Journal
BRITISH JOURNAL OF PHARMACOLOGY
Volume 170, Issue 6, Pages 1153-1166Publisher
WILEY
DOI: 10.1111/bph.12399
Keywords
exercise; endurance; resistance; nuclear receptors; insulin-like growth factor; myostatin; skeletal muscle
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Funding
- British Heart Foundation [PG/11/39/28890]
- British Heart Foundation [PG/11/39/28890] Funding Source: researchfish
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Humans are considered among the greatest if not the greatest endurance land animals. Over the last 50 years, as the population has become more sedentary, rates of cardiovascular disease and its associated risk factors such as obesity, type 2 diabetes and hypertension have all increased. Aerobic fitness is considered protective for all-cause mortality, cardiovascular disease, a variety of cancers, joint disease and depression. Here, I will review the emerging mechanisms that underlie the response to exercise, focusing on the major target organ the skeletal muscle system. Understanding the mechanisms of action of exercise will allow us to develop new therapies that mimic the protective actions of exercise.
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