Article
Endocrinology & Metabolism
Huajie Dai, Longyi Zheng, Zheng Zhu, Xin Geng, Tianzhichao Hou, Qi Wang, Yijie Zhu, Hong Lin, Shuangyuan Wang, Ruizhi Zheng, Zhiyun Zhao, Mian Li, Jieli Lu, Yu Xu, Tiange Wang, Jianmin Liu, Guang Ning, Weiqing Wang, Yufang Bi, Jie Zheng, Min Xu
Summary: This study aimed to evaluate the causal effect of SGLT2 inhibition on BMD, osteoporosis, and fracture risk using genetics. The results showed little evidence of association between genetically proxied SGLT2 inhibition and BMD, osteoporosis, or most types of fracture. Only a nominal significance was found for fracture of the lower leg and shoulder and upper arm. This study does not support an effect of genetically proxied SGLT2 inhibition on fracture risk.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Cell & Tissue Engineering
H. Xie, N. Wang, H. He, Z. Yang, J. Wu, T. Yang, Y. Wang
Summary: In this meta-analysis, the association between selenium status and bone health indicators was investigated. The results demonstrate a positive correlation between selenium intake and bone mineral density, as well as an inverse relationship with osteoporosis and hip fracture risk.
BONE & JOINT RESEARCH
(2023)
Article
Endocrinology & Metabolism
Chin-Hao Hsu, Sheng-Feng Sung, Hsin-Yi Yang, Wan-Ting Huang, Cheng-Yang Hsieh
Summary: Despite being at higher risk, stroke survivors are less likely to receive bone mineral density testing and osteoporosis treatment compared to non-stroke patients. Factors such as female sex, osteoporosis, prior BMD testing, and low-trauma fractures after stroke increase the likelihood of receiving these measures, while greater stroke severity reduces the likelihood.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
JJ. Liu, SB. Fu, J. Jiang, XL. Tang
Summary: Exposure to air pollution, specifically PM2.5 and NO2, was associated with an increased risk of osteoporosis, while PM10, NO, and O-3 did not show a significant excess risk. Despite the limited number of epidemiological studies, this research suggests a positive correlation between increased exposure to air pollutants and a higher osteoporosis risk. Further large cohort studies are needed to investigate the impact of different constituents and duration of air pollutants exposure.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Dan He, Huan Liu, Wenming Wei, Yijing Zhao, Qingqing Cai, Sirong Shi, Xiaoge Chu, Xiaoyue Qin, Na Zhang, Peng Xu, Feng Zhang
Summary: This study conducted a genome-wide trajectory analysis and identified the CPED1-WNT16-FAM3C locus as playing a significant role in bone mineral density (BMD) mean trajectories. They also discovered several novel candidate genes associated with BMD within-subject variability.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Orthopedics
Xiaozhi Sun, Xiaotao Wu
Summary: Higher levels of apolipoprotein A1 (ApoA1) are associated with increased risk of osteoporosis, indicating the involvement of lipid metabolism in bone metabolism.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Endocrinology & Metabolism
Julien Paccou, Sammy Badr, Daniela Lombardo, Huda Khizindar, Valerie Deken, Stefan Ruschke, Dimitrios C. Karampinos, Anne Cotten, Bernard Cortet
Summary: This study aimed to determine the association between proton density fat fraction (PDFF) and fractures. A case-control study was conducted on postmenopausal women, and it was found that MRI-based measurement of proximal femur PDFF can discriminate between postmenopausal women with and without clinical vertebral fractures, independent of age, CCI, and BMD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, General & Internal
Se-Won Lee, Younghyun Yoon, Junhyuk Kwon, Jun-Young Heu, Jihyo Hwang
Summary: The clinical significance of BMD discordance between the hip and spine for hip fractures was evaluated in this study. The results showed that the rates of BMD discordance and low hip discordance were significantly higher in the hip fracture group than in the non-fracture group, indicating a higher risk of hip fractures.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Edward Czerwinski, Jose Cardona, Rafal Plebanski, Chris Recknor, Tamara Vokes, Kenneth G. Saag, Neil Binkley, E. Michael Lewiecki, Jonathan Adachi, Dorota Knychas, David Kendler, Eric Orwoll, Yinzhong Chen, Leny Pearman, Y. Heather Li, Bruce Mitlak
Summary: The study shows that Abaloparatide significantly increases bone mineral density in men with osteoporosis and has a safety profile consistent with previous studies. These results suggest that Abaloparatide can be considered as an effective anabolic treatment option for male patients with osteoporosis.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Review
Food Science & Technology
Weili Feng, Xiaoping Wang, Daoqiang Huang, Anqi Lu
Summary: This study used an umbrella review and meta-analysis to summarize the association between dietary factors and the incidence of osteoporosis in adults. The findings suggest that dietary factors have an impact on osteoporosis, and consuming appropriate amounts of dairy products, vegetables, fruits, and micronutrients, while reducing alcohol and coffee intake, can help reduce the risk of osteoporosis.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Nutrition & Dietetics
Miroslav Vujasinovic, Lorena Nezirevic Dobrijevic, Ebba Asplund, Wiktor Rutkowski, Ana Dugic, Mashroor Kahn, Ingrid Dahlman, Maria Saaf, Hannes Hagstrom, Johannes-Matthias Lohr
Summary: This study found that only 23% of patients with CP underwent DXA examination, with 53.4% of patients having low BMD. The fracture rate was significantly higher in patients with low BMD compared to those with normal BMD.
