Article
Endocrinology & Metabolism
Fengyu Jia, Suxia Wang, Ying Jing, Hanhui Zhao, Peng Rong, Hongbin Zhang, Wenting Lu, Yan Xue, Gang Sun
Summary: The study found a significant elevation of osteocalcin (OC) in MHD patients, positively correlated with phosphorus, iPTH, FGF23, and negatively correlated with age. Age and OC were identified as risk factors for high AACs (>= 5).
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Urology & Nephrology
Hesham Kamal Habeeb Keryakos, Nagwa Ismail Okaily, Mariam Asaad Yacoub Boulis, Ahmed Mohamed Saadeldin Salama
Summary: The study revealed that functional vitamin K deficiency is present in maintenance hemodialysis patients, but serum osteocalcin is not associated with cardiovascular calcification.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2021)
Article
Cell Biology
Alexander Tacey, Sophie Millar, Tawar Qaradakhi, Cassandra Smith, Alan Hayes, Susan Anderson, Anthony Zulli, Saoirse O'Sullivan, Itamar Levinger
Summary: The study shows that ucOC has no significant effects on endothelial cell function, with no alteration in blood vessel relaxation or changes in cellular signalling markers observed.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Medicine, General & Internal
Ana P. Silva, Carla S. B. Viegas, Patricia Guilherme, Nelson Tavares, Carolina Dias, Fatima Rato, Nelio Santos, Marilia Faisca, Edgar de Almeida, Pedro L. Neves, Dina C. Simes
Summary: Accelerated and premature cardiovascular calcification is common in chronic kidney disease patients, with valvular calcification being a critical indicator of cardiovascular disease. Low levels of Gla-rich protein (GRP) and magnesium, along with high levels of phosphate, are associated with mitral and aortic valves calcification. The diagnostic value of GRP may be potentially useful in assessing cardiovascular risk in this population.
Review
Pharmacology & Pharmacy
Xinyue Pan, Caixia Pi, Xianchun Ruan, Hanhua Zheng, Demao Zhang, Xiaoheng Liu
Summary: Cardiovascular diseases have a high impact on millions of individuals each year. Vascular calcification, which involves the deposition of calcium-phosphate complexes, is closely related to various cardiovascular diseases. Sirtuins, a family of histone deacetylases, play important roles in bone homeostasis and the process of vascular calcification, offering new possibilities for the prevention and treatment of cardiovascular diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Yaxin Lian, Yue Li, Aiting Liu, Sounak Ghosh, Yuncong Shi, Hui Huang
Summary: This article provides an overview of the key role of oxidative stress in vascular calcification (VC) and discusses the challenges surrounding the use of dietary antioxidants in preventing VC.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Anubha Singh, Simran Tandon, Chanderdeep Tandon
Summary: Pathological calcification is a major cause of cardiovascular morbidities in populations with chronic kidney disease, end stage renal disease, and metabolic disorders. Studies have shown that vascular calcification is an active, cell-mediated process in patients with cardiovascular diseases, and novel clinical studies targeting cellular mechanisms of calcification provide potential avenues for drug development. However, there is currently a lack of significant preventive measures for calcifications.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Nutrition & Dietetics
Jundi Jia, Jie Zhang, Dan Ma, Zihao Zhang, Lin Zhao, Tongxin Wang, Hao Xu
Summary: This study aimed to evaluate the relationship between the healthy eating index-2015 (HEI-2015) and abdominal aortic calcification (AAC) in US adults. The results showed that higher HEI-2015 scores were associated with lower AAC scores and a decreased risk of having AAC. Specifically, a higher intake of fruits, greens, and beans was linked to lower AAC scores. These findings suggest that greater adherence to the 2015-2020 Dietary Guidelines for Americans, as assessed by HEI-2015, may be beneficial for preventing vascular calcification and cardiovascular disease among US adults.
