Arylamine N-acetyltransferases: from drug metabolism and pharmacogenetics to drug discovery
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Title
Arylamine N-acetyltransferases: from drug metabolism and pharmacogenetics to drug discovery
Authors
Keywords
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Journal
BRITISH JOURNAL OF PHARMACOLOGY
Volume 171, Issue 11, Pages 2705-2725
Publisher
Wiley
Online
2014-01-28
DOI
10.1111/bph.12598
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Note: Only part of the references are listed.- From Arylamine N-Acetyltransferase to Folate-Dependent Acetyl CoA Hydrolase: Impact of Folic Acid on the Activity of (HUMAN)NAT1 and Its Homologue (MOUSE)NAT2
- (2014) Nicola Laurieri et al. PLoS One
- Structure of arylamineN-acetyltransferase fromMycobacterium tuberculosisdetermined by cross-seeding with the homologous protein fromM. marinum: triumph over adversity
- (2013) Areej Abuhammad et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Design, synthesis and structure–activity relationships of 3,5-diaryl-1H-pyrazoles as inhibitors of arylamine N-acetyltransferase
- (2013) Elizabeth Fullam et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Association of N-acetyltransferase 2 and cytochrome P450 2E1 gene polymorphisms with antituberculosis drug-induced hepatotoxicity in Western India
- (2013) Vinod H Gupta et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- A practical guide to monitoring for adverse drug reactions during antihypertensive drug therapy
- (2013) Sarah E Mcdowell et al. JOURNAL OF THE ROYAL SOCIETY OF MEDICINE
- A Novel Color Change Mechanism for Breast Cancer Biomarker Detection: Naphthoquinones as Specific Ligands of Human Arylamine N-Acetyltransferase 1
- (2013) Nicola Laurieri et al. PLoS One
- Full-Gene-Sequencing Analysis of N-Acetyltransferase-2 in an Adult Indian Population
- (2012) Ashwini V. Tilak et al. Genetic Testing and Molecular Biomarkers
- The Differential Effect of NAT2 Variant Alleles Permits Refinement in Phenotype Inference and Identifies a Very Slow Acetylation Genotype
- (2012) Jhon D. Ruiz et al. PLoS One
- N-Acetyltransferase Polymorphism and Risk of Colorectal Adenoma and Cancer: A Pooled Analysis of Variations from 59 Studies
- (2012) Jinxin Liu et al. PLoS One
- Piperidinols That Show Anti-Tubercular Activity as Inhibitors of Arylamine N-Acetyltransferase: An Essential Enzyme for Mycobacterial Survival Inside Macrophages
- (2012) Areej Abuhammad et al. PLoS One
- Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors
- (2012) S. M. Batt et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Reduced 4-aminobiphenyl-induced liver tumorigenicity but not DNA damage in arylamine N-acetyltransferase null mice
- (2011) Kim S. Sugamori et al. CANCER LETTERS
- Functional analysis of arylamine N-acetyltransferase 1 (NAT1) NAT1*10 haplotypes in a complete NATb mRNA construct
- (2011) L. M. Millner et al. CARCINOGENESIS
- Novel Small-Molecule Inhibitors of Arylamine N-Acetyltransferases: Drug Discovery by High Throughput Screening
- (2011) Isaac M. Westwood et al. COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
- TheBacillus anthracisarylamineN-acetyltransferase ((BACAN)NAT1) that inactivates sulfamethoxazole, reveals unusual structural features compared with the other NAT isoenzymes
- (2011) Benjamin Pluvinage et al. FEBS LETTERS
- How Personalized Medicine Became Genetic, and Racial: Werner Kalow and the Formations of Pharmacogenetics
- (2011) D. S. Jones JOURNAL OF THE HISTORY OF MEDICINE AND ALLIED SCIENCES
- Conference Scene: Pharmacogenomics, biochemistry, toxicology, microbiology and cancer research in one go
- (2011) Fernando Rodrigues-Lima et al. PHARMACOGENOMICS
- Accuracy of various humanNAT2SNP genotyping panels to infer rapid, intermediate and slow acetylator phenotypes
- (2011) David W Hein et al. PHARMACOGENOMICS
- RNAi-Mediated Knock-Down of Arylamine N-acetyltransferase-1 Expression Induces E-cadherin Up-Regulation and Cell-Cell Contact Growth Inhibition
- (2011) Jacky M. Tiang et al. PLoS One
