Article
Surgery
Yi-Chang Chen, Tao-Wei Ke, Yuan-Yao Tsai, Abe Fingerhut, William Tzu-Liang Chen
Summary: This study retrospectively analyzed the charts of 15 consecutive patients and found that laparoscopic redo anastomosis was feasible and safe for the management of intraperitoneal anastomotic leakage after colonic surgery.
Article
Medicine, General & Internal
Eugenia Claudia Zarnescu, Narcis Octavian Zarnescu, Radu Costea
Summary: Anastomotic leakage is a severe complication following colorectal surgery, with multiple risk factors identified. There are both nonmodifiable and modifiable risk factors associated with this complication. Different preoperative and postoperative approaches may not necessarily reduce the occurrence of anastomotic leakage.
Article
Surgery
Daitlin E. Huisman, Muriel Reudink, Stefanus J. van Rooijen, Boukje T. Bootsma, Tim van de Brug, Jurre Stens, Wim Bleeker, Laurents P. S. Stassen, Audrey Jongen, Carlo Feo, Simone Targa, Niels Komen, Hidde M. Kroon, Tarik Sammour, Emmanuel A. G. L. Lagae, Aalbert K. Talsma, Johannes A. Wegdam, Tammo S. de Vries Reilingh, Bob van Wely, Marie J. van Hoogstraten, Dirk J. A. Sonneveld, Sanne C. Veltkamp, Emiel G. G. Verdaasdonk, Rudi M. H. Roumen, Gerrit D. Slooter, Freek Daams
Summary: This study aimed to assess the impact of potentially modifiable perioperative risk factors on anastomotic leakage in adult patients undergoing colorectal surgery.
Review
Surgery
Kun Wang, Shan-shan Dong, Wei Zhang, Yuan-yuan Ni, Fang Xie, Jun-chao Wang, Xing-hui Wang, Yue-wei Li
Summary: Background: Pancreaticoduodenectomy is the preferred surgical intervention for pancreatic tumors, but anastomotic fistula is a common and potentially fatal complication. The impact of different surgical methods, such as open pancreaticoduodenectomy (OPD), laparoscopic pancreaticoduodenectomy (LPD), and robotic pancreaticoduodenectomy (RPD), on the risk of anastomotic fistula is uncertain. Methods: A systematic literature search was conducted for studies reporting RPD, LPD, and OPD, and network meta-analysis was performed. Results: The risk probability rank for pancreatic fistula was better for RPD (0.00) compared to LPD (0.37) and OPD (0.62). The risk probability rank for biliary leakage was similar for RPD (0.15) and LPD (0.15), and both were better than OPD (0.68). Conclusions: This network meta-analysis provides rankings for different types of pancreaticoduodenectomy. RPD and LPD can effectively improve surgical quality and are safe and feasible alternatives to OPD.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Oncology
Liliana Mereu, Francesca Dalpra, Valeria Berlanda, Riccardo Pertile, Daniela Coser, Basilio Pecorino, Maria Gabriella D'Agate, Francesco Ciarleglio, Alberto Brolese, Saverio Tateo
Summary: This study evaluated the incidence, risk factors, and utility of drainage and stoma in patients undergoing intestinal surgery for ovarian cancer. The results showed that rectosigmoid resection for ovarian cancer is a standardized procedure with comparable results for anastomotic leakage (AL), and risk factors for AL are discretely homogeneous. The use of stomas and/or drains, however, was not standardized according to the literature. Therefore, further exploration is needed to verify the preventive role of protective stoma and/or intra-abdominal drains in selected and standardized situations.
Article
Oncology
V. T. Hoek, S. Buettner, C. L. Sparreboom, R. Detering, A. G. Menon, G. J. Kleinrensink, M. W. J. M. Wouters, J. F. Lange, J. K. Wiggers
Summary: This study aimed to develop a robust preoperative prediction model for anastomotic leakage after surgical resection for rectal cancer. Significant risk factors were identified and included in the prediction model, which can be used for patient counselling and risk-stratification before undergoing rectal resection for cancer.
