Journal
BULLETIN OF MATHEMATICAL BIOLOGY
Volume 73, Issue 1, Pages 248-260Publisher
SPRINGER
DOI: 10.1007/s11538-010-9541-4
Keywords
Dengue; Metapopulation models
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Funding
- Jeffress Memorial Trust
- National Institute of General Medical Sciences [R01GM090204]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM090204] Funding Source: NIH RePORTER
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We study the effect of migration between coupled populations, or patches, on the stability properties of multistrain disease dynamics. The epidemic model used in this work displays a Hopf bifurcation to oscillations in a single, well-mixed population. It is shown numerically that migration between two non-identical patches stabilizes the endemic steady state, delaying the onset of large amplitude outbreaks and reducing the total number of infections. This result is motivated by analyzing generic Hopf bifurcations with different frequencies and with diffusive coupling between them. Stabilization of the steady state is again seen, indicating that our observation in the full multistrain model is based on qualitative characteristics of the dynamics rather than on details of the disease model.
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