Article
Gastroenterology & Hepatology
Pepijn W. A. Thomas, Nathan den Broeder, Monique Derikx, Wietske Kievit, Rachel L. West, Maurice G. V. M. Russel, Jeroen M. Jansen, Tessa E. H. Romkens, Frank Hoentjen
Summary: Initiating biological therapy or tofacitinib can reduce work impairment in patients with IBD. Patients who achieve clinical remission or response show the greatest improvement, especially those with ulcerative colitis and IBD-unclassified.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Medicine, General & Internal
Mihaela Dranga, Lucian Vasile Boiculese, Iolanda Valentina Popa, Mariana Floria, Oana Irina Gavril, Oana-Bogdana Barboi, Anca Trifan, Cristina Cijevschi Prelipcean, Catalina Mihai, Otilia Gavrilescu
Summary: The study found a high prevalence of anemia among patients with Crohn's disease, which was associated with disease activity and corticosteroid use. Both disease activity and anemia were found to have a significant negative impact on the quality of life of patients.
MEDICINA-LITHUANIA
(2021)
Article
Gastroenterology & Hepatology
Lishan Peng, Shurong Hu, Qiao Yu, Yan Chen
Summary: This paper details the efforts of the China Crohn's and Colitis Foundation (CCCF) in improving the management of inflammatory bowel disease (IBD) over the past five years. CCCF is committed to enhancing the healthcare quality and quality of life for IBD patients through education programs, support activities, public awareness and advocacy, and research initiatives. The foundation aims to become a leading advocate for IBD patients in China, pioneering reforms in the medical system and serving as a successful model for developing countries.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Psychology, Multidisciplinary
Bonney Reed, Kelly E. Rea, Robyn Lewis Claar, Miranda A. L. van Tilburg, Rona L. Levy
Summary: This study explores the impact of self-esteem and passive coping strategies on health-related quality of life in pediatric patients with inflammatory bowel disease. Results show that self-esteem is positively associated with HRQOL but negatively associated with passive coping. Self-esteem indirectly affects HRQOL through passive coping, particularly catastrophizing.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Nutrition & Dietetics
Selina R. Cox, Wladyslawa Czuber-Dochan, Catherine L. Wall, Hazel Clarke, Candice Drysdale, Miranda C. Lomer, James O. Lindsay, Kevin Whelan
Summary: This study aimed to investigate the effectiveness and acceptability of a web resource in enhancing food-related quality of life in newly diagnosed inflammatory bowel disease patients. The results showed that FR-QoL increased more in the web resource group, and IBD distress reduced, while the control group showed opposite results.
Review
Medicine, General & Internal
Pauline Wils, Benedicte Caron, Ferdinando D'Amico, Silvio Danese, Laurent Peyrin-Biroulet
Summary: This review provides a comprehensive overview of the multifactorial etiology implicated in the chronic abdominal pain of IBD patients and highlights the necessity of pharmacological and non-pharmacological approaches for treatment. Integrating psychological support in care models of IBD can reduce disease burden and healthcare costs.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Cara De Galan, Marie Truyens, Harald Peeters, Francisco Mesonero Gismero, Ainara Elorza, Paola Torres, Liv Vandermeulen, Aranzazu Jauregui Amezaga, Rocio Ferreiro-Iglesias, Tom Holvoet, Yamile Zabana, Laia Peries Reverter, Gerard Bryan Gonzales, Jeroen Geldof, Gaelle Varkas, Martine De Vos, Triana Lobaton
Summary: This study compared the effects of vedolizumab and ustekinumab on articular extra-intestinal manifestations. The results showed no significant differences in the deterioration of pre-existing arthropathy and the rate of new-onset arthropathy between the two treatments. Patients taking vedolizumab had a higher risk of developing new arthralgia within 6 months, but this effect was not sustained during the 2-year follow-up.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Public, Environmental & Occupational Health
Kristina Aluzaite, Kay Greveson, Shomron Ben-Horin, Rupert Leong, Ola Haj, Michael Schultz
Summary: The study investigated challenges faced by patients with inflammatory bowel disease (IBD) during travel, their information-seeking behavior and associated factors. A significant percentage of participants sought medical advice or were hospitalized overseas, with common barriers including concerns about toilet facilities, cleanliness, and access to medical care. Although a majority sought travel advice, some did not obtain travel insurance coverage for their IBD, which was associated with lack of advice or difficulty in obtaining insurance. Participants traveling for work were more likely to face medical issues overseas and not obtain proper travel insurance.
