News Item
Multidisciplinary Sciences
Mariana Lenharo
Summary: The facility will produce up to five billion bacteria-infected mosquitoes per year.
Article
Medicine, General & Internal
A. Utarini, C. Indriani, R. A. Ahmad, W. Tantowijoyo, E. Arguni, M. R. Ansari, E. Supriyati, D. S. Wardana, Y. Meitika, I. Ernesia, I. Nurhayati, E. Prabowo, B. Andari, B. R. Green, L. Hodgson, Z. Cutcher, E. Rances, P. A. Ryan, S. L. O'Neill, S. M. Dufault, S. K. Tanamas, N. P. Jewell, K. L. Anders, C. P. Simmons
Summary: The cluster-randomized trial in Indonesia showed that deploying mosquitoes infected with the wMel strain of Wolbachia pipientis led to a reduction in symptomatic, virologically confirmed dengue infections and hospitalizations among residents.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Microbiology
David R. Martinez, Stefan W. Metz, Ralph S. Baric
Summary: This review outlines the challenges and advantages of developing a safe, effective, and balanced DENV vaccine, with the aim of providing uniform protection against all four serotypes. While T cell biology plays an important role in establishing protective immunity, the review focuses on B cell responses. Understanding the immune correlates of protection against DENV infection is crucial for informing the development of a vaccine that can offer long-term, uniform protection.
CELL HOST & MICROBE
(2021)
Article
Medicine, General & Internal
Triwibowo Ambar Garjito, Lulus Susanti, Mujiyono Mujiyono, Mega Tyas Prihatin, Dwi Susilo, Sidiq Setyo Nugroho, Mujiyanto Mujiyanto, Raden Ajeng Wigati, Tri Baskoro Tunggul Satoto, Sylvie Manguin, Laurent Gavotte, Roger Frutos
Summary: There are various methods to collect and assess the abundance of dengue vector mosquitoes, but the lack of long-term sampling methods may result in variability and lack of statistical significance in the results. There is no correlation between the collection methods and the presence of dengue virus in mosquitoes or the incidence of dengue, and the efficacy of a given method is inconsistent across different locations.
FRONTIERS IN MEDICINE
(2021)
Article
Multidisciplinary Sciences
Huiqing Yeo, Hui Zhen Tan, Qian Tang, Tyrone Ren Hao Tan, Nalini Puniamoorthy, Frank E. Rheindt
Summary: This study found that the gene flow rate of Ae. albopictus is higher in dense urban areas than in managed parks and forests, based on the analysis of the genome of wild-caught individuals from Singapore. The incidence of Wolbachia infections involving two strains was also documented. These findings challenge the misconception that substantial dispersal of Ae. albopictus is limited to urban greenery and have important implications for vector management and urban planning strategies to combat dengue transmission.
Article
Multidisciplinary Sciences
Benjamin Wong Wei Xiang, Wilfried A. A. Saron, James C. Stewart, Arthur Hain, Varsha Walvekar, Dorothee Misse, Frederic Thomas, R. Manjunatha Kini, Benjamin Roche, Adam Claridge-Chang, Ashley L. St. John, Julien Pompon
Summary: A study found that DENV infection increases mosquito attraction to hosts and hinders their biting efficiency, resulting in infected mosquitoes needing more bites to reach similar blood repletion. By establishing transmission models and mathematical models, the study also revealed that the number of infected hosts per infected mosquito tripled when mosquito behavior was influenced by DENV infection.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Christiano Calixto Conceicao, Jhenifer Nascimento da Silva, Angelica Arcanjo, Cintia Lopes Nogueira, Leonardo Araujo de Abreu, Pedro Lagerblad de Oliveira, Katia C. Gondim, Bruno Moraes, Stephanie Serafim de Carvalho, Renato Martins da Silva, Itabajara da Silva Vaz, Luciano Andrade Moreira, Carlos Logullo
Summary: This study established two novel cell lines from the mosquito Aedes fluviatilis with or without the symbiont bacteria Wolbachia. The presence of Wolbachia improved energy performance in A. fluviatilis cells and activated innate immunity mechanisms. The work confirms the natural, mutually co-regulating symbiotic relationship between W. pipientis and A. fluviatilis.
