Ginsenoside-Rp1 inhibits platelet activation and thrombus formation via impaired glycoprotein VI signalling pathway, tyrosine phosphorylation and MAPK activation

Trends in Ginseng Research in 2010

(2012) Si-Kwan Kim et al.   Journal of Ginseng Research

Panax ginseng: An Overview of the Clinical Evidence

(2011) Edzard Ernst   Journal of Ginseng Research

Role of phosphoinositide 3-kinase β in platelet aggregation and thromboxane A2generation mediated by Gisignalling pathways

(2010) Analia Garcia et al.   BIOCHEMICAL JOURNAL

Platelet JNK1 is involved in secretion and thrombus formation

(2010) F. Adam et al.   BLOOD

Deletion of the p110  isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo

(2010) V. Martin et al.   BLOOD

Guidelines for reporting experiments involving animals: the ARRIVE guidelines

(2010) JC McGrath et al.   BRITISH JOURNAL OF PHARMACOLOGY

Thrombin and Collagen Induce a Feedback Inhibitory Signaling Pathway in Platelets Involving Dissociation of the Catalytic Subunit of Protein Kinase A from an NFκB-IκB Complex

(2010) Stepan Gambaryan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibitory effects of Bulnesia sarmienti aqueous extract on agonist-induced platelet activation and thrombus formation involves mitogen-activated protein kinases

(2010) S.M. Kamruzzaman et al.   JOURNAL OF ETHNOPHARMACOLOGY

Inhibitory mechanisms of dihydroginsenoside Rg3 in platelet aggregation: Critical roles of ERK2 and cAMP

(2010) Whi Min Lee et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Antithrombotic drugs in coronary artery disease: risk benefit ratio and bleeding

(2010) S. SCHULMAN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Antiplatelet therapies for the treatment of cardiovascular disease

(2010) Alan D. Michelson   NATURE REVIEWS DRUG DISCOVERY

Platelets Amplify Inflammation in Arthritis via Collagen-Dependent Microparticle Production

(2010) E. Boilard et al.   SCIENCE

Pharmacology of ginsenosides: a literature review

(2010) Kar Leung et al.   Chinese Medicine

Genetic evidence for a predominant role of PI3K  catalytic activity in ITAM- and integrin-mediated signaling in platelets

(2009) I. Canobbio et al.   BLOOD

Current Evaluation of the Millennium Phytomedicine- Ginseng (II): Collected Chemical Entities, Modern Pharmacology, and Clinical Applications Emanated from Traditional Chinese Medicine

(2009) Lee Jia et al.   CURRENT MEDICINAL CHEMISTRY

Ginseng Compounds: An Update on their Molecular Mechanisms and Medical Applications

(2009) Jian-Ming Lu et al.   Current Vascular Pharmacology

A noble function of BAY 11-7082: Inhibition of platelet aggregation mediated by an elevated cAMP-induced VASP, and decreased ERK2/JNK1 phosphorylations

(2009) Hyun-Sub Lee et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Non-redundant Roles of Phosphoinositide 3-Kinase Isoforms α and β in Glycoprotein VI-induced Platelet Signaling and Thrombus Formation

(2009) Karen Gilio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Phosphoinositide 3-Kinase β in Glycoprotein VI-mediated Akt Activation in Platelets

(2009) Soochong Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphoinositide 3-Kinase p110β Regulates Integrin αIIbβ3Avidity and the Cellular Transmission of Contractile Forces

(2009) Simone M. Schoenwaelder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antiplatelet and anticoagulant effects of Panax notoginseng: Comparison of raw and steamed Panax notoginseng with Panax ginseng and Panax quinquefolium

(2009) Aik-Jiang Lau et al.   JOURNAL OF ETHNOPHARMACOLOGY

Non-genomic effects of PPARγ ligands: inhibition of GPVI-stimulated platelet activation

(2009) L. A. MORAES et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Ginsenoside Rp1, a Ginsenoside Derivative, Blocks Lipopolysaccharide-Induced Interleukin-1β Production via Suppression of the NF-κB Pathway

(2009) Byung Kim et al.   PLANTA MEDICA

Regulatory Role of Ginsenoside Rp1, a Novel Ginsenoside Derivative, on CD29-Mediated Cell Adhesion

(2009) Byung Kim et al.   PLANTA MEDICA

Cyclic nucleotides inhibit MAP kinase activity in low-dose collagen-stimulated platelets

(2009) Elke C.G. Jackson et al.   THROMBOSIS RESEARCH

Platelet-derived Growth Factor Expression and Function in Idiopathic Pulmonary Arterial Hypertension

(2008) Frédéric Perros et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cell Adhesion Mechanisms in Platelets

(2008) David Varga-Szabo et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Anti-metastatic Potential of Ginsenoside Rp1, a Novel Ginsenoside Derivative

(2008) Tae Yoon Park et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

A dual role for integrin-linked kinase in platelets: regulating integrin function and  -granule secretion

(2008) K. L. Tucker et al.   BLOOD

Future innovations in anti-platelet therapies

(2008) N E Barrett et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mitogen-activated protein kinases in hemostasis and thrombosis

(2008) F. ADAM et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Triggers, targets and treatments for thrombosis

(2008) Nigel Mackman   NATURE

Mechanisms of Thrombus Formation

(2008) Bruce Furie et al.   NEW ENGLAND JOURNAL OF MEDICINE

Korean red ginseng attenuates hypercholesterolemia-enhanced platelet aggregation through suppression of diacylglycerol liberation in high-cholesterol-diet-fed rabbits

(2008) Seock-Yeon Hwang et al.   PHYTOTHERAPY RESEARCH