Agomelatine: mechanism of action and pharmacological profile in relation to antidepressant properties

The Effects of Antidepressant Treatment in Prenatally Stressed Rats Support the Glutamatergic Hypothesis of Stress-Related Disorders

(2014) J. Marrocco et al.   JOURNAL OF NEUROSCIENCE

Chronic treatment with agomelatine or venlafaxine reduces depolarization-evoked glutamate release from hippocampal synaptosomes

(2013) Marco Milanese et al.   BMC NEUROSCIENCE

The Concise Guide to PHARMACOLOGY 2013/14: Transporters

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2013/14: G Protein-Coupled Receptors

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Like melatonin, agomelatine (S20098) increases the amplitude of oscillations of two clock outputs: melatonin and temperature rhythms

(2013) Amélie Castanho et al.   CHRONOBIOLOGY INTERNATIONAL

Modulation of the inflammatory response in rats chronically treated with the antidepressant agomelatine

(2013) Raffaella Molteni et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Agomelatine in the tree shrew model of depression: Effects on stress-induced nocturnal hyperthermia and hormonal status

(2013) Barthel Schmelting et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Circadian patterns of gene expression in the human brain and disruption in major depressive disorder

(2013) J. Z. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The antidepressant agomelatine inhibits stress-mediated changes in amino acid efflux in the rat hippocampus and amygdala

(2012) Lawrence P. Reagan et al.   BRAIN RESEARCH

P.2.d.005 Agomelatine reduces long-term fear memory but not acquisition or short-term fear memories – involvement of melatonergic and 5-HT2C receptors

(2012) E. Mocaër et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Chronic agomelatine treatment corrects the abnormalities in the circadian rhythm of motor activity and sleep/wake cycle induced by prenatal restraint stress in adult rats

(2012) Jerome Mairesse et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Agomelatine Versus Venlafaxine XR in the Treatment of Anhedonia in Major Depressive Disorder

(2012) Giovanni Martinotti et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Electrophysiological Effects of Repeated Administration of Agomelatine on the Dopamine, Norepinephrine and Serotonin Systems in the Rat Brain

(2012) Franck Chenu et al.   NEUROPSYCHOPHARMACOLOGY

Role of peripheral and spinal 5-HT2B receptors in formalin-induced nociception

(2012) Claudia Cervantes-Durán et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Agomelatine suppresses locomotor hyperactivity in olfactory bulbectomised rats: A comparison to melatonin and to the 5-HT2c antagonist, S32006

(2011) Trevor R. Norman et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The long-term abnormalities in circadian expression of Period 1 and Period 2 genes in response to stress is normalized by agomelatine administered immediately after exposure

(2011) Ori Koresh et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Regionally selective activation and differential regulation of ERK, JNK and p38 MAP kinase signalling pathway by protein kinase C in mood modulation

(2011) Nicoletta Galeotti et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Beneficial behavioural and neurogenic effects of agomelatine in a model of depression/anxiety

(2011) Quentin Rainer et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Serotonin Receptor 5-HT2B Mediates Serotonin-Induced Mechanical Hyperalgesia

(2011) S.-Y. Lin et al.   JOURNAL OF NEUROSCIENCE

Novel melatonin-based therapies: potential advances in the treatment of major depression

(2011) Ian B Hickie et al.   LANCET

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

(2011) Anita E. Autry et al.   NATURE

Circadian rhythms and depression: Human psychopathology and animal models

(2011) Noga Kronfeld-Schor et al.   NEUROPHARMACOLOGY

Chronic agomelatine and fluoxetine induce antidepressant-like effects in H/Rouen mice, a genetic mouse model of depression

(2011) Malika El Yacoubi et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Memory facilitating effects of agomelatine in the novel object recognition memory paradigm in the rat

(2011) Valérie Bertaina-Anglade et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Chronic agomelatine treatment corrects behavioral, cellular, and biochemical abnormalities induced by prenatal stress in rats

(2011) Sara Morley-Fletcher et al.   PSYCHOPHARMACOLOGY

Agomelatine (S20098) modulates the expression of cytoskeletal microtubular proteins, synaptic markers and BDNF in the rat hippocampus, amygdala and PFC

