Small-interfering RNAs (siRNAs) as a promising tool for ocular therapy

The Argus II epiretinal prosthesis system allows letter and word reading and long-term function in patients with profound vision loss

(2013) Lyndon da Cruz et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

ω-3 Intake in Patients With Retinitis Pigmentosa Receiving Vitamin A

(2013) Daniel Seigel et al.   JAMA Ophthalmology

Connective Tissue Growth Factor Causes Glaucoma by Modifying the Actin Cytoskeleton of the Trabecular Meshwork

(2012) Benjamin Junglas et al.   AMERICAN JOURNAL OF PATHOLOGY

ω-3 Intake and Visual Acuity in Patients With Retinitis Pigmentosa Receiving Vitamin A

(2012) Eliot L. Berson et al.   ARCHIVES OF OPHTHALMOLOGY

siRNA Silencing of Gene Expression in Trabecular Meshwork: RhoA siRNA Reduces IOP in Mice

(2012) Q. Liu et al.   CURRENT MOLECULAR MEDICINE

Update on animal models of diabetic retinopathy: from molecular approaches to mice and higher mammals

(2012) R. Robinson et al.   Disease Models & Mechanisms

TXNIP Links Innate Host Defense Mechanisms to Oxidative Stress and Inflammation in Retinal Muller Glia under Chronic Hyperglycemia: Implications for Diabetic Retinopathy

(2012) Takhellambam S. Devi et al.   Experimental Diabetes Research

Systemic thromboembolic adverse events in patients treated with intravitreal anti-VEGF drugs for neovascular age-related macular degeneration

(2012) Ciro Costagliola et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Phase 1 dose-escalation study of a siRNA targeting the RTP801 gene in age-related macular degeneration patients

(2012) Q D Nguyen et al.   EYE

Long-Term Rescue of Retinal Structure and Function by Rhodopsin RNA Replacement with a Single Adeno-Associated Viral Vector in P23H RHO Transgenic Mice

(2012) Haoyu Mao et al.   HUMAN GENE THERAPY

Targeted deletion of Vegfa in adult mice induces vision loss

(2012) Toshihide Kurihara et al.   JOURNAL OF CLINICAL INVESTIGATION

Contact Lenses: Promising Devices for Ocular Drug Delivery

(2012) Ana Guzman-Aranguez et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Ophthalmic drug discovery: novel targets and mechanisms for retinal diseases and glaucoma

(2012) Kang Zhang et al.   NATURE REVIEWS DRUG DISCOVERY

Diabetic Retinopathy

(2012) David A. Antonetti et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evaluation of the siRNA PF-04523655 versus Ranibizumab for the Treatment of Neovascular Age-related Macular Degeneration (MONET Study)

(2012) Quan Dong Nguyen et al.   OPHTHALMOLOGY

Interim Results from the International Trial of Second Sight's Visual Prosthesis

(2012) Mark S. Humayun et al.   OPHTHALMOLOGY

Cochlin, Intraocular Pressure Regulation and Mechanosensing

(2012) Manik Goel et al.   PLoS One

Corneal Neovascularization: An Anti-VEGF Therapy Review

(2012) Jin-Hong Chang et al.   SURVEY OF OPHTHALMOLOGY

Aqueous Humor Dynamics During the Day and Night in Volunteers With Ocular Hypertension

(2011) Shan Fan   ARCHIVES OF OPHTHALMOLOGY

Genetic and pharmacologic inactivation of cannabinoid CB1 receptor inhibits angiogenesis

(2011) S. Pisanti et al.   BLOOD

Guide to Receptors and Channels (GRAC), 5th edition

(2011) SPH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Silencing of P2Y2receptors reduces intraocular pressure in New Zealand rabbits

(2011) Alba Martin-Gil et al.   BRITISH JOURNAL OF PHARMACOLOGY

Treatments for Corneal Neovascularization: A Review

(2011) Deepak Gupta et al.   CORNEA

Hemangiogenesis and Lymphangiogenesis in Corneal Pathology

(2011) Makambo Tshionyi et al.   CORNEA

Anti-VEGF Compounds in the Treatment of Neovascular Age Related Macular Degeneration

(2011) C. Campa et al.   CURRENT DRUG TARGETS

Lentivirus-mediated expression of cDNA and shRNA slows degeneration in retinitis pigmentosa

(2011) Joaquin Tosi et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Transforming growth factor-beta2 utilizes the canonical Smad-signaling pathway to regulate tissue transglutaminase expression in human trabecular meshwork cells

(2011) Tara Tovar-Vidales et al.   EXPERIMENTAL EYE RESEARCH

Toll-like receptor 2 siRNA suppresses corneal inflammation and attenuates Aspergillus fumigatus keratitis in rats

(2011) Hui Guo et al.   IMMUNOLOGY AND CELL BIOLOGY

In vitro analyses of the anti-fibrotic effect of SPARC silencing in human Tenon’s fibroblasts: comparisons with mitomycin C

(2011) Li-Fong Seet et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Glaucoma

(2011) Harry A Quigley   LANCET

Short-interfering RNAs Induce Retinal Degeneration via TLR3 and IRF3

(2011) Mark E Kleinman et al.   MOLECULAR THERAPY

Ocular neuroprotection by siRNA targeting caspase-2

(2011) Z Ahmed et al.   Cell Death & Disease

RNAi-Based Treatment for Neovascular Age-Related Macular Degeneration by Sirna-027

(2010) Peter K. Kaiser et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

How Strong Is the Evidence That Nutritional Supplements Slow the Progression of Retinitis Pigmentosa?

