Article
Oncology
Laura E. Gould, Edward T. Pring, Morgan Moorghen, Elaine M. Burns, Anthony Antoniou, Colin W. Steele, Campbell SD. Roxburgh, John T. Jenkins
Summary: This study investigates the pathological factors influencing survival in patients undergoing pelvic exenteration for locally advanced or locally recurrent rectal cancer. The results indicate that a positive resection margin and poorly differentiated tumors are negative prognostic markers for survival and recurrence in LARC patients, while venous invasion is a negative factor for DFS in LRRC patients.
Article
Oncology
Arne M. Solbakken, Simen Sellevold, Milan Spasojevic, Lars Julsrud, Hanne-Line Emblemsvag, Henrik M. Reims, Olaf Sorensen, Ebbe B. Thorgersen, Lena Fauske, Joanna Sara Maria Agren, Bjorn Brennhovd, Truls Ryder, Stein G. Larsen, Kjersti Flatmark
Summary: This study evaluated the feasibility of navigation-assisted surgery in patients with rectal cancer. The results showed that navigation-assisted surgery using optical tracking was feasible and resulted in improved complete resection rates. Although preoperative planning was time-consuming, intraoperative navigation was accurate, and surgeons reported satisfaction with the feasibility of navigation and adherence to the resection plan.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Surgery
Laura E. Gould, Edward T. Pring, Ioanna Drami, Morgan Moorghen, Mani Naghibi, John T. Jenkins, Colin W. Steele, Campbell SD. Roxburgh
Summary: Despite undergoing exenterative surgery, patients with locally recurrent rectal cancer (LRRC) have poor 5-year survival rates. The pathological resection margin status is a key factor affecting disease-free and overall survival. In addition, involved lymph nodes and lymphovascular invasion are negative prognostic markers.
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Article
Medicine, General & Internal
Deborah Schrag, Qian Shi, Martin R. Weiser, Marc J. Gollub, Leonard B. Saltz, Benjamin L. Musher, Joel Goldberg, Tareq Al Baghdadi, Karyn A. Goodman, Robert R. McWilliams, Jeffrey M. Farma, Thomas J. George, Hagen F. Kennecke, Ardaman Shergill, Michael Montemurro, Garth D. Nelson, Brian Colgrove, Vallerie Gordon, Alan P. Venook, Eileen M. O'Reilly, Jeffrey A. Meyerhardt, Amylou C. Dueck, Ethan Basch, George J. Chang, Harvey J. Mamon
Summary: Preoperative FOLFOX chemotherapy is as effective as preoperative chemoradiotherapy for locally advanced rectal cancer eligible for sphincter-sparing surgery.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Medicine, General & Internal
Ailin C. Rogers, John T. Jenkins, Shahnawaz Rasheed, George Malietzis, Elaine M. Burns, Christos Kontovounisios, Paris P. Tekkis
Summary: Treatment strategies for advanced or recurrent rectal cancer now aim for complete pathological clearance through en bloc sacrectomy, especially when the sacrum is involved. Although sacral resection is technically challenging and has been described, standardization of the technique across units is still lacking, requiring further discussion and improvement.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Toshisada Aiba, Kay Uehara, Yuta Tsuyuki, Atsushi Ogura, Yuki Murata, Takashi Mizuno, Junpei Yamaguchi, Toshio Kokuryo, Yukihiro Yokoyama, Tomoki Ebata
Summary: The study aimed to clarify the impact of suitable radial margin (RM) on favorable outcomes after pelvic exenteration (PE). The results showed that narrow and exposed RMs had a similar impact on local recurrence and poor overall survival (OS), while wide RMs had better outcomes.
Article
Oncology
Melanie Lindenberg, Astrid Kramer, Esther Kok, Valesca Retel, Geerard Beets, Theo Ruers, Wim van Harten
Summary: The study evaluates the early cost-effectiveness of navigated surgery compared to standard surgery in locally advanced and locally recurrent rectal cancer. Navigated surgery showed higher costs in LARC, but was more cost-effective in LRRC.
Review
Oncology
Michael Eamon Kelly
Summary: Pelvic exenteration is a complex surgical procedure used for the treatment of advanced pelvic cancers. The goal is to achieve clear margins by removing adjacent or involved organs and tissues. Although the surgery can be associated with high morbidity, advancements in treatment and reconstructive techniques have led to improved recovery and quality of life outcomes for patients.
