Can neuropeptides treat obesity? A review of neuropeptides and their potential role in the treatment of obesity

Hit to lead SAR study on benzoxazole derivatives for an NPY Y5 antagonist

(2012) Naoki Omori et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Orexin Receptor Antagonism, a New Sleep-Enabling Paradigm: A Proof-of-Concept Clinical Trial

(2012) P Hoever et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Discovery and evaluation of pyrazolo[1,5-a]pyrimidines as neuropeptide Y1 receptor antagonists

(2011) David A. Griffith et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

NPY receptors as potential targets for anti-obesity drug development

(2011) Ernie Yulyaningsih et al.   BRITISH JOURNAL OF PHARMACOLOGY

Guide to Receptors and Channels (GRAC), 5th edition

(2011) SPH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

A One-Year Randomized Trial of Lorcaserin for Weight Loss in Obese and Overweight Adults: The BLOSSOM Trial

(2011) Meredith C. Fidler et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Sixteen years and counting: an update on leptin in energy balance

(2011) Laurent Gautron et al.   JOURNAL OF CLINICAL INVESTIGATION

Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER): a randomised, placebo-controlled, phase 3 trial

(2011) Kishore M Gadde et al.   LANCET

Weighing in the Role of BDNF in the Central Control of Eating Behavior

(2011) Joshua Cordeira et al.   MOLECULAR NEUROBIOLOGY

Controlled-Release Phentermine/Topiramate in Severely Obese Adults: A Randomized Controlled Trial (EQUIP)

(2011) David B. Allison et al.   Obesity

Chronic administration of brain-derived neurotrophic factor in the hypothalamic paraventricular nucleus reverses obesity induced by high-fat diet

(2010) ChuanFeng Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Therapeutic potential of neuropeptide Y (NPY) receptor ligands

(2010) Shaun P. Brothers et al.   EMBO Molecular Medicine

Galanin-like peptide and the regulation of feeding behavior and energy metabolism

(2010) Kanako Shiba et al.   FEBS Journal

Distribution of relaxin-3 and RXFP3 within arousal, stress, affective, and cognitive circuits of mouse brain

(2010) Craig M. Smith et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Discovery of the Dual Orexin Receptor Antagonist [(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia

(2010) Christopher D. Cox et al.   JOURNAL OF MEDICINAL CHEMISTRY

Melanocortin Signalling and the Regulation of Blood Pressure in Human Obesity

(2010) J. R. Greenfield   JOURNAL OF NEUROENDOCRINOLOGY

Rimonabant for prevention of cardiovascular events (CRESCENDO): a randomised, multicentre, placebo-controlled trial

(2010) Eric J Topol et al.   LANCET

Effect of naltrexone plus bupropion on weight loss in overweight and obese adults (COR-I): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial

(2010) Frank L Greenway et al.   LANCET

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

(2010) Elizabeth K Speliotes et al.   NATURE GENETICS

Synthesis, characterization, and monkey positron emission tomography (PET) studies of [18F]Y1-973, a PET tracer for the neuropeptide Y Y1 receptor

(2010) Eric D. Hostetler et al.   NEUROIMAGE

Multicenter, Placebo-Controlled Trial of Lorcaserin for Weight Management

(2010) Steven R. Smith et al.   NEW ENGLAND JOURNAL OF MEDICINE

Metabolic and Neuroendocrine Responses to RXFP3 Modulation in the Central Nervous System

(2009) Steven W. Sutton et al.   Annals of the New York Academy of Sciences

Optimization of a series of 2,4-diaminopyridines as neuropeptide Y Y1 receptor antagonists with reduced hERG activity

(2009) Minoru Kameda et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Lateral hypothalamic orexin/hypocretin neurons: A role in reward-seeking and addiction

(2009) Gary Aston-Jones et al.   BRAIN RESEARCH

Potent and Selective Agonism of the Melanocortin Receptor 4 With MK-0493 Does Not Induce Weight Loss in Obese Human Subjects: Energy Intake Predicts Lack of Weight Loss Efficacy

(2009) R Krishna et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Almorexant

(2009) R.T. Owen et al.   DRUGS OF THE FUTURE

Synergistic interaction between neuropeptide Y1 and Y5 receptor pathways in regulation of energy homeostasis

(2009) Satoshi Mashiko et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Bupropion and naltrexone: a review of their use individually and in combination for the treatment of obesity

(2009) Raymond A Plodkowski et al.   EXPERT OPINION ON PHARMACOTHERAPY

Comparison of Combined Bupropion and Naltrexone Therapy for Obesity with Monotherapy and Placebo

(2009) Frank L. Greenway et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Relaxin family peptide receptors – from orphans to therapeutic targets

(2008) Emma T. van der Westhuizen et al.   DRUG DISCOVERY TODAY

Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y1 receptor antagonist

(2008) Ildiko Antal-Zimanyi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

(9S)-9-(2-Hydroxy-4,4-dimethyl-6-oxo-1-cyclohexen-1-yl)-3,3-dimethyl-2,3,4,9-tetrahydro-1H-xanthen-1-one, a Selective and Orally Active Neuropeptide Y Y5 Receptor Antagonist

(2008) Nagaaki Sato et al.   JOURNAL OF MEDICINAL CHEMISTRY

Brain-Derived Neurotrophic Factor and Obesity in the WAGR Syndrome

(2008) Joan C. Han et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effects of a Novel Y5 Antagonist in Obese Mice: Combination With Food Restriction or Sibutramine

(2008) Satoshi Mashiko et al.   Obesity

The relative impact of chronic food restriction and acute food deprivation on plasma hormone levels and hypothalamic neuropeptide expression

(2008) Andreas Johansson et al.   PEPTIDES