(2010)   ARCHIVES OF OPHTHALMOLOGY

Clinical Trial of Lutein in Patients With Retinitis Pigmentosa Receiving Vitamin A

(2010)   ARCHIVES OF OPHTHALMOLOGY

A SiRNA Targeting Vascular Endothelial Growth Factor-A Inhibiting Experimental Corneal Neovascularization

(2010) Lei Zuo et al.   CURRENT EYE RESEARCH

Inhibition of experimental choroidal neovascularization in mice by anti-VEGFA/VEGFR2 or non-specific siRNA

(2010) Liping Gu et al.   EXPERIMENTAL EYE RESEARCH

Glaucoma patients present increased levels of diadenosine tetraphosphate, Ap4A, in the aqueous humour

(2010) Marta Castany et al.   EXPERIMENTAL EYE RESEARCH

RAGE-TXNIP axis is required for S100B-promoted Schwann cell migration, fibronectin expression and cytokine secretion

(2010) O. Sbai et al.   JOURNAL OF CELL SCIENCE

Diabetic retinopathy

(2010) Ning Cheung et al.   LANCET

Recent Progress in Chemically Modified siRNAs

(2010) M. Gaglione et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Corneal Neovascularization as a Risk Factor for Graft Failure and Rejection after Keratoplasty

(2010) Bjorn Bachmann et al.   OPHTHALMOLOGY

Ciliary blood flow and aqueous humor production

(2010) J.W. Kiel et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Inhibition of TXNIP expression in vivo blocks early pathologies of diabetic retinopathy

(2010) L Perrone et al.   Cell Death & Disease

Non-viral siRNA delivery into the mouse retina in vivo

(2010) Andrey Turchinovich et al.   BMC Ophthalmology

The role of CTGF in the diabetic rat retina and its relationship with VEGF and TGF-β2, elucidated by treatment with CTGFsiRNA

(2009) Hongwei Yang et al.   ACTA OPHTHALMOLOGICA

New treatments for ocular hypertension

(2009) Aránzazu Mediero et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Neurotrophin roles in retinal ganglion cell survival: Lessons from rat glaucoma models

(2009) Elaine C. Johnson et al.   EXPERIMENTAL EYE RESEARCH

Uveoscleral outflow – A review

(2009) Albert Alm et al.   EXPERIMENTAL EYE RESEARCH

Adenine nucleotide effect on intraocular pressure: Involvement of the parasympathetic nervous system

(2009) Assumpta Peral et al.   EXPERIMENTAL EYE RESEARCH

Connective tissue growth factor induces extracellular matrix deposition in human trabecular meshwork cells

(2009) Benjamin Junglas et al.   EXPERIMENTAL EYE RESEARCH

The trabecular meshwork outflow pathways: Structural and functional aspects

(2009) Ernst R. Tamm   EXPERIMENTAL EYE RESEARCH

Thioredoxin interacting protein (TXNIP) induces inflammation through chromatin modification in retinal capillary endothelial cells under diabetic conditions

(2009) Lorena Perrone et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth

(2009) W. G. Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Development of Topically Acting Carbonic Anhydrase Inhibitors as Antiglaucoma Agents

(2008) Claudiu Supuran et al.   CURRENT PHARMACEUTICAL DESIGN

Cysteine-Rich Protein 61 and Connective Tissue Growth Factor Induce Deadhesion and Anoikis of Retinal Pericytes

(2008) Haibo Liu et al.   ENDOCRINOLOGY

Delivery Vehicles for Small Interfering RNA In Vivo

(2008) Antonin R. de Fougerolles   HUMAN GENE THERAPY

Rhodopsin: Structure, signal transduction and oligomerisation

(2008) Michael B. Morris et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Inhibition of retinal neovascularization by gene transfer of small interfering RNA targeting HIF-1α and VEGF

(2008) Jian Jiang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

(2008) Mark E. Kleinman et al.   NATURE

Hypotensive effect of UDP on intraocular pressure in rabbits

(2007) Anna Markovskaya et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cell-penetrating Peptide for Enhanced Delivery of Nucleic Acids and Drugs to Ocular Tissues Including Retina and Cornea

(2007) Leslie N Johnson et al.   MOLECULAR THERAPY