Article
Multidisciplinary Sciences
Seung Ho Song, Jun Seok Park, Gyu-Seog Choi, An Na Seo, Soo Yeun Park, Hye Jin Kim, Sung-Min Lee, Ghilsuk Yoon
Summary: The study found a significant association between a short distal resection margin (< 1 cm) and local recurrence in patients with rectal cancer, especially in those with tumor stages ypT2-4.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Oliver J. Ott, Cihan Gani, Lars H. Lindner, Manfred Schmidt, Ulf Lamprecht, Sultan Abdel-Rahman, Axel Hinke, Thomas Weissmann, Arndt Hartmann, Rolf D. Issels, Daniel Zips, Claus Belka, Robert Grutzmann, Rainer Fietkau
Summary: The HyRec trial evaluated an intensified neoadjuvant and multimodality treatment schedule for locally recurrent rectal cancer patients, showing promising efficacy and high feasibility, with comparable toxicities and very high pathologically confirmed complete remission rates.
Review
Oncology
I Drami, A. C. Lord, P. Sarmah, R. P. Baker, I. R. Daniels, K. Boyle, B. Griffiths, H. M. Mohan, J. T. Jenkins
Summary: The pre-operative phase is crucial for planning pelvic exenteration or extended resections in patients with locally advanced rectal cancer. It involves multidisciplinary review, anaesthetic assessment, shared decision making, prehabilitation, and technical surgical planning. Optimizing patient outcomes requires achieving negative resection margins and ensuring patients are fit for extended surgery. Advanced communication and preoperative preparation are important, as well as physiotherapy, psychological support, and nutritional input. Image-based technical planning helps identify risk points and ensure the correct surgical strategy.
Article
Biology
Harald C. Groen, Anne G. den Hartog, Wouter J. Heerink, Koert F. D. Kuhlmann, Niels F. M. Kok, Ruben van Veen, Marijn A. J. Hiep, Petur Snaebjornsson, Brechtje A. Grotenhuis, Geerard L. Beets, Arend G. J. Aalbers, Theo J. M. Ruers
Summary: This exploratory study evaluates the use of image-guided surgical navigation during resection of locally recurrent rectal cancer (LRRC). The study shows that surgical navigation is safe and feasible, providing accurate surgical guidance during the procedure.
Article
Gastroenterology & Hepatology
Ilia van Campenhout, Jan M. M. van Rees, Wim Ceelen, Pieter J. J. Tanis, Joost Rothbarth, Cornelis Verhoef
Summary: This study aimed to assess the impact of omentoplasty on postoperative outcomes after long-course (chemo) radiotherapy and abdominoperineal resection in patients with locally advanced and locally recurrent rectal cancer. The results showed that omentoplasty was not associated with a reduced risk of short-term pelviperineal complications, but instead led to prolonged duration of nasogastric tube drainage and hospital stay.
DISEASES OF THE COLON & RECTUM
(2023)
Article
Oncology
Eva L. K. Voogt, Jan M. van Rees, Jan A. W. Hagemans, Joost Rothbarth, Grad A. P. Nieuwenhuijzen, Jeltsje S. Cnossen, Heike M. U. Peulen, Wim J. F. Dries, Joost Nuyttens, Inger-Karine Kolkman-Deurloo, Cornelis Verhoef, Harm J. T. Rutten, Jacobus W. A. Burger
Summary: This study compared the oncological outcomes of two IORT modalities in patients with LARC or LRRC, and found that HDR-IORT had significantly better local recurrence-free survival compared to IOERT, indicating a need for optimization of the IOERT technique.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Urology & Nephrology
Omeair Khan, Dimitrios Patsouras, Manoj Ravindraanandan, Mohammad Muneeb Abrar, Alexis Schizas, Mark George, Sachin Malde, Ramesh Thurairaja, Mohammed S. Khan, Arun Sahai
Summary: This study evaluated urological complications following total pelvic exenteration, finding that over half of the patients were affected by urinary complications, with urinary tract infection being the most common risk. Approximately one-third of patients required surgical, radiological, or endoscopic intervention, and intensive care admission may be necessary. Radiation prior to the operation did not affect urinary complications.
