Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 145, Issue 3, Pages 302-306Publisher
SPRINGER
DOI: 10.1007/s10517-008-0076-8
Keywords
stress; cholecystokinin-4; behavior; glyprolines
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Funding
- Russian Foundation for Basic Research [06-04-48833]
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Experiments on outbred albino male rats showed that psychoemotional stress induced by intraperitoneal injection of cholecystokinin-4 (100 mu g/kg) increased anxiety, impaired orientation and exploration activities in the elevated plus-maze and hole-board tests, and increased the level of depression of Porsolt test. Preliminary intranasal administration of glyprolines (15 min before cholecystokinin) in a dose of 3.7 mu mol/kg prevented the development of stress-induced behavioral disturbances. Administration of peptides 30 min after cholecystokinin-4, i.e. to rats with developed behavioral disturbances, almost completely abolished these disturbances.
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