Article
Microbiology
Yinjuan Guo, Linling Xu, Bingjie Wang, Lulin Rao, Yanlei Xu, Xinyi Wang, Huilin Zhao, Jingyi Yu, Ying Zhou, Fangyou Yu
Summary: Mupirocin is an important antimicrobial agent in the eradication of MRSA colonization. Mupirocin-resistant MR-MRSA isolates with different molecular characteristics were analyzed, and it was found that they carried different SCCmec types, spa types, and virulence genes. Most of the MR-MRSA isolates were also resistant to other antibiotics, especially erythromycin and clindamycin. The study identified a novel high-level mupirocin-resistant MR-MRSA strain, which poses a therapeutic challenge for MRSA infections.
MICROBIOLOGY SPECTRUM
(2023)
Article
Oncology
Eerde Mutu, Guilin Chen, Roushan Liu, Yingjun Wang
Summary: This study revealed a higher prevalence of mupirocin heteroresistance in S. aureus for the first time, and identified the correlation between the mutation of G1762T in the ileS gene and resistance.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Engineering, Biomedical
Ming-Chen Sun, Ying-Fang Chen, Di Liu, Xiao-Ling Xu, Yu-Chan You, Wei Lu, Yun-Juan Shi, Ming-Yang Ren, Yi-Bin Fan, Yong-Zhong Du, Xiao-Hua Tao
Summary: The widespread use of mupirocin for treating MRSA infections has led to the emergence of mupirocin-resistant Staphylococcus aureus (MuRSA), posing a serious medical threat. In order to combat MuRSA, researchers have developed a modified mupirocin and silver complex (TPGS/Mup-Ag) to enhance its antibacterial activity. The results showed that TPGS/Mup-Ag can effectively eliminate bacterial infection and accelerate wound healing in both in vitro and in vivo experiments.
MATERIALS TODAY BIO
(2023)
Article
Infectious Diseases
Zahoua Mentfakh Laceb, Seydina M. Diene, Rym Lalaoui, Mabrouk Kihal, Fella Hamaidi Chergui, Jean-Marc Rolain, Linda Hadjadj
Summary: This study determined the prevalence of Staphylococcus aureus in a hospital environment in western Algeria and investigated nasal carriage among healthcare workers and patients. The study found a high prevalence of S. aureus in all three groups, as well as the presence of resistance and virulence genes. It also identified the hospital environment and nasal carriage as potential reservoirs for the persistence and spread of the same pathogenic clone.
Article
Microbiology
Xiao-chao Duan, Xin-xin Li, Xiang-min Li, Shuang Wang, Fen-qiang Zhang, Ping Qian
Summary: In this study, a novel chimeric lysin ClyQ was constructed, which showed a broad host range and could synergize with mupirocin to treat S. aureus skin infections. The combination of ClyQ and mupirocin also delayed the development of S. aureus resistance to mupirocin.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Yi Nong, George Taiaroa, Shivani Pasricha, Romain Guerillot, Ian R. Monk, Sarah L. Baines, Glen P. Carter, Benjamin P. Howden, Deborah A. Williamson
Summary: This study provides experimental evidence of co-selection for multidrug resistance in Staphylococcus aureus following exposure to fusidic acid or mupirocin. Carriage of fusC and mupA confers resistance to these antibiotics and may also provide a competitive advantage, leading to the selection of unrelated antimicrobial resistance determinants such as mecA, blaZ, and qacA. This highlights the need for judicious use of topical antibiotics to prevent the development of broader antibiotic resistance.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Biophysics
Qiaofeng Li, Zhaoxia An, Tieqiang Sun, Shuaifeng Ji, Weiya Wang, Yuan Peng, Zhouping Wang, Gert I. J. Salentijn, Zhixian Gao, Dianpeng Han
Summary: This study reports a visual on-site detection system for macrolide-resistant Staphylococcus aureus (SA) in dairy products. Metagenomic sequencing was used to identify the most abundant macrolide resistance gene, and LAMP assays targeting the identified gene were developed. The use of polydiacetylene (PDA) as a color indicator and smartphone analysis enabled semi-quantitative detection. The method was successfully implemented on a real farm using freeze-dried reagents and portable devices.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Microbiology
Q. C. Truong-Bolduc, Y. Wang, J. L. Reedy, J. M. Vyas, D. C. Hooper
Summary: The study found that Mupirocin can induce the expression of genes encoding efflux pumps NorA and MepA, and it can also reduce the susceptibility to pump substrates ciprofloxacin and chlorhexidine by affecting the intact norA and mepA genes, respectively.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Microbiology
Ana G. Jop Vidal, Babek Alibayov, I. J. Frame, Landon Murin, Aidan Creel, Dongping Hu, Xueqing Wu, Jorge E. Vidal
Summary: Streptococcus pneumoniae kills Staphylococcus aureus through a contact-dependent mechanism that is facilitated by cations, including iron. Some strains of S. pneumoniae have acquired the Mega gene to resist macrolide antibiotics. Our study found that disrupting iron acquisition or using Mega to resist antibiotics did not inhibit the killing mechanism.
