Review
Oncology
Lilian Roth, Linda Russo, Sima Ulugoel, Rafael Freire dos Santos, Eva Breuer, Anurag Gupta, Kuno Lehmann
Summary: Surgical and locoregional treatments of peritoneal metastasis have gained acceptance worldwide. Locoregional therapies such as HIPEC or PIPAC may improve tumor control. Understanding the molecular characteristics of peritoneal metastasis is crucial for future therapeutic strategies.
Article
Medicine, General & Internal
Xiaomei Sun, Hui Xu, Kai Xin, Bo Sun
Summary: Metastasis of neuroblastoma to the mandible and spinal extradural regions is rare, and treatment involves chemotherapy and radiotherapy. Despite successful control of maxillofacial pain and soft tissue swelling, the patient eventually passed away due to tumor progression.
Review
Oncology
Hiroyuki Goto
Summary: Cutaneous adnexal malignancies are rare tumors with no established standard treatment options. Surgery is the mainstay of treatment, with Mohs micrographic surgery being a better option than wide local excision. Radiation therapy may be considered for unresectable tumors, while chemotherapy is an option for metastatic cases. Recent studies on genetic mutations have provided hope for future targeted therapy and immunotherapy.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2022)
Review
Dermatology
Milosz Lewandowski, Zuzanna Swierczewska, Wioletta Baranska-Rybak
Summary: Hidradenitis suppurativa is a chronic inflammatory skin disease that severely affects patients' quality of life. While there are multiple treatment options, no uniformly effective therapy has been found. A multidisciplinary approach is needed for the management of this disease.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2022)
Review
Surgery
Azadeh Azizian, Alexander Konig, Michael Ghadimi
Summary: VIPoma is a neuroendocrine tumor primarily located in the pancreas that produces high levels of vasoactive intestinal peptide (VIP). It presents with a wide range of symptoms and treatment options include symptomatic therapy, chemotherapy, targeted therapy, radiation, and surgery. However, due to the rarity of VIPoma, there is currently a lack of prospective studies or evidence-based therapeutic standards.
LANGENBECKS ARCHIVES OF SURGERY
(2022)
Review
Oncology
Moritz Bewarder, Stephan Stilgenbauer, Lorenz Thurner, Dominic Kaddu-Mulindwa
Summary: Standard treatment for chronic lymphocytic leukemia (CLL) has shifted towards the use of novel agents such as BTK inhibitors, Bcl-2 inhibitors, and PI3K inhibitors, which have shown effectiveness in treating CLL. Despite these advancements, there is ongoing exploration for new therapeutic approaches and the challenge of determining the optimal combination and sequence of treatments.
Review
Medicine, Research & Experimental
Daniel Constantin Branisteanu, Camelia Margareta Bogdanici, Daciana Elena Branisteanu, Minela Aida Maranduca, Mihail Zemba, Florian Balta, Catalina Ioana Branisteanu, Andreea Dana Moraru
Summary: Uveal melanoma, a rare condition, is most frequently diagnosed in individuals of northern European descent; iris melanoma has a better prognosis compared to choroidal melanoma which has a higher metastasis rate; treatment options focus on surgical excision and radiation therapy, with challenges in treating metastatic disease.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Review
Ophthalmology
Jason Bacharach, Wendy W. Lee, Andrew R. Harrison, Thomas F. Freddo
Summary: Blepharoptosis, or ptosis, is a common disorder of the upper eyelid which can affect appearance and visual function, impacting quality of life. This review focuses on the prevalence, causes, identification, differential diagnosis, and treatment of acquired ptosis, with specific attention to emerging treatment options. Acquired ptosis, which typically develops later in life, is the primary form of the condition.
