches and genetic modulation in the treatment of hypertension.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Review
Medicine, General & Internal
Vitor M. Martins, Patricia K. Ziegelmann, Lucas Helal, Filipe Ferrari, Marcelo B. Lucca, Sandra C. Fuchs, Flavio D. Fuchs
Summary: This study aims to systematically review and analyze the antihypertensive efficacy and safety of different thiazide diuretics alone or in combination with potassium-sparing diuretics, providing evidence for the best therapeutic strategies for hypertension.
SYSTEMATIC REVIEWS
(2022)
Review
Peripheral Vascular Disease
Gianfranco Parati, Sverre Kjeldsen, Antonio Coca, William C. Cushman, Jiguang Wang
Summary: Single-pill combination (SPC) therapy was found to lead to improved adherence and persistence compared to free-equivalent combination (FEC) therapy in patients with hypertension, resulting in better blood pressure control. Studies showed that patients receiving SPCs had significantly enhanced adherence and lower likelihood of discontinuation compared to those receiving FECs. Moreover, SPC therapy led to significant reductions in both systolic and diastolic blood pressure at week 12, highlighting its potential benefits for patients with hypertension.
Article
Peripheral Vascular Disease
Khalid M. Bashir, Tammy Burns, Samuel J. Pirruccello, Sarah J. Aurit, Daniel E. Hilleman
Summary: Chlorthalidone may be more effective than hydrochlorothiazide in reducing adverse cardiovascular events in hypertensive patients, possibly due to its antiplatelet effects. However, this study found that neither chlorthalidone nor hydrochlorothiazide had antiplatelet effects.
JOURNAL OF CLINICAL HYPERTENSION
(2022)
Article
Geriatrics & Gerontology
Nancy E. Lane, Jasmina Ivanova, Birol Emir, Ali Mobasheri, Morten Georg Jensen
Summary: The study characterized the osteoarthritis (OA) population in the US, analyzing their clinical characteristics and commonly used treatments, finding that the prevalence was associated with body mass index, exercise frequency, and comorbid diagnoses. The use of dietary supplements and prescription medications was prevalent among individuals with OA.
Review
Cardiac & Cardiovascular Systems
Zhengqing Ba, Ying Xiao, Ming He, Dong Liu, Hao Wang, Hanyang Liang, Jiansong Yuan
Summary: This review investigates the risk factors for comorbidity of renal cell carcinoma (RCC) and hypertension (HTN) and discusses measures to reduce the comorbidity and treat hypertension. The deficiencies in current studies are discussed and future research directions are proposed.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Respiratory System
Tracey J. Weiss, Dena Rosen Ramey, Lingfeng Yang, Xinyue Liu, Mahesh J. Patel, Swapnil Rajpathak, Ednan K. Bajwa, Dominik Lautsch
Summary: This study identified patients with PH associated with COPD in a US administrative claims database. The findings showed that very few of these patients received medications recommended for PAH, and only about two thirds received medications for COPD.
BMC PULMONARY MEDICINE
(2022)
Letter
Medicine, General & Internal
Kurt Stoschitzky
Summary: In the SECURE trial, it was found that the use of a polypill containing aspirin, ramipril, and atorvastatin significantly reduced the risk of cardiovascular events in older patients with recent myocardial infarction. However, the absence of beta-blockers in this polypill raised questions as these drugs have been known to be effective after myocardial infarction and are recommended in current guidelines.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, General & Internal
Timothy S. S. Anderson, Shoshana J. J. Herzig, Bocheng Jing, W. John Boscardin, Kathy Fung, Edward R. R. Marcantonio, Michael A. A. Steinman
Summary: This study found that intensive pharmacologic antihypertensive treatment was associated with a greater risk of adverse events among hospitalized older adults with elevated blood pressures. These findings do not support the treatment of elevated inpatient blood pressures without evidence of end organ damage, and highlight the need for randomized clinical trials of inpatient blood pressure treatment targets.
JAMA INTERNAL MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Patrick Pan, Darren Svirskis, Shaun W. P. Rees, David Barker, Geoffrey I. N. Waterhouse, Zimei Wu
Summary: Photosensitive nanoparticles have been developed as potential therapies in human health, particularly in cancer treatment through photodynamic and photothermal therapy. These nanoparticles achieve controlled drug release via phototriggerable mechanisms, with recent research focusing on improving treatment efficacy and safety.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Public, Environmental & Occupational Health
Juan Figueroa-Garcia, Victor Granados-Garcia, Ernesto Roldan-Valadez, David Rojano-Mejia, Jairo Enoc Cruz-Toledo, Silvia Palomo-Pinon
Summary: The objective of this study was to estimate the increase in drug treatment costs associated with predictive factors of hypertensive patients in family medicine units. The results showed that diabetes, age, and complications were the factors with the largest influence on hypertension pharmacological costs.
