Article
Surgery
Ho-Jung Shin, Chul-Kyu Roh, Sang-Yong Son, Hur Hoon, Sang-Uk Han
Summary: Low serum total cholesterol is associated with higher postoperative complication rate in gastric cancer patients, and decreasing total cholesterol is linked to poor prognosis. Therefore, preoperative total cholesterol can serve as a predictor for postoperative survival and complications in gastric cancer patients.
ASIAN JOURNAL OF SURGERY
(2021)
Article
Pharmacology & Pharmacy
Li Chen, Ruihu Zhao, Hao Sun, Rong Huang, Hongming Pan, Yanjiao Zuo, Lele Zhang, Yingwei Xue, Xingrui Li, Hongjiang Song
Summary: This study aimed to investigate the prognostic value of the gastric immune prognostic index (GIPI) in gastric cancer patients treated with PD-1/PD-L1 inhibitors. The results showed that patients with GIPI intermediate/poor had shorter progression-free survival (PFS) and overall survival (OS) compared to those with GIPI good, especially in subgroups of patients receiving immune checkpoint inhibitor (ICI) treatment and patients with PD-1/PD-L1 positive status. Therefore, GIPI may be useful for identifying gastric cancer patients who are unlikely to benefit from PD-1/PD-L1 inhibitor treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Sang Hoon Chun, Eun Young Kim, Jung-Sook Yoon, Hye Sung Won, Kwangil Yim, Hye Won Hwang, Soon Auck Hong, Minho Lee, Su Lim Lee, Sung-Soo Kim, Der Sheng Sun, Yoon Ho Ko
Summary: The study suggests that high Noggin expression is a crucial prognostic factor for favorable outcomes in patients with resected gastric cancer.
Article
Multidisciplinary Sciences
Hongtai Shi, Hongsheng Wang, Jie Pan, Zhenhua Liu, Zuoan Li
Summary: This study aims to explore the prognostic value of various inflammation indexes in patients with resectable gastric cancer. The results showed that MPV/PC was more accurate in determining the prognosis of patients with gastric cancer than other indexes, and it was an independent prognostic factor for patients with resectable gastric cancer.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Mengya He, Limin Yue, Haiyan Wang, Feiyan Yu, Mingyang Yu, Peng Ni, Ke Zhang, Shuaiyin Chen, Guangcai Duan, Rongguang Zhang
Summary: CBX1/2/3/4/5 were upregulated and CBX7 was downregulated in gastric cancer tissues. High mRNA expression levels of CBX3/8 were associated with prolonged overall survival in GC patients.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Yuting Pan, Yue Ma, Guanghai Dai
Summary: Monoclonal antibodies against PD-1 have shown therapeutic effects in patients with advanced gastric or gastroesophageal junction cancer. Identifying new biomarker combinations based on tumor characteristics and microenvironment can help screen suitable patients for precise immunotherapy. The prognostic nutritional index (PNI) is a cost-effective and easily obtainable evaluation index for immunonutritional status, and it has been shown to be an independent prognostic factor for patients receiving immunotherapy.
Article
Biotechnology & Applied Microbiology
Diqun Chen, Rouxin Zhang, Aosi Xie, Jinpeng Yuan, Jinhai Zhang, Yongjian Huang, Hongxia Zhang, Feiran Zhang
Summary: Gastric cancer is among the most common and deadly cancers globally. This study reveals that NUDT10 expression is significantly reduced in GC tissues compared to normal tissues, and high expression is associated with worse prognosis in terms of tumor malignancy and survival outcomes. NUDT10 shows potential as an independent biomarker for GC prognosis.
