Article
Critical Care Medicine
Angela L. F. Gibson, Bonnie C. Carney, Leila Cuttle, Christine J. Andrews, Christine J. Kowalczewski, Aiping Liu, Heather M. Powell, Randolph Stone, Dorothy M. Supp, Adam J. Singer, Jeffrey W. Shupp, Lily Stalter, Lauren T. Moffatt
Summary: Deep partial thickness burns are commonly seen in clinical practice but are hard to diagnose. Accurate animal models are crucial for developing methods to assess burn depth and therapies to treat these burns. Inconsistencies in evaluation approaches among different laboratories were found, leading to the development of a scoring rubric that improved reliability in assessing burn injury depth in pig models.
JOURNAL OF BURN CARE & RESEARCH
(2021)
Article
Medicine, General & Internal
Clement J. Staud, Annika Resch, Alexandra Christ, Anton Borger, Maximilian Zaussinger, Maryana Teufelsbauer, Nina Worel, Christine Radtke
Summary: Depending on the extent of burn injuries, different treatment strategies are required. Skin allografts are a well-established but rarely standardized option for temporary wound coverage in cases of severe large-area trauma. This retrospective study analyzed the results of skin allograft application in ten patients, obtained from the in-house skin bank at the Vienna Burn Center. The study showed that skin allografts provided sufficient wound coverage and proved to be successful in treating patients with extensive burn injuries.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Materials Science, Multidisciplinary
R. Moucka, M. Sedlacik, Z. Patikova
Summary: The viscoelasticity of porcine skin and its material substitute, modelled by bovine gelatin at various concentrations, was investigated using rotational rheometry. The creep compliance and complex shear modulus were determined in both static and dynamic modes. The shear and compression moduli of gelatin were also characterized using a large deformation compression test and correlated with its concentration dependence. The obtained data was fitted with fractional viscoelastic models to analyze the transition of gelatin's behavior with increasing concentration and crosslinking density. The potential of gelatin as a biomaterial for skin surrogate was identified, along with the concentration range where gelatin exhibits similar viscoelastic behavior to native porcine skin.
MECHANICS OF MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Ines Foessl, Christoph Walter Haudum, Ivan Vidakovic, Ruth Prassl, Joakim Franz, Selma Mautner, Sonja Kainz, Elisabeth Hofmann, Barbara Obermayer-Pietsch, Thomas Birngruber, Petra Kotzbeck
Summary: The study identified 43 miRNAs as potential regulators of the early burn response, with miR-497-5p being stably downregulated in tissue and dISF in the early phase after a burn injury. The altered levels of miRNAs in dISF of thermally injured skin suggest them as new biomarker candidates for burn injuries. This is the first study to report miRNAs altered in the dISF in the early phase of deep partial-thickness burns.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Economics
Gabriel Malta Castro, Claude Kloeckl, Peter Regner, Johannes Schmidt, Amaro Olimpio Pereira
Summary: With the increase in the use of renewable energies in electricity systems, studies have been conducted to determine the optimal technological and spatial mix, using Modern Portfolio Theory (MPT). However, these analyses often fail to address important aspects in energy planning. In this study, we propose several improvements to address these shortcomings and evaluate their impact. The results show that the new approach significantly differs from the traditional formulation, with a shorter range of acceptable standard deviation values and a higher probability of under-production for portfolios in regions with extreme standard deviations. Additionally, diversification plays a key role in smoothing output from portfolios of variable renewable sources.
Article
Medicine, General & Internal
Chin-Choon Yeh, Yu-San Lin, Chun-Chia Chen, Chung-Feng Liu
Summary: This study successfully utilized artificial intelligence/machine learning techniques to predict potential adverse outcomes in burn patients, including prolonged hospital stays, the need for skin grafts, and overall adverse complications. The results showed that the random forest model performed best in predicting prolonged hospital stays and the need for skin grafts, while the XGBoost and LightGBM models also achieved high AUC values.
Article
Computer Science, Interdisciplinary Applications
Christopher B. Marsh, Kevin R. Green, B. Wang, Raymond J. Spiteri
Summary: The study applies lookup tables (LUTs) to replace computationally intensive mathematical function evaluations in distributed hydrological models, resulting in reduced computational costs and improved runtime efficiency, contributing to enhanced model accuracy.