JOURNAL OF TRAVEL MEDICINE
(2021)
Review
Gastroenterology & Hepatology
Klaus R. Herrlinger, Eduard F. Stange
Summary: This review examines the current guidelines for the treatment of inflammatory bowel disease (IBD) and suggests personalized treatment options based on individual clinical cases. The analysis of relevant literature suggests that combined use of drugs such as infliximab and azathioprine can improve treatment outcomes for Crohn's disease and ulcerative colitis. In cases of steroid-refractory ulcerative colitis, the preference should be given to infliximab plus azathioprine or upadacitinib.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Nutrition & Dietetics
Kevin Whelan, Trevor Murrells, Myfanwy Morgan, Fraser Cummings, Catherine Stansfield, Anne Todd, Shaji Sebastian, Alan Lobo, Miranda C. E. Lomer, James O. Lindsay, Wladyslawa Czuber-Dochan
Summary: In patients with inflammatory bowel disease (IBD), impaired food-related quality of life (FR-QoL) is prevalent and associated with factors such as recurrent disease flares, reduced IBD-specific QoL, and greater IBD-related distress. Patients with poorer FR-QoL tend to have lower intakes of key nutrients important to IBD, including fiber, calcium, phosphorus, and magnesium, which are essential for gut health and bone mineralization.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Editorial Material
Gastroenterology & Hepatology
Chung Sang Tse, Melissa G. Hunt, Lily A. Brown, James D. Lewis
Summary: The diagnosis of IBD brings about significant changes in the lives of most adults. Despite advancements in treatment options, medical and surgical intervention alone may not be enough to completely restore health and prevent long-term disability due to the incurable nature of IBD.
INFLAMMATORY BOWEL DISEASES
(2023)
Review
Health Care Sciences & Services
Lanlan Pang, Hengyu Liu, Zhidong Liu, Jinyu Tan, Long-Yuan Zhou, Yun Qiu, Xiaoqing Lin, Jinshen He, Xuehua Li, Sinan Lin, Subrata Ghosh, Ren Mao, Minhu Chen
Summary: Telemedicine intervention has shown promising results in improving the quality of life among adolescents with IBD and reducing clinic visits among patients with IBD.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Review
Psychiatry
Nathalie Touma, Caroline Varay, Carolina Baeza-Velasco
Summary: This systematic review examined the determinants of quality of life and psychosocial adjustment to pediatric Crohn's disease. The findings indicate that disease activity and parental stress are strong predictors, while factors such as abdominal pain, negative illness perceptions, and internalizing symptoms also play a role in impacting outcomes.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2021)
Review
Gastroenterology & Hepatology
Ashwin N. Ananthakrishnan, Gilaad G. Kaplan, Charles N. Bernstein, Kristin E. Burke, Paul J. Lochhead, Alexa N. Sasson, Manasi Agrawal, Jimmy Ho Tuan Tiong, Joshua Steinberg, Wolfgang Kruis, Flavio Steinwurz, Vineet Ahuja, Siew C. Ng, David T. Rubin, Jean-Frederic Colombel, Richard Gearry
Summary: Environmental and lifestyle factors are crucial in the development of Crohn's disease and ulcerative colitis. A group of international experts have provided a series of consensus statements for the management of inflammatory bowel disease (IBD), including recommendations on smoking cessation, mental health screening, regular physical activity, and evidence-based dietary approaches.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2022)
Review
Medicine, General & Internal
Vassiliki Sinopoulou, Morris Gordon, Anthony K. Akobeng, Marco Gasparetto, Michael Sammaan, Jessica Vasiliou, Terence M. Dovey
Summary: Crohn's disease is a chronic disorder with no known cure, leading to a huge financial burden on healthcare systems. Abdominal pain is a common and debilitating symptom of Crohn's, which can persist even during remission. Various interventions have been studied for managing abdominal pain in Crohn's disease patients, but the evidence on their efficacy is very low due to limited studies and participants.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Gastroenterology & Hepatology
Craig Haifer, Laurence Don Wai Luu, Sudarshan Paramsothy, Thomas J. Borody, Rupert W. Leong, Nadeem O. Kaakoush
Summary: This study characterized the differences in gut microbiota between two FMT donors and found that donor microbiota stability and species evenness were associated with therapeutic efficacy in UC. These findings have important implications for improving FMT donor selection.
