Review
Nutrition & Dietetics
Luca Dalle Carbonare, Monica Mottes, Maria Teresa Valenti
Summary: Osteonecrosis of the jaw is a severe clinical condition characterized by exposed bone that does not heal over time. Diagnosis is primarily clinical with imaging feedback playing a confirmatory role. Medication-related osteonecrosis of the jaw, particularly induced by bisphosphonates, has been widely discussed, but the exact mechanism remains debatable.
Article
Endocrinology & Metabolism
Kazumitsu Aoki, Satoru Matsunaga, Shinichirou Ito, Takahiko Shibahara, Takeshi Nomura, Hideo Matsuzaki, Shinichi Abe, Akira Yamaguchi
Summary: BRONJ is characterized by numerous bone resorption lacunae on the necrotic bone surface, which is distinct from the limited resorption lacunae in DRONJ and suppurative osteomyelitis. The histopathological diagnosis of BRONJ can be distinguished based on the unique persistence of bone resorption lacunae on the necrotic bone surface.
JOURNAL OF BONE AND MINERAL METABOLISM
(2021)
Article
Multidisciplinary Sciences
Kota Morishita, Sakiko Soutome, Mitsunobu Otsuru, Saki Hayashida, Maho Murata, Miho Sasaki, Yukinori Takagi, Misa Sumi, Masahiro Umeda
Summary: The study found that a drug holiday of 3 months for medication-related osteonecrosis of the jaw in osteoporosis patients receiving antiresorptive agents does not promote sequestra separation or improve treatment outcomes, and early surgical therapy is recommended.
SCIENTIFIC REPORTS
(2022)
Review
Chemistry, Multidisciplinary
Krzysztof Wrobel, Maciej Sikora, Maciej Checinski, Maria Jas, Dariusz Chlubek
Summary: MRONJ is a condition that is becoming more common in dental and maxillofacial practice, requiring comprehensive, accessible, and up-to-date data. Besides bisphosphonates, angiogenesis inhibitors and anti-RANKL monoclonal antibodies can also increase the risk of the disease. Thorough physical examination, periodic correction of dental prostheses, and adequate preparation for oral procedures can prevent or minimize the risk of MRONJ.
APPLIED SCIENCES-BASEL
(2021)
Review
Endocrinology & Metabolism
L. dos Santos Ferreira, L. G. Abreu, C. B. Calderipe, M. D. Martins, L. F. Schuch, A. C. U. Vasconcelos
Summary: The study aimed to integrate data on the use of TPTD for MRONJ cases, finding that TPTD in combination with another therapy, especially antibiotic therapy, can be considered an effective protocol for MRONJ.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Sakiko Soutome, Mitsunobu Otsuru, Saki Hayashida, Maho Murata, Souichi Yanamoto, Shunsuke Sawada, Yuka Kojima, Madoka Funahara, Hiroshi Iwai, Masahiro Umeda, Toshiyuki Saito
Summary: Tooth extraction is not a risk factor for medication-related osteonecrosis of the jaw (MRONJ) in cancer patients receiving bone-modifying agents (BMAs), but rather helps reduce the risk of MRONJ development. Infected teeth and longer duration of BMA administration are independent risk factors for MRONJ.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Guang Yang, Sonal Singh, Caitrin W. McDonough, Jatinder K. Lamba, Issam Hamadeh, L. Shannon Holliday, Danxin Wang, Joseph Katz, Peter A. Lakatos, Bernadett Balla, Janos P. Kosa, Gian Andrea Pelliccioni, Douglas K. Price, Sara L. Van Driest, William D. Figg, Taimour Langaee, Jan S. Moreb, Yan Gong
Summary: The study identified a lead SNP, rs2736308 on chromosome 8, associated with an increased risk of MRONJ in patients with cancer and osteoporosis. This SNP is linked to genes regulating bone mineral density, providing insights into the potential mechanism of MRONJ.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Immunology
Shuxuan Wu, Feng Li, Jingjing Tan, Xiaoling Ye, Yushi Le, Nianke Liu, Vincent Everts, Qilong Wan
Summary: The present study explored the role of Porphyromonas gingivalis on the site-specificity of bisphosphonate-related osteonecrosis and its underlying mechanism. The findings suggest that P. gingivalis in the oral cavity might be one of the steering compounds for BRONJ to occur.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Masanori Nashi, Hiromitsu Kishimoto, Masaki Kobayashi, Akira Tachibana, Motoo Suematsu, Shigeyoshi Fujiwara, Yoshiyuki Ota, Susumu Hashitani, Takeshi Shibatsuji, Tetsuya Nishida, Kazuma Fujimura, Shungo Furudoi, Yoshiki Ishida, Shoichiro Ishii, Tsuyoshi Fujita, Soichi Iwai, Takashi Shigeta, Takeshi Harada, Daisuke Miyai, Daisuke Takeda, Masaya Akashi, Kazuma Noguchi, Toshihiko Takenobu
Summary: The incidence of medication-related osteonecrosis of the jaw is increasing worldwide, mostly due to the use of antiresorptive agents. However, the proportion of BP-related osteonecrosis of the jaw (BRONJ) and Dmab-related osteonecrosis of the jaw (DRONJ) among all ARA-related osteonecrosis of the jaw (ARONJ) cases is not clear. Therefore, a retrospective study was conducted to classify and compare patient characteristics with those having BRONJ and DRONJ.