MICROBIOLOGICAL RESEARCH
(2022)
Article
Immunology
Rachele M. Bochart, Kimberly Armantrout, Hugh Crank, Rachael Tonelli, Christine Shriver-Munsch, Tonya Swanson, Miranda Fischer, Helen Wu, Michael Axthelm, Jonah Sacha, Jeremy V. Smedley
Summary: Methicillin-resistant Staphylococcus aureus (MRSA) is a global health concern due to its resistance to beta-lactam antibiotics. Immunosuppressed patients have a higher risk of MRSA infections and experience prolonged recovery, morbidity, and mortality. A cohort of cynomolgus macaques in Oregon National Primate Research Center (ONPRC) was found to be carriers of vancomycin-resistant S. aureus (VRSA), with MRSA prevalence at 76.9% and VRSA at 70%. The study successfully demonstrated MRSA decolonization therapy and barrier practice techniques to prevent recolonization in the macaques.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Infectious Diseases
Chao Zhang, Bingshao Liang, Zhile Xiong, Zhuwei Liang, Hao Cai, Huamin Zhong, Yongqiang Xie, Yuanwei Xie, Xiaochun Liu, Shiying Xie, Fangjun Lan, Zhenwen Zhou
Summary: The purpose of this study was to investigate the distribution of biocide resistance genes among S. aureus isolates from school-age children in Guangzhou, and to explore the relationship between these genes and clonal complex genotypes as well as biofilm formation in biocide resistance. The results showed that mepA was the most prevalent biocide resistance gene, while qacG gene was not detected. The qacA/B and mupA genes were highly associated with resistance to CHG and mupirocin, and biofilm formation was found to contribute to this biocide resistance.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Microbiology
Seongman Bae, Eun Sil Kim, Hee Seung Kim, Eunmi Yang, Hyemin Chung, Yun Woo Lee, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sung-Han Kim, Sang-Ho Choi, Sang-Oh Lee, Yang Soo Kim
Summary: This study used competing risk analysis to identify risk factors for 90-day recurrence in patients with Staphylococcus aureus bacteremia. Results showed that the presence of a vascular graft, nasal MRSA carriage, methicillin resistance, and rifampicin resistance were significantly associated with recurrence risk.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Review
Chemistry, Medicinal
Chaofan Ji, Xiaozhou Xu
Summary: Staphylococcus aureus is a deadly pathogen responsible for nosocomial and community-acquired infections, with drug-resistant forms posing a heavy burden on the healthcare system. The development of novel macrolide candidates is crucial to combat this resistance.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2021)
Article
Immunology
Rafael San-Juan, Consuelo Alejandra Gotor-Perez, Francisco Lopez-Medrano, Mario Fernandez-Ruiz, David Lora, Manuel Lizasoain, Jose Tiago Silva, Maria Ruiz-Ruigomez, Laura Corbella, Isabel Rodriguez-Goncer, Esther Viedma, Maria Angeles Orellana, Emilio Renes Carreno, Jose Luis Perez-Vela, Victoria Benito-Arnaiz, Maria Jesus Lopez-Gude, Jose Maria Cortina-Romero, Jose Maria Aguado
Summary: Preoperative nasal decontamination with mupirocin significantly reduces the incidence of S. aureus PSM, with a statistically significant annual reduction observed after implementation. The data suggests a strong association between preoperative NDM and decreased S. aureus PSM rates.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
N. Hassoun-Kheir, N. Buetti, V. Olivier, M. Perez, J. Frossard, G. Renzi, J. Schrenzel, P. Saudan, S. Harbarth
Summary: This study investigated the mupirocin resistance in haemo-dialysis patients and found that it was infrequent in both blood and colonizing Staphylococcus aureus isolates. Moreover, a decreasing trend in the annual rate of S. aureus bloodstream infections was observed. Therefore, targeted mupirocin-based decolonization is a sustainable measure for preventing healthcare-associated infections in S. aureus carriers undergoing haemodialysis.