FRONTIERS IN NUTRITION
(2023)
Article
Medicine, General & Internal
Haitao Zhang, Guisen Li, Xueqing Yu, Junwei Yang, Aili Jiang, Hong Cheng, Junzhou Fu, Xinling Liang, Jun Liu, Jizhuang Lou, Mei Wang, Changying Xing, Aihua Zhang, Miao Zhang, Xiangcheng Xiao, Chen Yu, Rong Wang, Li Wang, Yuqing Chen, Tianjun Guan, Ai Peng, Nan Chen, Chuanming Hao, Bicheng Liu, Suxia Wang, Dan Shen, Zhenhua Jia, Zhihong Liu
Summary: Baseline findings from the China Dialysis Calcification Study revealed a high prevalence of vascular calcification among patients with end-stage kidney disease, but data on calcification progression were limited. This study aimed to understand the progression of calcification at different anatomical sites, identify risk factors, and assess the association with cardiovascular events and death. The results may have implications for improving the management of chronic kidney disease-mineral and bone disorder among dialysis patients.
Review
Biotechnology & Applied Microbiology
Taylor K. Brown, Sara Alharbi, Karen J. Ho, Bin Jiang
Summary: Calcification in prosthetic vascular conduits is a major challenge in cardiac and vascular surgery. However, recent advancements in biomaterial design have shown promise in attenuating calcification in prosthetic vascular grafts. Understanding the etiology of vascular calcification will guide the design of future grafts for better translational success.
BIOTECHNOLOGY AND BIOENGINEERING
(2023)
Article
Medicine, General & Internal
Ryosuke Hirota, Atsushi Teramoto, Mitsunori Yoshimoto, Hiroyuki Takashima, Naomi Yasuda, Arihiko Tsukamoto, Noriyuki Iesato, Makoto Emori, Kousuke Iba, Nobuyoshi Kawaharada, Toshihiko Yamashita
Summary: This study investigated the association between the incidence and severity of DISH with vascular calcification and the occurrence of cardiovascular events in heart failure patients. The results showed a higher incidence of DISH in the cardiovascular events group, and DISH patients had more calcification of the coronary arteries and aorta. These findings suggest a correlation between DISH and cardiovascular events.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Huan Zhao, Haojie Liu, Yueming Liu, Juan Jin, Qiang He, Bo Lin
Summary: This paper reviews the mechanism of the role of extracellular vesicles (EVs), especially exosomes, in vascular calcification (VC) in patients with chronic kidney disease (CKD), and discusses the potential application of related therapeutic targets in the clinical setting.
FRONTIERS IN MEDICINE
(2022)
Review
Urology & Nephrology
Chelsea Xu, Edward R. Smith, Mark K. Tiong, Irene Ruderman, Nigel D. Toussaint
Summary: Vascular calcification is associated with cardiovascular morbidity and mortality in people with CKD. Therapy involving magnesium or sodium thiosulfate appears most promising in attenuating the progression of vascular calcification, but the existing studies are small and of short duration. There is insufficient or conflicting data regarding other interventions, highlighting the need for more definitive trials in evaluating interventions targeting vascular calcification in people with CKD.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Nutrition & Dietetics
Jundi Jia, Jie Zhang, Qiao He, Mingqi Wang, Qiyu Liu, Tongxin Wang, Xuanye Chen, Wen Wang, Hao Xu
Summary: This study investigated the relationship between dietary vitamin C and abdominal aortic calcification among adults in the US. The results showed that higher intake of dietary vitamin C was associated with reduced abdominal aortic calcification score and lower risk of abdominal aortic calcification. It is recommended for adults in the US to increase their intake of vitamin C due to its potential benefits for protecting against vascular calcification and cardiovascular disease.
