Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 157, Issue 4, Pages 473-475Publisher
SPRINGER
DOI: 10.1007/s10517-014-2594-x
Keywords
phenolic antioxidants; GSTP1; NQO1; NF-kappa B; ATF-2
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The study examined dynamics of the effect of novel phenol antioxidant preparation 3-(3'-tertbutyl- 4'-hydroxyphenyl)propyl thiosulfonate sodium (TS-13) on expression of antioxidant protection enzymes genes GSTP1 and NQO1 and on the content of protein transcription factors NF-kappa B and ATF-2 in mouse liver. Expression of GSTP1 gene decreased significantly on days 4 and 7 after per os administration of TS-13 (100 mg/kg), but increased on post-administration day 14. On days 7 and 14 post-administration, expression of NQO1 gene was significantly increased. On day 7, the hepatic content of the phosphorylated form of ATF-2 and two subunits of nuclear factor NF-kappa B (p50, p65) decreased significantly.
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