Review
Oncology
Michelle M. Kim, Minesh P. Mehta, DeeDee K. Smart, Patricia S. Steeg, Julie A. Hong, Michael G. Espey, Pataje G. Prasanna, Laura Crandon, Christine Hodgdon, Niki Kozak, Terri S. Armstrong, Aki Morikawa, Nicole Willmarth, Kirk Tanner, Adrienne Boire, Melanie Hayden Gephart, Kim A. Margolin, Jona Hattangadi-Gluth, Hussein Tawbi, Daniel M. Trifiletti, Caroline Chung, Upal Basu-Roy, Robyn Burns, Isabella C. Glitza Oliva, Ayal A. Aizer, Carey K. Anders, Joanne Davis, Manmeet S. Ahluwalia, Veronica Chiang, Jing Li, Rupesh Kotecha, Silvia C. Formenti, Benjamin M. Ellingson, Vinai Gondi, Paul W. Sperduto, Jill S. Barnholtz-Sloan, Jordi Rodon, Eudocia Q. Lee, Mustafa Khasraw, Debra Nana Yeboa, Priscilla K. Brastianos, Evanthia Galanis, C. Norman Coleman, Mansoor M. Ahmed
Summary: Brain metastases are a global public health concern with increasing importance. Stakeholders gathered in a virtual workshop to define research priorities and address unmet needs for patients, aiming to achieve meaningful advances in patient outcomes. This Policy Review provides an overview of existing knowledge gaps, collaborative opportunities, and specific recommendations for future directions in brain metastases research. Enhanced coordination and the active engagement of patients and advocates are crucial for major advances in research.
Article
Biochemistry & Molecular Biology
Ariangela J. Kozik, Fernando Holguin, Leopoldo N. Segal, Talal A. Chatila, Anne E. Dixon, James E. Gern, Catherine Lozupone, Nicholas Lukacs, Carey Lumeng, Philip L. Molyneaux, Nichole Reisdorph, Ivan Vujkovic-Cvijin, Alkis Togias, Yvonne J. Huang
Summary: This report summarizes the proceedings of a virtual workshop on the microbiome, metabolism, and immunoregulation of asthma. The workshop brought together experts from different fields to discuss the current knowledge gaps and future directions in the research of microbial and metabolic mechanisms in asthma. The report highlights key points of discussion, including specific knowledge gaps, challenges, and suggested directions for future research.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Oncology
Amy Hatton, Natalie Heriot, John Zalcberg, Darshini Ayton, Jill Evans, David Roder, Boon H. Chua, Jolyn Hersch, Jocelyn Lippey, Jane Fox, Christobel Saunders, G. Bruce Mann, Jane Synnot, Robin J. Bell
Summary: The management diversity of women with DCIS cannot solely be explained by tumor characteristics, as patient preferences and underlying factors also play a significant role. A study on Australian women diagnosed with DCIS found that understanding of diagnosis, involvement in decision-making, and factors such as psychosexual impact of mastectomy and perceptions of radiotherapy influenced treatment decisions. It is important to recognize that treatment decisions are not solely determined by disease characteristics, but also by patient preferences and individual factors.
