Cellular Complexity of the Bone Marrow Hematopoietic Stem Cell Niche

Osteal Tissue Macrophages Are Intercalated throughout Human and Mouse Bone Lining Tissues and Regulate Osteoblast Function In Vitro and In Vivo

(2014) M. K. Chang et al.   JOURNAL OF IMMUNOLOGY

Marrow Fat and Bone—New Perspectives

(2013) Pouneh K. Fazeli et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

GSK3β regulates physiological migration of stem/progenitor cells via cytoskeletal rearrangement

(2013) Kfir Lapid et al.   JOURNAL OF CLINICAL INVESTIGATION

PDGFRα and CD51 mark human Nestin+sphere-forming mesenchymal stem cells capable of hematopoietic progenitor cell expansion

(2013) Sandra Pinho et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance

(2013) Adam Greenbaum et al.   NATURE

Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches

(2013) Lei Ding et al.   NATURE

Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment

(2013) César Nombela-Arrieta et al.   NATURE CELL BIOLOGY

CD169+ macrophages provide a niche promoting erythropoiesis under homeostasis and stress

(2013) Andrew Chow et al.   NATURE MEDICINE

N(o)-cadherin role for HSCs

(2012) J.-P. Levesque   BLOOD

PTH expands short-term murine hemopoietic stem cells through T cells

(2012) J.-Y. Li et al.   BLOOD

Pharmacologic stabilization of HIF-1  increases hematopoietic stem cell quiescence in vivo and accelerates blood recovery after severe irradiation

(2012) C. E. Forristal et al.   BLOOD

Osteoblastic expansion induced by parathyroid hormone receptor signaling in murine osteocytes is not sufficient to increase hematopoietic stem cells

(2012) L. M. Calvi et al.   BLOOD

N-cadherin in osteolineage cells is not required for maintenance of hematopoietic stem cells

(2012) A. M. Greenbaum et al.   BLOOD

Osteoblastic N-cadherin is not required for microenvironmental support and regulation of hematopoietic stem and progenitor cells

(2012) O. Bromberg et al.   BLOOD

Activated Gs signaling in osteoblastic cells alters the hematopoietic stem cell niche in mice

(2012) K. Schepers et al.   BLOOD

The HIF Signaling Pathway in Osteoblasts Directly Modulates Erythropoiesis through the Production of EPO

(2012) Erinn B. Rankin et al.   CELL

Noncanonical Wnt Signaling Maintains Hematopoietic Stem Cells in the Niche

(2012) Ryohichi Sugimura et al.   CELL

Regulation of Hematopoietic Stem and Progenitor Cell Mobilization by Cholesterol Efflux Pathways

(2012) Marit Westerterp et al.   Cell Stem Cell

Endogenous Bone Marrow MSCs Are Dynamic, Fate-Restricted Participants in Bone Maintenance and Regeneration

(2012) Dongsu Park et al.   Cell Stem Cell

Marrow Fat and the Bone Microenvironment: Developmental, Functional, and Pathological Implications

(2012) Clifford J. Rosen et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

(2012) Simon Yona et al.   IMMUNITY

Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow

(2012) Anna Mansour et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Expansion of bone marrow neutrophils following G-CSF administration in mice results in osteolineage cell apoptosis and mobilization of hematopoietic stem and progenitor cells

(2012) P Singh et al.   LEUKEMIA

Endothelial and perivascular cells maintain haematopoietic stem cells

(2012) Lei Ding et al.   NATURE

Monocytes-macrophages that express α-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow

(2012) Aya Ludin et al.   NATURE IMMUNOLOGY

Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance

(2012) Ingrid G Winkler et al.   NATURE MEDICINE

Cord-Blood Engraftment with Ex Vivo Mesenchymal-Cell Coculture

(2012) Marcos de Lima et al.   NEW ENGLAND JOURNAL OF MEDICINE

Silencing of parathyroid hormone (PTH) receptor 1 in T cells blunts the bone anabolic activity of PTH