Review
Medicine, Research & Experimental
Pilan Jaipanya, Pongsthorn Chanplakorn
Summary: The treatment of spinal metastasis has significantly improved in the past decade, with advancements in systemic therapy, minimally-invasive spinal procedures, and radiotherapy. These interventions have led to better survival rates and improved quality of life for patients.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2022)
Review
Biology
Logan T. Roberts, Peter P. Issa, Evan S. Sinnathamby, Mallory Granier, Holly Mayeux, Treniece N. Eubanks, Kevin Malone, Shahab Ahmadzadeh, Elyse M. Cornett, Sahar Shekoohi, Alan D. Kaye
Summary: This review discusses the treatment options for Helicobacter pylori infection. Multiple antibiotics are prescribed to prevent high resistance rates, but this can lead to adverse reactions and adherence issues. Single-capsule combination capsules have been introduced to address these concerns, but affordability may be a problem for patients. Therefore, effectiveness and affordability need to be considered when selecting a treatment regimen.
Review
Oncology
Victor Gabriel El-Hajj, Jenny Pettersson-Segerlind, Alexander Fletcher-Sandersjoo, Erik Edstrom, Adrian Elmi-Terander
Summary: Spinal meningiomas are the most common primary intradural spinal tumors in adults, with most patients being elderly females with WHO grade 1 tumors. Sensory and motor dysfunction, as well as pain, were the most common presenting symptoms. Despite some promising results, the benefits of non-surgical treatments remain controversial.
Review
Oncology
Michal Eid, Jakub Foukal, Dana Sochorova, Stepan Tucek, Karel Stary, Zdenek Kala, Jiri Mayer, Radim Nemecek, Jan Trna, Lumir Kunovsky
Summary: PCCs are rare neuroendocrine tumors derived from adrenal chromaffin cells, while PGLs arise from sympathetic and parasympathetic ganglia. Up to 25% of PCCs/PGLs are associated with genetic disorders. The heterogeneity of these tumors makes diagnosis challenging.
Review
Gastroenterology & Hepatology
Gui-Xia Wei, Yang Du, Yu-Wen Zhou, Lin-Juan Li, Meng Qiu
Summary: Peritoneal carcinomatosis (PC) is an advanced malignancy that is not sensitive to systemic conventional chemotherapy. Treatment options for PC are usually palliative rather than curative. However, the peritoneal cavity has a unique immune environment, making IP immunotherapy a promising strategy in patients with PC.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2022)
Review
Pharmacology & Pharmacy
Yanzhao Zhou, Kun Yuan, Yi Yang, Zemin Ji, Dezheng Zhou, Jingzhong Ouyang, Zhengzheng Wang, Fuqiang Wang, Chang Liu, Qingjun Li, Qi Zhang, Qiang Li, Xiao Shan, Jinxue Zhou
Summary: Surgery is still the preferred treatment for early-stage gallbladder cancer, but most patients are already at an advanced stage or have metastasis at the time of diagnosis. The postoperative recurrence rate and survival rate remain unsatisfactory, thus calling for more treatment options like neoadjuvant and adjuvant therapies, as well as treatments for local progression and metastasis. Molecular targeted drugs and immunotherapy show promise, but more research is needed for evidence-based medicine. This review provides a systematic analysis of the treatment trends in gallbladder cancer.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Oncology
Philip Posdzich, Christopher Darr, Thomas Hilser, Milan Wahl, Ken Herrmann, Boris Hadaschik, Viktor Gruenwald
Summary: Prostate cancer is the most common tumor in men and metastatic castration resistant prostate cancer remains a deadly disease despite new developments. This article provides an overview of current and new treatment options, including androgen deprivation therapy (ADT), combination therapies, chemotherapy, ARSI, PARP inhibitors, Lu-PSMA radioligand therapy, and bispecific T-cell engagers (BiTE). The role of immunotherapy in prostate cancer is still being investigated, but overall, the field of prostate cancer therapy is challenging and promising.
Article
Clinical Neurology
Maike H. J. Schepens, Miranda L. van Hooff, Judith A. van Erkelens, Ronald Bartels, Eric Hoebink, Margot Smits, Johannes L. P. Kuijpens, Jacques van Limbeek
Summary: This study aims to describe the undesirable outcomes after primary LDH surgery in Dutch patients. The results showed that about a quarter of the patients had serious complications in the first follow-up year, prompting further medical treatment. There was a considerable variation in complication rates between different hospitals.
