Article
Medicine, General & Internal
Deborah Schrag, Qian Shi, Martin R. Weiser, Marc J. Gollub, Leonard B. Saltz, Benjamin L. Musher, Joel Goldberg, Tareq Al Baghdadi, Karyn A. Goodman, Robert R. McWilliams, Jeffrey M. Farma, Thomas J. George, Hagen F. Kennecke, Ardaman Shergill, Michael Montemurro, Garth D. Nelson, Brian Colgrove, Vallerie Gordon, Alan P. Venook, Eileen M. O'Reilly, Jeffrey A. Meyerhardt, Amylou C. Dueck, Ethan Basch, George J. Chang, Harvey J. Mamon
Summary: Preoperative FOLFOX chemotherapy is as effective as preoperative chemoradiotherapy for locally advanced rectal cancer eligible for sphincter-sparing surgery.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Oncology
Sandra Chomicki, Sophie Chapet, Moussata Drifa, Mehdi Ouaissi, Pascal Bourlier, Kamel Debbi, Gokoulakrichenane Loganadane, Gilles Calais
Summary: This study evaluated the outcome of patients with stage II or III upper rectal cancer undergoing neoadjuvant (chemo) radiotherapy followed by total mesorectal excision. The results showed that this treatment approach was effective and safe, with improved overall survival and reduced local recurrence rate. However, it was associated with certain treatment-related toxicities and surgical complications.
ANTICANCER RESEARCH
(2022)
Article
Oncology
Anchuan Li, Tingxuan Huang, Rong Zheng, Pan Chi, Zhihua Li, Xiaozhong Wang, Benhua Xu
Summary: This study compared the survival outcomes, acute toxicities, and surgical complications in LARC patients who received preoperative chemoradiotherapy with triweekly XELOX or capecitabine. The results showed that both regimens had similar long-term survival outcomes, acute toxicities, and surgical complications.
Article
Oncology
Wei-Wei Xiao, Min Li, Zhi-Wei Guo, Rong Zhang, Shao-Yan Xi, Xiang-Guo Zhang, Yong Li, De-Qing Wu, Yu-Feng Ren, Xiao-Lin Pang, Xiang-Bo Wan, Kun Li, Chun-Lian Zhou, Xiang-Ming Zhai, Zhi-Kun Liang, Qiao-Xuan Wang, Zhi-Fan Zeng, Hui-Zhong Zhang, Xue-Xi Yang, Ying-Song Wu, Ming Li, Yuan-Hong Gao
Summary: The PGS-LARC model is a reliable predictive tool for pCR in LARC patients, showing superior predictive performance compared to clinical factors. For patients with clinical complete response (cCR), the positive prediction value is 94.7%.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Immunology
Yiyi Zhang, Bingjie Guan, Yong Wu, Fan Du, Jinfu Zhuang, Yuanfeng Yang, Guoxian Guan, Xing Liu
Summary: This study identified four lncRNAs associated with NCRT response and prognosis in CRC patients, with LINC00909 showing the strongest predictive ability and increasing cell line resistance to 5-FU and radiotherapy. These lncRNAs have the potential to serve as novel biomarkers for predicting NCRT response and prognosis in CRC patients.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Oncology
Yuma Wada, Mitsuo Shimada, Yuji Morine, Tetsuya Ikemoto, Yu Saito, Zhongxu Zhu, Xin Wang, Ane Etxart, Yangsoon Park, Luis Bujanda, In Ja Park, Ajay Goel
Summary: The study aimed to identify patients' response to preoperative chemoradiotherapy (PCRT) in locally advanced rectal cancer (LARC) through miRNA expression profiling in plasma. The miRNA panel accurately predicted response to PCRT and outperformed conventional clinical factors.
JCO PRECISION ONCOLOGY
(2021)
Article
Surgery
Sunseok Yoon, Yoon Oh, Seung Yeop Oh
Summary: The combination of lymphocyte count and neutrophil count is shown to be a powerful predictive factor for disease recurrence in patients with locally advanced rectal cancer who underwent chemoradiotherapy followed by curative surgery.
