Article
Surgery
Ryuichi Kuwahara, Hiroki Ikeuchi, Toshihiro Bando, Yoshiko Goto, Yuki Horio, Tomohiro Minagawa, Motoi Uchino
Summary: There are few reports comparing the outcomes of elderly ulcerative colitis (UC) patients undergoing colectomy for elderly-onset UC (EO) and nonelderly-onset UC (NEO). This study aimed to analyze the differences between EO and NEO patients who underwent UC-related surgery. The results showed that EO patients had poorer outcomes, including higher rates of emergency surgery and postoperative complications, compared to NEO patients.
Article
Gastroenterology & Hepatology
Asa H. Everhov, Rune Erichsen, Jacob Jaras, Lars Pedersen, Jonas Halfvarson, Johan Askling, Anders Ekbom, Jonas F. Ludvigsson, Henrik Toft Sorensen, Ola Olen
Summary: The increased risk of colorectal cancer (CRC) in inflammatory bowel disease (IBD) is limited to young-onset cases and not observed in elderly-onset cases. The risk of incident CRC is higher in the first year after IBD diagnosis but decreases afterwards. Once diagnosed with CRC, the risk of CRC death is similar for IBD patients and the general population.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
M. Aloi, M. Bramuzzo, L. Norsa, S. Arrigo, M. Distante, E. Miele, C. Romano, C. Giobbi, R. Panceri, S. Cucchiara, P. Alvisi, G. Lombardi, S. Salvatore, S. Gatti, C. De Giacomo, D. Knafelz, G. Barera, S. Provera, M. Pastore
Summary: The study aimed to define activity clusters in children with ulcerative colitis during the first 5 years after diagnosis and identify early prognostic risk factors. Results showed that more than one-third of children with UC had a chronically active or intermittent course in the first 5 years, with some experiencing sustained remission after initial active disease. Additionally, one-third of patients had well-controlled disease throughout the study period after initial treatment.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Gastroenterology & Hepatology
Jin Young Yoon, Jae Myung Cha, Chang Kyun Lee, Young Sook Park, Kyu Chan Huh, Jeong Eun Shin, You Sun Kim, Chang Soo Eun, Soon Man Yoon, Jae Hee Cheon, Young Soo Park, Byong Duk Ye, YoungJa Lee, Youngdoe Kim, Hyo Jong Kim
Summary: This study investigated the early clinical course of moderate-to-severe UC patients and found that Korean patients may have more favorable outcomes than Western patients in the short term. Factors influencing medication use were disease severity, extent, and endoscopic severity at baseline. Long-term outcomes of these patients require further investigation.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Masaaki Higashiyama, Shunsuke Komoto, Yasuo Suzuki, Mamoru Watanabe, Toshifumi Hibi, Soichiro Miura, Ryota Hokari
Summary: The study focused on the impact of malnutrition on the prognosis of elderly-onset ulcerative colitis (EOUC) patients in Japan, with a significant correlation found between malnutrition estimated by GNRI and poor clinical outcomes. This suggests that evaluating nutritional status at the onset may be useful in predicting risks of clinical courses for EOUC patients.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Medicine, General & Internal
Rahma Elmahdi, Camilla E. Lemser, Sandra B. Thomsen, Kristine H. Allin, Manasi Agrawal, Tine Jess
Summary: This meta-analysis revealed that patients with pediatric-onset IBD have a more than 2-fold increased rate of cancer compared to the general pediatric population, primarily due to an increased rate of gastrointestinal cancers.
Review
Gastroenterology & Hepatology
M. Ellen Kuenzig, Stephen G. Fung, Luba Marderfeld, Joyce W. Y. Mak, Gilaad G. Kaplan, Siew C. Ng, David C. Wilson, Fiona Cameron, Paul Henderson, Paulo G. Kotze, Jasmine Bhatti, Vixey Fang, Samantha Gerber, Evelyne Guay, Supun Kotteduwa Jayawarden, Leo Kadota, Fernando D. Maldonado, Jessica Amankwah Osei, Ryan Sandarage, Amanda Stanton, Melissa Wan, Eric Benchimol
Summary: The incidence of pediatric-onset inflammatory bowel disease (IBD) is increasing worldwide, with the highest rates in Northern Europe and North America and the lowest rates in Southern Europe, Asia, and the Middle East. Most studies reported significant increases in incidence, while there is limited data on very early onset IBD.