JOURNAL OF HOSPITAL INFECTION
(2023)
Article
Microbiology
Jaber Ghorbani, Farhad Bonakdar Hashemi, Fereshteh Jabalameli, Mohammad Emaneini, Reza Beigverdi
Summary: The study demonstrates that the MHRM assay can successfully identify five respiratory pathogens in less than 5 hours, with 100% sensitivity and 88.8-100% specificity.
Review
Medicine, General & Internal
Roghayeh Afifirad, Amir Darb Emamie, Rezvan Golmoradi Zadeh, Parisa Asadollahi, Roya Ghanavati, Atieh Darbandi
Summary: Pre/probiotic regimens are effective and safe for the treatment of bacterial vaginosis, reducing infection symptoms and restoring balanced vaginal microbiota. Probiotics can also prevent Group B streptococcal colonization among pregnant women.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2022)
Article
Microbiology
Mahsa Ghamari, Reza Beigverdi, Fereshteh Jabalameli, Mohammad Emaneini
Summary: In this study, the molecular characteristics, antibiotic resistance patterns, and distribution of virulence factors in Carbapenem-resistant Klebsiella pneumoniae (CRKP) isolated from clinical specimens were characterized. The results showed that CRKP infections have been associated with different genotypes and that the carbapenemase type (OXA-48) and AME gene (aac6'-Ib) were widely distributed in CRKP isolates in the hospital. It is recommended to continue compliance with existing phenotypes and genotypes, and strict enforcement of infection control guidelines to prevent and disseminate these strains.
FEMS MICROBIOLOGY LETTERS
(2022)
Article
Infectious Diseases
Soroor Erfanimanesh, Mohammad Emaneini, Mohammad Reza Modaresi, Mohammad Mehdi Feizabadi, Shahnaz Halimi, Reza Beigverdi, Vajiheh Sadat Nikbin, Fereshteh Jabalameli
Summary: This study investigated the bacterial profile and antibiotic resistance pattern in respiratory specimens from cystic fibrosis patients. Results showed that Staphylococcus aureus and Pseudomonas aeruginosa were the most prevalent bacterial isolates, with some strains showing resistance to multiple antibiotics. The study also found that S. aureus was more common in younger patients, while mucoid P. aeruginosa showed higher prevalence in older individuals.
CANADIAN JOURNAL OF INFECTIOUS DISEASES & MEDICAL MICROBIOLOGY
(2022)
Article
Microbiology
Hossein Kafi, Mohammad Emaneini, Shahnaz Halimi, Hossein Ali Rahdar, Fereshteh Jabalameli, Reza Beigverdi
Summary: The study developed a multiplex high-resolution melting assay for the simultaneous detection of multiple bacterial pathogens from urine samples. The assay showed high specificity and sensitivity, providing results in a short time, which can aid clinicians in starting treatment promptly.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Engineering, Electrical & Electronic
Alireza Bagheri, Hossein Iman-Eini, Mohammad Emaneini
Summary: In this article, a high-voltage underwater arc discharge system is proposed for the inactivation of E. coli bacteria. The system consists of a high-voltage capacitor charger and a discharge circuit, which are designed to protect and ensure stable operation of the arc discharge. By using a two-step spark gap scheme and an ultrafast high-voltage trigger circuit, the system can operate independently of water conductivity. The experimental results validate the effectiveness of the proposed system in achieving complete inactivation of E. coli bacteria in a short treatment time.
