Article
Medicine, Research & Experimental
Tomasz Korzeniowski, Jerzy Struzyna, Kamil Torres
Summary: This study evaluated the efficacy of bromelain-based enzymatic debridement combined with laser Doppler imaging (LDI) in the treatment of burns. The results showed that LDI can reliably assess perfusion of burn wounds and help predict healing time.
MEDICAL SCIENCE MONITOR
(2022)
Article
Critical Care Medicine
K. J. Zheng, E. Middelkoop, M. Stoop, P. P. M. van Zuijlen, A. Pijpe
Summary: This study assessed the validity of Laser Speckle Contrast Imaging (LSCI) for measuring burn wound healing potential (HP) in comparison to the reference standard of Laser Doppler Imaging (LDI). The results showed that LSCI was able to accurately discriminate between burn wounds with different healing potentials.
Article
Engineering, Biomedical
Que Bai, Caiyun Zheng, Na Sun, Wenting Chen, Qian Gao, Jinxi Liu, Fangfang Hu, Tong Zhou, Yanni Zhang, Tingli Lu
Summary: This study presents an oxygen-releasing hydrogel that promotes cell survival, migration, and tube formation under hypoxic conditions, and facilitates tissue repair by reducing inflammation, increasing angiogenesis, and collagen deposition.
ACTA BIOMATERIALIA
(2022)
Article
Critical Care Medicine
Shahab Shahid, Marco Correia Duarte, Jufen Zhang, Daniel Markeson, David Barnes
Summary: The aim of the study was to determine if the proportion of poor blood flow (blue) within an LDI image of a burn is independently correlated with healing time. The study found no significant correlation between the proportion of blue and healing time, but the presence of blue in an LDI image was associated with patient age and comorbidities.
Article
Chemistry, Multidisciplinary
Minting Liu, Ying Chen, Qiang Zhu, Junjun Tao, Changming Tang, Huajun Ruan, Yunlong Wu, Xian Jun Loh
Summary: This study discovered that supercritical CO2 extracted pearl peptide hydrogels have the potential to promote wound healing. These hydrogels can increase skin fibroblast viability, enhance antioxidant stress resistance, promote tissue remodeling and angiogenesis, and significantly accelerate wound healing.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Polymer Science
Abdul Qadir, Samreen Jahan, Mohd Aqil, Musarrat Husain Warsi, Nabil A. Alhakamy, Mohamed A. Alfaleh, Nausheen Khan, Athar Ali
Summary: Medicinal plants have been used since ancient times and are gradually proving their effectiveness in modern drug delivery systems, while nanotechnology is emerging as a promising strategy in disease control and shows potential advantages for treating skin burn wounds.
Article
Peripheral Vascular Disease
Axel Couturier, Raphael Bouvet, Jean-Luc Cracowski, Matthieu Roustit
Summary: This study found that high-resolution LSCI devices have good reproducibility in assessing healthy and wounded skin perfusion in mice, but the reproducibility of hemoglobin oxygenation is poor.
MICROVASCULAR RESEARCH
(2022)
Article
Engineering, Biomedical
Fateme Fayyazbakhsh, Michael J. Khayat, Ming C. Leu
Summary: This study utilized clinically relevant hydrogels to fabricate 3D-printed dressings for the treatment of deep partial-thickness burn wounds. The findings revealed that a 3D-printed dressing with 75% gelatin and 25% alginate exhibited the best balance between mechanical properties, hydration activity, and in vitro biological response.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2022)
Article
Pharmacology & Pharmacy
Cheng Yang, Yuhui Chen, Hai Huang, Shicai Fan, Chengliang Yang, Liping Wang, Wenqiang Li, Wenxin Niu, Jianwen Liao
Summary: The ROS-sensitive hydrogel prepared in this study showed strong free radical scavenging ability, accelerated wound healing, and promoted tissue regeneration in experiments.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Fatemeh Hassaninejad Farahani, Fatemeh Moraffah, Nasrin Samadi, Mohammad Sharifzadeh, Hamidreza Motasadizadeh, Alireza Vatanara