(2011) Nataly Ladurelle et al.   PSYCHOPHARMACOLOGY

Is neurogenesis relevant in depression and in the mechanism of antidepressant drug action? A critical review

(2011) Siu W. Tang et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Mode of action of agomelatine: Synergy between melatonergic and 5-HT2Creceptors

(2011) Giorgio Racagni et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

An update on the role of glutamate in the pathophysiology of depression

(2010) N. D. Mitchell et al.   ACTA PSYCHIATRICA SCANDINAVICA

Agomelatine reverses the decrease in hippocampal cell survival induced by chronic mild stress

(2010) Girstautė Dagytė et al.   BEHAVIOURAL BRAIN RESEARCH

Knockdown of Clock in the Ventral Tegmental Area Through RNA Interference Results in a Mixed State of Mania and Depression-Like Behavior

(2010) Shibani Mukherjee et al.   BIOLOGICAL PSYCHIATRY

Blockade of stress-induced increase of glutamate release in the rat prefrontal/frontal cortex by agomelatine involves synergy between melatonergic and 5-HT2C receptor-dependent pathways

(2010) Daniela Tardito et al.   BMC NEUROSCIENCE

Agomelatine in the Treatment of Major Depressive Disorder

(2010) Sidney H. Kennedy et al.   CNS DRUGS

The Novel Antidepressant Agomelatine Normalizes Hippocampal Neuronal Activity and Promotes Neurogenesis in Chronically Stressed Rats

(2010) Girstautė Dagytė et al.   CNS Neuroscience & Therapeutics

Emerging Opportunities and Concerns for Drug Discovery at Serotonin 5-5-HT2B Receptors

(2010) Jose Brea et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The melatonergic agonist and clinically active antidepressant, agomelatine, is a neutral antagonist at 5-HT2C receptors

(2010) Mark J. Millan et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Efficacy of the Novel Antidepressant Agomelatine on the Circadian Rest-Activity Cycle and Depressive and Anxiety Symptoms in Patients With Major Depressive Disorder

(2010) Siegfried Kasper et al.   JOURNAL OF CLINICAL PSYCHIATRY

Erratum: Agomelatine, the first melatonergic antidepressant: discovery, characterization and development

(2010) Christian de Bodinat et al.   NATURE REVIEWS DRUG DISCOVERY

5-HT2B receptors modulate visceral hypersensitivity in a stress-sensitive animal model of brain-gut axis dysfunction

(2010) S. M. O’mahony et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Is Glycogen Synthase Kinase-3 a Central Modulator in Mood Regulation?

(2010) Xiaohua Li et al.   NEUROPSYCHOPHARMACOLOGY

Subtype-specific changes in 5-HT receptor-mediated modulation of C fibre-evoked spinal field potentials are triggered by peripheral nerve injury

(2010) Z. Aira et al.   NEUROSCIENCE

Acute Stress Increases Depolarization-Evoked Glutamate Release in the Rat Prefrontal/Frontal Cortex: The Dampening Action of Antidepressants

(2010) Laura Musazzi et al.   PLoS One

The role of glutamate on the action of antidepressants

(2010) Kenji Hashimoto   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The role of cognitive impairment in general functioning in major depression

(2010) Bernhard T. Baune et al.   PSYCHIATRY RESEARCH

Modulation of neuroplastic molecules in selected brain regions after chronic administration of the novel antidepressant agomelatine

(2010) Francesca Calabrese et al.   PSYCHOPHARMACOLOGY

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

Synergistic mechanisms in the modulation of the neurotrophin BDNF in the rat prefrontal cortex following acute agomelatine administration

(2010) Raffaella Molteni et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Expression of the Circadian Clock Gene Period2 in the Hippocampus: Possible Implications for Synaptic Plasticity and Learned Behaviour

(2009) Louisa M-C Wang et al.   ASN Neuro

Vesicular glutamate transporter mRNA expression in the medial temporal lobe in major depressive disorder, bipolar disorder, and schizophrenia

(2009) Akihito Uezato et al.   BIPOLAR DISORDERS

Disruption of the Circadian Timing Systems

(2009) Julien Mendlewicz   CNS DRUGS

Cognitive impairment in major depression

(2009) Donatella Marazziti et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

P.2.d.019 Effects of chronic agomelatine administration on the expression of a panel of genes in various brain areas of rats