Article
Biochemistry & Molecular Biology
Rod A. Rahimi, Josalyn L. Cho, Claudia Jakubzick, Shabaana A. Khader, Bart N. Lambrecht, Clare M. Lloyd, Ari B. Molofsky, Sebastien Talbot, Catherine A. Bonham, Wonder P. Drake, Anne Sperling, Benjamin D. Singer
Summary: The mammalian airways and lungs are constantly exposed to various inhaled particles, allergens, and pathogens. The immune system plays a crucial role in protecting against respiratory pathogens, but an unbalanced immune response during respiratory infections can hinder pathogen clearance and cause immune-related diseases. Understanding the complex network of cells involved in sensing and responding to inhaled antigens is essential for developing effective mucosal vaccines and managing inflammatory pulmonary diseases. The American Thoracic Society has formed a working group to advance the study of lung immunology and improve human health.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Respiratory System
Mary B. Rice, Sarah B. Henderson, Allison A. Lambert, Kevin R. Cromar, John A. Hall, Wayne E. Cascio, Paul G. Smith, Brenda J. Marsh, Sarah Coefield, John R. Balmes, Ali Kamal, M. Ian Gilmour, Chris Carlsten, Kathleen M. Navarro, Gwen W. Collman, Ana Rappold, Mark D. Miller, Susan L. Stone, Daniel L. Costa
Summary: Wildland fires are reducing air quality and posing respiratory health risks. Research is needed to understand the short-term and long-term health effects of wildland fire smoke exposure, especially for vulnerable populations like children, adults, and occupational groups. It is important to invest in research, communication strategies, and public policy to address the growing problem of wildland fires and their health impacts.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2021)
Article
Automation & Control Systems
Enrique Herrera-Viedma, Ivan Palomares, Cong-Cong Li, Francisco Javier Cabrerizo, Yucheng Dong, Francisco Chiclana, Francisco Herrera
Summary: The article provides an overview of fuzzy and linguistic decision-making trends, studies, methodologies, and models developed in the last 50 years. It discusses core decision-making frameworks and new complex decision-making frameworks that have emerged in recent years. The challenges associated with these frameworks and key guidelines for future research in the field are highlighted.
IEEE TRANSACTIONS ON SYSTEMS MAN CYBERNETICS-SYSTEMS
(2021)
Article
Oncology
John Kang, Reid F. Thompson, Sanjay Aneja, Constance Lehman, Andrew Trister, James Zou, Ceferino Obcemea, Issam El Naqa
Summary: The article discusses the importance of training radiation oncologists and medical physicists in data science to effectively utilize AI in clinical practice. Action points for future trainees interested in radiation oncology AI include raising awareness, implementing practical curriculum, creating a database of resources, and accelerating learning and funding opportunities to facilitate the translation of AI into clinical practice.
PRACTICAL RADIATION ONCOLOGY
(2021)
Article
Medicine, General & Internal
Daniela Cihakova, Yang Shi, Bishow Adhikari, W. Patricia Bandettini, Madeleine W. Cunningham, Narasimhan Danthi, Matthias G. Friedrich, Peter Liu, Lisa Schwartz Longacre, Douglas L. Mann, Filip K. Swirski, W. H. Wilson Tang, Guofei Zhou, Leslie T. Cooper
Summary: The National Heart, Lung, and Blood Institute (NHLBI) organized a workshop in May 2021 to discuss new research opportunities in the field of myocarditis. International experts reviewed the current scientific knowledge and identified gaps and opportunities in basic research, diagnostics, translational research, and therapeutic approaches for future studies on myocarditis. The workshop focused not only on community-acquired myocarditis but also on emerging causes such as immune checkpoint inhibitors and SARS-CoV-2-related myocardial injuries. The potential use of systems biology and artificial intelligence methods to discover new disease mechanisms and therapeutic targets was also considered. Another important aspect discussed was the investigation of the relationship between social determinants of health (SDoH), including race and economic status, and inflammatory response and outcomes in myocarditis. The result of the workshop was a proposal for the reclassification of myocarditis based on the latest knowledge of immunological pathogenesis to improve prognosis estimation and target-specific treatments.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Cheryl L. Rock, Cynthia A. Thomson, Kristen R. Sullivan, Carol L. Howe, Lawrence H. Kushi, Bette J. Caan, Marian L. Neuhouser, Elisa Bandera, Ying Wang, Kimberly Robien, Karen M. Basen-Engquist, Justin C. Brown, Kerry S. Courneya, Tracy E. Crane, David O. Garcia, Barbara L. Grant, Kathryn K. Hamilton, Sheri J. Hartman, Stacey A. Kenfield, Maria Elena Martinez, Jeffrey A. Meyerhardt, Larissa Nekhlyudov, Linda Overholser, Alpa Patel, Bernardine M. Pinto, Mary E. Platek, Erika Rees-Punia, Colleen K. Spees, Susan M. Gapstur, Marjorie L. McCullough
Summary: This article discusses the impact of nutrition, physical activity, and diet on recurrence and overall survival rates among cancer survivors. It provides evidence-based recommendations for cancer survivors and highlights the importance of addressing survivors' needs through clinical care coordination and resources.