Review
Gastroenterology & Hepatology
Paula Sousa, Lorenzo Bertani, Claudio Rodrigues
Summary: The burden of Inflammatory Bowel Disease (IBD) is increasing worldwide, especially in the elderly population. Elderly IBD patients present specific challenges to the treating physician, and are often managed with frequent and continuous use of steroids and undertreated with effective medical therapies due to misconceptions and fear of adverse events.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Gastroenterology & Hepatology
Cristina Rodriguez, Alfonso Elosua, Carlos Prieto, Ernesto Perez, Rebeca Irisarri, Ana Campillo, Saioa Rubio, Oscar Nantes, Ramon Angos, Jose Manuel Zozaya
Summary: In our study of UC and UnC patients from the Navarra cohort, we found lower colectomy rates than typically reported. Most colectomies were performed within 5 years of diagnosis, with the majority being emergency procedures.
GASTROENTEROLOGIA Y HEPATOLOGIA
(2022)
Article
Gastroenterology & Hepatology
Kristine H. Allin, Rikke K. Jacobsen, Ryan C. Ungaro, Jean-Frederic Colombel, Alexander Egeberg, Marie Villumsen, Tine Jess
Summary: This study found that bariatric surgery is associated with an increased risk of new-onset Crohn's disease, particularly in women, but not ulcerative colitis. The underlying mechanisms remain unclear.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Public, Environmental & Occupational Health
Qian Zhang, Si Liu, Changzheng Yuan, Feng Sun, Shengtao Zhu, Shuilong Guo, Shanshan Wu, Shutian Zhang
Summary: Frailty and pre-frailty are associated with increased risk of elderly-onset IBD, particularly elderly-onset CD.
ANNALS OF EPIDEMIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Ryusuke Nambu, Katsuhiro Arai, Takahiro Kudo, Takatsugu Murakoshi, Reiko Kunisaki, Tatsuki Mizuochi, Sawako Kato, Hideki Kumagai, Mikihiro Inoue, Takashi Ishige, Takeshi Saito, Atsuko Noguchi, Toshifumi Yodoshi, Shin-Ichiro Hagiwara, Naomi Iwata, Shigeo Nishimata, Fumihiko Kakuta, Hitoshi Tajiri, Eitaro Hiejima, Nariaki Toita, Takahiro Mochizuki, Hirotaka Shimizu, Itaru Iwama, Yuri Hirano, Toshiaki Shimizu, JPIBD R
Summary: In this study, we investigated the management and treatment outcomes of children with severe-onset ulcerative colitis. We found that these children are likely to require powerful agents such as calcineurin inhibitors and biologic agents, and sometimes colectomy is ultimately necessary.
JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Amy Yu, Sonia Friedman, Ashwin N. Ananthakrishnan
Summary: This study analyzed patients with pregnancy-onset IBD, and found that they were more likely to develop ulcerative colitis and had a higher risk of disease-related hospitalizations.
INFLAMMATORY BOWEL DISEASES
(2021)
Review
Pharmacology & Pharmacy
Yafei Guo, Yang Li, Qiang Cao, Leilei Ye, Junmei Wang, Mei Guo
Summary: This paper discusses the role of natural polysaccharides in the treatment of ulcerative colitis (UC). Natural polysaccharides can modulate inflammatory factors, the immune system, and intestinal flora, as well as preserve the intestinal mucosa. Therefore, natural polysaccharides have the potential to be new medications for UC treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Jinlan Zhang, Shuhui Sun, Huan Chen, Yifan Feng, Ying Li, Zhengqi Dong
Summary: Ulcerative colitis (UC) is a chronic inflammatory bowel disorder that can be treated with natural active molecule-based nanomedicines. The gut microbiota and metabolites play important roles in UC and can be regulated by nanoparticles. The interaction between the gut microbiota and nanomedicines derived from natural compounds elucidates possible biological mechanisms and future directions for enhancing therapeutic efficacy.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
Kelvin Hei-Yeung Chiu, Cyril Chik-Yan Yip, Rosana Wing-Shan Poon, Kit-Hang Leung, Xin Li, Ivan Fan-Ngai Hung, Kelvin Kai-Wang To, Vincent Chi-Chung Cheng, Kwok-Yung Yuen
Summary: Cytokine dynamics in respiratory specimens of COVID-19 patients were studied in this retrospective case-control study. The study found that levels of MPO, ADA, CCL22, TNF alpha, and IL-6 mRNA were significantly higher in infected patients compared to controls, with ADA showing better performance. Additionally, severe COVID-19 patients had lower CCL22 mRNA levels. ADA may be a better biomarker for differentiating between infected and uninfected patients, while CCL22 has potential in stratifying the severity of COVID-19.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Medicine, General & Internal
James Y. W. Lau, Rui Li, Chen-huan Tan, Xiu-jing Sun, Hao-jun Song, Lan Li, Feng Ji, Bu-jiang Wang, Dong-tao Shi, Wai K. Leung, Imogen Hartley, Alan Moss, Karina Y. Y. Yu, Bing Y. Suen, Peng Li, Francis K. L. Chan
Summary: There is a clinically significant failure rate in current endoscopic methods for the control of acute nonvariceal bleeding. The role of over-the-scope clips (OTSCs) as the first treatment has not been defined. A multicenter, randomized controlled trial showed that compared to standard endoscopic hemostatic treatments, OTSCs can reduce the risk of further bleeding from nonvariceal upper gastrointestinal causes.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Tao Lyu, Ka Shing Cheung, Zijie Deng, Li Ni, Chuan Chen, Juan Wu, Wai K. Leung, Wai Kay Seto
Summary: Whole genome sequencing of Helicobacter pylori revealed potential novel genetic mutations associated with clarithromycin and levofloxacin resistance, including fliJ and cheA genes, which may improve predictive accuracy for targeted sequencing tests in the future.
