Article
Plant Sciences
Mehtap Kilic, Bilge Sener, Erdal Kaya
Summary: The aim of this study is to determine the cholinesterase inhibitory effects of Corydalis species growing in Turkey. Compounds such as canadine, berberine and dehydrocorydaline from protoberberine-type isoquinoline alkaloids were found to exert the most potent inhibitory effect against acetylcholinesterase and butyrylcholinesterase. This is the first study to identify anticholinesterase compounds from Corydalis species in Turkey.
PHYTOCHEMISTRY LETTERS
(2021)
Review
Biochemistry & Molecular Biology
Lamees Alhassen, Travis Dabbous, Allyssa Ha, Leon Hoang Lam Dang, Olivier Civelli
Summary: Corydalis yanhusuo extract contains over 160 compounds, with alkaloids being the most important for analgesic effects, as over 80 have been isolated and identified. This review aims to comprehensively discuss the phytochemical and pharmacological effects of these alkaloids in relation to pain relief.
Review
Biochemistry & Molecular Biology
Ai-Ping Deng, Yue Zhang, Li Zhou, Chuan-Zhi Kang, Chao-Gen Lv, Li-Ping Kang, Tie-Gui Nan, Zhi-Lai Zhan, Lan-Ping Guo, Lu-Qi Huang
Summary: The genus Corydalis, a botanical source of various pharmaceutically active components, has been widely used in traditional medicine, especially in China, for thousands of years. Its member species are known for treating a variety of ailments, with analgesia being the most important effect. These plants are rich in alkaloids and other chemical components, which have pharmacological efficacy against diseases of the nervous, cardiovascular and digestive systems.
Article
Plant Sciences
Zhichao Xu, Zhen Li, Fengming Ren, Ranran Gao, Zhe Wang, Jinlan Zhang, Tao Zhao, Xiao Ma, Xiangdong Pu, Tianyi Xin, Stephane Rombauts, Wei Sun, Yves Van de Peer, Shilin Chen, Jingyuan Song
Summary: This study presents the chromosome-level genome assembly of Corydalis tomentella, a species in the Papaveraceae family of the order Ranunculales, and reveals a shared whole-genome duplication event in Ranunculales. The study also investigates the biosynthetic pathways of benzylisoquinoline alkaloids in Ranunculales and highlights the role of gene duplications in their diversification.
Article
Chemistry, Applied
Hui-Na Yao, Zhi-Tian Peng, Yun-Feng Zhang, Di-Fa Liu, Bing-Feng Huang, Peng-Fei Tu, Yun-Fang Zhao, Hui-Xia Huo, Jun Li
Summary: Two new isoquinoline alkaloids and fourteen known alkaloids were isolated from Corydalis racemosa, and their structures were elucidated by analyzing spectroscopic data and comparing with literature values. The inhibitory activity against AChE was evaluated, with several compounds showing potential as inhibitors.
NATURAL PRODUCT RESEARCH
(2021)
Article
Microbiology
Gowoon Kim, Yijuan Xu, Jiarong Zhang, Zhongquan Sui, Harold Corke
Summary: This study identified and characterized a novel antibacterial agent, dehydrocorydaline, in the Corydalis turschaninovii rhizome. Dehydrocorydaline demonstrated strong antibacterial activity against L. monocytogenes, as well as inhibitory effects on biofilm formation and bacterial motility. Label-free quantitative proteomics revealed that dehydrocorydaline has multiple targets for combating L. monocytogenes, including dysregulation of carbohydrate metabolism, suppression of cell wall synthesis, and inhibition of bacterial motility.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yang Han, Tao Hou, Zi-Hui Zhang, Yun-Hui Zhu, Jun-Xiang Cheng, Han Zhou, Ji-Xia Wang, Jia-Tao Feng, Yan-Fang Liu, Zhi-Mou Guo, Xin-Miao Liang
Summary: Eleven undescribed isoquinoline alkaloids were isolated from the whole herb extract of Corydalis bungeana Turcz, including a protoberberine-type alkaloid, an isoquinoline alkaloid with a unique 6-norprotoberberine skeleton, one 13,14-seco-protoberberine-type alkaloid, two 1a,14-seco-protoberberine-type alkaloids with a 4-(hydroxymethyl)phenoxy moiety, and six aporphine alkaloids. (R)-stephanine exhibited high antagonistic activity against the dopamine D2 receptor in CHO-D2 cells.