ENVIRONMENTAL MODELLING & SOFTWARE
(2021)
Article
Multidisciplinary Sciences
Vanessa Hannay, F. N. U. Rahul, Kartik Josyula, Uwe Kruger, Samara Gallagher, Sangrock Lee, Hanglin Ye, Basiel Makled, Conner Parsey, Jack Norfleet, Suvranu De
Summary: This study compares the mechanical response of synthetic tissues and porcine skin tissues to guide the development of high-fidelity burn care simulators.
SCIENTIFIC REPORTS
(2022)
Editorial Material
Ecology
Byron B. Lamont
Summary: Zylstra et al. recently reported that after 75 years without burning, wet sclerophyll forest experiences a significant decrease in flammability, requiring a reevaluation of fire management. This finding also emphasizes the vertical dimension of fires, highlighting the benefits of a mosaic of fire types (high pyrodiversity) for species conservation.
TRENDS IN ECOLOGY & EVOLUTION
(2023)
Review
Dermatology
Josh Turner, Danielle A. O'Loughlin, Phill Green, Tom O. McDonald, Kevin J. Hamill
Summary: As the desire and popularity of achieving a tanned appearance without UV exposure continue to grow, this review provides a comprehensive overview of dihydroxyacetone-based sunless tanning products. It covers their formulation principles, safety considerations, and various delivery vehicles used for topical application.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Business
Hung-Yao Liu, Annapoornima M. Subramanian, Chang-Chieh Hang
Summary: The study validates the effectiveness of the integrated pretransfer matching framework and introduces the mvQCA method to management scholars by leveraging the unique technology transfer context between public research institutes and small and medium-sized enterprises in Singapore.
IEEE TRANSACTIONS ON ENGINEERING MANAGEMENT
(2021)
Article
Environmental Sciences
Oddny Ragnarsdottir, Mohamed Abou-Elwafa Abdallah, Stuart Harrad
Summary: Per- and polyfluoroalkyl substances (PFAS), a class of chemicals produced and used since the 1950s, have been linked to various health effects in humans even at low levels of exposure. Human biomonitoring data shows widespread exposure to PFAS across all age groups. While PFAS have been found in a wide range of products, little is known about dermal uptake as a possible route for human exposure.
ENVIRONMENTAL POLLUTION
(2022)
Article
Engineering, Biomedical
T. Irwin, A. Speirs, C. Merrett
Summary: The fracture properties of skin tissue are crucial in medical treatments and surgeries. Experimental results showed that skin tension has a significant impact on fracture properties, while insertion speed has a negligible effect. Additional parameters beyond the three independent variables influence the fracture process.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Computer Science, Information Systems
Yu-Kun Qiu, Fa-Ting Hong, Wei-Hong Li, Wei-Shi Zheng
Summary: This study proposes a People Relation Network (PRN) to address the problem of important people detection. PRN utilizes multiple modules to extract features, model relations, and estimate the importance of people, enabling effective differentiation of important people from other individuals.
IEEE TRANSACTIONS ON MULTIMEDIA
(2023)
Review
Pharmacology & Pharmacy
Diana Nicole Stanton, Gitali Ganguli-Indra, Arup Kumar Indra, Pankaj Karande
Summary: Research on skin diseases has shifted towards using 3D models to better replicate the complex interactions between cells and matrices within the skin. Three-dimensional human skin equivalents have emerged as a valuable tool for studying skin diseases.
Article
Biochemistry & Molecular Biology
Jemma Evans, Giuseppe Infusini, Jacqui McGovern, Leila Cuttle, Andrew Webb, Thomas Nebl, Liz Milla, Roy Kimble, Margit Kempf, Christine J. Andrews, David Leavesley, Lois A. Salamonsen
Article
Biochemical Research Methods
Tuo Zang, Leila Cuttle, Daniel A. Broszczak, James A. Broadbent, Catherine Tanzer, Tony J. Parker
JOURNAL OF PROTEOME RESEARCH
(2019)
Article
Medicine, Research & Experimental
Cody C. Frear, Bronwyn Griffin, Leila Cuttle, Steven M. McPhail, Roy Kimble
Article
Critical Care Medicine
J. D. Iljas, J. Rohl, J. A. McGovern, K. H. Moromizato, T. J. Parker, L. Cuttle
Summary: This study established a 3D deep burn wound model using human skin equivalent (HSE) and compared it to native skin. The HSE model demonstrated re-growth and formation of neo-epidermis after burn injury, while native skin did not. The model is effective for studying burn wound pathology and treatment.
