Article
Gastroenterology & Hepatology
Anthony Buisson, Stephane Nancey, Luc Manlay, David T. Rubin, Xavier Hebuterne, Benjamin Pariente, Mathurin Fumery, David Laharie, Xavier Roblin, Gilles Bommelaer, Bruno Pereira, Laurent Peyrin-Biroulet, Lucine Vuitton
Summary: This study compared the efficacy of ustekinumab versus azathioprine in preventing postoperative recurrence in Crohn's disease patients. Results showed that ustekinumab was more effective in reducing endoscopic postoperative recurrence rates compared to azathioprine at 6 months.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2021)
Article
Gastroenterology & Hepatology
Vincent Joustra, Joris van Sabben, Eline van der Does de Willebois, Marjolijn Duijvestein, Nanne de Boer, Jeroen Jansen, Jarmila van der Bilt, Wytze Lameris, Willem Bemelman, Christianne Buskens, Geert D'Haens
Summary: Immediate prophylactic treatment can reduce endoscopic postoperative recurrence rates in high-risk patients within 1 year, but the effect is not significant in low-risk patients. There is no significant difference in clinical postoperative recurrence within 3 years between prophylactic and endoscopy-driven treatment in both high-risk and low-risk patients, but there may be a cumulative effect in high-risk patients with multiple risk factors.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Chemistry, Multidisciplinary
Yongping Liang, Meng Li, Ying Huang, Baolin Guo
Summary: A biomaterials approach using ZIF-8 nanoparticle-enhanced multinetwork cryogels for rapid hemostasis and prevention of tumor recurrence during tumor resection is proposed in this study. The cryogels showed good hemostatic effect and significant cancer cell killing ability under ultrasound, reducing the risk of tumor recurrence post-surgery in a hepatocellular carcinoma model.
Article
Gastroenterology & Hepatology
Marc Ferrante, Lieven Pouillon, Miriam Manosa, Edoardo Savarino, Matthieu Allez, Christina Kapizioni, Naila Arebi, Michele Carvello, Par Myrelid, Annemarie C. De Vries, Paulo Gustavo European Crohns Colitis Org, Pauline Riviere, Yves Panis, Eugeni Domenech
Summary: Postoperative recurrence in patients with Crohn's disease undergoing ileocolonic resection can lead to further bowel damage and decreased quality of life. Available scientific data on prevention and treatment of postoperative recurrence were reviewed, and a management algorithm for daily clinical practice was developed.
JOURNAL OF CROHNS & COLITIS
(2023)
Review
Medicine, General & Internal
Tomonari Kinoshita, Taichiro Goto
Summary: Despite complete resection, cancer recurrence is common, indicating possible metastasis of cancer cells. Tumor microenvironment plays a crucial role in cancer development and metastasis, with cancer-associated inflammation possibly contributing to these processes. Although the relationship between inflammation and cancer recurrence has been extensively studied, it remains challenging to identify the status of cancer-associated inflammation in clinical settings.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Wongi Woo, Chong Hoon Kim, Bong Jun Kim, Seung Hwan Song, Duk Hwan Moon, Du-Young Kang, Sungsoo Lee
Summary: This study aimed to investigate the postoperative recurrence of primary spontaneous pneumothorax and classify recurrence events based on temporal patterns. Results showed that recurrence within 30 days postoperatively had a lower long-term recurrence rate, suggesting it may not be a true postoperative recurrence. Further studies are needed to improve the classification of postoperative recurrence.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Surgery
Nina S. Cohen, Jiselle M. Bock, Addison K. May
Summary: Surgical site infections are a significant cause of illness and death. There is strong evidence supporting several preventive measures, but their effective implementation is not optimal. It is crucial to identify high-risk patients and avoid pitfalls in diagnosing surgical site infections, especially in emergency surgery patients with physiological disorders. Maintaining a high level of suspicion after surgery is critical in identifying patients with surgical site infections and preventing failure to rescue.