JOURNAL OF DENTAL SCIENCES
(2023)
Article
Cell Biology
Xian Dong, Linhai He, Xiaolong Zang, Yang He, Jingang An, Baoping Wu, Xinhua Liu, Hongsen Bi, Yi Zhang, E. Xiao
Summary: This study found that local transplantation of ADSCs can effectively promote bone healing in BRONJ. The mechanism involves ADSCs promoting bone coupling through TGF-beta 1 activation, significantly rescuing necrotic jawbones in BRONJ and animal model jawbone samples.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Youngmin Kwon, Yi-Qin Fang, Seungjin Lee, Chunui Lee
Summary: In this retrospective study, new bone formation and factors influencing spontaneous bony bridge formation were examined in MRONJ patients who underwent segmental mandibulectomy with reconstruction using an R-plate without graft material. The results showed that all patients exhibited new bone formation, and 71.4% showed bony bridge formation within a year after surgery. Older patients had a lower tendency for bony bridge formation in the defect. Preservation of the periosteum may be a crucial factor for promoting new bone formation and an optimal treatment option for MRONJ patients after segmental mandibulectomy.
APPLIED SCIENCES-BASEL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Takazumi Yasui, Hiroki Nagamine, Kenta Tanaka, Moemi Kimura, Takeshi Karube, Hiromasa Kawana, Katsuhiro Onizawa
Summary: This study aimed to evaluate the prognostic treatment outcome of non-operative management of medication-related osteonecrosis of the jaw (MRONJ), particularly regarding the relationship between image findings and treatment outcomes. The study found that sequestrum formation on the internal texture and chemotherapy were significantly associated with treatment outcome. Sequestrum formation on the internal texture was associated with shorter time to healing and better outcomes, while sclerosis and normal findings were associated with longer healing times.
DENTOMAXILLOFACIAL RADIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Salvatore D'Amato, Antonio Troiano, Giorgio Lo Giudice, Davide De Cicco, Mario Rusciano, Gianpaolo Tartaro, Giuseppe Colella
Summary: Surgical resection showed higher complete healing cases and statistically significant difference in recurrence rate compared to debridement. Debridement is an unfavorable prognostic factor when compared to surgical resection, with a 4.9 times higher risk of recurrence. Quality of life mean values improved significantly in the surgical resection group and slightly in the debridement group.
APPLIED SCIENCES-BASEL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Polytimi Paschalidi, Ioannis Gkouveris, Akrivoula Soundia, Evangelos Kalfarentzos, Emmanouil Vardas, Maria Georgaki, Georgios Kostakis, Boban M. Erovic, Sotirios Tetradis, Christos Perisanidis, Nikolaos G. Nikitakis
Summary: This study investigated the relationship between M1 and M2 macrophage polarization and clinical stage in MRONJ patients. Early-stage patients showed a switch towards M2 phenotype, while advanced-stage patients demonstrated a shift towards the M1 phenotype. Macrophage density of both M1 and M2 subsets was significantly enhanced in patients receiving bisphosphonates.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Health Care Sciences & Services
Rieko Shimizu, Shintaro Sukegawa, Yuka Sukegawa, Kazuaki Hasegawa, Sawako Ono, Tomoya Nakamura, Ai Fujimura, Ayaka Fujisawa, Keisuke Nakano, Kiyofumi Takabatake, Hotaka Kawai, Hitoshi Nagatsuka, Yoshihiko Furuki
Summary: This study analyzed the risk factors and probabilities of developing ARONJ after tooth extraction in patients undergoing BMA therapy. The study found that hypoparathyroidism was an important factor associated with ARONJ development. Therefore, systemic factors are more strongly related to the onset of ARONJ after tooth extraction than local factors.