Article
Medicine, General & Internal
Yui Ogiso, Tatsunori Hanai, Kayoko Nishimura, Takao Miwa, Toshihide Maeda, Kenji Imai, Atsushi Suetsugu, Koji Takai, Masahito Shimizu
Summary: This cross-sectional study aimed to determine whether TBS can identify patients with liver cirrhosis that are at risk of vertebral fractures. The results showed a significant correlation between TBS and vertebral fractures, indicating that TBS can help identify patients at risk of vertebral fractures in liver cirrhosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Environmental Sciences
Ming Qin, Yue Gao, Meichen Zhang, Junhua Wu, Yang Liu, Yuting Jiang, Xiaodi Zhang, Xin Wang, Yanmei Yang, Yanhui Gao
Summary: This study investigates the effects of fluorine and ADAMTS14_rs4747096 on bone mineral density (BMD). The findings suggest that fluoride exposure and mutation G allele in ADAMTS14_rs4747096 may be risk factors for decreased BMD, and there is an interaction between the two influencing factors.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Katherine N. Haseltine, Tariq Chukir, Pinar J. Smith, Justin T. Jacob, John P. Bilezikian, Azeez Farooki
Summary: Bone mineral density measurement and FRAX assessment tools can help evaluate fracture risk and guide decisions for osteoporosis pharmacologic treatment. Specific populations like postmenopausal women and men over 50 should receive pharmacologic treatment according to guidelines. Monitoring BMD regularly and considering secondary causes or non-compliance is important during treatment.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Geriatrics & Gerontology
Hongxin Hu, Jian Mei, Yuanqing Cai, Haiqi Ding, Susheng Niu, Wenming Zhang, Xinyu Fang
Summary: This study used a two-sample Mendelian randomization method to investigate the causal relationship between osteoporosis and Alzheimer's disease (AD). The results showed no significant causal effect of osteoporosis on AD, regardless of the removal of potentially pleiotropic SNPs. The results were confirmed to be reliable and stable by sensitivity analysis. Although there is no bidirectional causal relationship, osteoporosis and AD share similar pathogenesis and pathways.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Endocrinology & Metabolism
Dima Alajlouni, Thach Tran, Dana Bliuc, Robert D. Blank, Peggy M. Cawthon, Eric S. Orwoll, Jacqueline R. Center
Summary: The study found that muscle strength and physical performance can improve fracture risk prediction in men, surpassing traditional risk assessment tools. Additionally, combining grip strength and relevant performance tests can further enhance the predictive models.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Angela Sheu, Dana Bliuc, Thach Tran, Christopher P. White, Jacqueline R. Center
Summary: The study found that individuals with type 2 diabetes have a significantly increased mortality risk following fractures. This risk is particularly high for those with diabetes duration of more than 5 years and experiencing hip/vertebral fractures (in men) or non-hip non-vertebral fractures (in women). Therefore, careful monitoring and management after fractures are crucial for individuals with type 2 diabetes.