Article
Biochemistry & Molecular Biology
Chunli Wang, Juanjuan Han, Ming Liu, Yuming Huang, Tingwen Zhou, Nan Jiang, Haipeng Hui, Kang Xu
Summary: This study uncovered the miRNA-mRNA interactome and related pathways in calcified aortic valve disease (CAVD) of the human aortic valve. A potential therapeutic target for inhibiting CAVD was identified.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Geriatrics & Gerontology
Scott R. Bauer, Peggy M. Cawthon, Kristine E. Ensrud, Anne M. Suskind, John C. Newman, Howard A. Fink, Kaiwei Lu, Rebecca Scherzer, Andrew R. Hoffman, Kenneth Covinsky, Lynn M. Marshall
Summary: The severity of LUTS is associated with incident mobility and ADL limitations among older men, but not with cognition-dependent task limitations. Increased clinical attention to the risk of functional limitations among older men with LUTS is likely warranted.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Article
Clinical Neurology
Meredith L. Wallace, Soomi Lee, Katie L. Stone, Martica H. Hall, Stephen F. Smagula, Susan Redline, Kristine Ensrud, Sonia Ancoli-Israel, Daniel J. Buysse
Summary: Similar sleep health profiles were identified in older men and women, with inadequate sleep health features associated with increased mortality risk. Research suggests that interventions targeting specific sleep health characteristics could potentially reduce mortality risk in older adults.
Article
Endocrinology & Metabolism
Peggy M. Cawthon, Katherine E. Peters, Steven R. Cummings, Eric S. Orwoll, Andrew R. Hoffman, Kristine E. Ensrud, Jane A. Cauley, William J. Evans
Summary: The study investigates the relationship between total skeletal muscle mass and incident fractures. The findings indicate that low D3Cr muscle mass is associated with an increased risk of hip and potentially other fractures in older men, and this association is partially mediated by physical performance.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Kristine E. Ensrud, Li-Yung Lui, Carolyn J. Crandall, Eric S. Orwoll, Lisa Langsetmo, John T. Schousboe, Howard A. Fink, Nancy E. Lane, Deborah M. Kado, Jane A. Cauley, Marcia L. Stefanick, Peggy M. Cawthon
Summary: This study evaluated the impact of a second bone mineral density (BMD) screening 7 years after the initial screening on fracture prediction in older men. The results showed that repeating the BMD screening did not significantly improve fracture prediction in community-dwelling older men.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Geriatrics & Gerontology
Elizabeth A. Bayliss, Kathleen Albers, Kathy Gleason, Lisa E. Pieper, Cynthia M. Boyd, Noll L. Campbell, Kristine E. Ensrud, Shelly L. Gray, Amy M. Linsky, Derelie Mangin, Lillian Min, Michael W. Rich, Michael A. Steinman, Justin Turner, Eduard E. Vasilevskis, Sascha Dublin
Summary: Interpreting and generating actionable evidence from deprescribing interventions is challenging due to inconsistent and heterogeneous outcome definitions. A scoping review and expert panel discussions were conducted to characterize deprescribing intervention outcomes and recommend measurement approaches. The review identified common outcomes such as medication discontinuation, medication appropriateness, and a range of clinical outcomes. Recommendations included defining meaningful medication outcomes, ensuring adequate sample size and follow-up time, and selecting appropriate data sources. Further development is needed for implementation outcomes and measures of adverse drug withdrawal events.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Article
Oncology
Juhua Luo, John T. Schousboe, Kristine E. Ensrud, Michael Hendryx
Summary: Our study aimed to examine long-term cognitive impairment among older breast cancer survivors. We found that breast cancer survivors had accelerated cognitive impairment after cancer diagnosis, especially among women diagnosed at older age or at advanced stage.