Article
Clinical Neurology
C. Maier, N. Thieme, B. Beck-Broichsitter, N. L. Beetz, T. C. Walter-Rittel, K. Rubarth, M. Heiland, K. Kreutzer, S. Koerdt, J. O. Voss
Summary: Orbital compartment syndrome is a sight-threatening emergency characterized by proptosis, optic nerve stretching, and decreased posterior globe angle. This study systematically evaluated the imaging features of orbital compartment syndrome and found that the pathophysiology involves an expanding pathology within the orbit.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Article
Oncology
Christian Doll, Friedrich Mrosk, Lea Freund, Felix Neumann, Kilian Kreutzer, Jan Voss, Jan-Dirk Raguse, Marcus Beck, Dirk Boehmer, Kerstin Rubarth, Max Heiland, Steffen Koerdt
Summary: The necessity of contralateral elective neck dissection in patients with lateralized oral squamous cell carcinoma and ipsilateral cervical lymph node metastasis is still controversial. This retrospective analysis conducted at a high-volume tumor center in Germany over a 10-year period suggests that occult contralateral neck metastases are rare in this cohort, and routine contralateral elective neck dissection may not be necessary.
Article
Oncology
Saskia Preissner, Max Heiland, Robert Preissner, Markus Wirth, Barbara Wollenberg
Summary: Antibiotics can alter the gut microbiome, affecting drug metabolism and leading to ineffective immunotherapy in cancer patients. A study on oral cancer patients found that those who received antibiotics had a significantly lower survival rate compared to those who did not, possibly due to antibiotic-related changes in the gut microbiome.
Article
Oncology
Raphaela Graessle, Carmen Stromberger, Marcus Beck, Max Heiland, Veit M. Hofmann, Heidi Olze, Steffen Dommerich, Ulrich Gauger, Iris Piwonski, Annekatrin Coordes
Summary: The aim of this study was to investigate the factors influencing the survival of elderly patients with HNSCC. It was found that non-smokers had a significantly higher chance of surviving HNSCC than smokers. Elderly non-smokers are also affected by HNSCC, but their overall survival and disease-free survival rates are increased compared to smokers.
Article
Oncology
Jonas Wuester, Max Heiland, Susanne Nahles, Robert Preissner, Saskia Preissner
Summary: Statins are commonly prescribed to lower cholesterol levels and have been found to have beneficial effects on cancer prevention and treatment. In this study, the effect of statin medication on head and neck cancer patients was investigated. The results showed that patients who received statins had significantly higher five-year survival rates and a lower risk of death compared to those who did not receive statins. However, further clinical research is needed to confirm these findings.
Article
Oncology
Peer W. Kaemmerer, Silke Tribius, Lena Cohrs, Gabriel Engler, Tobias Ettl, Kolja Freier, Bernhard Frerich, Shahram Ghanaati, Martin Gosau, Dominik Haim, Stefan Hartmann, Max Heiland, Manuel Herbst, Sebastian Hoefert, Juergen Hoffmann, Frank Hoelzle, Hans-Peter Howaldt, Kilian Kreutzer, Henry Leonhardt, Rainer Lutz, Maximilian Moergel, Ali Modabber, Andreas Neff, Sebastian Pietzka, Andrea Rau, Torsten E. Reichert, Ralf Smeets, Christoph Sproll, Daniel Steller, Joerg Wiltfang, Klaus-Dietrich Wolff, Kai Kronfeld, Bilal Al-Nawas
Summary: This is the first prospective study using a multicentric approach to investigate the effectiveness of adjuvant radiotherapy in patients with early squamous cell carcinoma of the oral cavity and oropharynx. The study found that adjuvant radiotherapy does not seem to influence overall survival, but it positively affects time to progression. However, irradiated patients report a significantly decreased quality of life up to three years after therapy.