Article
Cell Biology
Ningxin Dong, Xiaolong Ma, Jing Shen, Yunlu Zheng, Guiyuan Li, Shaoqiang Zheng, Xiaoyi Huang
Summary: A four-gene prognostic model was constructed to stratify GC patients into different prognosis score groups, with high-prognosis score groups showing significantly poorer survival rates. MYL9 was found to be associated with migration and metastasis of GC cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Dexin Chen, Meiting Fu, Liangjie Chi, Liyan Lin, Jiaxin Cheng, Weisong Xue, Chenyan Long, Wei Jiang, Xiaoyu Dong, Jian Sui, Dajia Lin, Jianping Lu, Shuangmu Zhuo, Side Liu, Guoxin Li, Gang Chen, Jun Yan
Summary: In this study, a pathomics signature (PSGC) derived from multiple features of haematoxylin and eosin-stained slides is proposed as an independent predictor of prognosis for gastric cancer patients. The PSGC, when combined with the TNM staging system, significantly improves the accuracy of predicting prognosis. Additionally, satisfactory chemotherapy benefits are observed in patients with a low PSGC, suggesting its potential usefulness as a predictive indicator for decision-making regarding adjuvant chemotherapy.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Xiao-Peng Duan, Ke Liu, Xiao-Dong Jiao, Bao-Dong Qin, Bing Li, Xi He, Yan Ling, Ying Wu, Shi-Qi Chen, Yuan-Sheng Zang
Summary: Tumor mutation burden (TMB) is a promising biomarker associated with immunotherapy benefit and chemotherapy outcome. This study demonstrated that TMB-high advanced gastric cancer patients had a poorer prognosis when treated with first-line chemotherapy, potentially due to downregulated metabolic activity.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Jun Kinoshita, Sachio Fushida, Takahisa Yamaguchi, Hideki Moriyama, Hiroto Saito, Mari Shimada, Shiro Terai, Koichi Okamoto, Keishi Nakamura, Itasu Ninomiya, Shintaro Yagi, Noriyuki Inaki
Summary: This study aimed to evaluate the association between tumor-infiltrating immune cells (TIICs) and the treatment outcome of conversion surgery (CS) in metastatic gastric cancer (MGC). The study found that patients in the CS group who had a pathological response to chemotherapy showed low infiltration of CD163(+) macrophages and high infiltration of CD8(+) lymphocytes. The low CD163 group had a significantly prolonged survival in patients who underwent CS.
Article
Oncology
Jian-Wei Xie, Jun Lu, Bin-bin Xu, Chao-Hui Zheng, Ping Li, Jia-Bin Wang, Jian-Xian Lin, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ze-Ning Huang, Ju-Li Lin, Mark J. Truty, Chang-Ming Huang
Summary: The study confirms the prognostic value of TRG for AGC patients treated with NACT plus surgery and identifies oxaliplatin-based regimens as independent predictors of TRG. Oxaliplatin-based regimens improve tumor response and may benefit overall survival in patients with nonsignet ring cell carcinoma.
FRONTIERS IN ONCOLOGY
(2021)
Article
Genetics & Heredity
Jiao Li, Shan Tian, Yingyun Guo, Weiguo Dong
Summary: AMAP1 mRNA and protein levels were found to be upregulated in gastric cancer specimens compared to normal tissues. High AMAP1 mRNA abundance was associated with poor overall survival and reduced progression-free survival in patients with gastric cancer. AMAP1 was negatively correlated with miR-192-3p and acted as a novel oncogene in gastric cancer, serving as a potential diagnostic and prognostic marker.
FRONTIERS IN GENETICS
(2021)
Article
Genetics & Heredity
Rongsheng Wang, Xiaohong Chen, Cuilan Huang, Xiaogang Yang, Huiwei He, Chenghong OuYang, Hainan Li, Jinghua Guo, Chunli Yang, Zhiying Lin
Summary: This study identified MYLK, MYL9, LUM, and CAV1 as potential and reliable prognostic key genes for gastric cancer. These key genes may exert their influence through the PI3K-Akt pathway, with extracellular matrix organization and focal adhesion playing significant roles in affecting the prognosis of gastric cancer patients.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Miaomiao Gou, Yong Zhang, Tiee Liu, Tongtong Qu, Haiyan Si, Zhikuan Wang, Huan Yan, Niansong Qian, Guanghai Dai
Summary: The study demonstrated that pretreatment Hb levels were an independent prognostic biomarker in patients with AGC and MGC undergoing immunotherapy, influencing both PFS and OS. Correction of anemia could be a strategy to improve survival with immunotherapy for gastric cancer patients. Further research is needed to validate these findings.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Gaia Codolo, Nicola Facchinello, Nicole Papa, Ambra Bertocco, Sara Coletta, Clara Benna, Luigi Dall'Olmo, Simone Mocellin, Natascia Tiso, Marina de Bernard
Summary: The Helicobacter pylori Neutrophil Activating Protein (HP-NAP) possesses immunomodulatory properties and can activate cytotoxic Th1 responses, inhibiting tumor growth and impacting the activity of macrophages. Using a zebrafish model, it was found that HP-NAP efficiently inhibits melanoma growth and metastasis by recruiting macrophages with a pro-inflammatory profile, highlighting the crucial role of activated macrophages in countering tumor growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dermatology
Alessandra Buja, Massimo Rugge, Giuseppe De Luca, Manuel Zorzi, Chiara De Toni, Claudia Cozzolino, Antonella Vecchiato, Paolo Del Fiore, Saveria Tropea, Romina Spina, Vincenzo Baldo, Carlo Riccardo Rossi, Simone Mocellin
Summary: This study investigated the association between direct costs for melanoma and the patients' clinical and histological characteristics. The results showed that factors such as mitoses, vertical growth, and absence of tumor-infiltrating lymphocytes were associated with higher direct costs.