Article
Gastroenterology & Hepatology
Fang Jiang, Chengsheng Ju, Chuan-Guo Guo, Ka Shing Cheung, Bofei Li, Simon Y. K. Law, Wallis C. Y. Lau, Wai K. Leung
Summary: This study investigated the risk of hospitalization for upper gastrointestinal bleeding (UGIB) in patients who had received H. pylori eradication therapy and were newly started on warfarin or DOACs. The results showed that DOACs had a significantly lower risk of UGIB compared to warfarin in H. pylori-eradicated patients. Additionally, there was no significant difference in UGIB risk between H. pylori-eradicated and H. pylori-negative patients newly started on warfarin or DOACs.
Article
Biochemistry & Molecular Biology
Lui Ng, Ryan Wai-Yan Sin, David Him Cheung, Wai-Keung Leung, Abraham Tak-Ka Man, Oswens Siu-Hung Lo, Wai-Lun Law, Dominic Chi-Chung Foo
Summary: Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease that is increasing worldwide, and it is associated with colorectal polyps. This study aimed to investigate the potential of serum microRNAs (miRNAs) in identifying NAFLD in colorectal polyp patients. The results showed that a serum miRNA panel composed of four miRNA pairs significantly identified NAFLD in colorectal polyp patients, and its performance improved when patients with other concurrent metabolic disorders were removed from the analysis. The serum miRNA panel could be a potential diagnostic biomarker for screening NAFLD in colorectal polyp patients for early diagnosis and prevention of disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Xuxiao Ye, Caige Huang, Vincent Ka Chun Yan, Wei Kang, Min Fan, Gigi Kwan Chi Tsang, Clarissa Mung Yee Ho, Gregory Y. H. Lip, Kai-Hang Yiu, Hung-Fat Tse, Tiantian Ma, Xiwen Qin, Celine Sze Ling Chui, Francisco Tsz Tsun Lai, Carlos King Ho Wong, Eric Yuk Fai Wan, Xue Li, Cheuk Kwong Lee, Ivan Fan Ngai Hung, Ian Chi Kei Wong, Esther Wai Yin Chan
Summary: This study aimed to evaluate the risk of ischaemic stroke or systemic embolism and bleeding following COVID-19 vaccination in patients with atrial fibrillation (AF), with a focus on sex differences. The results showed that there was an increased risk of ischaemic stroke or systemic embolism in female patients with AF after receiving the first dose of BNT162b2 or CoronaVac. However, the risk was even higher after COVID-19 infection.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Article
Immunology
Ruiqi Zhang, Kwok-Hung Chan, Pui Wang, Runhong Zhou, Henry Kwong-Chi Yau, Creany Ka-Wai Wong, Meena Wai-Lam Au, Anthony Raymond Tam, Chi-Tao Ng, Matthew Kwok-Chung Lou, Na Liu, Haode Huang, Shaofeng Deng, Rachel Chun-Yee Tam, Ying Liu, Teng Long, Hoi-Wah Tsoi, Miko K. W. Ng, Jian-Piao Cai, Kelvin Kai-Wang To, Man-Fung Yuen, Zhiwei Chen, Honglin Chen, Kwok-Yung Yuen, Ivan Fan-Ngai Hung
Summary: An intranasal COVID-19 vaccine, DelNS1-based RBD vaccines composed of H1N1 subtype (DelNS1-nCoV-RBD LAIV) was developed and tested for safety and immunogenicity in healthy adults. The study recruited 29 participants who were randomly assigned to receive the low or high dose vaccine or a placebo. The vaccine showed moderate mucosal immunogenicity and was well-tolerated, indicating the need for further clinical trials.