Article
Surgery
Jae-Woo Ju, Ho-Jin Lee, Min Jung Kim, Seung-Bum Ryoo, Won Ho Kim, Seung-Yong Jeong, Kyu Joo Park, Ji Won Park
Summary: This study aimed to investigate the association between early postoperative NSAID use and anastomotic leakage (AL) in patients who underwent colorectal cancer surgery. The findings showed a significant association between early postoperative NSAID use and AL.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Surgery
Thomas W. A. Koedam, Boukje T. Bootsma, Charlotte L. Deijen, Tim van de Brug, Geert Kazemier, Miguel A. Cuesta, Alois Furst, Antonio M. Lacy, Eva Haglind, Jurriaan B. Tuynman, Freek Daams, Hendrik J. Bonjer
Summary: Anastomotic leakage after rectal cancer surgery negatively affects long-term oncological outcomes, leading to increased local recurrences and decreased disease-free survival. However, its impact on outcomes after colon cancer surgery remains inconclusive.
Article
Surgery
Xiumin Liu, Yuting Tang, Zhiming Li, Jie Tan, Jixiang Zheng, Mingyuan Feng, Jinliang Wan, Shijie Wang, Kemao Qiu, Hongli Ji, Jun Yan
Summary: The study evaluated anastomotic microcirculation in different perfusion models using CLE, finding that poor perfusion led to reduced capillaries, lower blood cell flow, and more severe intestinal adhesion and ischemia, with a higher incidence of anastomotic leakage and abdominal infection. This suggests that CLE is a feasible technique for real-time imaging and intraoperative evaluation in various anastomotic perfusion situations, laying the groundwork for future in vivo research in humans.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Gastroenterology & Hepatology
Izel Ozmen, Vera E. M. Grupa, Sergei Bedrikovetski, Nagendra N. Dudi-Venkata, Daitlin E. Huisman, Muriel Reudink, Gerrit D. Slooter, Tarik Sammour, Hidde M. Kroon, Freek Daams
Summary: This study tested the validity of an AL risk nomogram and identified risk-factors for AL. The nomogram was not predictive, but low preoperative hemoglobin, intraoperative hypothermia, contamination of the operative field, and use of epidural analgesia were found to be independent risk-factors for AL.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Surgery
Christiaan F. Elsenbroek, Martin Brand
Summary: Triclosan coated PDS is as safe as uncoated PDS in performing colo-colonic anastomosis, according to this study. There were no significant differences in tensile strength and local inflammatory response between the two suture materials.
SURGICAL INNOVATION
(2023)
Article
Oncology
Tim Michael Feenstra, Charlotte Julia Verberne, Niels F. M. Kok, Arend Geert Johan Aalbers
Summary: The study investigates anastomotic leakage after colorectal surgery and the effects of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) after Cytoreductive Surgery (CRS). Assessing the risk factors in these patients can aid surgeons in making perioperative decisions.
Article
Oncology
Toshiaki Wada, Kenji Kawada, Keita Hanada, Kazutaka Obama
Summary: The study aimed to investigate whether quantitative analysis of colonic perfusion using indocyanine green (ICG) angiography could predict anastomotic leakage (AL) in a rat model. Results showed that the slope parameter could be a useful predictor for AL. Quantitative analysis of ICG fluorescence angiography can predict AL in a rat model.