DERMATOLOGY AND THERAPY
(2022)
Article
Public, Environmental & Occupational Health
Alessandra Buja, Massimo Rugge, Giovanni Damiani, Giuseppe De Luca, Manuel Zorzi, Riccardo Fusinato, Chiara De Toni, Antonella Vecchiato, Paolo Del Fiore, Francesca Falasco, Romina Spina, Carlo Riccardo Rossi, Simone Mocellin
Summary: By combining clinical and administrative data, this study demonstrates that almost one in ten CMM patients did not undergo wide local excision surgery. Monitoring how diagnostic-therapeutic protocols are actually implemented in the real world may significantly contribute to promoting quality improvements in the management of oncological patients.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Francesco Giganti, Laurene Aupin, Camille Thoumin, Ingrid Faouzi, Hippolyte Monnier, Matthieu Fontaine, Alexandre Navidi, Paul-Gydeon Ritvo, Valentin Ong, Cecile Chung, Imen Bibi, Raphaele Lehrer, Nicolas Hermieu, Eric Barret, Alessandro Ambrosi, Veeru Kasivisvanathan, Mark Emberton, Clare Allen, Alex Kirkham, Caroline M. Moore, Raphaele Renard-Penna
Summary: This pilot study suggests that an interactive teaching course can improve the accuracy of assessing radiological change in prostate MRI during active surveillance.
INSIGHTS INTO IMAGING
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Gabriele Fragasso, Francesca Sanvito, Giuseppe Monaca, Valentina Ardizzone, Michele De Bonis, Federico Pappalardo, Chanel Smart, Claudia Montanaro, Elisabetta Lapenna, Maria Chiara Calabrese, Alessandro Castiglioni, Stefano Benussi, Francesco Maisano, Alberto Zangrillo, Alessandro Ambrosi, Claudio Doglioni, Ottavio Alfieri, Alberto Margonato
EUROPEAN HEART JOURNAL SUPPLEMENTS
(2022)
Article
Biochemistry & Molecular Biology
Silvia Galbiati, Daniela Gabellini, Alessandro Ambrosi, Nadia Soriani, Federica Pasi, Massimo Locatelli, Roberta Luciano, Massimo Candiani, Luca Valsecchi, Gianpaolo Zerbini, Maddalena Smid
Summary: Preeclampsia is a severe complication of pregnancy, and finding predictive biomarkers is crucial for prevention. This study compared the diagnostic accuracy of carbonic anhydrase IX (CAIX) and sFlt1/PlGF ratio as biomarkers for predicting preeclampsia. CAIX levels significantly increased before the onset of preeclampsia, and it performed better than sFlt1/PlGF ratio in predicting the disease. CAIX could be an effective predictive biomarker for preeclampsia, but further studies are needed to confirm this finding.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Oncology
Laura Cristina Gironi, Elia Esposto, Francesca Zottarelli, Roberto Giorgione, Pamela Farinelli, Elisa Zavattaro, Edoardo Cammarata, Nunzia Di Cristo, Paola Ogliara, Lara Camillo, Mara Giordano, Simona Mellone, Barbara Pasini, Alessandro Ambrosi, Paola Savoia
Summary: We investigated the correlation between the occurrence of cutaneous melanoma and noncutaneous tumors in CDKN2A mutation carriers and wild-type melanoma patients. The study found that mutation carriers had a significantly higher number of cutaneous melanoma cases compared to the wild-type patients. Additionally, both groups had a similar rate of diagnosis for malignant NCTs. The onset of cutaneous melanoma generally preceded the occurrence of NCTs, emphasizing the importance of comprehensive surveillance for melanoma patients.
Article
Clinical Neurology
Pietro Panni, Lucia Riccio, Roberta Cao, Alessandro Pedicelli, Enrico Marchese, Anselmo Caricato, Alberto Feletti, Mattia Testa, Paolo Zanatta, Nicola Gitti, Simone Piva, Dikran Mardighian, Vittorio Semeraro, Giordano Nardin, Emilio Lozupone, Giafranco Paiano, Edoardo Picetti, Vito Montanaro, Massimo Petranca, Carlo Bortolotti, Antonino Scibilia, Luigi Cirillo, Andrea Luigi Lanterna, Alessandro Ambrosi, Pietro Mortini, Luigi Beretta, Andrea Falini
Summary: This study aimed to investigate predictors and clinical impact of rebleeding in poor-grade aneurysmal subarachnoid hemorrhage (aSAH). The study found that ultra-early vasospasm (UEV) and presence of dissecting aneurysm were the strongest predictors of aneurysmal rebleeding, while a history of hypertension reduced the chances of rebleeding. Additionally, rebleeding emerged as an independent predictor of intrahospital mortality.