Article
Gastroenterology & Hepatology
Eleanor Liu, Robyn Laube, Rupert W. Leong, Aileen Fraser, Christian Selinger, Jimmy K. Limdi
Summary: Objective assessment shows that gastroenterology health care professionals have good knowledge of pregnancy-specific IBD, but there is inconsistency in applying this knowledge in decision-making. Further education for clinicians is needed to provide optimal standardized care for IBD in pregnancy.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Thomas C. Mules, Akhilesh Swaminathan, Esther Hirschfeld, Grace M. Borichevsky, Chris M. Frampton, Andrew S. Day, Richard B. Gearry
Summary: This study investigated the association between disease activity and sexual dysfunction in patients with inflammatory bowel disease. The results showed that objective measures of disease activity were not associated with sexual dysfunction, but psychological symptoms played a role.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Lucy Hocking, Gianluca Ianiro, Rupert W. Leong, Tariq Iqbal, Dina Kao, Mark Cabling, Stephanie Stockwell, Robert J. Romanelli, Sonja Marjanovic
Summary: This study explores the key components of faecal microbiota transplantation (FMT) provision for recurrent Clostridioides difficile infection (CDI) and highlights the challenges and improvement opportunities in healthcare capacity, donors and donations, patient access, regulation, costs, and reimbursement. The findings emphasize the importance of building appropriate FMT capacity to effectively bring FMT to patients in healthcare systems.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Medicine, General & Internal
Amanda Flanagan, Susan M. Allsopp, Sam A. O'Connor, Jacinta Tobin, Casper Pretorius, Ian S. Brown, Sally Bell, A. James M. Daveson
Summary: This study is the first to determine the incidence of IBD in Northern Australia and compare it with Southern Australia. The crude incidence rate of IBD in Australia is the highest reported. The findings suggest a possible correlation between the increased availability and early uptake of endoscopic procedures and the higher incidence of upper gastrointestinal Crohn's disease and complicated disease at diagnosis.
INTERNAL MEDICINE JOURNAL
(2023)
Letter
Medicine, General & Internal
Martin Harb, Jessica Yang, Rupert Leong
INTERNAL MEDICINE JOURNAL
(2023)
Article
Biotechnology & Applied Microbiology
Emilia Anderson, Karen Waller, Aravind Gokul Tamilarasan, Huiyu Lin, Sudarshan Paramsothy, Rupert W. Leong
Summary: This article compares and contrasts originator and biosimilar adalimumab agents, identifying key differences such as product formulation, dosages available, delivery devices, physician support, patient support, and the supply of other biosimilar products by the company. Therefore, the choice of agent should be individualized to the needs of the patient and the healthcare service.