Summary: Lactiplantibacillus plantarum cells were encapsulated in a mixture of cationic and anionic polymers and freeze-dried, resulting in a stable composition. The effects of polymer concentrations and prebiotics on probiotic viability and swelling behavior were examined using a D-optimal design. The optimized formulation showed a viability percentage of over 82% and should be stored refrigerated. In vivo testing demonstrated improved wound healing indicators and the ability to modify wound inflammatory responses, making it comparable to silver sulfadiazine ointment.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biophysics
Karan Razdan, Shashi Kanta, Ekta Chaudhary, Seema Kumari, Deepak Kumar Rahi, Ashok Kumar Yadav, Vivek Ranjan Sinha
Summary: The study developed and characterized levofloxacin-loaded clove oil nanoscale emulgel and evaluated its therapeutic efficacy in Pseudomonas aeruginosa biofilm-infected burn wounds in mice. The results showed that the emulgel dispersed biofilms, closed wounds, promoted re-epithelialization and collagen deposition, and cleared the infection within 7 days, indicating its effectiveness in treating biofilm-infected burn wounds.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Physical
Na Li, Wan Liu, Xiaoyan Zheng, Qing Wang, Lixin Shen, Junfeng Hui, Daidi Fan
Summary: Burns are a common medical problem worldwide, with wound infection as a major complication. To tackle this issue, a new strategy has been proposed to develop a pH-responsive antimicrobial P-ZIF by loading PHMB into ZIF-8 nanoparticles. These nanoparticles can release PHMB in the weak acid environment of an infected wound. Furthermore, P-ZIF nanoparticles were incorporated into a hydrogel dressing made of SA and H-A, which exhibited antibacterial and wound healing properties with dual pH responsiveness. The P-ZIF nanoparticles and corresponding hydrogel dressing are highly significant in antimicrobial, drug delivery, and wound repair applications.
Article
Biotechnology & Applied Microbiology
Chuwei Zhang, Qingrong Zhang, Dongmei Yang, Yating Qiao, Bolin Wang, Jun Yan, Zihan Li, Zhanghao Huang, Youlang Zhou, Kesu Hu, Yi Zhang
Summary: Burns can impair skin barrier function and have high mortality rates. Chitooligosaccharides (COS) have potential in burn wound therapy by promoting wound healing through regulation of the MAPK pathway and HGF.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Ying Huang, Lei Mu, Xin Zhao, Yong Han, Baolin Guo
Summary: Researchers have developed a self-healing hydrogel with good electrical conductivity and antioxidant activity for burn wound repair. The hydrogel can release antibiotics on demand and shows excellent antibacterial properties, in vivo antibacterial activity, and wound inflammation control compared to conventional dressings. This smart release hydrogel is highly advantageous for bacterial-infected burn wound healing.
Article
Pharmacology & Pharmacy
Badriyah Shadid Alotaibi, Maryam Shoukat, Manal Buabeid, Abida Kalsoom Khan, Ghulam Murtaza
Summary: The use of neomycin-loaded CG/PAN/PU nanofibers can promote wound healing, especially in burn wounds, indicating great potential in this field.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Myra H. Wyckoff, Eunice M. Singletary, Jasmeet Soar, Theresa M. Olasveengen, Robert Greif, Helen G. Liley, David Zideman, Farhan Bhanji, Lars W. Andersen, Suzanne R. Avis, Khalid Aziz, Jason C. Bendall, David C. Berry, Vere Borra, Bernd W. Boettiger, Richard Bradley, Janet E. Bray, Jan Breckwoldt, Jestin N. Carlson, Pascal Cassan, Maaret Castren, Wei-Tien Chang, Nathan P. Charlton, Adam Cheng, Sung Phil Chung, Julie Considine, Daniela T. Costa-Nobre, Keith Couper, Katie N. Dainty, Peter G. Davis, Maria Fernanda de Almeida, Allan R. de Caen, Edison F. de Paiva, Charles D. Deakin, Therese Djarv, Matthew J. Douma, Ian R. Drennan, Jonathan