(2012) B. Bedi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prostaglandin E2 Increases Hematopoietic Stem Cell Survival and Accelerates Hematopoietic Recovery After Radiation Injury

(2012) Rebecca L. Porter et al.   STEM CELLS

Differential Regulation of CXCL5 by FGF2 in Osteoblastic and Endothelial Niche Cells Supports Hematopoietic Stem Cell Migration

(2012) Kyung-Ae Yoon et al.   STEM CELLS AND DEVELOPMENT

Concise Review: Hematopoietic Stem Cell Aging, Life Span, and Transplantation

(2012) Gary Van Zant et al.   Stem Cells Translational Medicine

Functional inhibition of osteoblastic cells in an in vivo mouse model of myeloid leukemia

(2011) B. J. Frisch et al.   BLOOD

Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche

(2011) Satoshi Yamazaki et al.   CELL

Prostaglandin E2 Enhances Human Cord Blood Stem Cell Xenotransplants and Shows Long-Term Safety in Preclinical Nonhuman Primate Transplant Models

(2011) Wolfram Goessling et al.   Cell Stem Cell

Drosophila Stem Cell Niches: A Decade of Discovery Suggests a Unified View of Stem Cell Regulation

(2011) Vicki P. Losick et al.   DEVELOPMENTAL CELL

Osteal macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model

(2011) Kylie A Alexander et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow

(2011) Yusuke Shiozawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Expression of the G-CSF receptor in monocytic cells is sufficient to mediate hematopoietic progenitor mobilization by G-CSF in mice

(2011) Matthew J. Christopher et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization

(2011) Kana Miyamoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bone marrow CD169+macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche

(2011) Andrew Chow et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A novel role for CCL3 (MIP-1α) in myeloma-induced bone disease via osteocalcin downregulation and inhibition of osteoblast function

(2011) S Vallet et al.   LEUKEMIA

Inhibition of osteoclast function reduces hematopoietic stem cell numbers in vivo

(2010) S. Lymperi et al.   BLOOD

Knockdown of N-cadherin suppresses the long-term engraftment of hematopoietic stem cells

(2010) K. Hosokawa et al.   BLOOD

Loss of Cxcl12/Sdf-1 in adult mice decreases the quiescent state of hematopoietic stem/progenitor cells and alters the pattern of hematopoietic regeneration after myelosuppression

(2010) Y.-S. Tzeng et al.   BLOOD

Isolation and characterization of endosteal niche cell populations that regulate hematopoietic stem cells

(2010) Y. Nakamura et al.   BLOOD

Impact of interactions of cellular components of the bone marrow microenvironment on hematopoietic stem and progenitor cell function

(2010) B. R. Chitteti et al.   BLOOD

Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs

(2010) I. G. Winkler et al.   BLOOD

Positioning of bone marrow hematopoietic and stromal cells relative to blood flow in vivo: serially reconstituting hematopoietic stem cells reside in distinct nonperfused niches

(2010) I. G. Winkler et al.   BLOOD

Cadherin-Based Adhesion Is a Potential Target for Niche Manipulation to Protect Hematopoietic Stem Cells in Adult Bone Marrow

(2010) Kentaro Hosokawa et al.   Cell Stem Cell

Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells

(2010) Keiyo Takubo et al.   Cell Stem Cell

Endothelial Cells Are Essential for the Self-Renewal and Repopulation of Notch-Dependent Hematopoietic Stem Cells

(2010) Jason M. Butler et al.   Cell Stem Cell

Intramarrow injection of β-catenin-activated, but not naïve mesenchymal stromal cells stimulates self-renewal of hematopoietic stem cells in bone marrow

(2010) Ji-Yeon Ahn et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

“Mesenchymal” Stem Cells in Human Bone Marrow (Skeletal Stem Cells): A Critical Discussion of Their Nature, Identity, and Significance in Incurable Skeletal Disease