Article
Endocrinology & Metabolism
Yosuke Tarumi, Taisuke Mori, Koki Shimura, Yuko Izumi, Hiroyuki Okimura, Hisashi Kataoka, Tetsuya Kokabu, Fumitake Ito, Akemi Koshiba, Khaleque N. Khan, Izumi Kusuki, Jo Kitawaki
Summary: This study investigates the association between progesterone receptor (PR) expression levels in ovarian endometrioma and the recurrence of endometriosis. The results suggest that low PR expression levels in ovarian endometrioma epithelial cells may predict the recurrence of endometriosis.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Gastroenterology & Hepatology
Gabriele Dragoni, Mariangela Allocca, Paer Myrelid, Nurulamin M. Noor, Nassim Hammoudi, Yves Panis, Marc Ferrante
Summary: This article describes the different methodologies used to report postoperative recurrence in patients with Crohn's disease, including endoscopic, histological, radiological, biochemical, clinical, and surgical approaches. The potential benefits and limitations of these methods, as well as the optimal timing of evaluation, are reviewed.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Oncology
Min-Young Park, In-Ja Park, Hyo-Seon Ryu, Jay Jung, Min-Sung Kim, Seok-Byung Lim, Chang-Sik Yu, Jin-Cheon Kim
Summary: This study found that frequent postoperative surveillance did not improve overall survival or recurrence-free survival in patients with colorectal cancer, but it did improve post-recurrence survival. Intensive surveillance was associated with improved post-recurrence survival and overall survival in high-risk patients.
Review
Gastroenterology & Hepatology
Alessandro Ble, Cecilia Renzulli, Fabio Cenci, Maria Grimaldi, Michelangelo Barone, Rocio Sedano, Joshua Chang, Tran M. Nguyen, Malcolm Hogan, Guangyong Zou, John K. MacDonald, Christopher Ma, William J. Sandborn, Brian G. Feagan, Emilio Merlo Pich, Vipul Jairath
Summary: The study found a significant association between endoscopic recurrence and subsequent clinical recurrence in postoperative Crohn's disease patients, supporting the use of endoscopic recurrence as a monitoring tool for disease activity and a primary endpoint in clinical trials.
JOURNAL OF CROHNS & COLITIS
(2022)
Review
Chemistry, Medicinal
Junyu Wu, Yau-Tuen Chan, Yuanjun Lu, Ning Wang, Yibin Feng
Summary: Surgery is the main treatment for hepatocellular carcinoma (HCC), but postoperative recurrence, caused by intrahepatic metastasis or de novo tumorigenesis, significantly impairs its efficacy. Recent research shows that the postoperative tumor microenvironment (TME) plays a crucial role in tumor recurrence. This review discusses the impact of surgical stress and perturbation on the TME and highlights the potential of targeting the postoperative TME for adjuvant therapeutics.
MEDICINAL RESEARCH REVIEWS
(2023)
Review
Gastroenterology & Hepatology
Evelien M. J. Beelen, Daan Nieboer, Jeanine H. C. Arkenbosch, Miguel D. Regueiro, Jack Satsangi, Sandro Ardizzone, Antonio Lopez-Sanroman, Edoardo Savarino, Alessandro Armuzzi, C. Janneke van der Woude, Annemarie C. de Vries
Summary: This meta-analysis found that anti-TNF-alpha treatment is superior to thiopurine prophylaxis for preventing endoscopic and clinical recurrence of Crohn's disease after ileocolonic resection. This advantage was confirmed in subgroup analysis and after risk stratification.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Lalin Navaratne, Katherine-Helen Hurndall, Daniel M. Richardson, Robert Stephenson, Niall Power, Holly Gillott, Susana Ruiz Sanchez, Kuresh Khodatars, Christopher L. H. Chan
Summary: This study investigated the risk factors for symptomatic anastomotic postoperative recurrence in patients with ileo-colonic Crohn's disease. The study found that patients diagnosed at age <17 years and with gastrointestinal involvement >30 cm were at increased risk of symptomatic anastomotic postoperative recurrence.
COLORECTAL DISEASE
(2021)
Article
Multidisciplinary Sciences
Marie Bouly, Francois-Xavier Laborne, Caroline Tourte, Elodie Henry, Alfred Penfornis, Dured Dardari
Summary: This study aims to investigate the correlation between post-healing follow-up and recurrence rates of diabetic foot ulcer patients, and evaluate the impact of multidisciplinary follow-up on foot wound recurrence.