EXPERT OPINION ON BIOLOGICAL THERAPY
(2023)
Letter
Gastroenterology & Hepatology
Eva Zhang, Thi H. O. Nguyen, Lilith F. Allen, Lukasz Kedzierski, Louise C. Rowntree, So Young Chang, Wuji Zhang, Jennifer R. Habel, Isabelle J. Foo, Tejas Menon, Jeni Mitchell, Rupert W. Leong, Katherine Bond, Deborah A. Williamson, Katherine Kedzierka, Britt Christensen
Review
Immunology
Philip J. Smith, Mathurin Fumery, Rupert W. Leong, Kerri Novak, Axel Dignass
Summary: This article provides an overview of the clinical trial and real-world data for the subcutaneous formulation of infliximab (IFX SC) for the treatment of inflammatory bowel disease (IBD). It highlights the potential benefits of switching from intravenous (IV) to SC administration and discusses therapeutic drug monitoring and patient perspectives. The evidence suggests that IFX SC is well tolerated and effective in patients with stable disease.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2023)
Letter
Gastroenterology & Hepatology
John David Chetwood, Sudarshan Paramsothy, Craig Haifer, Rupert W. Leong, Nadeem O. Kaakoush
Article
Gastroenterology & Hepatology
Emily K. Wright, Maria Chaparro, Paolo Gionchetti, Amy L. Hamilton, Julien Schulberg, Javier P. Gisbert, Maria Chiara Valerii, Fernando Rizzello, Peter De Cruz, John C. Panetta, Annelie Everts-van der Wind, Michael A. Kamm, Thierry Dervieux
Summary: This study found that adalimumab drug clearance is a critical factor in determining the therapeutic outcome of Crohn's disease patients. Patients with lower drug clearance showed better endoscopic remission, while drug concentration did not significantly differ between patients in remission and those with recurrence. Sustained clinical remission based on C-reactive protein and lower faecal calprotectin levels were generally associated with lower clearance and higher drug concentration.
JOURNAL OF CROHNS & COLITIS
(2023)
Review
Gastroenterology & Hepatology
Alexander T. Elford, Rupert W. Leong, Emma P. Halmos, Manal Morgan, Kate Kilpatrick, Peter J. Lewindon, Richard B. Gearry, Britt Christensen
Summary: Australasia, including Australia, New Zealand, and Papua New Guinea, has a high prevalence of inflammatory bowel disease (IBD), and the practice of IBD medicine varies within this region. This review discusses barriers to IBD care across Australasia from the perspective of local healthcare professionals, including access to multidisciplinary teams, nutritional therapies, mental health disorders associated with IBD, medication availability, endoscopy access, rural barriers to care, Indigenous IBD care, and pediatric issues. The aim is to identify areas for improvement in IBD care and address research needs in Australasia.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Christian P. Selinger, Robyn Laube, Helen Steed, Matthew Brookes, Rupert W. L. NIHR BioResource, Rupert W. L. Leong
Summary: In female IBD patients, planning to conceive within the next year is associated with better medication adherence and greater disease-related knowledge.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2023)
Article
Pediatrics
Stephanie Christine Brown, Catherine L. Wall, Richard B. Gearry, Andrew S. Day
Summary: Crohn's disease (CD) is a chronic, incurable and relapsing disease that affects the gastrointestinal tract. Exclusive enteral nutrition (EEN) is the first-line therapy for CD, but little is known about the patient experience of EEN. This study aimed to assess children's experiences of EEN and understand their mindset. The findings show that limited formula flavors and the need for support are important challenges for children on EEN. Psychological support strategies should be developed to ensure successful implementation of EEN in children.
PEDIATRIC GASTROENTEROLOGY HEPATOLOGY & NUTRITION
(2023)
Correction
Gastroenterology & Hepatology
Thomas C. Mules, Akhilesh Swaminathan, Esther Hirschfeld, Grace M. Borichevsky, Chris M. Frampton, Andrew S. Day, Richard B. Gearry
INFLAMMATORY BOWEL DISEASES
(2023)