Article
Medicine, General & Internal
Alice Bergamini, Giorgia Mangili, Alessandro Ambrosi, Gianluca Taccagni, Emanuela Rabaiotti, Luca Bocciolone, Giorgio Candotti, Raffaella Cioffi, Francesca Pella, Giulia Sabetta, Costanza Saponaro, Massimo Candiani
Summary: The study compares data from patients with endometrioid and clear cell ovarian tumors associated with endometriosis to investigate the hypothesis of a dichotomy in their histogenesis. It found that the occurrence of endometriosis is more frequent in patients with clear cell ovarian cancer. The EAOEC group showed higher bilateral occurrences and a higher solid/cystic rate at gross pathology. ECC patients had a more advanced disease stage and a synchronous endometrial carcinoma was found in 38% of EAEOC patients.
Article
Medicine, General & Internal
Cinzia Giacometti, Kathrin Ludwig, Monica Guidi, Elvira Colantuono, Anna Coracina, Marcello Rigano, Mauro Cassaro, Alessandro Ambrosi
Summary: Gestational diabetes mellitus (GDM) can affect placental villous maturation and vascularity. The expression of hENT1 and the formation of vasculo-syncytial membranes (VSM) are reduced in GDM placentas, while the proliferative pattern of trophoblasts is increased.
Article
Clinical Neurology
Claudia Godi, Francesco Destro, Paolo Garofalo, Enrico Tombetti, Alessandro Ambrosi, Antonella Iadanza, Caterina Michelozzi, Andrea Falini, Nicoletta Anzalone
Summary: Vessel wall imaging (VWI) with black-blood (BB) technique can reveal aneurysmal enhancement prior to growth/rupture in treatment-naive cerebral aneurysms. Recent studies suggest that BB enhancement may also occur in endovascularly treated aneurysms, but its significance is debatable. This study explores the relationship between BB enhancement and incomplete occlusion status and coil packing density, hypothesizing a flow-related mechanism.
Article
Neurosciences
Alessandra Pisciottani, Laura Croci, Fabio Lauria, Chiara Marullo, Elisa Savino, Alessandro Ambrosi, Paola Podini, Marta Marchioretto, Filippo Casoni, Ottavio Cremona, Stefano Taverna, Angelo Quattrini, Jean-Michel Cioni, Gabriella Viero, Franca Codazzi, G. Giacomo Consalez
Summary: Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disease primarily affecting individuals between 50-60 years old. The presence of TDP-43 proteinopathy, characterized by cytoplasmic aggregates formed by TDP-43 protein, disrupts mRNA transport and localization. This study generated and analyzed cellular models of TDP-43 proteinopathy, showing that neurons expressing TDP-43 fusion proteins have impaired axonal protein synthesis, increased oxidative stress, and defects in presynaptic function and electrical activity. These changes are correlated with deregulation of axonal mRNA levels involved in the same processes.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Review
Endocrinology & Metabolism
Giovanna Laura Di Domenico, Margherita Minoli, Nicola Discepoli, Alessandro Ambrosi, Massimo de Sanctis
Summary: This study aimed to assess the effect of non-surgical periodontal therapy on glycemic control in patients with type 2 diabetes and periodontitis. The findings showed that non-surgical periodontal therapy was effective in improving glycemic control in these patients.
ACTA DIABETOLOGICA
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Francesco Giganti, Alexander P. Cole, Fiona M. Fennessy, Timothy Clinton, Pedro Lopes Da Frota Moreira, Mariana Costa Bernardes, Carl-Fredrik Westin, Deepa Krishnaswamy, Andriy Fedorov, Daniel A. Wollin, Bjoern Langbein, Nicola Frego, Muhieddine Labban, Joy S. Badaoui, Steven L. Chang, Logan G. Briggs, Junichi Tokuda, Alessandro Ambrosi, Alex Kirkham, Mark Emberton, Veeru Kasivisvanathan, Caroline M. Moore, Clare Allen, Clare M. Tempany
Summary: This study assessed the impact of a prostate MRI quality training lecture on the participants' ability to apply the PI-QUAL scoring system. The results showed that the teaching course significantly improved the participants' ability to evaluate the quality of prostate MRI examinations using the PI-QUAL score.
EUROPEAN RADIOLOGY
(2023)
Article
Oncology
Alessandra Buja, Massimo Rugge, Giuseppe De Luca, Emanuela Bovo, Manuel Zorzi, Chiara De Toni, Claudia Cozzolino, Antonella Vecchiato, Paolo Del Fiore, Romina Spina, Sandro Cinquetti, Vincenzo Baldo, Carlo Riccardo Rossi, Simone Mocellin
Summary: This study focuses on the changing incidence of cutaneous malignant melanoma (CMM) in Veneto region and its Alpine area in Northeast Italy, finding a significant increase in CMM incidence over the past 30 years, particularly among Alpine residents, especially younger females. Clinicopathological profile of CMM is associated with the place of residence. These findings have important implications for CMM prevention strategies.
