Journal
BULLETIN OF MATHEMATICAL BIOLOGY
Volume 75, Issue 1, Pages 82-93Publisher
SPRINGER
DOI: 10.1007/s11538-012-9795-0
Keywords
Hepatitis A; Hepatitis C; Competitive exclusion principle; Mathematical models
Categories
Funding
- HCFMUSP [LIM-01]
- CNPq
- FAPESP
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We address the observation that, in some cases, patients infected with the hepatitis C virus (HCV) are cleared of HCV when super-infected with the hepatitis A virus (HAV). We hypothesise that this phenomenon can be explained by the competitive exclusion principle, including the action of the immune system, and show that the inclusion of the immune system explains both the elimination of one virus and the co-existence of both infections for a certain range of parameters. We discuss the potential clinical implications of our findings.
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