Article
Biochemistry & Molecular Biology
Caroline Santos, Claudia Bueno dos Reis Martinez
Summary: The study on the multixenobiotic resistance mechanism (MXR) activity in different organs of Prochilodus lineatus revealed that the liver and brain exhibit rapid MXR induction (6 h) while the kidney responds slowest (24 h) and the gills do not seem to play a significant role in xenobiotics efflux. The integrated response of all organs may be promoted by the circulation of xenobiotics through the bloodstream.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Environmental Sciences
Alexandre Oliveira Fernandes da Silva, Vanessa Bezerra, Paulo Cesar Meletti, Juliana Delatim Simonato, Claudia Bueno dos Reis Martinez
Summary: Cd exposure in Neotropical fish led to metal accumulation in various organs, DNA damage, lipid peroxidation, changes in catalase activity and swimming behavior.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Environmental Sciences
Ritu Sharma, Rajinder Jindal
Summary: This study elucidates the genotoxic effects of commercial grade cypermethrin on peripheral erythrocytes of Catla catla. It shows that exposure to cypermethrin at environmentally relevant concentrations can induce DNA damage and erythrocyte abnormalities, potentially harming non-target aquatic organisms.
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
(2022)
Article
Food Science & Technology
Merve Bacanli, Ozgur Esim, Hakan Erdogan, Meral Sarper, Onur Erdem, Yalcin Ozkan
Summary: This study evaluated the cytotoxicity and genotoxicity of paclitaxel nanoencapsulated with PLGA in human neuroblastoma cells. Results showed that PLGA nanoparticles can be considered as a biocompatible carrier system for drug delivery and might be a promising agent against neuroblastoma.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Food Science & Technology
Julia Buchmueller, Anne-Margarethe Enge, Antonia Peters, Johanna Ebmeyer, Jan-Heiner Kuepper, Bernd Schaefer, Albert Braeuning, Stefanie Hessel-Pras
Summary: This study investigated the genotoxic profile of varying degrees of esterification of unsaturated pyrrolizidine alkaloids (PAs). The results revealed that diester-type PAs had more pronounced effects than monoester-type PAs, including cytotoxicity, DNA damage, and cell cycle perturbation. Additionally, in vitro experiments showed that lasiocarpine had aneugenic effects.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Environmental Sciences
Luiza Flavia Veiga Francisco, Debora da Silva Baldivia, Bruno do Amaral Crispim, Syla Maria Farias Ferraz Klafke, Pamella Fukuda de Castilho, Lucilene Finoto Viana, Edson Lucas dos Santos, Kelly Mari Pires de Oliveira, Alexeia Barufatti
Summary: The study found that high concentrations of aluminum and manganese exhibit cytotoxic and genotoxic effects on cell lines, but do not show a clear mutagenic response.
Article
Environmental Sciences
Manuela Macri, Marta Gea, Irene Piccini, Luca Dessi, Alfredo Santovito, Simona Bonelli, Tiziana Schiliro, Sara Bonetta
Summary: Atmospheric pollution and particularly PM poses a significant threat to the environment and human health. In this study, the suitability of a wild cabbage butterfly species (Pieris brassicae) as a bioindicator organism to assess the genotoxic effects of PM10 collected from different sites was evaluated. The results showed that all PM extracts induced significant DNA damage in exposed larvae compared to controls, suggesting that butterflies like P. brassicae could be used as sensitive bioindicators to investigate air quality and PM genotoxicity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Eslem Amac, Recep Liman
Summary: This study evaluated the dose-dependent cytotoxicity and genotoxicity of clopyralid on Allium cepa roots, showing that clopyralid affects root growth and induces chromosome abnormalities at different concentrations. These results confirm the cytotoxic and genotoxic effects of clopyralid on non-target organisms.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Muryllo Santos Castro, Larissa Cristine Carvalho Penha, Thamires Alexsandra Torres, Marianna Basso Jorge, Luis Fernando Carvalho-Costa, Gilberto Fillmann, Ricardo Luvizotto-Santos
Summary: The study found that even at the lowest dose tested (0.35 μg g(-1)), chlorothalonil showed genotoxic and mutagenic effects, which increased in a dose-dependent manner with higher doses. This evidence suggests that the compound should be banned due to potential hazards to aquatic ecosystems and human health, outweighing any benefits to food production.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Alice Lopes, Marcelino Benvindo-Souza, Wanessa Fernandes Carvalho, Hugo Freire Nunes, Phamella Neres de Lima, Matheus Santos Costa, Edson Jose Benetti, Vinicius Guerra, Simone Maria Teixeira Saboia-Morais, Carolina Emilia Santos, Karina Simoes, Rogerio Pereira Bastos, Daniela de Melo e Silva
Summary: The study evaluated the genotoxic, mutagenic, and histopathological hepatic responses of Dendropsophus minutus tadpoles to acute exposure to the herbicide glyphosate and the surfactant polyoxyethylene amine. Results showed that both glyphosate and polyoxyethylene amine have potential genotoxic, mutagenic, and hepatotoxic effects in the tadpoles, with polyoxyethylene amine showing a higher impact. Findings emphasize the need for continued monitoring of amphibian populations in agricultural areas to mitigate the long-term impacts of pollutants on anuran tadpoles.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Sardar Khan, Zahir Qamar, Ajmal Khan, Muhammad Waqas, Javed Nawab, Muhmmmad Khisroon, Ajmal Khan
Summary: This study investigated the genotoxic effects of polycyclic aromatic hydrocarbons (PAHs) present in vehicle-wash wastewater (VWW) on fish and freshwater mussels. The results showed that the genotoxicity of VWW on both fish and mussels increased with the duration of exposure, indicating the high genotoxicity of VWW and the need for treatment before discharge into aquatic ecosystems.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Sidney Fernandes Sales Junior, Isabele Campos Costa Amaral, Camille Ferreira Mannarino, Rachel Ann Hauser-Davis, Fabio Verissimo Correia, Enrico Mendes Saggioro
Summary: This study evaluated the toxicity of Brazilian leachate on earthworms, revealing alterations in the antioxidant system, inflammatory processes, and DNA damage due to exposure. These sublethal effects in leachate-exposed earthworms provide important insights for solid waste management.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Marcelino Benvindo-Souza, Daiany Folador Sotero, Cirley Gomes Araujo dos Santos, Rhayane Alves de Assis, Rinneu Elias Borges, Lia Raquel de Souza Santos, Daniela de Melo e Silva
Summary: Pollution from mining activities can cause genotoxic damage to bats, particularly in species like Carollia perspicillata and Glossophaga soricina. High levels of elements such as Mn, Cr, Pb, and Zn were found in water samples from the mining area. The study suggests that bats in mining areas are susceptible to increased DNA damage, similar to what has been observed in other species.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Danielle Mulder, Cornelius Johannes Francois Taute, Mari van Wyk, Pieter J. Pretorius
Summary: The study found that functionalized GNPs caused genotoxicity in HepG2 cells, but the cells were able to initiate repair mechanisms and recover DNA damage, except for two functionalization chemistries.
Article
Biology
Burcu Yuksel, Asuman Deveci Ozkan, Duygu Aydin, Zeynep Betts
Summary: This study evaluated the biochemical and genotoxic changes in cell death control caused by NaBu treatment in breast cancer cells. The results showed that NaBu inhibited cell proliferation and affected antioxidant enzymes and oxidative stress parameters, leading to increased DNA damage.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