JOURNAL OF CANCER SURVIVORSHIP
(2023)
Article
Endocrinology & Metabolism
Dima A. Alajlouni, Dana Bliuc, Thach S. Tran, Robert D. Blank, Peggy M. Cawthon, Kristine E. Ensrud, Nancy E. Lane, Eric S. Orwoll, Jane A. Cauley, Jacqueline R. Center
Summary: Muscle strength and physical performance are associated with the risk of subsequent fracture and postfracture mortality. Low muscle strength and poor physical performance are related to higher postfracture mortality risk, while index measurements are not associated with subsequent fracture.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Geriatrics & Gerontology
Mary E. Winger, Paolo Caserotti, Jane A. Cauley, Robert M. Boudreau, Sara R. Piva, Peggy M. Cawthon, Eric S. Orwoll, Kristine E. Ensrud, Deborah M. Kado, Elsa S. Strotmeyer
Summary: This study investigated the application of lower-extremity power and upper-extremity strength in fall injuries and found that lower leg power and grip strength predicted future fall injury risk in older men, independent of physical performance.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Lisa Langsetmo, John T. Schousboe, Brent C. Taylor, Jane A. Cauley, Howard A. Fink, Peggy M. Cawthon, Marcia L. Stefanick, Deborah M. Kado, Allyson M. Kats, Kristine E. Ensrud
Summary: This study evaluated the risks of clinical fracture, hip fracture, and mortality prior to fracture among men aged at least 80 years. The results showed that fall history, hip bone mineral density, and recent fracture were strong predictors of clinical fracture and hip fracture. Age and multimorbidity were strong predictors of mortality before fracture. The study results have important implications for guiding osteoporosis drug treatment decisions.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Critical Care Medicine
Sobhan Salari Shahrbabaki, Dominik Linz, Susan Redline, Katie Stone, Kristine Ensrud, Mathias Baumert
Summary: Arousal during sleep triggers ventricular repolarization lability, which may increase the risk of long-term cardiovascular mortality. The QT variability index during arousal is independently associated with all-cause and cardiovascular mortality, indicating maladaptation of ventricular repolarization to the arousal stimulus. Further study is needed to determine if arousal suppression can reduce ventricular repolarization lability and subsequent mortality, and if arousal-related QT variability index can be used for more accurate risk stratification.
Article
Geriatrics & Gerontology
Alexandra Cours, Mei-Hua Huang, Howard Fink, Kristine E. Ensrud, John T. Schousboe, Wendy Katzman, Diane Schneider, Nancy E. Lane, Peggy Cawthon, Deborah M. Kado
Summary: This study found that increasing blocks-measured kyphosis is associated with a higher risk of mortality in older men, indicating that hyperkyphosis should be considered as a clinically significant problem.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Geriatrics & Gerontology
Terri L. Blackwell, Mariana G. Figueiro, Gregory J. Tranah, Jamie M. Zeitzer, Kristine Yaffe, Sonia Ancoli-Israel, Deborah M. Kado, Kristine E. Ensrud, Nancy E. Lane, Yue Leng, Katie L. Stone
Summary: This study found that older men with worse alignment of activity and light had lower levels of cognition and increased rates of cognitive decline. However, there was no association between phasor angle and cognition. Interventions that improve the alignment of light and activity may help slow cognitive decline in older adults.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Medicine, General & Internal
Dana A. Bliuc, Thach Tran, Weiwen Chen, Dunia E. Alarkawi, Dima D. Alajlouni, Fiona R. Blyth, Lyn March, Kristine Ensrud, Robert Blank, Jacqueline Center
Summary: This study investigated the association between multimorbidity and osteoporosis investigation and treatment in fracture patients, and found that multimorbidity significantly impacted the treatment of osteoporosis. This suggests that fracture risk may be underestimated or underprioritized in the presence of other chronic conditions, highlighting the need for improved fracture care in these patients.
Letter
Medicine, General & Internal
Carolyn J. Crandall, Kristine E. Ensrud
JAMA INTERNAL MEDICINE
(2023)
Article
Geriatrics & Gerontology
S. R. Bauer, C. E. McCulloch, P. M. Cawthon, K. E. Ensrud, A. M. Suskind, J. C. Newman, S. L. Harrison, A. Senders, K. Covinsky, L. M. Marshall
Summary: Change in phenotypic frailty is associated with non-linear increases in lower urinary tract symptoms (LUTS) severity among older men, independent of age and comorbidities.
JOURNAL OF FRAILTY & AGING
(2023)