Article
Chemistry, Analytical
Zi-Xuan Yue, Yu-Xin Gu, Tian-Ci Yan, Min-Hui Li, Hui Zheng, Jun Cao
Summary: In this study, a supercritical fluid chromatography method using ion pair reagents was successfully applied to separate alkaloids with improved efficiency. The chromatographic parameters were optimized, leading to satisfactory retention rates and resolution of the analytes. The method demonstrated good baseline separation of alkaloids from Rhizoma corydalis.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Plant Sciences
Hao Wu, Qingyue Sun, Huirong Dong, Jiasen Qiao, Ying Lin, Chen Yu, Yanni Li
Summary: This study aims to evaluate the efficacy of Corydalis yanhusuo as complementary or alternative modes of treatment against H. pylori-related diseases and ascertain the active substances of C. yanhusuo to develop non-toxic, natural, and inexpensive products. The results showed that C. yanhusuo extracts exhibited anti-H. pylori activity in different degrees, with chloroform extract showing significant antibacterial, gastroprotective, and anti-inflammatory activities.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Anastasiia O. Whaley, Andrei K. Whaley, Valeria Toporkova, Ekaterina Fock, Natalia Rukoyatkina, Sergey N. Smirnov, Gayrat B. Satimov, Baxtiyar A. Abduraxmanov, Stepan Gambaryan
Summary: Two new compounds, bracteatinine and isogroenlandicine, were isolated from Corydalis bracteata, along with four known alkaloids. The isolated compounds did not significantly affect platelet function.
Article
Pharmacology & Pharmacy
Lingyan Wang, Guiyang Xia, Huan Xia, Xiaohong Wei, Yanan Wang, Sheng Lin
Summary: A chemical investigation on the aqueous extract of Corydalis yanhusuo tubers led to the isolation and structural elucidation of three pairs of trace enantiomeric hetero-dimeric alkaloids. These compounds exhibited potent inhibition of NO production and antinociceptive effects.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Chemistry, Medicinal
Yang Han, Tao Hou, Zi-Hui Zhang, Yao-Dong Wang, Jun-Xiang Cheng, Han Zhou, Ji-Xia Wang, Jia-Tao Feng, Yan-Fang Liu, Zhi-Mou Guo, Xin-Miao Liang
Summary: Four new isoquinoline alkaloids, a benzophenanthridine alkaloid, a morphine derivative, a narceine-type alkaloid, and a simple isoquinoline alkaloid, along with a new amide alkaloid and a new phthalic acid derivative, were isolated from the whole herbs extract of Corydalis bungeana Turcz. The structures and absolute configurations of these compounds were determined through extensive spectroscopic analysis. The compounds were also evaluated for their dopamine D2 receptor activity, with compound 16 exhibiting the highest antagonistic activity.
Article
Chemistry, Multidisciplinary
E. Atta, T. Al Faifi, A. El-Shabasy
Summary: The chemical constituents and morphological traits of six species of Indigofera were surveyed and compared. The chemical analysis revealed common features and different active substances among all species. Morphological studies identified 26 main traits, showing variations between species. Cluster analysis demonstrated similarities and differences between species, and confirmed the presence of a transitional species.
JOURNAL OF SAUDI CHEMICAL SOCIETY
(2022)
Article
Integrative & Complementary Medicine
Chu Xue, Si-Xue Liu, Jie Hu, Jin Huang, Hong-Min Liu, Zhi-Xia Qiu, Fang Huang
Summary: The total alkaloids of Corydalis saxicola Bunting have shown potential therapeutic effects on paclitaxel-induced peripheral neuropathy, effectively alleviating pain symptoms and regulating cytokines and neuropeptides levels in different tissues.
Article
Chemistry, Analytical
Le Wang, Xueyang Ren, Yu Wang, Xiaoyun Liu, Ying Dong, Jiamu Ma, Ruolan Song, AXiang Yu, Jing Wei, Qiqi Fan, Xiuhuan Wang, Gaimei She
Summary: This study utilized HPLC fingerprint and UV-Vis spectroscopy technologies combined with chemometrics to quickly discriminate and quantitatively analyze Curcumae Radix samples. The results showed distinct differences in composition and absorption peaks among the four botanical origins of Curcumae Radix, with LDA and Bagged Trees models established based on HPLC fingerprint data achieving over 90% discrimination accuracy. UV-Vis spectra also indicated clear distinctions in absorption peaks between different species of Curcumae Radix.
MICROCHEMICAL JOURNAL
(2021)