SCIENTIFIC REPORTS
(2021)
Editorial Material
Urology & Nephrology
Daniel Koehler
Summary: Prostate-specific membrane antigen-PET is valuable for diagnosis, and the second version of the Prostate Cancer Molecular Imaging Standardized Evaluation framework aims to standardize evaluation and reporting for primary staging and reassessment of advanced prostate cancer.
NATURE REVIEWS UROLOGY
(2023)
Article
Biology
Jiayue Yan, Chang-Hyun Kim, Leta Chesser, Jose L. Ramirez, Chris M. Stone
Summary: Diet-induced nutritional stress can impact mosquito traits, infection outcomes, and immune responses, affecting the transmission potential of dengue virus. Inadequate nutrition during both larval and adult stages compromises key life history traits, increases vulnerability to dengue infection, and suppresses the immune response. Understanding the role of nutritional stress is crucial for studying mosquito vector competence for dengue transmission.
COMMUNICATIONS BIOLOGY
(2023)
Article
Parasitology
Shih-Che Weng, Po-Nien Tsao, Shin-Hong Shiao
Summary: This study found that blood glucose enhances DENV replication in mosquitoes, leading to increased virus transmission. The activation of AKT and TOR signaling pathways plays a crucial role in facilitating this process. This insight may contribute to understanding the relationship between dengue fever and diabetes mellitus and could potentially offer new targets for antiviral therapies.
PARASITES & VECTORS
(2021)
Article
Virology
Avian V. White, Ming Fan, Jordan M. Mazzara, Rachel L. Roper, Stephanie L. Richards
Summary: The study revealed that Aedes aegypti is the primary vector of dengue virus. Espirito Santo virus does not infect mammalian cells but inhibits dengue virus replication in mosquito cells.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Virology
Jiang Du, Liyuan Zhang, Xiaoyuan Hu, Ruoyan Peng, Gaoyu Wang, Yi Huang, Wenqi Wang, Kunliang Wu, Qiang Wang, Haoxiang Su, Fan Yang, Yun Zhang, Chuanning Tang, Xiuji Cui, Lina Niu, Gang Lu, Meifang Xiao, Yongguo Du, Feifei Yin
Summary: In 2019, a Dengue Fever outbreak lasting over a month occurred in Haikou City, Hainan Province. Research found that the newly isolated strain of Dengue virus had 18 amino acid mutations in the coding sequences, posing a new threat to public health. Regular molecular epidemiological surveillance is necessary for the control and prevention of Dengue virus transmission.
Review
Multidisciplinary Sciences
Diawo Diallo, Babacar Diouf, Alioune Gaye, El Hadji NDiaye, Ndeye Marie Sene, Ibrahima Dia, Mawlouth Diallo
Summary: Dengue fever is becoming increasingly important public health issue in Africa. More studies are needed to understand the vectors, transmission routes, and control strategies in Africa.
Article
Multidisciplinary Sciences
Aurelien Mercier, Thomas Obadia, Davide Carraretto, Enkelejda Velo, Gaelle Gabiane, Silvia Bino, Marie Vazeille, Giuliano Gasperi, Catherine Dauga, Anna R. Malacrida, Paul Reiter, Anna-Bella Failloux
Summary: The invasive mosquito Ae. albopictus can transmit CHIKV and DENV, and temperature is a key factor in limiting their transmission. Local transmissions of these viruses have been reported in southern Europe, but it is uncertain how far north transmission could occur.
SCIENTIFIC REPORTS
(2022)
Article
Public, Environmental & Occupational Health
Lina Tian, Chumin Liang, Xiaorong Huang, Zhe Liu, Juan Su, Chuan Guo, Guanghu Zhu, Jiufeng Sun
Summary: In this study, the genomic epidemiology of a dengue outbreak in Shantou, China in 2019 was investigated using whole-genome sequencing. The outbreak lasted from July to December, with a total of 944 confirmed cases and no gender bias or fatalities. Multiple introductions and internal transmission were observed, highlighting the importance of genomic epidemiology in real-time monitoring of disease outbreaks.
FRONTIERS IN PUBLIC HEALTH
(2023)