WORLD JOURNAL OF SURGERY
(2021)
Article
Medicine, General & Internal
Alfonso Martin-Carnicero, Enrique Ramalle-Gomara, Susana Rubio-Mediavilla, Martina Alonso-Lago, Miriam Zorrilla-Larraga, Isabel Manrique-Abos, Maria E. de las Heras-Duena, Ignacio M. Larrayoz, Alfredo Martinez
Summary: This retrospective study focuses on the clinical, analytical, and pathological parameters of locally advanced rectal cancer patients who received neoadjuvant chemoradiotherapy (CRT) and surgery. The study found that lower hemoglobin levels, lower lymphocyte/monocyte ratio, and higher platelet/lymphocyte ratio were associated with relapse. Additionally, the number of positive nodes after surgery and KRAS mutations were linked to worse prognosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Mursel Duzova, Hamit Basaran, Gokcen Inan, Osman Vefa Gul, Orhan Onder Eren, Muslu Kazim Korez
Summary: This study compared preoperative chemoradiotherapy (CRT) with postoperative CRT for locally advanced rectal cancer treatment and found no significant difference in recurrence and survival rates between the two groups. Preoperative CRT showed better overall treatment compliance, reduced toxicity, and increased sphincter preservation in low-lying tumors.
TRANSPLANT IMMUNOLOGY
(2021)
Review
Surgery
Qingbin Wu, Jiahao Zhou, Jun Huang, Xiangbing Deng, Changtao Li, Wenjian Meng, Yazhou He, Ziqiang Wang
Summary: This meta-analysis aimed to compare the differences in pathological complete response rate and survival outcomes among patients who received different treatments for rectal cancer. It showed that total neoadjuvant therapy with short-course radiotherapy or long-course chemoradiotherapy improved the pathological complete response rate compared to long-course chemoradiotherapy alone. Total neoadjuvant therapy with long-course chemoradiotherapy and consolidation chemotherapy was associated with better disease-free survival. Both total neoadjuvant therapy with short-course radiotherapy and total neoadjuvant therapy with long-course chemoradiotherapy had similar outcomes in terms of pathological complete response rate and survival.
BRITISH JOURNAL OF SURGERY
(2023)
Article
Oncology
Lucrezia D'Alimonte, Quoc Riccardo Bao, Gaya Spolverato, Giulia Capelli, Paola Del Bianco, Laura Albertoni, Antonino De Paoli, Mario Guerrieri, Giovanna Mantello, Maria Antonietta Gambacorta, Vincenzo Canzonieri, Vincenzo Valentini, Claudio Coco, Salvatore Pucciarelli
Summary: In highly selected patients, the local excision approach after neoadjuvant chemoradiotherapy is associated with excellent long-term outcomes, high rates of rectum preservation, and absence of a permanent stoma.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shanshan Lian, Huiming Liu, Tiebao Meng, Lidi Ma, Weilong Zeng, Chuanmiao Xie
Summary: This study found that the synthetic MRI-derived T1 relaxation time and T2 relaxation time values are promising imaging markers for predicting a good response to neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer.
EUROPEAN RADIOLOGY
(2023)
Review
Oncology
Fausto Petrelli, Francesca Trevisan, Gianluca Tomasello, Agostina De Stefani, Matteo Viti, Ornella Garrone, Andrea Luciani, Michele Ghidini
Summary: Neoadjuvant therapy is crucial for the treatment of locally advanced rectal adenocarcinoma, and adopting total neoadjuvant therapy improves outcomes compared to preoperative strategies such as fluoropyrimidine-based chemoradiotherapy.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Review
Oncology
Huaqin Lin, Lei Wang, Xiaohong Zhong, Xueqing Zhang, Lingdong Shao, Junxin Wu
Summary: This meta-analysis comparing neoadjuvant chemotherapy (NAC) and neoadjuvant chemoradiotherapy (NACRT) for locally advanced rectal cancer (LARC) found that NAC was superior to NACRT in terms of sphincter preservation rate, but noninferior in terms of other outcomes. Further validation is needed for these conclusions.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Ana Sofia Ore, Gabrielle E. Dombek, Carlos A. Cordova-Cassia, Jeanne F. Quinn, Thomas E. Cataldo, Benjamin L. Schlechter, Matthew J. Abrams, Evangelos Messaris
Summary: This study evaluated the impact of preoperative chemoradiotherapy on radial margin disease involvement in locally advanced rectal cancer patients. Results showed a higher risk of radial margin positivity in patients who did not receive preoperative chemoradiotherapy or had poor response to it.