Article
Surgery
Marco Catarci, Giacomo Ruffo, Massimo Giuseppe Viola, Felice Pirozzi, Paolo Delrio, Felice Borghi, Gianluca Garulli, Gianandrea Baldazzi, Pierluigi Marini, Giuseppe Sica
Summary: This study revealed significant room for improvement in compliance with several ERAS program items and found no significant association between institutionalization and/or adherence rates to ERAS program with primary endpoints. The outcomes were independently influenced by gender, intra- and postoperative blood transfusions, non-standard resections, and standard anesthesia protocol.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Letter
Gastroenterology & Hepatology
Maria Michela Chiarello, Valentina Bianchi, Pietro Fransvea, Giuseppe Brisinda
Summary: Anastomotic leakage is a serious complication with varying treatment options depending on the patient's symptoms and timing of the leak. There is a recent trend towards more conservative management, considering surgery as a last resort.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Surgery
Yulong Tian, Shougen Cao, Xiaodong Liu, Leping Li, Qingsi He, Lixin Jiang, Xinjian Wang, Xianqun Chu, Hao Wang, Lijian Xia, Yinlu Ding, Weizheng Mao, Xizeng Hui, Yiran Shi, Huanhu Zhang, Zhaojian Niu, Zequn Li, Haitao Jiang, Henrik Kehlet, Yanbing Zhou
Summary: This study compared the effects of ERAS and conventional programs on short-term outcomes after LDG. The results showed that the ERAS program led to faster recovery, shorter hospitalization, lower medical costs, and earlier initiation of adjuvant chemotherapy without increasing complications and readmission rates.
Letter
Anesthesiology
Kariem El-Boghdadly, James M. Jack, Aine Heaney, Nick D. Black, Marina Englesakis, Henrik Kehlet, Vincent Chan
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2022)
Article
Surgery
Mirjana Cihoric, Henrik Kehlet, Morten Laksafoss Lauritsen, Jakob Hojlund, Nicolai Bang Foss
Summary: Emergency high-risk abdominal surgery patients often present with preoperative alkalosis shifting to postoperative acidosis. Both pre- and postoperative hypochloremia were independently associated with impaired short- and long-term outcomes in patients with intestinal obstruction, potentially influencing the choice of resuscitation fluids.
WORLD JOURNAL OF SURGERY
(2022)
Article
Anesthesiology
N. I. Nielsen, H. Kehlet, K. Gromov, A. Troelsen, N. B. Foss, E. K. Aasvang
Summary: Skipping the post-anaesthesia care unit after knee and hip arthroplasty can be considered for low-risk patients, leading to improved flow and resource utilization in the operating theatre, without compromising safety. Further confirmation is needed, considering variations in peri-operative protocols and settings.
Article
Anesthesiology
Christoffer C. C. Jorgensen, Pelle B. B. Petersen, Louise O. O. Daugberg, Thomas Jakobsen, Kirill Gromov, Claus Varnum, Mikkel R. R. Andersen, Henrik Palm, Henrik Kehlet
Summary: Routine use of peripheral nerve blocks was not associated with early discharge or 30-days readmissions in fast-track THA and TKA. Future studies should focus on benefits of PNB in high-risk patients.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2023)
Article
Anesthesiology
Nina Brendborg Rasmussen, Henrik Kehlet, Troels Bygum Knudsen, Pernille Printzlau, Christoffer Calov Jorgensen
Summary: Background evaluation of regular medication is crucial in the preanesthetic consultation, especially for elective surgical patients with increasing age and pharmacologically treated comorbidities. However, there is limited data on prescribed drugs and polypharmacy in these patients.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2023)
Article
Anesthesiology
Maja Vejlgaard, Sophia L. Maibom, Ulla N. Joensen, Henrik Kehlet, Morten Bundgaard-Nielsen, Eske K. Aasvang, Andreas Roder
Summary: This study compared the intraoperative and immediate postoperative outcomes between open radical cystectomy (ORC) and robot-assisted radical cystectomy (iRARC). The results showed that iRARC patients had similar recovery compared to ORC patients.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2023)
