Role of Innate Immunity in Pregnant Patients with Vulvovaginal Infections in the Development of Intrauterine Infection in the Newborn

A total of 115 pregnant women were examined: 59 patients with opportunistic vulvovaginal infections and 56 without infection. Congenital immunity parameters (TLR-2, NF-kappa B, and IL-2 receptors in placental tissue) were studied by immunohistochemical methods. Realization of congenital infection was associated with activation of IL-6 receptors and TLR-2 in the placenta and an increase of NF-kappa B level. These changes seemed to reflect the strained status of congenital immunity and were responsible for the intensity of local inflammatory response.