Editorial Material
Gastroenterology & Hepatology
Nathalie Van Den Berghe, Bram Verstockt, Severine Vermeire, Debby Thomas, Paul Declerck
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Kevin L. Winthrop, Severine Vermeire, Millie D. Long, Julian Panes, Siew C. Ng, Nicole Kulisek, Rajiv Mundayat, Nervin Lawendy, Ivana Vranic, Irene Modesto, Chinyu Su, Gil Y. Melmed
Summary: The incidence rates of herpes zoster in patients with ulcerative colitis remained stable during 7.8 years of tofacitinib exposure. Older age, lower weight, geographic region, and prior tumor necrosis factor inhibitor failure were identified as significant risk factors for herpes zoster.
INFLAMMATORY BOWEL DISEASES
(2023)
Letter
Gastroenterology & Hepatology
Dahham Alsoud, Bram Verstockt, Severine Vermeire
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Medicine, Research & Experimental
Walter Reinisch, Adrian Serone, Xavier Hebuterne, Tanja Kuehbacher, Maria Klopocka, Xavier Roblin, Jens Brodbeck, Kim Etchevers, Rene Galien, Ethan Grant, Chantal Tasset, Oh Kyu Yoon, Shiva Zaboli, Severine Vermeire
Summary: This study examines the relationship between endoscopic, histologic, and molecular activity in patients with Crohn's disease. The findings suggest that histologic activity should be considered when assessing inflammatory burden in CD patients.
Review
Gastroenterology & Hepatology
Pieter Sinonquel, Severine Vermeire, Frederik Maes, Raf Bisschops
Summary: This article reviews the latest developments in advanced GI endoscopy, focusing on screening, diagnosis, and surveillance of common upper and lower GI pathology. The importance of artificial intelligence in the field is emphasized, and the potential future impact of the literature is assessed.
GE PORTUGUESE JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Gary R. Lichtenstein, Brian Bressler, Carlos Francisconi, Severine Vermeire, Nervin Lawendy, Leonardo Salese, Gosford Sawyerr, Hongjiong Shi, Chinyu Su, Donna T. Judd, Thomas Jones, Edward V. Loftus
Summary: Age is considered a risk factor for adverse events in the tofacitinib ulcerative colitis clinical program, with older individuals potentially having a higher risk of herpes zoster, malignancies (excluding nonmelanoma skin cancer), and nonmelanoma skin cancer compared to younger patients.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Sara Deleu, Kaline Arnauts, Lowie Deprez, Kathleen Machiels, Marc Ferrante, Geert R. B. Huys, Johan M. M. Thevelein, Jeroen Raes, Severine Vermeire
Summary: Short-chain fatty acids and their bacterial producers are gaining increasing attention in inflammatory bowel diseases. Acetate, although less studied compared to butyrate, shows potential in being less toxic to epithelial cells, stimulating butyrate-producing bacteria, and having anti-inflammatory and barrier-protective properties. In a study using organoid-based monolayer cultures from ulcerative colitis patients, high acetate concentrations were found to improve epithelial resistance, decrease pro-inflammatory markers, and enhance barrier gene expression. These findings suggest that acetate may offer a promising approach for managing barrier defects and inflammation in IBD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Wannee Kantasiripitak, Sebastian G. Wicha, Debby Thomas, Ilse Hoffman, Marc Ferrante, Severine Vermeire, Karen van Hoeve, Erwin Dreesen
Summary: The study aimed to develop a multi-model model-based software tool for guiding personalized infliximab induction treatment in pediatric inflammatory bowel disease patients. The study found that using the tool for individualized dosing improved the chances for children to achieve deep remission at 6 months.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Loris Riccardo Lopetuso, Sara Deleu, Lihi Godny, Valentina Petito, Pierluigi Puca, Federica Facciotti, Harry Sokol, Gianluca Ianiro, Luca Masucci, Maria Abreu, Iris Dotan, Samuel Paul Costello, Ailsa Hart, Tariq H. Iqbal, Sudarshan Paramsothy, Maurizio Sanguinetti, Silvio Danese, Herbert Tilg, Fabio Cominelli, Theresa T. Pizarro, Alessandro Armuzzi, Giovanni Cammarota, Antonio Gasbarrini, Severine Vermeire, Franco Scaldaferri
Summary: An international panel of experts has generated evidence-based guidelines for the evaluation and management of inflammatory bowel disease (IBD) using faecal microbiota transplantation (FMT). The guidelines provide specific statements and recommendations to promote FMT as a recognized strategy for the treatment of IBD.