(2010) Paolo Bianco et al.   HUMAN GENE THERAPY

Production of leukemia inhibitory factor mRNA and protein by malignant and immortalized bone cells

(2010) Ana Marušić et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Impact of maturational status on the ability of osteoblasts to enhance the hematopoietic function of stem and progenitor cells

(2010) Ying-Hua Cheng et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Osteoblast lineage cells expressing high levels of Runx2 enhance hematopoietic progenitor cell proliferation and function

(2010) Brahmananda R. Chitteti et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

(2010) Simón Méndez-Ferrer et al.   NATURE

Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells

(2010) Hideki Kobayashi et al.   NATURE CELL BIOLOGY

Disruption of PTH Receptor 1 in T Cells Protects against PTH-Induced Bone Loss

(2010) Hesham Tawfeek et al.   PLoS One

Restoration and reversible expansion of the osteoblastic hematopoietic stem cell niche after marrow radioablation

(2009) M. Dominici et al.   BLOOD

Defects in osteoblast function but no changes in long-term repopulating potential of hematopoietic stem cells in a mouse chronic inflammatory arthritis model

(2009) Y. D. Ma et al.   BLOOD

In vivo prostaglandin E2 treatment alters the bone marrow microenvironment and preferentially expands short-term hematopoietic stem cells

(2009) B. J. Frisch et al.   BLOOD

Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma

(2009) M. Fulciniti et al.   BLOOD

Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization

(2009) M. J. Christopher et al.   BLOOD

T Lymphocytes Amplify the Anabolic Activity of Parathyroid Hormone through Wnt10b Signaling

(2009) Masakazu Terauchi et al.   Cell Metabolism

Stem Cell States, Fates, and the Rules of Attraction

(2009) Tariq Enver et al.   Cell Stem Cell

Engraftment and Reconstitution of Hematopoiesis Is Dependent on VEGFR2-Mediated Regeneration of Sinusoidal Endothelial Cells

(2009) Andrea T. Hooper et al.   Cell Stem Cell

Cotransplantation with MSCs improves engraftment of HSCs after autologous intra-bone marrow transplantation in nonhuman primates

(2009) Shigeo Masuda et al.   EXPERIMENTAL HEMATOLOGY

Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter

(2009) Michael J. Chen et al.   NATURE

Forcing cells to change lineages

(2009) Thomas Graf et al.   NATURE

Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment

(2009) Olaia Naveiras et al.   NATURE

Studies on the mechanisms of the skeletal anabolic action of endogenous and exogenous parathyroid hormone

(2008) David Goltzman   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

CD150- cells are transiently reconstituting multipotent progenitors with little or no stem cell activity

(2008) M. J. Kiel et al.   BLOOD

Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: a potential mechanism underlying osteolytic bone lesions in multiple myeloma

(2008) Y.-W. Qiang et al.   BLOOD

TGF-  as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation

(2008) S. Yamazaki et al.   BLOOD

Exported 18-kDa Isoform of Fibroblast Growth Factor-2 Is a Critical Determinant of Bone Mass in Mice

(2008) Liping Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CXCR4 is required for the quiescence of primitive hematopoietic cells

(2008) Yuchun Nie et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche

(2008) Cristina Lo Celso et al.   NATURE

Detection of functional haematopoietic stem cell niche using real-time imaging

(2008) Yucai Xie et al.   NATURE

Haematopoietic stem cell release is regulated by circadian oscillations

(2008) Simón Méndez-Ferrer et al.   NATURE

Of lineage and legacy: the development of mammalian hematopoietic stem cells

(2008) Elaine Dzierzak et al.   NATURE IMMUNOLOGY

Leukemic Cells Create Bone Marrow Niches That Disrupt the Behavior of Normal Hematopoietic Progenitor Cells

(2008) Angela Colmone et al.   SCIENCE