GLOBAL SPINE JOURNAL
(2023)
Article
Clinical Neurology
Lysanne van Silfhout, Allard J. F. Hosman, Henk van de Meent, Ronald H. M. A. Bartels, Michael J. R. Edwards
Summary: This study investigated the expectations of individuals with spinal cord injury regarding exoskeletons and found that exoskeleton technology is considered a positive and desirable innovation among them. However, significant improvements are still needed for exoskeletons to replace wheelchairs in the future.
JOURNAL OF SPINAL CORD MEDICINE
(2023)
Article
Neuroimaging
Joost de Vries, Rene Aquarius, Leif Sorensen, Hieronymus D. Boogaarts, Bernd Turowski, Wim H. van Zwam, Thomas R. Marotta, Ronald H. M. A. Bartels
Summary: This study presented the efficacy and safety results of the eCLIPs device for the treatment of bifurcation aneurysms. The technical success rate was 90% and no major strokes or deaths occurred. After 365 days of follow-up, 60% of patients achieved complete occlusion and 80% achieved adequate occlusion.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Oncology
Danielle L. van de Graaf, Carla Vlooswijk, Nadine Bol, Emiel J. Krahmer, Rhode Bijlsma, Suzanne Kaal, Sophia H. E. Sleeman, Winette T. A. van der Graaf, Olga Husson, Mies C. van Eenbergen
Summary: Adolescents and young adults diagnosed with cancer often rely on the Internet for cancer-related information, but healthcare professionals' perceptions of their needs may not align with their actual needs. A survey found discrepancies between AYAs' online information and eHealth needs and HCPs' perceptions, highlighting the potential for insufficient guidance.
Article
Oncology
Sophie J. M. Reijers, Nicolo Gennaro, Annemarie Bruining, Hester van Boven, Petur Snaebjornsson, Elise M. M. Bekers, Frits van Coevorden, Astrid N. N. Scholten, Yvonne Schrage, Winette T. A. van der Graaf, Rick L. M. Haas, Winan J. J. van Houdt
Summary: This study aimed to assess the association between radiological and histopathological response after neoadjuvant radiotherapy in soft tissue sarcoma, and the prognostic value of different response evaluation methods. The results showed that radiological response was not significantly associated with survival rates, while only necrosis in histopathological parameters was associated with overall survival.
Article
Health Care Sciences & Services
Hinke E. Hoffstaedt, Jannie A. Boogaard, Marcella C. Tam, Leti van Bodegom-Vos, Arianne Stoppelenburg, Iris D. Hartog, Yvette M. van der Linden, Jenny T. van der Steen
Summary: This study examined the practice and influencing factors of healthcare professionals in supporting family caregivers. The results revealed that support for family caregivers, especially after the patient's death, is not consistently integrated into the work procedures of healthcare professionals.
AMERICAN JOURNAL OF HOSPICE & PALLIATIVE MEDICINE
(2023)
Review
Surgery
Tinatin Natroshvili, Milly S. van de Warenburg, Erwin P. Heine, Nicholas J. Slater, Erik T. Walbeehm, Ronald H. M. A. Bartels
Summary: This article provides a systematic review and meta-analysis of conservative treatment options for ulnar compression at the elbow. The results suggest that both steroid/lidocaine injections and splint devices are effective in improving symptoms, making them suitable options for patients who do not want surgery or need a bridge to surgery.
ARCHIVES OF PLASTIC SURGERY-APS
(2023)
Article
Oncology
Cas Drabbe, Elena S. Coenraadts, Winan J. van Houdt, Michiel A. J. van de Sande, Johannes J. Bonenkamp, Jacco J. de Haan, Johanna W. M. Nin, Cornelis Verhoef, Winette T. A. van der Graaf, Olga Husson
Summary: This study aims to identify AYA sarcoma survivors with impaired social functioning (ISF) and determine the clinical and psychosocial factors associated with ISF. The study found that more than one-quarter of AYA sarcoma survivors experience ISF long after diagnosis. Unemployment and having to make lifestyle changes due to financial problems caused by physical conditions or medical treatment were associated with ISF, while better social support was associated with non-ISF. These results emphasize the importance of follow-up care that focuses not only on the disease but also on the psychological and social domains.
