Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 149, Issue 6, Pages 734-738Publisher
SPRINGER
DOI: 10.1007/s10517-010-1039-4
Keywords
Rhodococcus rubber; glycolipid biosurfactant; interleukin-10; interleukin-18 and interleukin-12; chemiluminescence
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Funding
- Program for Support of Leading Scientific Schools [NSh-4112-2008.4]
- Presidium of the Russian Academy of Sciences
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The glycolipid biosurfactant complex from Rhodococcus ruber IEGM 231 had a stimulatory effect on the production of IL-12, IL-18, and reactive oxygen species by cells of the innate immunity. This effect depended on the composition of cell cultures and presence of LPS. It was primarily observed in non-stimulated cultures. The glycolipid biosurfactant complex had little effect on IL-10 secretion by monocytes and mononuclear cells.
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