EUROPEAN UROLOGY FOCUS
(2021)
Article
Oncology
Job P. van Kooten, Arvind Oemrawsingh, Nadine L. de Boer, Cornelis Verhoef, Jacobus W. A. Burger, Eva V. E. Madsen, Alexandra R. M. Brandt-Kerkhof
Summary: This study analyzed the predictive value of postoperative inflammatory biomarkers CRP and WBC in assessing complications after CRS and HIPEC. The results indicated that patients with continuously increasing CRP levels from the second to fifth postoperative day were more likely to develop SAE >= 3 complications. CRP concentrations above 166 mg/L on POD3 and 116 mg/L on POD4 were associated with the highest risk of SAE >= 3, while postoperative WBC levels did not show significant differences between patients with different SAE levels.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Florian E. Buisman, Wills F. Filipe, Nancy E. Kemeny, Raja R. Narayan, Rami M. Srouji, Vinod P. Balachandran, Thomas Boerner, Jeffrey A. Drebin, William R. Jarnagin, T. Peter Kingham, Alice C. Wei, Dirk J. Grunhagen, Cornelis Verhoef, Bas Groot Koerkamp, Michael I. D'Angelica
Summary: This study investigated the effectiveness of adjuvant hepatic arterial infusion pump (HAIP) chemotherapy after complete resection or ablation of recurrent colorectal liver metastases and found that adjuvant HAIP is associated with superior hepatic disease-free survival and overall survival.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Marjaneh Taghavi, Stefano Trebeschi, Rita Simoes, David B. Meek, Rianne C. J. Beckers, Doenja M. J. Lambregts, Cornelis Verhoef, Janneke B. Houwers, Uulke A. van der Heide, Regina G. H. Beets-Tan, Monique Maas
Summary: A machine learning-based radiomics model was able to predict the occurrence of colorectal liver metastases in patients with colorectal cancer and provide valuable biomarkers for identifying high-risk patients. The predictive models including radiomics features, clinical features, and a combination of both showed promising results with AUC values of 86%, 71%, and 86% in the validation cohort, respectively.
ABDOMINAL RADIOLOGY
(2021)
Review
Oncology
Jeske R. E. Boeding, Winesh Ramphal, Arjen M. Rijken, Rogier M. P. H. Crolla, Cornelis Verhoef, Paul D. Gobardhan, Jennifer M. J. Schreinemakers
Summary: Treatment options for obstructing colon cancer are controversial, with emergency resection resulting in higher mortality and complication rates compared to staged treatment for potentially curable right-sided OCC. Staged treatment appears to have lower mortality rates, fewer complications, and fewer anastomotic leaks and stomas created compared to emergency resection in these patients.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Review
Oncology
Enrico Martin, Ritchie T. J. Geitenbeek, J. Henk Coert, David F. Hanff, Laura H. Graven, Dirk J. Grunhagen, Cornelis Verhoef, Walter Taal
Summary: Noninvasive tests like MRI, FDG-PET, and liquid biopsies are useful for distinguishing MPNST from BPNST, with MRI showing high sensitivity and specificity for certain features, and FDG-PET having an ideal SUVmax threshold of >=3.5 for accuracy.
Review
Oncology
Lorraine J. Lauwerends, Hidde A. Galema, Jose A. U. Hardillo, Aniel Sewnaik, Dominiek Monserez, Pieter B. A. A. van Driel, Cornelis Verhoef, Robert J. Baatenburg de Jong, Denise E. Hilling, Stijn Keereweer
Summary: Laryngeal cancer is a common head and neck malignancy with poor prognosis, especially in advanced stages. Current optical imaging techniques are limited in deep margin assessment, highlighting the need for new technologies to guide surgical resection and reduce local recurrence rates.
Article
Clinical Neurology
Enrico Martin, Courtney Pendleton, Cornelis Verhoef, Robert J. Spinner, J. Henk Coert
Summary: This study aimed to investigate postoperative morbidity and the use and outcomes of functional reconstructions in patients with malignant peripheral nerve sheath tumors (MPNSTs). The results showed that the incidence of postoperative motor and sensory deficits is still unknown, and the use of functional reconstructions is infrequent.
Article
Radiology, Nuclear Medicine & Medical Imaging
Martijn P. A. Starmans, Milea J. M. Timbergen, Melissa Vos, Michel Renckens, Dirk J. Grunhagen, Geert J. L. H. van Leenders, Roy S. Dwarkasing, Francois E. J. A. Willemssen, Wiro J. Niessen, Cornelis Verhoef, Stefan Sleijfer, Jacob J. Visser, Stefan Klein
Summary: In this study, radiomics was used to distinguish gastrointestinal stromal tumors (GISTs) from other intra-abdominal tumors and predict the mutational status and mitotic index of GISTs. The results showed that the radiomics model performed similarly to three radiologists in distinguishing GISTs from non-GISTs, but it was less observer dependent. However, the model was unable to predict any genetic or molecular features, limiting its use in treatment planning.