IEEE JOURNAL OF EMERGING AND SELECTED TOPICS IN POWER ELECTRONICS
(2023)
Article
Microbiology
Elahe Taki, Fereshteh Jabalameli, Mohammad Reza Mohajeri Tehrani, Mohammad Mehdi Feizabadi, Shahnaz Halimi, Mahnaz Sanjari, Mohammad Reza Amini, Reza Beigverdi, Mohammad Emaneini
Summary: This study aimed to determine the genetic diversity and antibiotic resistance profile of Staphylococcus aureus isolates in nasal and wound samples from diabetic patients. The findings showed that nasal transmission of S. aureus increased the risk of endogenous infection. Methicillin-resistant S. aureus (MRSA) was notably prevalent in nasal specimens, and the most common spa-type in both nasal and wound samples was t14870.
CURRENT MICROBIOLOGY
(2023)
Review
Medicine, General & Internal
Maryam Banar, Azin Sattari-Maraji, Ghazal Bayatinejad, Elahe Ebrahimi, Leila Jabalameli, Reza Beigverdi, Mohammad Emaneini, Fereshteh Jabalameli
Summary: This study conducted a comprehensive analysis of the global prevalence and antibiotic resistance of Stenotrophomonas maltophilia. The results showed an increasing trend in the prevalence of S. maltophilia infections, with higher prevalence in the Western Pacific Region and lower prevalence in the American regions. The analysis of antibiotic resistance revealed high resistance to cefuroxime and low resistance to minocycline. Trimethoprim-sulfamethoxazole was still considered effective for treating S. maltophilia infections.
FRONTIERS IN MEDICINE
(2023)
Article
Veterinary Sciences
Samira Abani, Nima Farzaneh, Hesam Seifi, Mohsen Ghavami, Abolfazl Mohammadi, Babak Khoramian
Summary: The present study evaluated the efficacy of macrolides in eliminating intramammary infection caused by Staphylococcus aureus and Streptoccus spp. The results showed that antibiotic therapy with macrolides before calving improved the cure rate numerically, but the difference was not statistically significant.
VETERINARY RESEARCH FORUM
(2022)
Article
Microbiology
Samaneh Bourbour, Reza Beigverdi, Maryam Beheshti, Fereshteh Jabalameli, Mohammad Emaneini
Summary: This study aimed to investigate the prevalence and molecular characteristics of AME genes in aminoglycoside-resistant Staphylococcus aureus and Staphylococcus epidermidis strains isolated from clinical specimens in Iran. The results showed that the main mechanism of aminoglycoside resistance was the presence of aac(6')-Ie-aph(2 '')-Ia and aph(3') IIIa genes, and the dominant clones were ST239 and ST2. This information is critical for clinicians and healthcare workers to make appropriate treatment and infection control decisions.
IRANIAN JOURNAL OF MICROBIOLOGY
(2022)
Article
Veterinary Sciences
Masoud Saeedipanah Ardakani, Babak Khoramian Toosi, Mohammad Azizzadeh, Masoud Rajabioun
Summary: The study aimed to evaluate the correlation between fetal parameters measured by ultrasonography and fetal age in Baluchi sheep for developing a formula to estimate fetal age. The results showed that most parameters had a significant correlation with fetal age, with biparietal diameter, femural length, and fetal heart rate showing the highest correlation. Gestation Sac diameter had a low correlation with fetal age, and placentome diameter had a significant non-linear correlation. The study recommended using occipito-snout diameter as the best parameter for estimating gestational age in Baluchi sheep between days 36-109.
VETERINARY RESEARCH FORUM
(2022)
Article
Infectious Diseases
Mahsa Ghamari, Fereshteh Jabalameli, Mohammad Emaneini, Reza Beigverdi
Summary: This study investigated the resistance of Group B Streptococcus (GBS) to macrolide antibiotics in Tehran, Iran, and analyzed the genetic relationships among resistant strains. The results showed that the most common antimicrobial resistance gene in the resistant strains was tetM, and there was diversity among the resistant strains. Therefore, careful usage of macrolide antibiotics, continuous surveillance, and infection control measures are necessary.
NEW MICROBES AND NEW INFECTIONS
(2022)