SALUD PUBLICA DE MEXICO
(2022)
Article
Chemistry, Inorganic & Nuclear
Chengyuan Zhu, Zhengxi Guo, Aijia Yang, Bang-Ping Jiang, Hong Liang, Xing-Can Shen
Summary: A novel metallopolysaccharide-based nanotheranostic (Cu-NH2-HA) was developed through a one-step coordination-driven nanoassembly. It can achieve photoacoustic imaging-guided photothermal therapy in laser-focused fields and in non-laser-focused fields, it can be transformed by overexpressed endogenous hyaluronidase. This study demonstrates the potential of metallopolysaccharide-based smart nanotheranostics for precise phototheranostic and enzyme-driven programmed chemotherapy in solid tumors.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Obstetrics & Gynecology
W. Chen, J. Chen, M. Peng, J. Luo, Y. Chen, H. Qiu, J. Li
Summary: This study includes a retrospective case and literature review of 72 pregnant women with ES from 11 studies. The results suggest that targeted drugs may be crucial in reducing maternal mortality in pregnant women with ES.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Min Jun, Anish Scaria, Jason Andrade, Sunil Badve, Peter Birks, Sarah E. Bota, Anna Campain, Ognjenka Djurdjev, Amit X. Garg, Jeffrey Ha, Ziv Harel, Brenda Hemmelgarn, Carinna Hockham, Matthew T. James, Meg J. Jardine, Adeera Levin, Eric McArthur, Pietro Ravani, Selena Shao, Manish M. Sood, Zhi Tan, Navdeep Tangri, Reid Whitlock, Martin Gallagher
Summary: This study found that the use of DOACs in atrial fibrillation patients was associated with a lower or similar risk of all-cause death, ischemic stroke, and major bleeding compared to the use of warfarin, regardless of kidney function levels.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Review
Cardiac & Cardiovascular Systems
Finlay A. McAlister, Harsh Parikh, Douglas S. Lee, Harindra C. Wijeysundera
Summary: There has been a significant increase in morbidity and mortality during the COVID-19 pandemic, including non-COVID-19 deaths related to cardiovascular diseases. The pandemic has had profound indirect effects, leading to a higher burden of cardiovascular disease and risk factors in both COVID-19 survivors and those who were never infected. This report examines the direct impact of SARS-CoV-2 infection on cardiovascular and cardiometabolic disease burden in survivors, as well as the indirect effects of the pandemic on the cardiovascular health of non-infected individuals. It also discusses the consequences of delayed or foregone healthcare during the pandemic and the broader implications for cardiovascular health and healthcare systems.
CANADIAN JOURNAL OF CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Eloisa Colin-Ramirez, Nariman Sepehrvand, Sarah Rathwell, Heather Ross, Jorge Escobedo, Peter Macdonald, Richard Troughton, Clara Saldarriaga, Fernando Lanas, Robert Doughty, Finlay A. McAlister, Justin A. Ezekowitz
Summary: This study analyzed data from randomized controlled trials to evaluate the effects of sodium restriction on clinical outcomes in heart failure patients. The results showed that sodium restriction did not reduce the risk of death or hospitalization, but it may improve symptoms and quality of life.
CIRCULATION-HEART FAILURE
(2023)
Review
Cell Biology
Sabine Kuznia, Anna Zhu, Taisuke Akutsu, Julie E. Buring, Carlos A. Camargo Jr, Nancy R. Cook, Li-Ju Chen, Ting-Yuan David Cheng, Sari Hantunen, I. -Min Lee, JoAnn E. Manson, Rachel E. Neale, Robert Scragg, Aladdin H. Shadyab, Sha Sha, John Sluyter, Tomi-Pekka Tuomainen, Mitsuyoshi Urashima, Jyrki K. Virtanen, Ari Voutilainen, Jean Wactawski-Wende, Mary Waterhouse, Hermann Brenner, Ben Schoettker
Summary: A systematic review and meta-analysis of randomized, placebo-controlled trials (RCTs) and individual patient data (IPD) was conducted to evaluate the effect of vitamin D3 supplementation on cancer mortality in the general population and on prognosis in cancer patients. The main meta-analysis of the 14 RCTs showed a non-significant reduction in cancer mortality by 6%. Subgroup analyses revealed a significant reduction in cancer mortality in trials with daily dosing, while no reduction was seen in trials using a bolus regimen. The IPD meta-analysis confirmed the findings of all trials.