Article
Biotechnology & Applied Microbiology
Christine Knabe, Michael Stiller, Marian Kampschulte, Janka Wilbig, Barbara Peleska, Jens Guenster, Renate Gildenhaar, Georg Berger, Alexander Rack, Ulf Linow, Max Heiland, Carsten Rendenbach, Steffen Koerdt, Claudius Steffen, Alireza Houshmand, Li Xiang-Tischhauser, Doaa Adel-Khattab
Summary: Efforts towards the development of patient-specific 3D printed scaffolds for bone tissue engineering from bioactive ceramics have intensified recently. The current study investigated the effect of different scaffold microarchitecture on vascularization and bone regeneration for reconstructing segmental defects. The results showed that the RP scaffolds with cells and AVB had significantly higher bone area fraction, blood vessel volume, blood vessel surface/volume, blood vessel thickness, density, and linear density compared to other scaffold configurations.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Ana Prates Soares, Heilwig Fischer, Vincenzo Orassi, Max Heiland, Sara Checa, Katharina Schmidt-Bleek, Carsten Rendenbach
Summary: Patients have a high acceptance of bone replacement materials, especially scientifically developed biomaterials and autologous sources of blood and tissue. This study's findings are important for the development of new bone biomaterials.
BIOMEDICAL ENGINEERING ONLINE
(2023)
Article
Infectious Diseases
Florian Gaertner, Saskia Preissner, William Arthur Petri, Olubunmi Atolani, Max Heiland, Susanne Nahles, Robert Preissner, Moritz Hertel
Summary: By retrospectively comparing the recent outbreak of monkeypox with historical outbreaks, it was found that the risk of hospital admission, ventilation, and pneumonitis was relatively low in the recent outbreak. However, some patients still required hospitalization and experienced severe complications.
BMC INFECTIOUS DISEASES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Maria Ebker, Maximilian Goedecke, Tobias Wollersheim, Max Heiland, Tobias Ebker
Summary: This retrospective analysis evaluated the safety of maxillomandibular advancement with rotation in patients with OSA. The study found that MMA is a safe surgical procedure and can be effectively used for the treatment of OSA.
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Claudius Steffen, Ana Prates Soares, Thelma Heintzelmann, Heilwig Fischer, Jan Oliver Voss, Susanne Nahles, Jonas Wuester, Steffen Koerdt, Max Heiland, Carsten Rendenbach
Summary: The impact of bone origin at the intersegmental gap on osseous union in mandibular reconstruction was evaluated in this study. The results showed that the bone interface did not significantly influence the change in bone volume at the intersegmental gap. Radiotherapy, time between CBCT scans, and wound healing disorders were identified as independent risk factors for osseous non-union. Preliminary analysis of the intersegmental bone microstructure did not reveal morphological differences.
HEAD & FACE MEDICINE
(2023)
Review
Dentistry, Oral Surgery & Medicine
Tabea Fluegge, Christian Gross, Ute Ludwig, Johanna Schmitz, Susanne Nahles, Max Heiland, Katja Nelson
Summary: MRI is increasingly used in various dental specialities, such as orthodontics, endodontics, prosthodontics, periodontics, oral surgery, pediatric dentistry, and operative dentistry. It is used for cephalometry, detection of dental pulp inflammation, characterization of periodontal pathologies, caries detection, and dental implant planning, among others.
DENTOMAXILLOFACIAL RADIOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Norbert Neckel, Daniel Troeltzsch, Dario Zocholl, Steffen Koerdt, Yvonne Motzkus, Andrej Trampuz, Jan-Dirk Raguse, Max Heiland, Susanne Nahles
Summary: The purpose of this study was to compare different assessment methods for peri-implant inflammation, evaluate potential risk factors, and establish a comprehensive algorithm for clinical staging, treatment, and evaluation of success in periorbital implants. The results showed that probing depth and skin reaction to be valuable quick assessment tools, which can be complemented with sulcus fluid flow rate for improved accuracy. Patient-specific factors did not have a significant impact on peri-implant inflammation.
INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS
(2023)
Article
Oncology
Elena Hofmann, Saskia Preissner, Moritz Hertel, Robert Preissner, Carsten Rendenbach, Anne Floercken, Max Heiland
Summary: This study aimed to evaluate the impact of adjuvant or neoadjuvant chemotherapy on the survival outcomes of patients with craniofacial bone sarcomas. The results showed that patients who received neoadjuvant chemotherapy had better survival rates compared to those who received adjuvant chemotherapy. Further randomized controlled studies are needed to validate these findings.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2023)
Article
Oncology
Elena Hofmann, Christian Doll, Alize Rogge, Robert Preissner, Max Heiland, Saskia Preissner, Steffen Koerdt
Summary: This study aimed to assess survival outcomes and potential prognostic factors in female and male patients with oral cancer. The results showed that females had better five-year disease-free survival and overall survival compared to males. However, females diagnosed with depression after the initial cancer diagnosis had worse survival outcomes than male patients.
FRONTIERS IN ONCOLOGY
(2023)