Article
Surgery
C. C. Frear, L. Cuttle, S. M. McPhail, M. D. Chatfield, R. M. Kimble, B. R. Griffin
BRITISH JOURNAL OF SURGERY
(2020)
Article
Critical Care Medicine
Angela L. F. Gibson, Bonnie C. Carney, Leila Cuttle, Christine J. Andrews, Christine J. Kowalczewski, Aiping Liu, Heather M. Powell, Randolph Stone, Dorothy M. Supp, Adam J. Singer, Jeffrey W. Shupp, Lily Stalter, Lauren T. Moffatt
Summary: Deep partial thickness burns are commonly seen in clinical practice but are hard to diagnose. Accurate animal models are crucial for developing methods to assess burn depth and therapies to treat these burns. Inconsistencies in evaluation approaches among different laboratories were found, leading to the development of a scoring rubric that improved reliability in assessing burn injury depth in pig models.
JOURNAL OF BURN CARE & RESEARCH
(2021)
Article
Cell Biology
Cody C. Frear, Tuo Zang, Bronwyn R. Griffin, Steven M. McPhail, Tony J. Parker, Roy M. Kimble, Leila Cuttle
Summary: The study aimed to characterize the proteome of wound fluid collected using negative pressure wound therapy from children with small-area thermal burns. Results suggest that negative pressure wound therapy may enhance wound healing through modulation of factors involved in the inflammatory response, granulation tissue synthesis, and extracellular matrix maintenance.
WOUND REPAIR AND REGENERATION
(2021)
Article
Dermatology
Elissa Henderson, Margaretha Kempf, Charlotte Yip, Lisa Davenport, Emily Jones, Sara Kong, Ella Pearson, Anastasia Kearns, Leila Cuttle
Summary: Studying the effects of heat exposure on skin cells helps in understanding the extent of damage caused by heat and provides important information for studying the mechanisms of heat-induced cell death.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2022)
Review
Dermatology
Philippa Davies, Leila Cuttle, Amber Young
Summary: This scoping review summarizes the methodology and recent advances in studies of genetic influences on keloid or hypertrophic scarring after acute wounding, highlighting the significant variation in study designs and scar assessment methods. The review identified a limited body of evidence, indicating the need for further research, particularly in diverse populations.
ADVANCES IN WOUND CARE
(2021)
Article
Surgery
Lisa M. Davenport, Leila Cuttle, Craig A. McBride, Roy Kimble
Summary: Escharotomies in children result in significant morbidity, with 71% of survivors requiring operative revisions of their scars. Further investigation into decompression methods and long-term morbidity is needed.
ANZ JOURNAL OF SURGERY
(2021)
Article
Multidisciplinary Sciences
Cody C. Frear, Bronwyn R. Griffin, Leila Cuttle, Roy M. Kimble, Steven M. McPhail
Summary: The study evaluated the cost-effectiveness of negative pressure wound therapy (NPWT) for pediatric burns, finding NPWT to accelerate wound re-epithelialisation and reduce overall costs. NPWT is likely to be a cost-effective and dominant treatment for small-area pediatric burns.
SCIENTIFIC REPORTS
(2021)
Review
Pediatrics
Leila Cuttle, Mark Fear, Fiona M. Wood, Roy M. Kimble, Andrew J. A. Holland
Summary: This review aims to summarize the key factors and interventions to improve the long-term outcomes of pediatric burns, including first aid treatment, assessment of burn severity, referral to burns center, scar prevention or treatment, and patient follow-up after discharge.
LANCET CHILD & ADOLESCENT HEALTH
(2022)
Letter
Surgery
Cody C. Frear, Leila Cuttle, Steven M. McPhail, Mark D. Chatfield, Roy Kimble, Bronwyn R. Griffin
BRITISH JOURNAL OF SURGERY
(2021)
Review
Emergency Medicine
Morgan Carlton, Joanne Voisey, Tony J. Parker, Chamindie Punyadeera, Leila Cuttle
Summary: This review identifies numerous biomarkers associated with burn injury in children, suggesting that future research should focus on broad screening methods, exploring biological interactions among different biomarkers, utilizing child-appropriate biological fluids, and incorporating a range of burn severity in studies. Through further research, a better understanding of the biological response to burn injury may lead to the development of clinically relevant diagnostic tests and treatment therapies for improving healing outcomes in paediatric burn patients.
