Article
Anatomy & Morphology
Zhao-Hui Sun, Fang Li, Yun-Fei Li, Min Wang, Ya-Nan Li, Li Li, Hua Yu, Guang-Xian Tang, Rui-Xue Sun
Summary: This study found that treatment with anti-CXCL10 mAb could alleviate retinal pathology in mice with diabetic retinopathy, reducing inflammation and oxidative stress.
Review
Cell Biology
Renu. A. A. Kowluru
Summary: Diabetic retinopathy is a complex disease with a multifactorial and unknown molecular pathogenesis. High blood glucose induces oxidative stress and inflammation in the retina, which can form a positive loop. Furthermore, diabetes can also lead to epigenetic modifications that affect genes associated with oxidative stress and inflammation. Understanding the cross-talk between oxidative stress, inflammation, and epigenetics may contribute to the development of novel strategies for treating diabetic retinopathy.
Article
Biochemistry & Molecular Biology
Jesus Silvestre Albert-Garay, Juan Rafael Riesgo-Escovar, Gustavo Sanchez-Chavez, Rocio Salceda
Summary: Diabetic retinopathy is a common cause of vision loss in diabetic patients, but the mechanism is unclear. The study focusing on Nrf2 and Keap1 expression in the retina of diabetic rats provides insights on oxidative stress response in diabetic retinopathy.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Qiang Su, Jing Dong, Donglei Zhang, Lu Yang, Rupak Roy
Summary: Diabetic retinopathy (DR) is a common complication of diabetes, particularly in developed countries. The bioactive compound bilobalide, found in Ginkgo biloba, has been shown to have antioxidant properties and may attenuate DR. Bilobalide improves caloric management, lowers blood glucose levels, and reduces oxidative stress and inflammation in diabetic rats, thereby exerting therapeutic effects against DR.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xing Wang, Caina Li, Yi Huan, Hui Cao, Sujuan Sun, Lei Lei, Quan Liu, Shuainan Liu, Wenming Ji, Kaixun Huang, Zhufang Shen, Jun Zhou
Summary: DPDS supplementation improved hyperglycemia, glucose intolerance, dyslipidemia, and renal pathological abnormalities in STZ-induced DN rats. It also promoted antioxidant enzyme activities, reduced pro-inflammatory factors levels, and activated the renal Nrf2/Keap1 signaling pathway while attenuating NF kappa B/MAPK signaling pathways, suggesting DPDS as a potential therapeutic approach for DN.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Medicine, Research & Experimental
Muhammad Zulfiqah Sadikan, Nurul Alimah Abdul Nasir, Igor Iezhitsa, Renu Agarwal
Summary: This study found that oral TRF (100 mg/kg) supplementation for 12 weeks reduces retinal oxidative stress in STZ-induced DR rats, which in turn reduces retinal cell apoptosis and protects retinal morphology. These findings were associated with preservation of the visual-behaviour responses.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Sajed Amjadi, Fatemeh Shahnaz, Behrooz Shokouhi, Yadollah Azarmi, Mohammadreza Siahi-Shadbad, Saeed Ghanbarzadeh, Maryam Kouhsoltani, Alireza Ebrahimi, Hamed Hamishehkar
Summary: Encapsulation of rutin into nanophytosomes showed enhanced therapeutic effects in diabetic rats by controlling hyperglycemia and hyperlipidemia, regulating liver marker enzymes, improving antioxidant defenses, and alleviating diabetic complications.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Abdulaziz M. F. Shayea, Waleed M. Renno, Bedoor Qabazard, Willias Masocha
Summary: This study demonstrated the protective properties of hydrogen sulfide (H2S) in diabetic neuropathy, showing that it can prevent the development of neuropathy-related behavior and suppress apoptosis activation pathways and inflammation in the spinal cord.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Jian-Ping Xia, Sheng-Qiang Liu, Shuai Wang
Summary: Conbercept significantly inhibited retinal pathological changes, inflammation, and oxidative response in PDR mice, revealing its molecular mechanisms in treating PDR.
Article
Pharmacology & Pharmacy
Alessio Canovai, Rosario Amato, Alberto Melecchi, Massimo Dal Monte, Dario Rusciano, Paola Bagnoli, Maurizio Cammalleri
Summary: In diabetic retinopathy, high blood glucose causes chronic oxidative stress and inflammation, leading to vascular abnormalities, retinal cell death, and altered electroretinogram (ERG). This study shows that nutrients with anti-inflammatory/antioxidant properties can prevent the progression of DR. The compound containing cyanidin-3-glucoside, verbascoside, and zinc effectively inhibits oxidative stress and inflammation, preventing DR-associated vasculopathy and retinal damage.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Shuangyu Lv, Huiyang Liu, Honggang Wang
Summary: Autophagy plays a crucial role in physiological processes, while hydrogen sulfide (H2S) has been identified as an important gas signal transduction molecule with protective effects in diabetes-related diseases. Recent studies suggest that H2S regulates autophagy in various diseases, although the exact mechanisms remain unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Tapan Behl, Thirumurthy Velpandian, Anita Kotwani
Summary: The study investigated the effect of Terminalia catappa fruit extract on streptozotocin-induced diabetic retinopathy in rats. Results showed that the extract significantly reduced blood glucose levels, improved cataracts, decreased arteriole and venule tortuosity, and modulated oxidative, angiogenic, and inflammatory biomarkers in diabetic rats.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2021)
Article
Food Science & Technology
Lucia Recinella, Maria Loreta Libero, Valentina Citi, Annalisa Chiavaroli, Alma Martelli, Roberta Foligni, Cinzia Mannozzi, Alessandra Acquaviva, Simonetta Di Simone, Vincenzo Calderone, Giustino Orlando, Claudio Ferrante, Serena Veschi, Anna Piro, Luigi Menghini, Luigi Brunetti, Sheila Leone
Summary: Multiple studies have shown that aged black garlic has anti-inflammatory, antioxidant, and cardioprotective effects. This study investigated the protective effects of aged black garlic extract (ABGE) alone or in combination with multivitamins on mouse hearts exposed to E. coli lipopolysaccharide. The study also examined the hydrogen sulfide releasing properties and membrane hyperpolarization effect of the formulation composed of ABGE and multivitamins using human aortic smooth muscle cells (HASMCs). The results showed that ABGE, vitamins D and C, and the formulation suppressed the expression of inflammatory genes on mouse hearts and the formulation increased intracellular hydrogen sulfide formation, suggesting its potential use in cardiovascular disease.
Review
Immunology
Xin Zhao, Feng Ling, Guang Wei Zhang, Na Yu, Jing Yang, Xiang Yang Xin
Summary: MiRNAs play an important role in diabetic retinopathy, particularly in inflammation, oxidative stress, and neurodegeneration. Targeting specific miRNAs for the treatment of diabetic retinopathy has gained significant attention. This review focuses on the pathophysiological roles of miRNAs in diabetic retinopathy, diabetic macular edema, and proliferative diabetic retinopathy, and discusses the future development potential and application limitations of therapy that targets specific miRNAs for diabetic retinopathy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Lindan Wei, Xin Sun, Chenxi Fan, Rongli Li, Shuanglong Zhou, Hongsong Yu
Summary: This article reviews the pathophysiological changes in diabetic retinopathy (DR) and discusses the factors contributing to its occurrence and development. The findings provide a theoretical reference for the development of new treatment strategies for DR.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)