Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 148, Issue 6, Pages 937-939Publisher
SPRINGER
DOI: 10.1007/s10517-010-0856-9
Keywords
diabetes mellitus; endocrine beta-cells; apoptosis; streptozotocin
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Administration of streptozotocin caused selective damage to endocrine beta-cells in rat pancreatic islets, which was related to activation of apoptosis. The cytotoxic effect of streptozotocin was associated not only with DMA damage due to dysfunction of the antioxidant defense system, but also with activation of the caspase cascade and TNF-related apoptosis-inducing ligand.
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