P. Duff, Kathryn J. Eastwood, Walid El-Naggar, Jonathan L. Epstein, Raffo Escalante, Jorge G. Fabres, Joe Fawke, Judith C. Finn, Elizabeth E. Foglia, Fredrik Folke, Karoline Freeman, Elaine Gilfoyle, Craig A. Goolsby, Amy Grove, Ruth Guinsburg, Tetsuo Hatanaka, Mary Fran Hazinski, George S. Heriot, Karen G. Hirsch, Mathias J. Holmberg, Shigeharu Hosono, Ming-Ju Hsieh, Kevin K. C. Hung, Cindy H. Hsu, Takanari Ikeyama, Tetsuya Isayama, Vishal S. Kapadia, Mandira Daripa Kawakami, Han-Suk Kim, David A. Kloeck, Peter J. Kudenchuk, Anthony T. Lagina, Kasper G. Lauridsen, Eric J. Lavonas, Andrew S. Lockey, Carolina Malta Hansen, David Markenson, Tasuku Matsuyama, Christopher J. D. McKinlay, Amin Mehrabian, Raina M. Merchant, Daniel Meyran, Peter T. Morley, Laurie J. Morrison, Kevin J. Nation, Michael Nemeth, Robert W. Neumar, Tonia Nicholson, Susan Niermeyer, Nikolaos Nikolaou, Chika Nishiyama, Brian J. O'Neil, Aaron M. Orkin, Osokogu Osemeke, Michael J. Parr, Catherine Patocka, Jeffrey L. Pellegrino, Gavin D. Perkins, Jeffrey M. Perlman, Yacov Rabi, Joshua C. Reynolds, Giuseppe Ristagno, Charles C. Roehr, Tetsuya Sakamoto, Claudio Sandroni, Taylor Sawyer, Georg M. Schmolzer, Sebastian Schnaubelt, Federico Semeraro, Markus B. Skrifvars, Christopher M. Smith, Michael A. Smyth, Roger F. Soll, Takahiro Sugiura, Sian Taylor-Phillips, Daniele Trevisanuto, Christian Vaillancourt, Tzong-Luen Wang, Gary M. Weiner, Michelle Welsford, Jane Wigginton, Jonathan P. Wyllie, Joyce Yeung, Jerry P. Nolan, Katherine M. Berg
Summary: The latest annual summary from the International Liaison Committee on Resuscitation reviews recently published evidence on various topics related to cardiopulmonary resuscitation, including video-based dispatch systems, head-up CPR, early coronary angiography, and more. The summary includes consensus treatment recommendations and highlights priority knowledge gaps for further research.
Article
Medicine, General & Internal
Sang-Min Kim, Seung Mok Ryoo, Tae Gun Shin, Yoo Seok Park, You Hwan Jo, Tae Ho Lim, Sung Phil Chung, Sung-Hyuk Choi, Gil Joon Suh, Won Young Kim
Summary: This study investigated prognostic factors associated with late mortality in septic shock patients surviving 28 days after admission. Non-survivors were older, had higher lactate levels, and were more likely to have pulmonary, hepatobiliary infections, and a history of malignancy. Independent risk factors for late death included age, malignancy, hemoglobin, blood urea nitrogen, albumin levels, length of intensive care unit stay, and Sequential Organ Failure Assessment score. About one-seventh of septic shock patients surviving past day 28 died by day 90. Physicians should pay attention to survivors with these risk factors to mitigate the increased mortality risk.
INTERNAL AND EMERGENCY MEDICINE
(2022)
Letter
Emergency Medicine
Hyun Sim Lee, Jinwoo Myung, Min Ji Choi, Hye Jung Shin, Incheol Park, Sung Phil Chung, Ji Hoon Kim
WORLD JOURNAL OF EMERGENCY MEDICINE
(2022)
Review
Emergency Medicine
Ji Hwan Lee, Yoo Seok Park, Min Joung Kim, Hye Jung Shin, Yun Ho Roh, Ji Hoon Kim, Hyun Soo Chung, Incheol Park, Sung Phil Chung
Summary: This systematic review and meta-analysis found that the Clinical Frailty Scale (CFS) is an accurate and reliable tool for predicting short-term mortality in emergency department patients.
ACADEMIC EMERGENCY MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Sol Ji Choi, Min Joung Kim, Jinwoo Myung, Ju Young Hong, Hyun Soo Chung, Sung Phil Chung, Ji Hwan Lee
Summary: This study examined the characteristics of motorcycle crashes involving delivery riders and compared them with other motorcycle crashes. While the severity of delivery motorcycle crashes was low, the number of patients increased significantly. The results suggest the need to improve the working environment to prevent accidents and consider policies for wearing extremity protective gears.
