Article
Chemistry, Physical
Viola, Niaz Muhammad, Ishaq N. Khan, Zafar Ali, Mohammad Ibrahim, Shaukat Shujah, Saqib Ali, Muhammad Ikram, Sadia Rehman, Gul Shahzada Khan, Abdul Wadood, Awal Noor, Carola Schulzke
Summary: This study successfully synthesized two copper(II) carboxylate complexes, which exhibited excellent antioxidant, anti-pathogen, and anti-tumor activities, as well as good DNA binding abilities. These complexes have potential applications.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Biochemistry & Molecular Biology
Paulraj Adwin Jose, Murugesan Sankarganesh, Jeyaraj Dhaveethu Raja, Gurusamy Sankararaj Senthilkumar, Radhakrishnan Nandini Asha, Samuelraj Johnson Raja, Clarence Dorothy Sheela
Summary: The interactions of DMPMM and DMPMM-NiNPs with biomolecules were studied using various methods, revealing that DMPMM-NiNPs exhibited higher activity in biological systems. The synthesized compounds showed good performance in DNA and BSA binding, antimicrobial, anticancer, and antioxidant activities.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Review
Biochemistry & Molecular Biology
Gina Vasile Scaeteanu, Catalin Maxim, Mihaela Badea, Rodica Olar
Summary: This review discusses the applications of Zn(II) carboxylate-based coordination polymers (Zn-CBCPs) in sensors, catalysts, infection and cancer treatment, as well as storage and drug-carrier materials. The luminescence properties of Zn-CBCPs, which are modulated by the nature of organic luminophores and their intermolecular interactions, allow for the sensing of various inorganic and organic pollutants. Zn-CBCPs, due to the Lewis acidity of Zn(II), can be used for dye elimination in wastewater through photocatalysis or inhibition of pathogenic microorganisms and tumors. Additionally, the porous structure of Zn-CBCPs enables the storage of gaseous or liquid molecules and improved drug delivery.
Article
Chemistry, Inorganic & Nuclear
Rahman Bikas, Maria Korabik, Joaquin Sanchiz, Nader Noshiranzadeh, Prinaz Mirzakhani, Amanda Galkowska, Daria Szeliga, Anna Kozakiewicz-Piekarz
Summary: A new 1D copper(II) coordination polymer was synthesized with azido and alkoxido bridges connecting copper ions, along with the presence of Schiff base and azide ligands. Magnetic study indicated an overall ferromagnetic interaction among the copper(II) ions dominated by the coupling through the alkoxido bridge. Magnetic coupling constants were calculated by DFT calculations and compared with values from magnetic susceptibility measurements.
JOURNAL OF SOLID STATE CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Yogesh Kumar, Nikhil Kumar Singh, Vishwa Deepak Singh, Irshad Ali, Rajan Kumar Tiwari, Ajay Kumar, Daya Shankar Pandey
Summary: This study describes the synthesis of azo-Schiff base ligands and their zinc complexes, as well as their spectral characterization and interaction studies. The complexes showed strong binding affinity towards DNA and BSA, and exhibited high cytotoxicity against Hut-78 cell line. Furthermore, the complexes underwent photo isomerization under UV light irradiation.