(2009) T.J. Varcoe et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

P.1.c.014 The novel antidepressant, agomelatine, blocks cerebral 5-HT2C receptors in vivo: a phMRI challenge study in rats

(2009) I. Linnik et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

The NGF saga: From animal models of psychosocial stress to stress-related psychopathology

(2009) Francesca Cirulli et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Behavioural and neuroplastic effects of the new-generation antidepressant agomelatine compared to fluoxetine in glucocorticoid receptor-impaired mice

(2009) Eleni Païzanis et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

An evaluation of the neuroprotective effects of melatonin in an in vitro experimental model of age-induced neuronal apoptosis

(2009) Marta Tajes Orduña et al.   JOURNAL OF PINEAL RESEARCH

Early-life stress and antidepressant treatment involve synaptic signaling and Erk kinases in a gene-environment model of depression

(2009) Laura Musazzi et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis

(2009) D Taliaz et al.   MOLECULAR PSYCHIATRY

Neurogenesis-Dependent and -Independent Effects of Fluoxetine in an Animal Model of Anxiety/Depression

(2009) Denis J. David et al.   NEURON

Reduced expression of glutamate transporters vGluT1, EAAT2 and EAAT4 in learned helpless rats, an animal model of depression

(2009) M. Zink et al.   NEUROPHARMACOLOGY

Mechanisms Contributing to the Phase-Dependent Regulation of Neurogenesis by the Novel Antidepressant, Agomelatine, in the Adult Rat Hippocampus

(2009) Amélie Soumier et al.   NEUROPSYCHOPHARMACOLOGY

Ketamine and the next generation of antidepressants with a rapid onset of action

(2009) Rodrigo Machado-Vieira et al.   PHARMACOLOGY & THERAPEUTICS

Influence of the novel antidepressant and melatonin agonist/serotonin2C receptor antagonist, agomelatine, on the rat sleep–wake cycle architecture

(2009) Amandine Descamps et al.   PSYCHOPHARMACOLOGY

Chronic disruption of circadian rhythms impairs hippocampal memory in the rat

(2008) Laura A. Craig et al.   BRAIN RESEARCH BULLETIN

Circadian abnormalities, molecular clock genes and chronobiological treatments in depression

(2008) J. N. Bunney et al.   BRITISH MEDICAL BULLETIN

Circadian rhythm disturbances in depression

(2008) Anne Germain et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Serotonin 5-HT 2B Receptor Blockade Prevents Reactive Oxygen Species–Induced Cardiac Hypertrophy in Mice

(2008) Laurent Monassier et al.   HYPERTENSION

The antidepressant agomelatine blocks the adverse effects of stress on memory and enables spatial learning to rapidly increase neural cell adhesion molecule (NCAM) expression in the hippocampus of rats

(2008) Lisa Conboy et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

A Double-Blind Comparison of Sexual Functioning, Antidepressant Efficacy, and Tolerability Between Agomelatine and Venlafaxine XR

(2008) Sidney H. Kennedy et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

The mood-improving actions of antidepressants do not depend on neurogenesis but are associated with neuronal remodeling

(2008) J M Bessa et al.   MOLECULAR PSYCHIATRY

Fluoxetine increases the activity of the ERK-CREB signal system and alleviates the depressive-like behavior in rats exposed to chronic forced swim stress

(2008) Xiaoli Qi et al.   NEUROBIOLOGY OF DISEASE

RNA editing of the serotonin 5HT2C receptor and its effects on cell signalling, pharmacology and brain function

(2008) Tim D. Werry et al.   PHARMACOLOGY & THERAPEUTICS

Current status of inverse agonism at serotonin2A (5-HT2A) and 5-HT2C receptors

(2008) V.J. Aloyo et al.   PHARMACOLOGY & THERAPEUTICS

S32006, a novel 5-HT2C receptor antagonist displaying broad-based antidepressant and anxiolytic properties in rodent models

(2008) Anne Dekeyne et al.   PSYCHOPHARMACOLOGY

Regionally Specific Regulation of ERK MAP Kinase in a Model of Antidepressant-Sensitive Chronic Depression

(2007) Shannon L. Gourley et al.   BIOLOGICAL PSYCHIATRY