- Arylamine N-Acetyltransferase 2 (NAT2) Genetic Diversity and Traditional Subsistence: A Worldwide Population Survey
- (2011) Audrey Sabbagh et al. PLoS One
- Effects of Single Nucleotide Polymorphisms on Human N-Acetyltransferase 2 Structure and Dynamics by Molecular Dynamics Simulation
- (2011) M. Rajasekaran et al. PLoS One
- Improvement of the expression and purification of Mycobacterium tuberculosis arylamine N-acetyltransferase (TBNAT) a potential target for novel anti-tubercular agents
- (2011) Areej Abuhammad et al. PROTEIN EXPRESSION AND PURIFICATION
- Small molecule inhibition of arylamine N-acetyltransferase Type I inhibits proliferation and invasiveness of MDA-MB-231 breast cancer cells
- (2010) Jacky M. Tiang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Analysis of β-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase
- (2010) Elizabeth Fullam et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Arylamine N-acetyltransferase 1 gene regulation by androgens requires a conserved heat shock element for heat shock factor-1
- (2010) N. J. Butcher et al. CARCINOGENESIS
- Genes, Environment, and Orofacial Clefting
- (2010) Robert P. Erickson JOURNAL OF CRANIOFACIAL SURGERY
- A Novel Mechanism for Azoreduction
- (2010) Ali Ryan et al. JOURNAL OF MOLECULAR BIOLOGY
- Codominant Expression of N-Acetylation and O-Acetylation Activities Catalyzed by N-Acetyltransferase 2 in Human Hepatocytes
- (2010) M. A. Doll et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Small Molecule Colorimetric Probes for Specific Detection of Human ArylamineN-Acetyltransferase 1, a Potential Breast Cancer Biomarker
- (2010) Nicola Laurieri et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Probing the architecture of the Mycobacterium marinum arylamine N-acetyltransferase active site
- (2010) Areej M. Abuhammad et al. Protein & Cell
- Reaction mechanism of azoreductases suggests convergent evolution with quinone oxidoreductases
- (2010) Ali Ryan et al. Protein & Cell
- Identification of arylamine N-acetyltransferase inhibitors as an approach towards novel anti-tuberculars
- (2010) Isaac M. Westwood et al. Protein & Cell
- Isoform-Selective Inactivation of Human ArylamineN-Acetyltransferases by Reactive Metabolites of Carcinogenic Arylamines
- (2009) Li Liu et al. CHEMICAL RESEARCH IN TOXICOLOGY
- N-acetyltransferase SNPs: emerging concepts serve as a paradigm for understanding complexities of personalized medicine
- (2009) David W Hein Expert Opinion on Drug Metabolism & Toxicology
- Characterisation of CpG methylation in the upstream control region of mouse Nat2: Evidence for a gene–environment interaction in a polymorphic gene implicated in folate metabolism
- (2009) Larissa Wakefield et al. GENE
- Prospective virtual screening with Ultrafast Shape Recognition: the identification of novel inhibitors of arylamine N-acetyltransferases
- (2009) P. J. Ballester et al. Journal of the Royal Society Interface
- N-acetyltransferase 2 activity and folate levels
- (2009) Wen Cao et al. LIFE SCIENCES
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- (2009) Elizabeth Fullam et al. PROTEIN JOURNAL
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- (2009) Katherine C. Yam et al. PLoS Pathogens
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- (2008) Nathan A. Lack et al. BIOCHEMICAL JOURNAL
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- (2008) Akane Kawamura et al. BIOCHEMICAL PHARMACOLOGY
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- (2008) Alison L. Sikora et al. BIOCHEMISTRY
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- Divergence of Cofactor Recognition across Evolution: Coenzyme A Binding in a Prokaryotic Arylamine N-Acetyltransferase
- (2007) Elizabeth Fullam et al. JOURNAL OF MOLECULAR BIOLOGY
- Confirmation of the role of N-acetyltransferase 2 in teratogen-induced cleft palate using transgenics and knockouts
- (2007) Robert P. Erickson et al. MOLECULAR REPRODUCTION AND DEVELOPMENT
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