Article
Oncology
Deborah van de Wal, Shreenila Venkatesan, Charlotte Benson, Winette T. A. van der Graaf, Colin D. Johnson, Olga Husson, Samantha C. Sodergren
Summary: The aim of this study was to explore the side effects of tyrosine kinase inhibitors on gastrointestinal stromal tumor patients from the patient's perspective, and compare it with the perspective of healthcare professionals. Semi-structured interviews were conducted with 19 advanced or metastatic gastrointestinal stromal tumor patients, and a focus group was held with five patients and six healthcare professionals. Thematic analysis revealed that most participants reported gastrointestinal symptoms, tiredness, edema, muscle cramps, skin problems, eye problems, and trouble sleeping. Patients, but not healthcare professionals, reported cognitive problems or symptoms of depression. These findings highlight the importance of including the patient's perspective in symptom reporting.
Article
Nursing
Anne-Floor Q. Dijxhoorn, Yanouk Heijnen, Yvette M. van der Linden, Carlo Leget, Natasja J. H. Raijmakers, Linda Brom
Summary: This exploratory qualitative study examines the perceived emotional impact of providing palliative care among nursing assistants in Dutch nursing homes, their coping strategies, and associated needs. The study findings suggest that nursing assistants should be better supported in coping with the emotional impact of providing palliative care. They use different coping strategies, including emotional processing activities, their attitude towards death and work, and gaining experience. There is a need for more education in palliative care and organized peer group meetings.
JOURNAL OF ADVANCED NURSING
(2023)
Article
Oncology
Ties M. Siebinga, Silvie H. M. Janssen, Anke W. Boumans, Mies C. Van Eenbergen, Bettina Siflinger, Winette T. A. Van der Graaf, Olga Husson
Summary: This study explored the long-term income patterns and determinants among adolescent and young adult (AYA) cancer survivors, and compared them with their peers. It was found that, on average, AYA cancer survivors experience an 8.5% decrease in annual earnings compared to the control group. Younger age, marriage, female gender, diagnosis of stage IV disease, and central nervous system cancer were associated with the largest decline in income.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Review
Clinical Neurology
Jesco Streumer, Ashok K. Selvaraj, Erkan Kurt, Bastiaan R. Bloem, Rianne A. J. Esselink, Ronald H. M. A. Bartels, Dejan Georgiev, R. Saman Vinke
Summary: Axial disability, including gait disturbances, is common in Parkinson's disease (PD), especially in advanced stages. Epidural spinal cord stimulation (SCS) has been investigated as a treatment option for gait disorders in PD. This review examines the literature on SCS in PD and evaluates its efficacy, optimal stimulation parameters, optimal electrode locations, possible effects of concurrent deep brain stimulation, and possible working mechanisms on gait.
PARKINSONISM & RELATED DISORDERS
(2023)
Review
Oncology
Milou J. P. Reuvers, Asiye Gedik, Kirsty M. Way, Sanne M. van de Stadt, Winette T. A. van der Graaf, Olga Husson
Summary: This review provides an overview of the impact of being a caregiver for an AYA cancer patient on different domains of their lives and reports the unmet needs they identify. By being more attentive to the caregivers and intervening accordingly, caregivers' quality of life can increase, resulting in better caregiving capabilities. This not only benefits the patient but also decreases caregiver burden.
Letter
Medicine, General & Internal
Winette T. A. van der Graaf, Olga Husson, Winan J. van Houdt
Review
Health Care Sciences & Services
Rolf A. H. Snijders, Linda Brom, Sami O. Simons, Simone M. C. H. Langenberg, Yvette M. van der Linden, Natasja J. H. Raijmakers
Summary: This study aimed to synthesize research studies on COVID-19 patients to gain insights into the number of patients referred to hospital-based palliative care services, the characteristics and palliative care needs of these patients, and the reasons for referral. The results of the study show that 16% of all COVID-19 inpatients and 55% of all deceased COVID-19 inpatients were referred to a palliative care service. The majority of referrals were for end-of-life care management, with many patients having comorbidities and experiencing shortness of breath.
AMERICAN JOURNAL OF HOSPICE & PALLIATIVE MEDICINE
(2023)
