Identifying novel interventional strategies for psychiatric disorders: integrating genomics, ‘enviromics’ and gene-environment interactions in valid preclinical models

Rapid-Acting Glutamatergic Antidepressants: The Path to Ketamine and Beyond

(2013) John H. Krystal et al.   BIOLOGICAL PSYCHIATRY

Prenatal Poly(I:C) Exposure and Other Developmental Immune Activation Models in Rodent Systems

(2013) Urs Meyer   BIOLOGICAL PSYCHIATRY

Toward the future of psychiatric diagnosis: the seven pillars of RDoC

(2013) Bruce N Cuthbert et al.   BMC Medicine

A Nondegenerate Code of Deleterious Variants in Mendelian Loci Contributes to Complex Disease Risk

(2013) David R. Blair et al.   CELL

Integrative Functional Genomic Analyses Implicate Specific Molecular Pathways and Circuits in Autism

(2013) Neelroop N. Parikshak et al.   CELL

Towards Environmental Construct Validity in Animal Models of CNS Disorders: Optimizing Translation of Preclinical Studies

(2013) Emma Burrows et al.   CNS & Neurological Disorders-Drug Targets

What have we learned from recent twin studies about the etiology of neurodevelopmental disorders?

(2013) Danielle Posthuma et al.   CURRENT OPINION IN NEUROLOGY

Risk architecture of schizophrenia

(2013) Dragan M. Svrakic et al.   CURRENT OPINION IN PSYCHIATRY

Depression and cardiovascular disease: a clinical review

(2013) D. L. Hare et al.   EUROPEAN HEART JOURNAL

Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis

(2013)   LANCET

Questions about DISC1 as a genetic risk factor for schizophrenia

(2013) P F Sullivan   MOLECULAR PSYCHIATRY

Neurodevelopmental and neuropsychiatric disorders represent an interconnected molecular system

(2013) A S Cristino et al.   MOLECULAR PSYCHIATRY

Autism-Associated Neuroligin-3 Mutations Commonly Disrupt Tonic Endocannabinoid Signaling

(2013) Csaba Földy et al.   NEURON

Imaging Patients with Psychosis and a Mouse Model Establishes a Spreading Pattern of Hippocampal Dysfunction and Implicates Glutamate as a Driver

(2013) Scott A. Schobel et al.   NEURON

Rapid Anxiolytic Effects of a 5-HT4 Receptor Agonist Are Mediated by a Neurogenesis-Independent Mechanism

(2013) Indira Mendez-David et al.   NEUROPSYCHOPHARMACOLOGY

Dopamine Signaling in reward-related behaviors

(2013) Ja-Hyun Baik   Frontiers in Neural Circuits

Decanalization mediating gene-environment interactions in schizophrenia and other psychiatric disorders with neurodevelopmental etiology

(2013) Emma L. Burrows   Frontiers in Behavioral Neuroscience

Recovery in Remitted First-Episode Psychosis at 7 Years of Follow-up of an Early Dose Reduction/Discontinuation or Maintenance Treatment Strategy

(2013) Lex Wunderink et al.   JAMA Psychiatry

A Tale of Two Maladies? Pathogenesis of Depression with and without the Huntington’s Disease Gene Mutation

(2013) Xin Du et al.   Frontiers in Neurology

Hippocampal Angiogenesis and Progenitor Cell Proliferation Are Increased with Antidepressant Use in Major Depression

(2012) Maura Boldrini et al.   BIOLOGICAL PSYCHIATRY

Depression and epilepsy: Epidemiologic and neurobiologic perspectives that may explain their high comorbid occurrence

(2012) Andres M. Kanner et al.   EPILEPSY & BEHAVIOR

Patterns and rates of exonic de novo mutations in autism spectrum disorders

(2012) Benjamin M. Neale et al.   NATURE

Synaptic scaffold evolution generated components of vertebrate cognitive complexity

(2012) Jess Nithianantharajah et al.   NATURE NEUROSCIENCE

Neurogenesis and generalization: a new approach to stratify and treat anxiety disorders

