Journal
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
Volume 90, Issue 3, Pages 382-386Publisher
SPRINGER
DOI: 10.1007/s00128-012-0947-6
Keywords
MC-RR-GSH; MC-RR-Cys; Common carp; LC-MS; Risk assessment
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Funding
- Fundamental Research Funds for the Central Universities
- South Central University for Nationalities [CZQ11023]
- Chinese Academy of Science [KZCX1-YW-14-6-1]
- National Basic Research Program of China (973 Program) [2008CB418101]
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Tissue distributions and seasonal dynamics of glutathione and cysteine S-conjugates of microcystin-RR in feral fish from Lake Taihu were studied. High MC-RR-Cys was found in tissues, Mean MC-RR-Cys in kidney (0.253 mu g g(-1) DW) was 4 times of that in liver (0.063 mu g g(-1) DW). Ratios of MC-RR-Cys/MC-RR in liver/kidney reached as high as 5.3/39.8, respectively, meanwhile, kidney showed low accumulation of MC-RR and higher formation efficiency of MC-RR-Cys than liver (7.51x to liver), this suggested that MC-RR-Cys were significantly accumulated with the depletion of MC-RR, and it was selectively biotransformed to MC-RR-Cys in kidney for further excretion.
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