INORGANICA CHIMICA ACTA
(2022)
Article
Chemistry, Inorganic & Nuclear
Andres Alguacil, Franco Scalambra, Pablo Lorenzo-Luis, Adrian Puerta, Aday Gonzalez-Bakker, Zenaida Mendoza, Jose M. Padron, Antonio Romerosa
Summary: Compounds 1 and 2 were synthesized and characterized. They exhibited nanomolar GI(50) values against six human solid tumors. Further investigation revealed their effects on colony formation in SW1573 cells, the action mechanism in HeLa cells, and their interaction with the pBR322 DNA plasmid.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Applied
Shagun Sharma, Navneet Agnihotri, Keshav Kumar, Swati Sihag, Vinay Randhawa, Ramandeep Kaur, Raghubir Singh, Varinder Kaur
Summary: A series of glutamine conjugated organotin(IV) Schiff base compounds were synthesized and characterized, with compounds 1, 3, and 4 identified as potential candidates based on their DNA/protein binding properties. Compound 3 was found to be the most promising for further in vivo studies according to QSAR regression models.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Spectroscopy
Haiyan Qi, Yan Wang, Xiuwen Wang, Liqiang Su, Ying Wang, Shu Wang
Summary: Paclitaxel and artemisinin were found to statically quench the fluorescence of BSA when complexed, with a 1:1 stoichiometric ratio. Particularly, the BSA-paclitaxel complex was more stable than the BSA-artemisinin complex, and the binding interactions were mainly driven by electrostatic forces. Additionally, the study concluded that the free drug concentration of paclitaxel in blood was low and the duration time of artemisinin was shorter.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Biochemistry & Molecular Biology
Gina Vasile Scaeteanu, Constantin G. Daniliuc, Rodica Olar, Mihaela Badea
Summary: A complex [Zn(bpy)(acr)(2)]center dot H2O was converted into a coordination polymer [Zn(bpy)(acr)(HCOO)](n) in a DMF medium. The polymer was fully characterized through crystallographic analysis, IR, and thermogravimetric analysis. The obtained complex, with its unique composition and structure, is of current interest and rarely reported in the literature.
Article
Electrochemistry
Victor Rojas, Gustavo Caceres, Silvana Lopez, Rodrigo Henriquez, Paula Grez, Emilio Navarrete, Francisco Herrera, Alvaro Caballero, Juan Luis Gomez-Camer, Eduardo Munoz
Summary: The influence of synthesis parameters on the electrochemical performance of KCoOCM as a cathode material for lithium-ion batteries was studied. The material showed a change in morphology and specific capacity based on synthesis conditions, reaching values close to theoretical. A statistical method was used to find conditions to maximize material capacity. The first performance report of a lithium-ion battery based on a KCoOCM cathode was presented.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2021)
Article
Biochemistry & Molecular Biology
Evgeny Goreshnik, Svitlana Petrusenko
Summary: Three compounds based on a copper-thiocyanate-dabco combination were synthesized and characterized. The crystal structures of these compounds were studied using various analytical techniques. The charge of the organic cation was found to influence the dimensionality of the crystal structure. The compounds exhibited different types of structures, including polymeric anionic frameworks, simple ionic structures, and neutral molecular complexes.
Article
Biochemistry & Molecular Biology
Paulraj Adwin Jose, Murugesan Sankarganesh, Jeyaraj Dhaveethu Raja, Sakthivel Arumugam
Summary: The objective of this research was to synthesize stable nickel nanoparticles using nickel chloride salt and a Schiff base ligand called DPMN. The synthesis process involved a two-step phase transfer procedure. Spectroscopic techniques, SEM, and TEM were used to characterize the nanoparticles, and in vitro studies were conducted to evaluate their anticancer, DNA binding, antimicrobial, antioxidant, and catalytic activities.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Inorganic & Nuclear
Qing-Xu Wang, Zhong-Cheng Guo, Yin Qin, Xin Wang, Gang Li
Summary: Three ferrocene-based phenyl carboxylate frameworks have been synthesized and found to exhibit high thermal and water stability as well as proton conductivity that increases with humidity and temperature. Their optimal proton conductivity values under specific conditions make them potential candidates for proton exchange membrane fuel cells.
INORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Murugesan Sankarganesh, Paul Raj Adwin Jose, Jeyaraj Dhaveethu Raja, Rajadurai Vijay Solomon, Clarence Dorothy Sheela, Shunmugasundaram Gurusamy
Summary: A new octahedral platinum complex [PtLCl4] of Schiff base ligand containing pyrimidine and morpholine skeleton was synthesized and characterized. The compound exhibited interaction with DNA and BSA through electrostatic interactions and static quenching, respectively. The platinum complex showed promising anticancer activity against various cancer cell lines, while also demonstrating good radical scavenging and antimicrobial abilities.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Chemistry, Multidisciplinary
Divambal Appavoo, Lara C. Spencer, Ilia A. Guzei, Carlos J. Gomez-Garcia, Juanita L. van Wyk, James Darkwa
Summary: In this study, four copper complexes were synthesized and characterized, showing the ability to catalyze the ring opening polymerization of ε-caprolactone and d,l-lactide to obtain polymers with low molecular weights and polydispersity indices. The end group analysis revealed the presence of benzoate, hydroxyl, methoxy, and cyclic end groups in the polymers.