Article
Endocrinology & Metabolism
Manju Chandran, Peter R. Ebeling, Paul J. Mitchell, Tuan Nguyen
Summary: In the Asia Pacific region, osteoporosis and fragility fractures are not widely recognized as a major public health problem. The Asia Pacific Consortium on Osteoporosis (APCO) aims to develop tangible solutions for the challenges of underdiagnosis and undertreatment. They have developed a harmonized set of standards of care, called The Framework, to address the large osteoporosis treatment gap in the region. APCO is working on embedding the Framework in clinical practice by partnering with regulatory bodies, conducting education programs, and benchmarking current services.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Dima A. Alajlouni, Dana Bliuc, Thach S. Tran, Robert D. Blank, Peggy M. Cawthon, Kristine E. Ensrud, Nancy E. Lane, Eric S. Orwoll, Jane A. Cauley, Jacqueline R. Center
Summary: Muscle strength and physical performance are associated with the risk of subsequent fracture and postfracture mortality. Low muscle strength and poor physical performance are related to higher postfracture mortality risk, while index measurements are not associated with subsequent fracture.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Lisanne Vranken, Irma J. A. de Bruin, Annemariek H. M. Driessen, Piet P. M. Geusens, John A. Eisman, Jacqueline R. Center, Robert Y. van der Velde, Heinrich M. J. Janzing, Sjoerd Kaarsemaker, Joop P. van den Bergh, Caroline E. Wyers
Summary: Fracture liaison services (FLS) are effective in preventing secondary fractures. This study evaluated whether FLS care is associated with reduced subsequent fracture and mortality risk over a 3-year follow-up period. The results showed that FLS care was associated with a lower mortality risk and lower subsequent major/hip fracture risk in the first year for patients with a major/hip index fracture, but not for patients with a non-major/non-hip fracture.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Dana Bliuc, Thach Tran, Weiwen Chen, Dunia Alarkawi, Dima A. Alajlouni, Fiona Blyth, Lyn March, Robert D. Blank, Jacqueline R. Center
Summary: This study aimed to determine the association between oral bisphosphonate (oBP) or denosumab (Dmab) use and cardiovascular events (CVEs). The results showed that there was no association between oBP or Dmab use and CVEs.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, General & Internal
Dana A. Bliuc, Thach Tran, Weiwen Chen, Dunia E. Alarkawi, Dima D. Alajlouni, Fiona R. Blyth, Lyn March, Kristine Ensrud, Robert Blank, Jacqueline Center
Summary: This study investigated the association between multimorbidity and osteoporosis investigation and treatment in fracture patients, and found that multimorbidity significantly impacted the treatment of osteoporosis. This suggests that fracture risk may be underestimated or underprioritized in the presence of other chronic conditions, highlighting the need for improved fracture care in these patients.
Article
Endocrinology & Metabolism
Thao P. Ho-Le, Thach S. Tran, Huy G. Nguyen, Jacqueline R. Center, John A. Eisman, Tuan Nguyen
Summary: This study aims to examine the association between a polygenic risk score (PRS) and lifetime fracture risk. The findings suggest that individuals with high PRS are at a greater risk of fractures, especially hip fractures. The study highlights the potential significance of incorporating the polygenic risk score into personalized fracture risk assessment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biology
Thach Tran, Thao Ho-Le, Dana Bliuc, Bo Abrahamsen, Louise Hansen, Peter Vestergaard, Jacqueline R. Center, Tuan Nguyen
Summary: The concept of "Skeletal Age" is introduced to convey the combined risk of fracture and fracture-associated mortality. Skeletal Age is defined as the sum of chronological age and the number of years of life lost associated with a fragility fracture. The study found that men tend to lose more years of life after a fragility fracture than women, and hip fractures result in the greatest loss of life years.
Article
Endocrinology & Metabolism
Thach S. Tran, Thao P. Ho-Le, Dana Bliuc, Jacqueline R. Center, Robert D. Blank, Tuan V. Nguyen
Summary: This study provides evidence that a population-wide strategy aimed at enhancing bone mineral density can lead to a substantial decrease in the incidence of hip fractures.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Review
Medicine, General & Internal
Rebekah Jane Moles, Lin Perry, Justine M. Naylor, Jacqueline Center, Peter Ebeling, Gustavo Duque, Gabor Major, Christopher White, Christopher Yates, Matthew Jennings, Mark Kotowicz, Thach Tran, Dana Bliuc, Lei Si, Kathryn Gibson, Benjamin Joseph Basger, Patrick Bolton, Stephen Barnett, Geraldine Hassett, Ayano Kelly, Barbara Bazarnik, Wafaa Ezz, Kate Luckie, Stephen Ross Carter
Summary: This paper describes a protocol for a randomized controlled trial to determine the efficacy of a home medication review (HMR) service for patients who have sustained minimal trauma fractures (MTFs). The trial will evaluate the impact of the HMR service on patients' intake of sedative/anticholinergic drugs, adherence to antiosteoporosis medications, and other secondary outcomes.
Article
Multidisciplinary Sciences
Malgorzata M. Brzozowska, Michelle Isaacs, Dana Bliuc, Paul A. Baldock, John A. Eisman, Chris P. White, Jerry R. Greenfield, Jacqueline R. Center
Summary: This study examined the impact of three types of bariatric surgery compared with dietary intervention on changes in insulin resistance and appetite hormones over 3 years. The results showed that all surgical groups experienced significant reductions in insulin resistance, with the Roux-en-Y gastric bypass showing the greatest difference at 12-36 months. Furthermore, the increase in postprandial PYY and adiponectin was associated with improvements in insulin resistance during weight stability.
SCIENTIFIC REPORTS
(2023)