TRAFFIC INJURY PREVENTION
(2022)
Article
Medicine, General & Internal
Shin Young Park, Min Joung Kim, Incheol Park, Ha Yan Kim, Myeongjee Lee, Yoo Seok Park, Sung Phil Chung
Summary: This study investigated the incidence and factors associated with elevated pancreatic enzyme levels after out-of-hospital cardiac arrest (OHCA) in patients treated with targeted temperature management (TTM). The results showed that elevated pancreatic enzyme levels were associated with unfavorable neurologic outcomes and higher mortality rates.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jinwoo Myung, Jin-Ho Beom, Ju-Hee Kim, Ji-Sun Woo, Incheol Park, Sung-Phil Chung, Yong-Eun Chung, Je-Sung You
Summary: This study found that the administration of recombinant klotho (rKL) protein can attenuate the inflammation and cell death caused by myocardial ischemia and reperfusion injury (I/R) by inhibiting the extracellular release of HMGB1. This provides a theoretical basis for the clinical adjunctive treatment of acute myocardial infarction.
Article
Emergency Medicine
Taeyoung Kong, Je Sung You, Hye Sun Lee, Soyoung Jeon, Yoo Seok Park, Sung Phil Chung
Summary: Targeted temperature management (TTM) at 32°C-36°C improves outcomes for out-of-hospital cardiac arrest (OHCA) patients. This study investigated the therapeutic relations between targeted temperatures and automated temperature management devices with feedback systems (TFDs) for TTM patients. The study found that in the absence of TFDs, TTM at 36°C was associated with more favorable clinical outcomes compared to TTM at 33°C.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Medicine, Research & Experimental
Jin-Ho Choi, Byeong Jo Chun, Seok Ran Yeom, Sung Phil Chung, Young Hwan Lee, Yun-Hee Kim, Ji Sung Lee, Jin Hwan Lee, Hwan Goo Lee, Jing Yu Jin, Chun San An, Byoung Joo Gwag
Summary: This study aims to assess the feasibility and potential of using Neu2000K to reduce ischemic brain injury in resuscitated OHCA patients. It is a multicenter, randomized, double-blinded, prospective clinical trial to evaluate the safety and efficacy of the drug. Various outcomes, including blood biomarkers and imaging, will be measured.
Article
Medicine, General & Internal
Hui Jai Lee, Byuk Sung Ko, Seung Mok Ryoo, Eunah Han, Gil Joon Suh, Sung-Hyuk Choi, Sung Phil Chung, Tae Ho Lim, Won Young Kim, Woon Yong Kwon, Sung Yeon Hwang, You Hwan Jo, Jonghwan Shin, Tae Gun Shin, Kyuseok Kim
Summary: The Sepsis-3 criteria introduced the use of the Sequential Organ-Failure Assessment (SOFA) score to define sepsis. This study aimed to develop and validate a modified Cardiovascular SOFA (CV SOFA) score, considering changes in recommended vasopressors. The modified CV SOFA score showed higher predictive validity and identified more patients at risk of septic mortality among patients with suspected infection, sepsis, and septic shock.
Article
Cardiac & Cardiovascular Systems
Myra H. Wyckoff, Robert Greif, Peter T. Morley, Kee-Chong Ng, Theresa M. Olasveengen, Eunice M. Singletary, Jasmeet Soar, Adam Cheng, Ian R. Drennan, Helen G. Liley, Barnaby R. Scholefield, Michael A. Smyth, Michelle Welsford, David A. Zideman, Jason Acworth, Richard Aickin, Lars W. Andersen, Diane Atkins, David C. Berry, Farhan Bhanji, Joost Bierens, Vere Borra, Bernd W. Bottiger, Richard N. Bradley, Janet E. Bray, Jan Breckwoldt, Clifton W. Callaway, Jestin N. Carlson, Pascal Cassan, Maaret Castren, Wei-Tien Chang, Nathan P. Charlton, Sung Phil Chung, Julie Considine, Daniela T. Costa-Nobre, Keith Couper, Thomaz Bittencourt Couto, Katie N. Dainty, Peter G. Davis, Maria Fernanda de Almeida, Allan R. de Caen, Charles D. Deakin, Therese Djarv, Michael W. Donnino, Matthew J. Douma, Jonathan P. Duff, Cody L. Dunne, Kathryn Eastwood, Walid El-Naggar, Jorge G. Fabres, Joe Fawke, Judith Finn, Elizabeth E. Foglia, Fredrik Folke, Elaine Gilfoyle, Craig A. Goolsby, Asger Granfeldt, Anne-Marie