Article
Chemistry, Physical
Qi Wang, Zhixia Sun, Danping Li, Kai Ye, Changjian Xie, Shujing Zhang, Liu Jiang, Kang Zheng, Qiuxiang Pang
Summary: A new MXD molecular salt formed by MXD and 2,4-dihydroxybenzoic acid (24HA) was prepared and characterized. Experimental results showed that the MXD/24HA salt is superior to raw MXD and can potentially be a candidate drug for hair loss. The combination of theory and experiment enables an innovative methodology to understand the differences in structure and properties of pharmaceutical salts.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Computer Science, Information Systems
Shaoyue Song, Zhenjiang Miao, Hongkai Yu, Jianwu Fang, Kang Zheng, Cong Ma, Song Wang
Summary: This paper investigates salient object detection on multi-spectral images and proposes a deep domain adaptation model. Experimental results on a collected multi-spectral dataset demonstrate the effectiveness and accuracy of the proposed approach.
IEEE TRANSACTIONS ON MULTIMEDIA
(2022)
Article
Chemistry, Physical
Danping Li, Sijia Gao, Kai Ye, Qi Wang, Changjian Xie, Weiwei Wu, Ling Feng, Liu Jiang, Kang Zheng, Qiuxiang Pang
Summary: The La(III) and Ce(III) complexes with mixed ligands of salicylic acid and 1,10-phenanthroline were synthesized and characterized. The Ce(III) complex shares the same crystal structure with the La(III) complex, and may be membrane-active against bacteria, showing potential as effective antimicrobial candidates.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Review
Immunology
Yingqi Jin, Chen Hou, Yonghao Li, Kang Zheng, Chuan Wang
Summary: The development of safe and effective vaccines is crucial to prevent and control the global pandemic of COVID-19 caused by SARS-CoV-2. mRNA vaccines, as an emerging technology, have significant advantages in safety, efficacy, and production capacity. This review introduces the current status of SARS-CoV-2 vaccines, specifically mRNA vaccines, focusing on the challenges of developing mRNA vaccines against SARS-CoV-2 and discussing relevant strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shuo Liu, Meishan Chen, Xi Liu, Kang Zheng, Baohua Liu, Weiwei Wu, Qiuxiang Pang
Summary: The study reveals the crucial roles of DjApi5 and its interacting molecule DjAcinus in planarian homeostasis and regeneration, which may be correlated with their specific localization in neoblasts and anti-apoptotic functions.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Jianye Wang, Simin Lu, Kang Zheng, Zhangping He, Weiwei Li, Jie Liu, Ningyuan Guo, Yafeng Xie, Dejun Chen, Man Xu, Yimou Wu
Summary: It has been discovered that Treponema pallidum can be phagocytosed by human polymorphonuclear neutrophils (hPMNs) in vitro, and it can significantly inhibit the apoptosis of these neutrophils. This effect is not influenced by bacterial viability and might be achieved through the production of the anti-apoptotic cytokine IL-8.
