Journal
BURNS
Volume 35, Issue 3, Pages 348-351Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.burns.2008.06.018
Keywords
Fibroblast; Keloid; MCP-1; MMP-2; TIMP-2
Categories
Funding
- National Science Council [NSC91-2314-B-075-095]
- Taipei Veterans General Hospital, Taiwan, ROC
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Keloid tissue results from aberrant wound healing. The underlying mechanism responsible for keloid formation remains unclear. The aim of this study was to analyse the production of tissue inflammatory mediators by normal and keloid-derived human dermal fibroblasts cultured in vitro. Production of monocyte chemoattractant protein 1 (MCP-1), matrix metalloproteinase 2 (MMP-2) and tissue inhibitor of metalloproteinase 2 (TIMP-2), with and without the addition of interleukin-1 beta, was determined by enzyme-linked immunosorbant assay. Our results showed that IL-1 beta (10 ng/ml) stimulated a statistically significant increase in MCP-1 and MMP-2 production and decreased production of TIMP-2 by both normal and keloid-derived fibroblasts (Student's t-test, p < 0.05), but to differing extents. This may contribute to factors leading to keloid formation. (c) 2008 Elsevier Ltd and ISBI. All rights reserved.
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