(2012) Mazen A Kheirbek et al.   NATURE NEUROSCIENCE

Has an Angel Shown the Way? Etiological and Therapeutic Implications of the PCP/NMDA Model of Schizophrenia

(2012) D. C. Javitt et al.   SCHIZOPHRENIA BULLETIN

The conundrums of understanding genetic risks for autism spectrum disorders

(2011) Matthew W State et al.   NATURE NEUROSCIENCE

Avoiding mouse traps in schizophrenia genetics: lessons and promises from current and emerging mouse models

(2011) M. Kvajo et al.   NEUROSCIENCE

Epigenetic modifications induced by early enrichment are associated with changes in timing of induction of BDNF expression

(2011) Igor Branchi et al.   NEUROSCIENCE LETTERS

Decanalization, brain development and risk of schizophrenia

(2011) J J McGrath et al.   Translational Psychiatry

Research Domain Criteria (RDoC): Toward a New Classification Framework for Research on Mental Disorders

(2010) Thomas Insel et al.   AMERICAN JOURNAL OF PSYCHIATRY

Using glutamate homeostasis as a target for treating addictive disorders

(2010) Kathryn J. Reissner et al.   BEHAVIOURAL PHARMACOLOGY

Trends in Risks Associated With New Drug Development: Success Rates for Investigational Drugs

(2010) J A DiMasi et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Maternal Care and DNA Methylation of a Glutamic Acid Decarboxylase 1 Promoter in Rat Hippocampus

(2010) T.-Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysis

(2010) Nigel M Williams et al.   LANCET

SZGR: a comprehensive schizophrenia gene resource

(2010) P Jia et al.   MOLECULAR PSYCHIATRY

Functional impact of global rare copy number variation in autism spectrum disorders

(2010) Dalila Pinto et al.   NATURE

Gene–environment interactions and construct validity in preclinical models of psychiatric disorders

(2010) Emma L. Burrows et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Developmental Vitamin D Deficiency and Risk of Schizophrenia: A 10-Year Update

(2010) J. J. McGrath et al.   SCHIZOPHRENIA BULLETIN

Candidate gene studies of ADHD: a meta-analytic review

(2009) Ian R. Gizer et al.   HUMAN GENETICS

A Loss of Parvalbumin-Containing Interneurons Is Associated with Diminished Oscillatory Activity in an Animal Model of Schizophrenia

(2009) D. J. Lodge et al.   JOURNAL OF NEUROSCIENCE

A genome-wide linkage and association scan reveals novel loci for autism

(2009) Lauren A. Weiss et al.   NATURE

Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes

(2009) Juan E Belforte et al.   NATURE NEUROSCIENCE

Rare structural variants in schizophrenia: one disorder, multiple mutations; one mutation, multiple disorders

(2009) Jonathan Sebat et al.   TRENDS IN GENETICS

Tandem repeat polymorphisms: modulators of disease susceptibility and candidates for ‘missing heritability’

(2009) Anthony J. Hannan   TRENDS IN GENETICS

Antipsychotic subtypes can be characterized by differences in their ability to modify GABAergic promoter methylation

(2009) Erbo Dong et al.   Epigenomics

Long-lasting behavioural and molecular alterations induced by early postnatal fluoxetine exposure are restored by chronic fluoxetine treatment in adult mice

(2008) Nina N. Karpova et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Meta-analysis of 32 genome-wide linkage studies of schizophrenia

(2008) M Y M Ng et al.   MOLECULAR PSYCHIATRY

Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database

(2008) Nicole C Allen et al.   NATURE GENETICS

Association between Microdeletion and Microduplication at 16p11.2 and Autism

(2008) Lauren A. Weiss et al.   NEW ENGLAND JOURNAL OF MEDICINE

AutDB: a gene reference resource for autism research

(2008) Saumyendra N. Basu et al.   NUCLEIC ACIDS RESEARCH

Gene-Environment Interplay Between Cannabis and Psychosis

(2008) C. Henquet et al.   SCHIZOPHRENIA BULLETIN

Psychosocial Stress and Psychosis. A Review of the Neurobiological Mechanisms and the Evidence for Gene-Stress Interaction

(2008) R. van Winkel et al.   SCHIZOPHRENIA BULLETIN