Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 145, Issue 2, Pages 259-262Publisher
SPRINGER
DOI: 10.1007/s10517-008-0065-y
Keywords
nerve growth factor; polybutylcyanoacrylate nanoparticles coated with polysorbate-80; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Parkinsonian disease
Categories
Ask authors/readers for more resources
The study examined the antiparkinsonian effect of nerve growth factor adsorbed on the surface of polybutylcyanoacrylate nanoparticles coated with polysorbate-80 surfactant. The parkinsonian syndrome in C57B1/6 mice was provoked by intraperitoneal injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. The basic symptoms of the parkinsonian syndrome decreased under the action of the nerve growth factor adsorbed on nanoparticles coated with polysorbate-80, which was seen from decreased rigidity and increased locomotor activity compared to control mice receiving with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine alone. This effect of nerve growth factor on nanoparticles persisted after 7 and 21 days after single injection of the neurotoxin. These data attest to the possibility of using nanoparticles prepared from amphiphilic polymers and coated with polysorbate-80 for the delivery of nerve growth factor into the brain during systemic treatment.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available