DISEASES OF THE COLON & RECTUM
(2021)
Review
Surgery
W. A. A. Borstlap, T. J. Coeymans, P. J. Tanis, C. A. M. Marijnen, C. Cunningham, W. A. Bemelman, J. B. Tuynman
BRITISH JOURNAL OF SURGERY
(2016)
Article
Oncology
Lisette M. Wiltink, Remi A. Nout, Jochem R. N. van der Voort van Zyp, Heleen M. Ceha, Marta Fiocco, Elma Meershoek-Klein Kranenbarg, Andreas W. K. S. Marinelli, Cornelis J. H. van de Velde, Corrie A. M. Marijnen
CLINICAL COLORECTAL CANCER
(2016)
Article
Cell Biology
Steven L. Bosch, Thomas A. Vermeer, Nicholas P. West, Hendrik A. M. Swellengrebel, Corrie A. M. Marijnen, Annemieke Cats, Cornelis Verhoef, Ineke van Lijnschoten, Johannes H. W. de Wilt, Harm J. Rutten, Iris D. Nagtegaal
Article
Oncology
A. H. Pieterse, M. Kunneman, E. G. Engelhardt, N. J. Brouwer, J. R. Kroep, C. A. M. Marijnen, A. M. Stiggelbout, E. M. A. Smets
Article
Oncology
Eva C. Rijkmans, Annemieke Cats, Remi A. Nout, Desiree H. J. G. van den Bongard, Martijn Ketelaars, Jeroen Buijsen, Tom Rozema, Jan-Huib Franssen, Laura A. Velema, Baukelien van Triest, Corrie A. M. Marijnen
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2017)
Letter
Oncology
Lisette M. Wiltink, Remi A. Nout, Marta Fiocco, Carien L. Creutzberg, Cornelia A. M. Marijnen
JOURNAL OF CLINICAL ONCOLOGY
(2017)
Article
Oncology
Steven L. Bosch, Stefan J. van Rooijen, Guus M. J. Bokketink, Hidde J. W. Braam, Lauranne A. A. P. Derikx, Philip Poortmans, Corrie A. M. Marijnen, Iris D. Nagtegaal, Johannes H. W. de Wilt
RADIOTHERAPY AND ONCOLOGY
(2017)
Article
Gastroenterology & Hepatology
M. A. P. van Ruler, F. P. Peters, M. Slingerland, M. Fiocco, D. A. R. H. Grootenboers, A. J. E. Vulink, C. A. M. Marijnen, K. J. Neelis
DISEASES OF THE ESOPHAGUS
(2017)
Article
Oncology
Roy P. J. van den Ende, Eva C. Rijkmans, Ellen M. Kerkhof, Remi A. Nout, Martijn Ketelaars, Mirjam S. Laman, Corrie A. M. Marijnen, Uulke A. van der Heide
Article
Oncology
D. H. M. Jacobs, G. Speijer, A. L. Petoukhova, E. M. A. Roeloffzen, M. Straver, A. Marinelli, U. Fisscher, A. G. Zwanenburg, J. Merkus, C. A. M. Marijnen, M. E. Mast, P. C. M. Koper
BREAST CANCER RESEARCH AND TREATMENT
(2018)
Article
Oncology
E. C. Rijkmans, B. van Triest, R. A. Nout, E. M. Kerkhof, J. Buijsen, T. Rozema, J. H. Franssen, L. A. Velema, M. S. Laman, A. Cats, C. A. M. Marijnen
RADIOTHERAPY AND ONCOLOGY
(2018)
Article
Oncology
Paulien G. Westhoff, Alexander de Graeff, Evelyn M. Monninkhof, Ilse de Pree, Marco van Vulpen, Jan Willem H. Leer, Corrie A. M. Marijnen, Yvette M. van der Linden
JOURNAL OF RADIATION ONCOLOGY
(2018)
Article
Medicine, General & Internal
Anouk J. M. Rombouts, Issam Al-Najami, Natalie L. Abbott, Ane Appelt, Gunnar Baatrup, Simon Bach, Aneel Bhangu, Karen-Lise Garm Spindler, Richard Gray, Kelly Handley, Manjinder Kaur, Ellen Kerkhof, Camilla Jensenius Kronborg, Laura Magill, Corrie A. M. Marijnen, Iris D. Nagtegaal, Lars Nyvang, Femke P. Peters, Per Pfeiffer, Cornelis Punt, Philip Quirke, David Sebag-Montefiore, Mark Teo, Nick West, Johannes H. W. de Wilt
Article
Oncology
Paulien G. Westhoff, Alexander de Graeff, Evelyn M. Monninkhof, Maaike J. Berveling, Marco van Vulpen, Jan Willem H. Leer, Corrie A. M. Marijnen, Anna K. L. Reyners, Yvette M. van der Linden
Article
Oncology
L. Gietelink, M. W. J. M. Wouters, C. A. M. Marijnen, J. van Groningen, N. van Leersum, R. G. H. Beets-Tan, R. A. E. M. Tollenaar, P. J. Tanis