Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 155, Issue 3, Pages 360-362Publisher
SPRINGER
DOI: 10.1007/s10517-013-2153-x
Keywords
alpha 1-adrenomimetics; radioprotector; indralin; bone marrow; oxygen consumption by cells in vitro
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In vitro experiments with excessive and normal oxygenation of the culture medium showed unchanged oxygen consumption by mouse bone marrow cells under the influence of radioprotector indralin belonging to alpha 1-adrenomimetics (100 mu g/ml). After exhaustion of oxygen in the medium below 10 mu M and progressive decrease in cellular respiration, indralin stimulated oxygen consumption by bone marrow cells by 1.5 times. The role of the observed effect of indralin in the realization of its radioprotective properties is discussed.
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