Article
Immunology
Ka Shing Cheung, Lok Ka Lam, Xianhua Mao, Jing Tong Tan, Poh Hwa Ooi, Ruiqi Zhang, Kwok Hung Chan, Ivan F. N. Hung, Wai Kay Seto, Man Fung Yuen
Summary: The study aimed to investigate the impact of non-alcoholic fatty liver disease (NAFLD) on the immunogenicity of the BNT162b2 vaccine against wild-type and variant strains of SARS-CoV-2, as well as infection outcome. The results showed that NAFLD patients who received two doses of the BNT162b2 vaccine had good immunogenicity against wild-type and delta variant strains, but poor immunogenicity against the omicron variant, and they were not at a higher risk of infection compared to the control group.
Review
Gastroenterology & Hepatology
Khean-Lee Goh, Yeong Yeh Lee, Alex Hwong-Ruey Leow, Raja Affendi Raja Ali, Shiaw Hooi Ho, Sanjiv Mahadeva, Rosaida Hj Mohd Said, Raman Muthukaruppan Chettiar, Hoi Poh Tee
Summary: There are misconceptions in Malaysian clinical practice regarding the appropriate diagnostic method and treatment strategies for Helicobacter pylori infection. To address this, an expert panel of nine key opinion leaders in gastroenterology developed a set of consensus statements relevant to the Malaysian healthcare practice. The panel achieved consensus in three areas of H. pylori infection management: indications for testing, diagnosis, and treatment. They proposed 19 consensus statements, which can serve as a guide for physicians across various healthcare settings in Malaysia.
Editorial Material
Gastroenterology & Hepatology
Kee-Huat Chuah, Christopher J. Black, Vincent Tee, Sze-Zee Lim, Wen-Xuan Hian, Nur-Fazimah Sahran, Yeong-Yeh Lee, Sanjiv Mahadeva, Alexander C. Ford
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Public, Environmental & Occupational Health
Ainaa Almardhiyah Abd Rashid, Lydiatul Shima Ashari, Nor Hamizah Shafiee, Raja Affendi Raja Ali, Lee Yeong Yeh, Mohd Razif Shahril, Hamid Jan Jan Mohamed
Summary: A study in Malaysia found that the processed diet pattern, characterized by a high intake of confectionaries and fast foods, was associated with an increased risk of colorectal cancer. Further research is needed to understand the impact of different dietary patterns on the gut microbiota associated with colorectal cancer, in order to develop prevention measures through lifestyle changes.
Review
Biochemistry & Molecular Biology
Ho-Yu Ng, Wai K. Leung, Ka-Shing Cheung
Summary: Despite the global decline in prevalence, efforts are needed to optimize H. pylori treatment regimens due to increasing antibiotic resistance. Advancements in sequencing technology have helped broaden our understanding of molecular mechanisms behind resistance and facilitated testing of antibiotic susceptibility. Establishing routine antibiotic susceptibility surveillance programs and enforcing antibiotic stewardship are important for managing H. pylori in a sustainable manner.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Tom Wai-Hin Chung, Hui Zhang, Fergus Kai-Chuen Wong, Siddharth Sridhar, Tatia Mei-Chun Lee, Gilberto Ka-Kit Leung, Koon-Ho Chan, Kui-Kai Lau, Anthony Raymond Tam, Deborah Tip-Yin Ho, Vincent Chi-Chung Cheng, Kwok-Yung Yuen, Ivan Fan-Ngai Hung, Henry Ka-Fung Mak
Summary: This pilot trial recruited long COVID patients with persistent olfactory dysfunction and found that a combination treatment of oral vitamin A and olfactory training was effective in improving olfactory function.
Article
Gastroenterology & Hepatology
Chuan-Guo Guo, Feifei Zhang, Fang Jiang, Lingling Wang, Yijun Chen, Wenxue Zhang, Anni Zhou, Shutian Zhang, Wai K. Leung
Summary: This population-based retrospective cohort study aimed to determine whether H. pylori eradication therapy reduces the risk of colorectal cancer (CRC). The results showed that the risk of CRC was initially higher in H. pylori-infected subjects but gradually decreased over time and became lower than the general population after 10 years of H. pylori eradication, particularly for rectal cancer.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Suhana Ahmad, Lidawani Lambuk, Naveed Ahmed, Ali Mussa, Vincent Tee, Ros Akmal Mohd Idris, Nur Fazimah Sahran, Yean Yean Chan, Rosline Hassan, Yeong Yeh Lee, Rohimah Mohamud
Summary: Nab-paclitaxel demonstrates good efficacy and safety in the treatment of metastatic gastric cancer, providing better disease response and longer survival.