Journal
BRITISH JOURNAL OF PHARMACOLOGY
Volume 167, Issue 2, Pages 238-255Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1476-5381.2012.02008.x
Keywords
ATP; adenosine; purinoceptors; pain; stroke; cancer
Categories
Ask authors/readers for more resources
There has been a remarkable growth of papers published about purinergic signalling via ATP since 1972. I am most grateful to the wonderful PhD students and postdoctoral fellows who have worked with me over the years to pursue the purinergic hypothesis despite early opposition and to the many outstanding scientists around the world who are currently extending the story. Recently, therapeutic approaches to pathological disorders include the development of selective P1 and P2 receptor subtype agonists and antagonists, as well as of inhibitors of extracellular ATP breakdown and of ATP transport enhancers and inhibitors. Medicinal chemists are starting to develop small molecule purinergic drugs that are orally bioavailable and stable in vivo.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available