Article
Anesthesiology
Anders H. Springborg, Claus Varnum, Niklas I. Nielsen, Lasse E. Rasmussen, Per Kjaersgaard-Andersen, Lina Pleckaitiene, Kirill Gromov, Anders Troelsen, Henrik Kehlet, Nicolai B. Foss
Summary: Pain after total knee arthroplasty is a common problem, and perioperative glucocorticoids have been shown to reduce pain and facilitate recovery. However, the optimal timing and dose of glucocorticoids are still unknown. This study aims to evaluate the effect of a repeat moderate dose of glucocorticoids in high pain catastrophizers who experience moderate to severe pain 24 hours after surgery.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2023)
Article
Anesthesiology
M. Cihoric, H. Kehlet, J. Hojlund, M. L. Lauritsen, K. Kanstrup, N. B. Foss
Summary: The feasibility of assessing hydration status and fluid distribution using Bioimpedance spectroscopy Analysis (BIA) in surgical patients was evaluated. BIA measurements correlated with fluid balance, weight changes, and postoperative clinical complications.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2023)
Article
Orthopedics
Martin Lindberg-Larsen, Claus Varnum, Thomas Jakobsen, Mikkel Rathsach Andersen, Kim Sperling, Soren Overgaard, Torben Baek Hansen, Christoffer Calov Jorgensen, Henrik Kehlet, Kirill Gromov
Summary: This study aims to investigate the feasibility, safety, and socioeconomic aspects of discharge on the day of surgery after hip and knee arthroplasty in 8 fast-track centers. The study will enroll 9,000 patients over a 3-year period and record the discharge rate, readmissions, complications, and patient-reported information. The outcome data will be used to develop a prediction model for successful discharge on the day of surgery.
Article
Clinical Neurology
Elisabeth Kjaer Jensen, Thomas K. Ringsted, Joakim M. Bischoff, Morten A. Petersen, Kirsten Moller, Henrik Kehlet, Mads U. Werner
Summary: This study aimed to investigate and describe the underlying pathophysiological changes in the groin areas and examine the effects of re-surgery on pain and function using quantitative somatosensory testing (QST). The results showed that re-surgery can improve pain and function, and QST analyses are useful for mechanism-based somatosensory research.
JOURNAL OF PAIN RESEARCH
(2023)
Article
Anesthesiology
Ana-Marija Hristovska, Bodil Uldall-Hansen, Jesper Mehlsen, Louise B. Andersen, Henrik Kehlet, Nicolai B. Foss
Summary: This study aimed to investigate the effects of mild acute blood loss on autonomic function and orthostatic intolerance, simulating postoperative hypovolemia. The results showed a specific hypovolemic component of postoperative orthostatic intolerance, independent of autonomic dysfunction, inflammation, opioids, and pain.
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2023)
Article
Critical Care Medicine
Mirjana Cihoric, Henrik Kehlet, Jakob Hojlund, Morten Laksafoss Lauritsen, Katrine Kanstrup, Nicolai Bang Foss
Summary: This study examines the fluid distribution and haemodynamic implications in acute high-risk abdominal surgery. It found that there is a progressive increase in fluid balance and extracellular volume throughout the perioperative period, which can lead to overhydration. Patients with overhydration are less haemodynamically stable compared to those with normo- or dehydration.
Letter
Gastroenterology & Hepatology
Henrik Kehlet
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Article
Urology & Nephrology
Maja Vejlgaard, Sophia Liff Maibom, Ulla Nordstrom Joensen, Peter Ole Thind, Malene Rohrsted, Eske Kvanner Aasvang, Henrik Kehlet, Martin Andreas Roder
Summary: This study aimed to compare the impact of robot-assisted laparoscopy with intracorporeal urinary diversion (iRARC) and open radical cystectomy (ORC) on patients' quality of life (QoL) before and after the surgery. The results showed that the surgical technique does not appear to affect QoL significantly, and patients reported stable or improved QoL within the first 90 days postoperatively, except for sexual functioning.
WORLD JOURNAL OF UROLOGY
(2022)