MOLECULAR IMMUNOLOGY
(2022)
Article
Computer Science, Interdisciplinary Applications
Fakai Wang, Kang Zheng, Le Lu, Jing Xiao, Min Wu, Chang-Fu Kuo, Shun Miao
Summary: This paper proposes a method to predict bone mineral density (BMD) from chest X-ray, which shows a strong correlation with the gold standard DXA measurement and achieves high classification performance for osteoporosis screening.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2023)
Article
Chemistry, Physical
Liu Jiang, Kang Zheng
Summary: Glycine betaine (GB), a natural osmolyte, is widely used in various applications and primarily exists as a zwitterion. Researchers employed a combination of molecular dynamics simulations and electronic structure calculations to investigate the hydration structures of GB and its protonated form, GBH. By analyzing the electron density distributions and interaction energies, it was found that GB can interact with more water molecules compared to GBH. The study also demonstrated the effectiveness of a hybrid explicit-implicit solvation approach in reproducing experimental spectra. These findings provide important insights into understanding the hydration structures of zwitterionic and charged molecules.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Engineering, Biomedical
Zhihui Niu, Mingxiao Xie, Zicheng Wei, Yang Guo, Mengxuan Han, Yingying Ding, Jianyu Huang, Kang Zheng, Yao Zhang, Yuanda Song, Dechao Niu, Yongsheng Li, Guangwu Wen, Xiaowei Li, Jianlin Shi
Summary: A pH-ultrasensitive in situ structure transformation based on MnSiO3 is reported to enhance the adhesion between material and bacteria, shorten the diffusion distance, and improve the nano-catalytic antibacterial performance in weakly acidic conditions. A separated spray bottle is designed for in situ gelation at the wound site, allowing for long-term nano-catalyst release and efficient promotion of bacterial-infected wound healing.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Kai Ye, Xi Liu, Danping Li, Lili Gao, Kang Zheng, Jicheng Qu, Nianhong Xing, Fengtang Yang, Baohua Liu, Ao Li, Qiuxiang Pang
Summary: This study cloned 5 MMP genes from Dugesia japonica, and found that DjMMPA is associated with regeneration, maintenance and destruction of neoblast cells. Loss of DjMMPA leads to neoblasts proliferation disorder and eventual death. Knockdown of DjMMPA also impairs regeneration and affects cell differentiation, particularly in ectoderm, possibly by inhibiting Wnt signaling.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Neurosciences
Hao Liang, Xingyuan Zhang, Yuxuan Hou, Kang Zheng, Huifei Hao, Bingqiang He, Hui Li, Chunshuai Sun, Ting Yang, Honghua Song, Rixin Cai, Yingjie Wang, Haiyan Jiang, Lei Qi, Yongjun Wang
Summary: Gecko thrombin (gthrombin), a potential candidate for clinical application in rapid blood clotting, showed super-high catalytic and fibrinogenolytic efficiency compared to human thrombin, while being non-toxic to central nerve cells.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Fisheries
Shujing Zhang, Shuang Jiao, Dongwu Liu, Changjian Xie, Yuling Dong, Kang Zheng, Baozhong Liu, Qiuxiang Pang
Summary: In this study, a lipidomics approach was used to analyze the changes in lipid profiles during Vibrio infection in clams. The results showed that Vibrio infection altered the lipid homeostasis in clams, and specific lipid species such as ceramide, phosphatidylcholine, and triglyceride could be potential biomarkers for this infection. Furthermore, the sphingolipid metabolism pathway was found to be enriched in the differentially expressed lipid species. These findings provide new insights into the response of marine bivalves to pathogen infection.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Food Science & Technology
Liu Jiang, Kang Zheng
Summary: The cyclic voltammetry technique was used to detect the electrochemical response of 15 green tea products stored for different periods of time, and ten electrochemical feature parameters were extracted. An artificial neural network (ANN) prediction model was established to predict the changes in antioxidant activity descriptors of stored green tea. The ANN model showed good predictive accuracy with a mean absolute percentage error within 2%.
Article
Immunology
Zhenyu Li, Yan Wang, Kang Zheng, Xianzhou Lu, Zhangping He, Siqin He, Yumeng Li, Dingxin Long
Summary: Chlamydia psittaci has a significant impact on immunity, posing a major risk to the animal industry and public health. The expression of Tim-3 in effector T cells negatively regulates Th1 and Th17 immune responses against C. psittaci respiratory infection. Blocking Tim-3 signaling accelerates C. psittaci clearance and reduces lung pathology, while also enhancing Th1 and Th17-mediated immune responses and decreasing Treg immune responses.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Chemistry, Applied
Liu Jiang, Kang Zheng
Summary: Biodegradable packaging films containing natural bioactive ingredients, including chia seed mucilage and chitosan, have been constructed using Xanthoceras sorbifolium leaf extract as an active component. The effects of different active component contents on the properties of the composite film were studied. The results show that the CSM/CS/X4 film with 4% X. sorbifolium leaf extract has the best micromorphology and performance, and exhibits good antioxidant and antibacterial activities compared to the blank CSM/CS film. Molecular dynamics simulations reveal the helix structure of the CSM/CS/X films, and suggest that introducing extract enhances the formation of the composite film through improved interactions.
FOOD HYDROCOLLOIDS
(2023)