Guerguerian, Ruth Guinsburg, Karen G. Hirsch, Mathias J. Holmberg, Shigeharu Hosono, Ming-Ju Hsieh, Cindy H. Hsu, Takanari Ikeyama, Tetsuya Isayama, Nicholas J. Johnson, Vishal S. Kapadia, Mandira Daripa Kawakami, Han-Suk Kim, Monica Kleinman, David A. Kloeck, Peter J. Kudenchuk, Anthony T. Lagina, Kasper G. Lauridsen, Eric J. Lavonas, Henry C. Lee, Yiqun (Jeffrey) Lin, Andrew S. Lockey, Ian K. Maconochie, R. John Madar, Carolina Malta Hansen, Siobhan Masterson, Tasuku Matsuyama, Christopher J. D. McKinlay, Daniel Meyran, Patrick Morgan, Laurie J. Morrison, Vinay Nadkarni, Firdose L. Nakwa, Kevin J. Nation, Ziad Nehme, Michael Nemeth, Robert W. Neumar, Tonia Nicholson, Nikolaos Nikolaou, Chika Nishiyama, Tatsuya Norii, Gabrielle A. Nuthall, Brian J. O'Neill, Yong-Kwang Gene Ong, Aaron M. Orkin, Edison F. Paiva, Michael J. Parr, Catherine Patocka, Jeffrey L. Pellegrino, Gavin D. Perkins, Jeffrey M. Perlman, Yacov Rabi, Amelia G. Reis, Joshua C. Reynolds, Giuseppe Ristagno, Antonio Rodriguez-Nunez, Charles C. Roehr, Mario Rudiger, Tetsuya Sakamoto, Claudio Sandroni, Taylor L. Sawyer, Steve M. Schexnayder, Georg M. Schmolzer, Sebastian Schnaubelt, Federico Semeraro, Markus B. Skrifvars, Christopher M. Smith, Takahiro Sugiura, Janice A. Tijssen, Daniele Trevisanuto, Patrick Van de Voorde, Tzong-Luen Wang, Gary M. Weiner, Jonathan P. Wyllie, Chih-Wei Yang, Joyce Yeung, Jerry P. Nolan, Katherine M. Berg
Summary: This article summarizes the International Liaison Committee on Resuscitation's International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. It covers a wide range of topics related to resuscitation and provides consensus treatment recommendations based on evidence quality assessment. The article also highlights knowledge gaps for future research.
Review
Emergency Medicine
Gil Joon Suh, Tae Gun Shin, Woon Yong Kwon, Kyuseok Kim, You Hwan Jo, Sung-Hyuk Choi, Sung Phil Chung, orean Shock Soc Investigators
Summary: This review focuses on the recent updates in the hemodynamic management of septic shock, emphasizing the importance of personalized management and proposing monitoring and intervention strategies according to different phases of shock.
CLINICAL AND EXPERIMENTAL EMERGENCY MEDICINE
(2023)
Article
Medicine, General & Internal
Eunah Han, Gina Yu, Hye Sun Lee, Goeun Park, Sung Phil Chung
Summary: This study aimed to investigate the prevalence of carbon monoxide (CO) poisoning and provision of hyperbaric oxygen therapy (HBOT) in South Korea. The data were obtained from the Korea Health Insurance Review and Assessment service. The prevalence of CO poisoning was 8.64/10,000 people with a gradual annual increment. HBOT was claimed from 15 hospitals in 2010 and increased to 30 hospitals in 2019. A total of 4,473 patients received HBOT in 10 years and 2,684 (60%) were treated for more than 2 hours. The study showed an increasing prevalence of CO poisoning and HBOT in Korea over the past 10 years, with regional disparities.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Ji Hwan Lee, Min Joung Kim, Yoo Seok Park, EungNam Kim, Hyun Soo Chung, Sung Phil Chung
Summary: The purpose of this study was to investigate the epidemiologic status of bee sting injuries in Korea and to identify risk factors associated with severe systemic reactions (SSRs). The study found that male sex, age, bee sting location, winter season, and bee venom acupuncture were associated with SSRs. These findings emphasize the need for implementing safety policies and education to protect high-risk groups.
YONSEI MEDICAL JOURNAL
(2023)
Review
Critical Care Medicine
Dianne L. Atkins, Jason Acworth, Sung Phil Chung, Amelia Reis, Patrick Van de Voorde
Summary: The application of AED by lay rescuers is associated with improved survival and discharge rate for children aged 1-18 experiencing out-of-hospital cardiac arrest. Data for children younger than 1 year is limited.
RESUSCITATION PLUS
(2022)