AGEING RESEARCH REVIEWS
(2023)
Letter
Medicine, General & Internal
Hermann Brenner, Thomas Heisser, Rafael Cardoso, Michael Hoffmeister
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Oncology
Ben Schoettker, Li-Ju Chen, Reiner Caspari, Hermann Brenner
Summary: The aim of this study is to improve the quality of life in older cancer patients through a medication review using the FORTA list. A total of 514 cancer patients aged 65 and above will be recruited in German rehabilitation clinics. The primary outcome will be assessed with self-administered questionnaires 8 months after baseline.
Letter
Cardiac & Cardiovascular Systems
Finlay A. McAlister, Yuan Dong
CANADIAN JOURNAL OF CARDIOLOGY
(2023)
Letter
Medicine, General & Internal
Finlay A. McAlister
CANADIAN MEDICAL ASSOCIATION JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
David J. T. Campbell, Chad Mitchell, Brenda Hemmelgarn, Marcello Tonelli, Peter Faris, Jianguo Zhang, Ross T. Tsuyuki, Jane Fletcher, Flora Au, Scott Klarenbach, Derek Exner, Braden J. Manns
Summary: This study tested whether providing free high-value medications to low-income older adults at high cardiovascular risk would improve clinical outcomes. However, the results showed that although medication adherence improved, providing free medications did not improve clinical outcomes or reduce healthcare costs.
Article
Cardiac & Cardiovascular Systems
David J. T. Campbell, Marcello R. Tonelli, Brenda Hemmelgarn, Peter Faris, Jianguo Zhang, Flora T. Au, Ross Tsuyuki, Chad Mitchell, Raj Pannu, Tavis Campbell, Noah Ivers, Jane V. Fletcher, Derek J. Exner, Braden Manns
Summary: In a randomized trial conducted in Alberta, Canada, a tailored self-management education and support (SMES) program designed using advertising principles was found to reduce the rate of clinical outcomes among low-income older adults. The intervention included health promotion messaging and relay of clinical information to patients' healthcare providers. The study showed that the rate of the primary outcome, including death, myocardial infarction, stroke, coronary revascularization, and hospitalizations for cardiovascular-related conditions, was lower in the SMES group compared to the control group.
Article
Cardiac & Cardiovascular Systems
Nariman Sepehrvand, Majid Nabipoor, Erik Youngson, Finlay A. Mcalister, Justin A. Ezekowitz
Summary: This study aimed to explore the time to initiation of triple therapy and identify barriers to its use in patients with de novo heart failure with reduced ejection fraction (HFrEF). The results showed that the time to initiation of triple therapy was slow and its utilization rate was low in patients with HFrEF. Patients who received triple therapy had better clinical outcomes compared to those who did not receive it.
JOURNAL OF CARDIAC FAILURE
(2023)
Letter
Oncology
Megha Bhardwaj, Ben Schoettker, Bernd Holleczek, Hermann Brenner
CANCER COMMUNICATIONS
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Finlay A. Mcalister
EUROPEAN HEART JOURNAL
(2023)
Article
Medicine, General & Internal
Marcello Tonelli, Natasha Wiebe, Meg Lunney, Maoliosa Donald, Tanis Howarth, Julie Evans, Scott W. Klarenbach, David Nicholas, Tiffany Boulton, Stephanie Thompson, Kara Schick Makaroff, Braden Manns, Brenda Hemmelgarn
Summary: Hearing loss is a common disability worldwide and is associated with a wide range of adverse clinical outcomes. This population-based cohort study in Alberta, Canada, found that individuals with hearing loss had higher rates of hospitalization, falls, adverse drug events, and emergency visits compared to those without hearing loss. They also had increased risks of death, cardiovascular events, depression, dementia, and other health issues.
Article
Urology & Nephrology
Jeffrey T. Ha, Anish Scaria, Jason Andrade, Sunil V. Badve, Peter Birks, Sarah E. Bota, Anna Campain, Ognjenka Djurdjev, Amit X. Garg, Ziv Harel, Brenda Hemmelgarn, Carinna Hockham, Matthew T. James, Meg J. Jardine, Dickson Lam, Adeera Levin, Eric McArthur, Pietro Ravani, Selena Shao, Manish M. Sood, Zhi Tan, Navdeep Tangri, Reid Whitlock, Martin Gallagher, Min Jun
Summary: The benefit-risk profile of rivaroxaban versus warfarin for atrial fibrillation (AF) in patients with chronic kidney disease is uncertain. This study compared the effectiveness and bleeding risk of rivaroxaban and warfarin in adults with AF across different levels of kidney function. The results showed that rivaroxaban was associated with lower or similar risk of all-cause death, ischemic stroke, and transient ischemic attack, as well as similar risk of bleeding, compared to warfarin, regardless of kidney function.