Article
Gastroenterology & Hepatology
Julian Panes, Severine R. Vermeire, Geert D'Haens, Silvio Danese, Fernando Magro, Maciej Nazar, Manuela Le Bars, Marjolein Lahaye, Lioudmila Ni, Ivana R. Bravata, Daniel Gaya, Laurent Peyrin-Biroulet, Axel Dignass
Summary: This study compared two treatment strategies for Crohn's disease patients and found that regardless of whether the treatment was "treat-to-target" or "standard of care", ustekinumab was effective in improving the health-related quality of life and work productivity of patients over a 2-year follow-up period.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Article
Immunology
Jeroen Geldof, Marie Truyens, Joao Sabino, Marc Ferrante, Jo Lambert, Hilde Lapeere, Tom Hillary, An Van Laethem, Kurt de Vlam, Patrick Verschueren, Elizaveta Padalko, Triana Lobaton, Severine Vermeire
Summary: The BELCOMID study confirms the benign course of COVID19 infection and vaccination in a large real-life population of patients with immune-mediated inflammatory diseases. However, the results emphasize the need for repeated vaccination and smoking cessation in IMID patients treated with immune-modulating therapies or systemic steroids during the pandemic.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Gabriele Bislenghi, Julie Van Den Bossch, Steffen Fieuws, Albert Wolthuis, Marc Ferrante, Gert de Hertogh, Severine Vermeire, Andre D'Hoore
Summary: The macroscopic appearance of the bowel and associated mesentery during surgery does not appear to be predictive of postoperative recurrence after ileocecal resection for Crohn's disease. Prospective studies investigating risk factors for Crohn's disease recurrence after surgery are scarce.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Silvio Danese, Remo Panaccione, Maria T. Abreu, David T. Rubin, Subrata Ghosh, Axel Dignass, Anita Afzali, Douglas C. Wolf, Michael Chiorean, Severine Vermeire, Anjali Jain, Lorna Charles, Garrett Lawlor, Mark T. Osterman, Hsiuanlin Wu, James B. Canavan, Annkatrin Petersen, Jean-Frederic Colombel, Miguel Regueiro
Summary: This interim analysis examines the efficacy and safety of ozanimod treatment in patients with ulcerative colitis over a period of approximately 3 years. The results show that a high percentage of patients maintain clinical and mucosal efficacy during the treatment. No new safety concerns arise from long-term use of ozanimod.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Biochemical Research Methods
Bryan Linggi, Jonathan Cremer, Zhongya Wang, Tanja Van Viegen, Severine Vermeire, Pavine Lefevre, Lisa M. Shackelton, Vipul Jairath, Wendy Teft, Niels Vande Casteele, Bram Verstockt
Summary: Clinical trials of novel therapies for ulcerative colitis may benefit from immune cell profiling, but implementation is limited by the necessity of timely isolation and processing of peripheral blood mononuclear cells (PBMC). The use of Becton Dickinson Vacutainer CPTTM Cell Preparation Tubes (CPTTM) allows for delayed processing of PBMC, with ideal processing within 48 hours. Delayed processing may be considered for cell types that are robust to these conditions.
JOURNAL OF IMMUNOLOGICAL METHODS
(2023)
Article
Gastroenterology & Hepatology
Severine Vermeire, Jurij Hanzel, Mark Lowenberg, Marc Ferrante, Peter Bossuyt, Frank Hoentjen, Denis Franchimont, Karoly Palatka, Harald Peeters, Aart Mookhoek, Gert de Hertogh, Tamas Molnar, Wouter van Moerkercke, Triana Lobaton, Esme Clasquin, Melanie S. Hulshoff, Filip Baert, Geert D'Haens
Summary: This study explored the differential efficacy of vedolizumab in early and late ulcerative colitis and evaluated clinical, endoscopic, and histological outcomes. The results showed no significant differences between early and late UC in terms of clinical, endoscopic, and histological improvement.
JOURNAL OF CROHNS & COLITIS
(2023)