CA-A CANCER JOURNAL FOR CLINICIANS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Minping Hong, Sijia Fan, Zhexuan Yu, Chen Gao, Zhen Fang, Liang Du, Shiwei Wang, Xiaobo Chen, Maosheng Xu, Changyu Zhou
Summary: This study aimed to establish an MRI-based radiomics nomogram for predicting the upstaging of ductal carcinoma in situ (DCIS) and assisting with risk stratification.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Respiratory System
Anne E. Holland, Narelle S. Cox, Linzy Houchen-Wolloff, Carolyn L. Rochester, Chris Garvey, Richard ZuWallack, Linda Nici, Trina Limberg, Suzanne C. Lareau, Barbara P. Yawn, Mary Galwicki, Thierry Troosters, Michael Steiner, Richard Casaburi, Enrico Clini, Roger S. Goldstein, Sally J. Singh
Summary: Pulmonary rehabilitation is effective for chronic lung disease but underused globally. New models aim to improve access. Workshop identified essential components and requirements for implementation. Delphi process determined key components and need for further research on patient characteristics. Personalized assessment and quality assurance are crucial for success. Future success will depend on delivery of key components and achieving expected outcomes.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2021)
Article
Geriatrics & Gerontology
Peter M. Abadir, Karen Bandeen-Roche, Cindy Bergeman, David Bennett, Daniel Davis, Amy Kind, Nathan LeBrasseur, Yaakov Stern, Ravi Varadhan, Heather E. Whitson
Summary: Resilience declines with age and comorbidity in older adults, and different disciplines have used different frameworks to study resilience. The conference discussed the commonalities and differences among these frameworks in physical, cognitive, and psychosocial domains and made recommendations for future research and translation of findings into patient care.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Oncology
Andrew M. D. Wolf, Kevin C. Oeffinger, Tina Ya-Chen Shih, Louise C. Walter, Timothy R. Church, Elizabeth T. H. Fontham, Elena B. Elkin, Ruth D. Etzioni, Carmen E. Guerra, Rebecca B. Perkins, Karli K. Kondo, Tyler B. Kratzer, Deana Manassaram-Baptiste, William L. Dahut, Robert A. Smith
Summary: Lung cancer is the leading cause of cancer-related deaths and years of life lost in the US. Early detection through screening has been shown to reduce mortality. The American Cancer Society has updated its guidelines for lung cancer screening, recommending annual low-dose CT screening for individuals aged 50-80 who currently smoke or formerly smoked and have a significant smoking history.
CA-A CANCER JOURNAL FOR CLINICIANS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Julie A. Hong, Martin Brechbiel, Jeff Buchsbaum, Christie A. Canaria, C. Norman Coleman, Freddy E. Escorcia, Michael Espey, Charles Kunos, Frank Lin, Deepa Narayanan, Jacek Capala
Summary: The article reviews the National Cancer Institute's support for Radiopharmaceutical targeted therapy (RPT), including organizing workshops and interest groups, funding extramural programs, and conducting preclinical and clinical studies. The goal is to encourage the development of RPT to bring multidisciplinary treatment to patients.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Oncology
Parsa Erfani, Ayotomiwa Ojo, E. John Orav, Fumiko Chino, Miranda B. Lam
Summary: This study found that Medicaid-eligible, American Indian/Alaska Native, and older patients are less likely to use National Cancer Institute-designated cancer centers (NCICCs), while black, Hispanic, and Asian/Pacific Islander patients are more likely to use them.
ANNALS OF SURGICAL ONCOLOGY
(2022)