Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 155, Issue 6, Pages 764-766Publisher
SPRINGER
DOI: 10.1007/s10517-013-2247-5
Keywords
tuberculosis; metal complex; chitosan
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We studied the effects of an analogue of isonicotinic acid hydrazide on the treatment course of experimental tuberculosis. Complex analysis has demonstrated the efficiency of isonicotinic acid hydrazide immobilized on a carrier that consisted of water-soluble cation-active analogue of chitosan (N-chlorohydroxypropyl chitosan) in a complex with cobalt ions in the therapy of experimental tuberculosis. Immunostimulating activity of the polymeric metal complex was revealed. The obtained data can be used for the development of highly effective methods for tuberculosis treatment.
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