JOURNAL OF DIGITAL IMAGING
(2022)
Article
Oncology
Anne-Rose W. Schut, Emma Lidington, Milea J. M. Timbergen, Eugenie Younger, Winette T. A. van der Graaf, Winan J. van Houdt, Johannes J. Bonenkamp, Robin L. Jones, Dirk. J. Grunhagen, Stefan Sleijfer, Cornelis Verhoef, Spyridon Gennatas, Olga Husson
Summary: Desmoid-type fibromatosis (DTF) is a rare soft-tissue tumor that can negatively impact health-related quality of life (HRQoL). A specific HRQoL tool, the DTF-QoL, was previously developed for assessing DTF-specific issues. This study pre-tested the DTF-QoL and selected 96 questions to form the final questionnaire, which can be used to evaluate HRQoL of DTF patients in clinical and research settings, aiming to personalize care and improve patient experience.
Article
Oncology
Gijsbert M. Kalisvaart, Ruben P. J. Meijer, Okker D. Bijlstra, Hidde A. Galema, Wobbe O. de Steur, Henk H. Hartgrink, Cornelis Verhoef, Lioe-Fee de Geus-Oei, Dirk J. Grunhagen, Yvonne M. Schrage, Alexander L. Vahrmeijer, Jos A. van der Hage
Summary: This study assessed the potential and limitations of near-infrared fluorescence imaging with indocyanine green in intraoperative tumor identification of GISTs. The results showed that GISTs typically have similar fluorescence intensity to the surrounding tissue, indicating that intraoperatively administered indocyanine green is currently not suitable for adequate tumor identification.
Article
Oncology
Evalyn E. A. P. Mulder, Iva Johansson, Dirk J. Grunhagen, Dennie Tempel, Barbara Rentroia-Pacheco, Jvalini T. Dwarkasing, Danielle Verver, Antien L. Mooyaart, Astrid A. M. van der Veldt, Marlies Wakkee, Tamar E. C. Nijsten, Cornelis Verhoef, Jan Mattsson, Lars Ny, Loes M. Hollestein, Roger Olofsson Bagge
Summary: This study assessed the performance of a clinicopathologic and gene expression model to identify patients with stage I-II melanoma at risk of disease relapse. The model successfully stratified patients into high risk and low risk groups, suggesting its potential usefulness in clinical practice.
Article
Oncology
Anne-Rose W. Schut, Emma Lidington, Milea J. M. Timbergen, Eugenie Younger, Winette T. A. van der Graaf, Winan J. van Houdt, Johannes J. Bonenkamp, Robin L. Jones, Dirk J. Grunhagen, Stefan Sleijfer, Cornelis Verhoef, Spyridon Gennatas, Olga Husson
Summary: Desmoid-type fibromatosis (DTF) is a rare soft tissue tumor that significantly impacts the health-related quality of life (HRQoL) of patients. This study evaluated HRQoL among different groups of DTF patients and identified factors such as age, sex, presence of comorbidities, and treatment type that were associated with DTF-specific HRQoL.
Article
Oncology
Ibtissam Acem, Veroniek M. van Praag, Cassidy Q. B. Mostert, Robert J. P. van der Wal, Ralph M. L. Neijenhuis, Cornelis Verhoef, Dirk J. Grunhagen, Michiel A. J. van de Sande
Summary: This study aimed to assess the ability of an easy-to-use electronic nose to differentiate between patients with soft tissue sarcoma (STS) and those without STS based on their exhaled breath. It is the first pilot study to show that an electronic nose could serve as a diagnostic tool for STS detection with good performance. Future studies are needed to validate these findings in larger cohorts.
Article
Health Care Sciences & Services
N. J. M. C. Vrancken Peeters, Z. L. R. Kaplan, M. E. Clarijs, M. A. M. Mureau, C. Verhoef, T. van Dalen, O. Husson, L. B. Koppert
Summary: This study examined the long-term effects of axillary treatments on health-related quality of life in breast cancer patients. Except for axillary lymph node dissection (ALND) with axillary radiotherapy, other axillary treatments showed no significant impact on physical and psychosocial wellbeing. Patients who received ALND with radiotherapy experienced a significant decrease in physical and psychosocial wellbeing postoperatively.
QUALITY OF LIFE RESEARCH
(2023)
Article
Surgery
Hidde A. Galema, Tessa M. van Ginhoven, Gaston J. H. Franssen, Johannes Hofland, Claire G. O. T. Bouman, Cornelis Verhoef, Alexander L. Vahrmeijer, Merlijn Hutteman, Denise E. Hilling, Stijn Keereweer
BRITISH JOURNAL OF SURGERY
(2023)