Article
Otorhinolaryngology
Kayva L. L. Crawford, Yu-Jin Lee, Marisa Hom, Eben L. L. Rosenthal, Ryan K. K. Orosco, Quyen T. T. Nguyen
Summary: We demonstrate the efficacy of ALM-488 in labeling degenerated facial nerves using quantitative image analysis and qualitative survey data in a murine facial nerve transection model.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Surgery
Kasey Leigh Wood, Marina I. Adrianzen Fonseca, Kirsten A. Gunderson, Zeeda H. Nkana, Aaron M. Dingle, Jacqueline S. Israel, Samuel O. Poore
Summary: This study investigated differential gene expression in transected nerves repaired under high and minimal tension. The findings suggest that the improved outcomes achieved with minimal-tension nerve repair may be associated with a favorable gene expression profile. Further exploration of biochemical pathways in nerve regeneration may help identify potential therapeutic targets to optimize primary nerve repair outcomes.
JOURNAL OF SURGICAL RESEARCH
(2022)
Review
Medicine, General & Internal
Clifford T. Pereira, Elise E. Hill, Anastasiya Stasyuk, Neil Parikh, Jannat Dhillon, Aijun Wang, Andrew Li
Summary: Peripheral nerve injuries requiring surgical repair have three accepted methods: end-to-end, end-to-side, and side-to-side neurorrhaphy, each with specific indications. Understanding the circumstances for each method is important, but having a deeper understanding of the molecular mechanisms underlying repair can aid surgeons in decision-making and guide technique nuances. This paper aims to summarize the similarities and divergences of the three commonly used nerve repair strategies and the scope of molecular mechanisms and signal transduction pathways in nerve regeneration, as well as identify knowledge gaps for improving clinical outcomes in patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Kasey Leigh Wood, Marina I. Adrianzen Fonseca, Kirsten A. Gunderson, Zeeda H. Nkana, Jacqueline S. Israel, Samuel O. Poore, Aaron M. Dingle
Summary: The study compared gene expression in regenerating nerves transposed into bone and tacked to muscle, showing that nerves housed in bone have a more predictable molecular profile, which is important for neuroma prevention and neural interfacing technologies.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Acoustics
Hideki Kawai, Akira Ito, Tianshu Wang, Shixuan Xu, Hiroshi Kuroki
Summary: This study found that ultrasound therapy initiated 1 day after peripheral nerve injury promotes maximum regeneration.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Article
Anatomy & Morphology
T. B. Sivanarayanan, Irfan Ahmad Bhat, Khan Sharun, Sangeetha Palakkara, Rashmi Singh, V Remya, Mehtab Singh Parmar, Rahul Bhardwaj, Vikash Chandra, Palanivelu Munuswamy, Prakash Kinjavdekar, A. M. Pawde, Amarpal Amarpal, G. Taru Sharma
Summary: The study evaluated the healing potential of BM-MSCs and BM-MSCs-CM in acute and subacute injuries in a rabbit peripheral nerve injury model. Results showed that both BM-MSCs and BM-MSCs-CM enhanced the regenerative capacity, with slightly better improvement in the subacute injury group. It can be concluded that BM-MSCs support the healing of injured peripheral nerves, and BM-MSCs-CM accelerates the healing of acute and subacute peripheral nerve injuries in rabbits.
Article
Biochemical Research Methods
Qianru He, Fanhui Yu, Meng Cong, Yuhua Ji, Qi Zhang, Fei Ding
Summary: Peripheral nerve repair and functional recovery depend on the rate of nerve regeneration and the quality of target reinnervation. A quantitative proteomic technique was used to analyze the protein expression pattern between injured motor and sensory nerves, revealing 176 proteins with differential expressions. Functional categorization indicated that these differentially expressed proteins are linked to various molecular functions, which might play a crucial role in peripheral nerve regeneration.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Clinical Neurology
Steven J. Charous, Michael J. Hutz, Samantha E. Bialek, Jane K. Schumacher, Eileen M. Foecking
Summary: The study compared different nerve repair techniques for functional recovery in rat facial nerve injury, with MNN grafting showing promising results in faster return of vibrissae movement and less muscle atrophy compared to other techniques.
