Pharmacology of AMG 181, a human anti-α4β7antibody that specifically alters trafficking of gut-homing T cells

943b Induction Therapy for Ulcerative Colitis: Results of GEMINI I, a Randomized, Placebo-Controlled, Double-Blind, Multicenter Phase 3 Trial

(2015) B.G. Feagan et al.   GASTROENTEROLOGY

Su2082 Pharmacokinetics (PK), Pharmacodynamics (PD), and Safety of Amg 181, a Fully Human Anti-α4β7 Antibody for Treating Inflammatory Bowel Diseases (IBD)

(2015) Wei-Jian Pan et al.   GASTROENTEROLOGY

Sa2025 Etrolizumab-Mediated Ex Vivo Modulation of Beta7 Cell Surface Receptors in Nonhuman Primate and Human Peripheral Blood Supports the Proposed Mechanism of Action

(2015) Marna Williams et al.   GASTROENTEROLOGY

Exclusive antagonism of the α4β7 integrin by vedolizumab confirms the gut-selectivity of this pathway in primates

(2012) Eric R. Fedyk et al.   INFLAMMATORY BOWEL DISEASES

P019 Internalization of the vedolizumab/α4β7 complex and kinetics of restoring functional activity

(2012) L.-L. Yang et al.   Journal of Crohns & Colitis

A humanized monoclonal antibody targeting the β7 integrin selectively blocks intestinal homing of T lymphocytes

(2011) EG Stefanich et al.   BRITISH JOURNAL OF PHARMACOLOGY

The mucosal addressin cell adhesion molecule antibody PF-00547,659 in ulcerative colitis: a randomised study

(2011) S. Vermeire et al.   GUT

Vedolizumab for the Treatment of Active Ulcerative Colitis: A Randomized Controlled Phase 2 Dose-ranging Study

(2011) Asit Parikh et al.   INFLAMMATORY BOWEL DISEASES

Targeting leukocyte migration and adhesion in Crohn’s disease and ulcerative colitis

(2011) Saskia Thomas et al.   INFLAMMOPHARMACOLOGY

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

Pharmacological characterization of PF-00547659, an anti-human MAdCAM monoclonal antibody

(2009) N Pullen et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Binding Specificity and Selective Antagonism of Vedolizumab, an Anti- 4 7 Integrin Therapeutic Antibody in Development for Inflammatory Bowel Diseases

(2009) D. Soler et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Treatment of Active Crohn's Disease With MLN0002, a Humanized Antibody to the α4β7 Integrin

(2008) Brian G. Feagan et al.   Clinical Gastroenterology and Hepatology

Monoclonal Antibody Pharmacokinetics and Pharmacodynamics

(2008) W Wang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Role of β7 Integrin and the Chemokine/Chemokine Receptor Pair CCL25/CCR9 in Modeled TNF-Dependent Crohn's Disease

(2008) Maria Apostolaki et al.   GASTROENTEROLOGY

Clearance of influenza virus from the lung depends on migratory langerin+CD11b−but not plasmacytoid dendritic cells

(2008) Corine H. GeurtsvanKessel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

High-affinity binding measurements of antibodies to cell-surface-expressed antigens

(2007) Palaniswami Rathanaswami et al.   ANALYTICAL BIOCHEMISTRY