FRONTIERS IN NEUROLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Alois Hopf, Lina Al-Bayati, Dirk J. Schaefer, Daniel F. Kalbermatten, Raphael Guzman, Srinivas Madduri
Summary: This study aimed to develop a new method of decellularizing large-diameter nerves suitable for human transplantation. The optimized method effectively removed immunogenic material and preserved the extracellular structure, showing potential for cell culture studies and clinical trials.
BIOENGINEERING-BASEL
(2022)
Article
Veterinary Sciences
Thibaut Troupel, Nicolas Van Caenegem, Aurelien Jeandel, Jean-Laurent Thibaud, Audrey Nicolle, Stephane Blot
Summary: The study found that TBPI often occurs in animals before the age of 2 and 57% of dogs weighed over 20 kg. The radial compound muscle action potential (CMAP) amplitude was higher in dogs and cats with clinical improvement compared to those without improvement. A discriminating radial CMAP amplitude threshold value of 5 mV had a specificity of 93% to predict recovery.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Article
Surgery
Elif Sanli, Gungor Cagdas Dincel, Ebru Umay
Summary: The study found that DMSO has a beneficial effect on peripheral nerve regeneration in rats, with notably better outcomes in the DMSO-L group, indicating improved functional nerve recovery.
JOURNAL OF INVESTIGATIVE SURGERY
(2021)
Article
Multidisciplinary Sciences
Mehmet Sxerif Aydin, Sadik Bay, Esra Nur Yigit, Cemil Ozgul, Elif Kaval Oguz, Elcin Yenidunya Konuk, Nesxe Aysxit, Nureddin Cengiz, Ender Erdogan, Aydin Him, Mehmet Kocak, Emrah Eroglu, Gurkan Ozturk
Summary: This study demonstrates that axotomy triggers actomyosin contraction and calpain activity in neurons, causing them to shrink and force water out through aquaporin channels to prevent swelling and bursting. Inhibiting this cellular response increases the likelihood of neuronal cell death. These findings provide new insights into the pathophysiological processes in the nervous system.
Article
Neurosciences
Tim Ruhl, Tim Christer, Sophie Ch. Rhode, Justus P. Beier
Summary: The rat sciatic nerve is a commonly used model to study peripheral nerve injuries. The grasping test is a valid method to evaluate functional recovery after sciatic nerve resection in rats, as demonstrated in this study. Autograft showed the strongest improvement in grasping ability after 7 weeks, while nerve tube required 12 weeks.
NEUROSCIENCE RESEARCH
(2023)
Review
Clinical Neurology
Dong-Xu Huang, Ming-Xi Yang, Zhen-Min Jiang, Miao Chen, Kun Chang, Yong-Xin Zhan, Xu Gong
Summary: The healing process of a transected peripheral nerve trunk consists of angiogenesis, nerve fiber regeneration, and scarring. Nerve trunk healing and neuroma formation may share similar molecular mediators and regulations. Angiogenesis is necessary for nerve fiber regeneration at the site of nerve transection. Angiogenesis and nerve fiber regeneration have a positive correlation in the early stage, while scarring and nerve fiber regeneration show a negative correlation in the late phase. Anti-angiogenesis may suppress neuromas, and potential protocols are provided to test this hypothesis. The use of anti-angiogenic small-molecule protein kinase inhibitors is recommended for studying nerve transection injuries.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Daichi Shima, Tokio Kinoshita, Yasunori Umemoto, Yoshinori Yasuoka, Takamasa Hashizaki, Makoto Asaeda, Yukihide Nishimura, Tamaki Yahata, Takashi Shimoe, Fumihiro Tajima
Summary: This study reported on a patient with adductor paralysis due to obturator neurotmesis, including the clinical symptoms, characteristics of activities of daily living (ADL) impairment, and effective movement instruction. This case suggests that movement instruction is important for acute rehabilitation therapy for patients with hip adductor muscle group with obturator neurotmesis.
FRONTIERS IN NEUROLOGY
(2023)